苄星青霉素与普鲁卡因青霉素治疗妊娠梅毒的效果比较
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摘要
目的比较苄星青霉素与普鲁卡因青霉素治疗妊娠梅毒的效果。方法随机选取2012年5月至2017年5月榆林市第一医院诊治的60例妊娠梅毒患者作为研究对象,依据不同治疗方法将其分为苄星青霉素组和普鲁卡因青霉素组,每组30例患者。苄星青霉素组患者接受苄星青霉素治疗,普鲁卡因青霉素组患者接受普鲁卡因青霉素治疗,然后对两组患者的临床疗效、不良妊娠结局、正常出生、梅毒垂直传播有效阻断情况进行统计分析。结果两组患者治疗的总有效率分别为83.3%(25/30)、76.7%(23/30),其差异无统计学意义(P>0.05)。两组患者的不良妊娠结局发生率分别为26.7%(8/30)和26.7%(8/30),其差异无统计学意义(P>0.05)。两组患者的正常出生率、梅毒垂直传播有效阻断率分别为83.3%(25/30)、86.7%(26/30)和76.7%(23/30)、83.3%(25/30),其差异均无统计学意义(均P>0.05)。结论苄星青霉素与普鲁卡因青霉素治疗妊娠梅毒的效果相当。
Objective To compare the effects of benzyl penicillin and procaine penicillin in the treatment of pregnancy syphilis. Methods 60 pregnant women with pregnancy syphilis from May 2012 to May 2017 in Yulin First Hospital were randomly selected and divided into benzyl penicillin group(n=30) and procaine penicillin group(n=30) according to the treatment methods received The benzyl penicillin group was treated with benzyl penicillin, while the penicillin procaine group was treated with procaine penicillin. The clinical curative effects, incidence of adverse pregnancy outcomes and normal birth, effectively blocking vertical transmission of syphilis in the two groups were statistically analyzed. Results The total effective rate in the two groups was 83.3%(25/30) and 76.7%(23/30) respectively, without statistically significant differences(P>0.05). The incidence of adverse pregnancy outcomes in the two groups was 26.7%(8/30) and 26.7%(8/30) respectively, without statistically significant differences(P>0.05). The differences in the normal birth rates and effectively blocking rate of vertical transmission of syphilis between the two groups were not statistically significant [83.3%(25/30), 86.7%(26/30) vs 76.7%(23/30) and 83.3%(25/30)](all P>0.05). Conclusions Benzyl penicillin and procaine penicillin is of comparable effect in the treatment of pregnancy syphilis.
Objective To compare the effects of benzyl penicillin and procaine penicillin in the treatment of pregnancy syphilis. Methods 60 pregnant women with pregnancy syphilis from May 2012 to May 2017 in Yulin First Hospital were randomly selected and divided into benzyl penicillin group(n=30) and procaine penicillin group(n=30) according to the treatment methods received The benzyl penicillin group was treated with benzyl penicillin, while the penicillin procaine group was treated with procaine penicillin. The clinical curative effects, incidence of adverse pregnancy outcomes and normal birth, effectively blocking vertical transmission of syphilis in the two groups were statistically analyzed. Results The total effective rate in the two groups was 83.3%(25/30) and 76.7%(23/30) respectively, without statistically significant differences(P>0.05). The incidence of adverse pregnancy outcomes in the two groups was 26.7%(8/30) and 26.7%(8/30) respectively, without statistically significant differences(P>0.05). The differences in the normal birth rates and effectively blocking rate of vertical transmission of syphilis between the two groups were not statistically significant [83.3%(25/30), 86.7%(26/30) vs 76.7%(23/30) and 83.3%(25/30)](all P>0.05). Conclusions Benzyl penicillin and procaine penicillin is of comparable effect in the treatment of pregnancy syphilis.
引文
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[12] 马燕,陈亚群,金博弘,等.不同孕周开始治疗妊娠梅毒患者的妊娠结局对比研究[J].中国性科学,2017,26 (2):114-116.
[13] 卢永丽,袁勤.妊娠梅毒的孕期干预时机对妊娠结局的影响研究[J].中国性科学,2017,26(3):141-143.
[14] 毕云丽,张春华.不同孕期治疗对妊娠梅毒分娩的预后影响及安全性评价[J].中国性科学,2015,24(11):65-68.
