盐酸曲马多联合黄体酮治疗急性肾绞痛效果研究
|
摘要
目的:观察肌肉注射盐酸曲马多联合肌肉注射黄体酮治疗急性肾绞痛的临床效果。方法:86例确诊为急性肾绞痛患者随机分为观察组和对照组,观察组(44例)给予肌肉注射盐酸曲马多100mg同时肌肉注射黄体酮40mg,对照组(42例)给予肌肉注射盐酸哌替啶100mg及硫酸阿托品0.5mg。给药前、后15min、30min、1h、4h对患者疼痛采用视觉模拟评分(VAS)评价其疗效,并观察其起效时间和不良反应。结果:观察组止痛总有效率为90.91%,对照组总有效率为90.48%,两组止痛疗效比较无统计学差异(P>0.05);两组药物起效时间比较无统计学差异(P>0.05)。给药后15min后至4h,观察组VAS评分均低于对照组(P<0.05);观察组患者发生眩晕、口干、尿潴留不良反应的比例明显低于对照组(P<0.05)。连续3d对观察组给予肌肉注射黄体酮40mg/QD后,12例患者出现排石,与对照组相比差别有显著性(P<0.05)。结论:肌肉注射盐酸曲马多联合肌肉注射黄体酮对急性肾绞痛有明显的镇痛作用,可作为治疗急性肾绞痛的急诊用药。
Objective: To explore the effect of intramuscular tramadol hydrochloride combined with progesterone on acute renal colic. Method: 86 cases of acute renal colic were randomly divided into observation group( 44 cases) and control group( 42 cases). The observation group was given 100 mg tramadol intravenous drip combined with 40 mg progesterone,the control group was given 100 mg meperidine hydrochloride injection with 0.5mg atropine sulfate. Visual analog scale( VAS) was used to record patients pain degree and analyze the onset time and adverse effects before and after drug delivery 15 min,30min,1h,4h respectively.Result: There were no significant differences on effective rate and drug onset time between the two groups( P>0.05). The VAS scores of observation group after drug delivery from 15 min to 4 hours were lower than the control group( P <0.05),rates of adverse drug reactions such as dizziness,xerostomia,uroschesis in observation group were lower than control group( P < 0. 05). Meanwhile,progesterone intramuscular injection were given to observe group with 30 mg / QD in three days,Kidney stones were excluded of 12 cases which showed significant difference with the control group. Conclusion: Intramuscular tramadol hydrochloride combined with progesterone on acute renal colic shows significant effect,which would be used as the emergency medicine on acute renal colic.
Objective: To explore the effect of intramuscular tramadol hydrochloride combined with progesterone on acute renal colic. Method: 86 cases of acute renal colic were randomly divided into observation group( 44 cases) and control group( 42 cases). The observation group was given 100 mg tramadol intravenous drip combined with 40 mg progesterone,the control group was given 100 mg meperidine hydrochloride injection with 0.5mg atropine sulfate. Visual analog scale( VAS) was used to record patients pain degree and analyze the onset time and adverse effects before and after drug delivery 15 min,30min,1h,4h respectively.Result: There were no significant differences on effective rate and drug onset time between the two groups( P>0.05). The VAS scores of observation group after drug delivery from 15 min to 4 hours were lower than the control group( P <0.05),rates of adverse drug reactions such as dizziness,xerostomia,uroschesis in observation group were lower than control group( P < 0. 05). Meanwhile,progesterone intramuscular injection were given to observe group with 30 mg / QD in three days,Kidney stones were excluded of 12 cases which showed significant difference with the control group. Conclusion: Intramuscular tramadol hydrochloride combined with progesterone on acute renal colic shows significant effect,which would be used as the emergency medicine on acute renal colic.
引文
[1]Sivrikaya A,Cel IL OF,Sivrikaya N,et al.The effect of diclofenac soditim and papaverine on isolated human ureteric smooth muscle[J].Int Urol Nephrol,2003,35(4):479~483.
[2]蔡桂青.吲哚美辛栓联合曲马多治疗中老年男性肾绞痛疗效观察[J].江苏医药,2012,38(22):2769.
[3]麦海棠.杜冷丁与盐酸曲马多治疗肾绞痛的疗效对比观察[J].国际医药卫生导报,2009,15(3):52~54.
[4]陶雪飞,秦伟毅,钱洪津,等.盐酸曲马多治疗胆绞痛给药途径不同的临床疗效比较[J].临床军医杂志,2012,40(5):1236~1237.
[5]Davenport K,Timoney AG,Keeley FX Jr.Effect of smooth musele relaxant drugs on proximal human uretoric activity in vivo:a Pilot study[J].Urol Res,2007,35:207~213.
[6]赵开亮,麦泉云,杨新疆,等.酮咯酸氨丁三醇与盐酸哌替啶在输尿管结石绞痛患者中的镇痛效果比较[J].广西医学,2011,3(7):938~939.
[7]李增平,范天祥,申向阳.硫酸镁治疗顽固性肾绞痛48例[J].河北医学,2006,10:1043~1044.
[8]张峰海,叶业兴,武卫.酮咯酸氨丁三醇治疗肾绞痛的疗效观察[J].临床医学,2008,28(6):50.
[9]杨丽.黄体酮治疗肾绞痛的临床应用[J].内蒙古中医药,2013,6:68~69.
[10]王玉清,崔可欣,万水,等.输尿管镜在输尿管结石合并顽固性肾绞痛治疗中的应用体会[J].临床和实验医学,2013,10:758~759.
[2]蔡桂青.吲哚美辛栓联合曲马多治疗中老年男性肾绞痛疗效观察[J].江苏医药,2012,38(22):2769.
[3]麦海棠.杜冷丁与盐酸曲马多治疗肾绞痛的疗效对比观察[J].国际医药卫生导报,2009,15(3):52~54.
[4]陶雪飞,秦伟毅,钱洪津,等.盐酸曲马多治疗胆绞痛给药途径不同的临床疗效比较[J].临床军医杂志,2012,40(5):1236~1237.
[5]Davenport K,Timoney AG,Keeley FX Jr.Effect of smooth musele relaxant drugs on proximal human uretoric activity in vivo:a Pilot study[J].Urol Res,2007,35:207~213.
[6]赵开亮,麦泉云,杨新疆,等.酮咯酸氨丁三醇与盐酸哌替啶在输尿管结石绞痛患者中的镇痛效果比较[J].广西医学,2011,3(7):938~939.
[7]李增平,范天祥,申向阳.硫酸镁治疗顽固性肾绞痛48例[J].河北医学,2006,10:1043~1044.
[8]张峰海,叶业兴,武卫.酮咯酸氨丁三醇治疗肾绞痛的疗效观察[J].临床医学,2008,28(6):50.
[9]杨丽.黄体酮治疗肾绞痛的临床应用[J].内蒙古中医药,2013,6:68~69.
[10]王玉清,崔可欣,万水,等.输尿管镜在输尿管结石合并顽固性肾绞痛治疗中的应用体会[J].临床和实验医学,2013,10:758~759.