卵巢储备功能降低患者的药物辅助治疗研究进展
摘要
卵巢储备功能降低(diminished ovarian reserve,DOR)患者常常发生卵巢低反应,获卵数少,给患者和社会带来了极大的心理和经济负担。应用药物辅助治疗,改善卵巢反应性,提高卵子细胞质量是现今的研究热点之一。临床常用的药物有生长激素(growth hormone,GH)、脱氢表雄酮(dehydroepiandrosterone,DHEA)、辅酶Q10(coenzyme Q10,CoQ10)和褪黑素等,本文就DOR患者的辅助治疗研究进展做如下综述。
引文
[1]Chang Y,Li J,Li X,et al. Egg Quality and Pregnancy Outcome in Young Infertile Women with Diminished Ovarian Reserve[J]. Med Sci Monit,2018,24:7279-7284.
[2]Li X,Wang L,Lv F,et al. The influence of different growth hormone addition protocols to poor ovarian responders on clinical outcomes in controlled ovary stimulation cycles[J]. MEDICINE,2017,96(12):e6443.
[3]Dakhly D M R,Bassiouny Y A,Bayoumi Y A,et al. The addition of growth hormone adjuvant therapy to the long down regulation protocol in poor responders undergoing in vitro fertilization:Randomized control trial[J]. EUR J OBSTET GYN R B,2018,228:161-165.
[4]Schwarze J E,Canales J,Crosby J,et al. DHEA use to improve likelihood of IVF/ICSI success in patients with diminished ovarian reserve:A systematic review and meta-analysis[J]. JBRA Assist Reprod,2018,22(4):369-374.
[5]Lin L,Cheng J,Wang P,et al. Dehydroepiandrosterone as a potential agent to slow down ovarian aging[J]. J OBSTET GYNAECOL RE,2017,43(12):1855-1862.
[6]Mahmoud Y I,Mahmoud A A,Abo-Zeid F S,et al. Effects of dehydroepiandrosterone on the ovarian reserve and pregnancy outcomesinperimenopausalrats(DHEAandfertilityin perimenopausal rats)[J]. LIFE SCI,2018,199:131-138.
[7]Xu Y,Nisenblat V,Lu C,et al. Pretreatment with coenzyme Q10improves ovarian response and embryo quality in low-prognosis young women with decreased ovarian reserve:a randomized controlled trial[J]. REPROD BIOL ENDOCRIN,2018,16(1).
[8]Tamura H,Takasaki A,Miwa I,et al. Oxidative stress impairs oocyte quality and melatonin protects oocytes from freeradical damage and improves fertilization rate[J]. J PINEAL RES,2008,44(3):280-287.
[9]Karakas A,Kaya A,Gunduz B. The effect of pinealectomy,melatonin and leptin hormones on ovarian follicular development in female Syrian hamsters(Mesocricetus auratus)[J]. ACTA BIOL HUNG,2010,61(4):380-390.
[10] Eryilmaz O G,Devran A,Sarikaya E,et al. Melatonin improves the oocyte and the embryo in IVF patients with sleep disturbances,but does not improve the sleeping problems[J]. J ASSIST REPROD GEN,2011,28(9):815-820.
[11] Jahromi B N,Sadeghi S,Alipour S,et al. Effect of Melatonin on the Outcome of Assisted Reproductive Technique Cycles in Women with Diminished Ovarian Reserve:A Double-Blinded Randomized Clinical Trial[J]. Iran J Med Sci,2017,42(1):73-78.
[12] Song C,Peng W,Yin S,et al. Melatonin improves age-induced fertility decline and attenuates ovarian mitochondrial oxidative stress in mice[J]. SCI REP-UK,2016,6(1).
[13] Wurfel W. Treatment with granulocyte colony-stimulating factor in patients with repetitiveimplantation failures and/or recurrent spontaneous abortions[J]. J REPROD IMMUNOL,2015,108:123-135.
[14] Li C,Zhao Y,Hao H,et al. Resveratrol significantly improves the fertilisation capacity of bovine sex-sorted semen by inhibiting apoptosis and lipid peroxidation[J]. SCI REP-UK,2018,8(1).