[15] 戴红艳,王昊珏,徐燕,等.不同滴度的妊娠梅毒患者的治疗结局分析[J].中国性科学,2017,26(11):100-102.
[16] Kanyangarara M,Munos MK,Walker N.Quality of antenatal care service provision in health facilities across sub-Saharan Africa:Evidence from nationally representative health facility assessments[J].J Glob Health,2017,7(2):021101.
[17] Domingues RMSM,Leal MDC,Pereira APE,et al.Prevalence of syphilis and HIV infection during pregnancy in incarcerated women and the incidence of congenital syphilis in births in prison in Brazil[J].Cad Saude Publica,2017,33(11):e00183616.
[18] Maddox BLP,Wright SS,Namadingo H,et al.Assessing stakeholder perceptions of the acceptability and feasibility of national scale-up for a dual HIV/syphilis rapid diagnostic test in Malawi [J].Sex Transm Infect,2017,93(S4):S59-S64.
[2] 窦丽霞,王爱玲,王潇滟,等.妊娠合并梅毒孕妇的治疗及其不良妊娠结局的影响因素分析[J].中华妇产科杂志,2016,51(7):538-541.
[3] 叶兴东,伍军平,张金陶,等.驱梅干预对孕妇梅毒妊娠不良结局的影响及危险因素探讨[J].热带医学杂志,2017,17(11):1478-1482.
[4] 逯素艳.苄星青霉素联合头孢曲松治疗快速血浆反应素高滴度妊娠梅毒的临床疗效[J].中国保健营养,2017,27(14):121-122.
[5] 徐美凤,魏青,何婷,等.梅毒孕妇抗梅毒治疗时机对新生儿梅毒感染的影响研究[J].中华医院感染学杂志,2017,27(6):1387-1390.
[6] 张红燕,梅吉,徐玉娟,等.对行快速血浆反应素试验结果呈高滴度的妊娠梅毒患者联用两种药物进行治疗的效果观察[J].当代医药论丛,2017,15(10):75-76.
[7] 苏敏,梅吉,徐玉娟,等.浅析产前进行抗梅毒治疗对妊娠期梅毒患者妊娠结局的影响[J].当代医药论丛,2017,15(14):53-54.
[8] 梅吉,凌静,朱玉莲,等.苄星青霉素在不同孕周开始治疗妊娠梅毒对妊娠结局的影响[J].临床合理用药杂志,2018,11(1):109-110.
[9] 郑将跃,张群英,范垂前,等.早期先天性梅毒误诊一例[J].实用皮肤病学杂志,2014,7(2):142,144.
[10] 李素文,杨淑岭,孙丽娟,等.妊娠期梅毒治疗药物对妊娠结局和新生儿预后的影响研究[J].河北医药,2017,39(14):2124-2127.
[11] 彭石潜,张荣,黄志明,等.苄星青霉素和普鲁卡因青霉素治疗妊娠梅毒研究[J].岭南皮肤性病科杂志,2007,14(1):17-18.
[12] 马燕,陈亚群,金博弘,等.不同孕周开始治疗妊娠梅毒患者的妊娠结局对比研究[J].中国性科学,2017,26 (2):114-116.
[13] 卢永丽,袁勤.妊娠梅毒的孕期干预时机对妊娠结局的影响研究[J].中国性科学,2017,26(3):141-143.
[14] 毕云丽,张春华.不同孕期治疗对妊娠梅毒分娩的预后影响及安全性评价[J].中国性科学,2015,24(11):65-68.
[15] 戴红艳,王昊珏,徐燕,等.不同滴度的妊娠梅毒患者的治疗结局分析[J].中国性科学,2017,26(11):100-102.
[16] Kanyangarara M,Munos MK,Walker N.Quality of antenatal care service provision in health facilities across sub-Saharan Africa:Evidence from nationally representative health facility assessments[J].J Glob Health,2017,7(2):021101.
[17] Domingues RMSM,Leal MDC,Pereira APE,et al.Prevalence of syphilis and HIV infection during pregnancy in incarcerated women and the incidence of congenital syphilis in births in prison in Brazil[J].Cad Saude Publica,2017,33(11):e00183616.
[18] Maddox BLP,Wright SS,Namadingo H,et al.Assessing stakeholder perceptions of the acceptability and feasibility of national scale-up for a dual HIV/syphilis rapid diagnostic test in Malawi [J].Sex Transm Infect,2017,93(S4):S59-S64.