[15] Kwak S S,Cheong S A,Jeon Y,et al. The effects of resveratrol on porcine oocyte in vitro maturation and subsequent embryonic development after parthenogenetic activation and in vitro fertilization[J]. THERIOGENOLOGY,2012,78(1):86-101.
[16] Keane K N,Hinchliffe P M,Rowlands P K,et al. DHEA Supplementation Confers No Additional Benefit to that of Growth Hormone on Pregnancy and Live Birth Rates in IVF Patients Categorized as Poor Prognosis[J]. FRONT ENDOCRINOL,2018,9.
[17] Gat I,Blanco Mejia S,Balakier H,et al. The use of coenzyme Q10 and DHEA during IUI and IVF cycles in patients with decreased ovarian reserve[J]. Gynecological endocrinology:the official journal of the International Society of Gynecological Endocrinology,2016,32(7):534-537.
[18] Teng B,Peng J,Ong M,et al. Successful Pregnancy after Treatment with Chinese Herbal Medicine in a 43-Year-Old Woman with Diminished Ovarian Reserve and Multiple Uterus Fibrosis:A Case Report[J]. Medicines(Basel),2017,4(1).
[19] Zhang C,Xu X. Advancement in the treatment of diminished ovarian reserve by traditional Chinese and Western medicine[J].EXP THER MED,2016,11(4):1173-1176.
[20] Wang Y,Li Y,Chen R,et al. Electroacupuncture for reproductive hormone levels in patients with diminished ovarian reserve:a prospective observational study[J]. ACUPUNCT MED,2016,34(5):386-391.
[2]Li X,Wang L,Lv F,et al. The influence of different growth hormone addition protocols to poor ovarian responders on clinical outcomes in controlled ovary stimulation cycles[J]. MEDICINE,2017,96(12):e6443.
[3]Dakhly D M R,Bassiouny Y A,Bayoumi Y A,et al. The addition of growth hormone adjuvant therapy to the long down regulation protocol in poor responders undergoing in vitro fertilization:Randomized control trial[J]. EUR J OBSTET GYN R B,2018,228:161-165.
[4]Schwarze J E,Canales J,Crosby J,et al. DHEA use to improve likelihood of IVF/ICSI success in patients with diminished ovarian reserve:A systematic review and meta-analysis[J]. JBRA Assist Reprod,2018,22(4):369-374.
[5]Lin L,Cheng J,Wang P,et al. Dehydroepiandrosterone as a potential agent to slow down ovarian aging[J]. J OBSTET GYNAECOL RE,2017,43(12):1855-1862.
[6]Mahmoud Y I,Mahmoud A A,Abo-Zeid F S,et al. Effects of dehydroepiandrosterone on the ovarian reserve and pregnancy outcomesinperimenopausalrats(DHEAandfertilityin perimenopausal rats)[J]. LIFE SCI,2018,199:131-138.
[7]Xu Y,Nisenblat V,Lu C,et al. Pretreatment with coenzyme Q10improves ovarian response and embryo quality in low-prognosis young women with decreased ovarian reserve:a randomized controlled trial[J]. REPROD BIOL ENDOCRIN,2018,16(1).
[8]Tamura H,Takasaki A,Miwa I,et al. Oxidative stress impairs oocyte quality and melatonin protects oocytes from freeradical damage and improves fertilization rate[J]. J PINEAL RES,2008,44(3):280-287.
[9]Karakas A,Kaya A,Gunduz B. The effect of pinealectomy,melatonin and leptin hormones on ovarian follicular development in female Syrian hamsters(Mesocricetus auratus)[J]. ACTA BIOL HUNG,2010,61(4):380-390.
[10] Eryilmaz O G,Devran A,Sarikaya E,et al. Melatonin improves the oocyte and the embryo in IVF patients with sleep disturbances,but does not improve the sleeping problems[J]. J ASSIST REPROD GEN,2011,28(9):815-820.
[11] Jahromi B N,Sadeghi S,Alipour S,et al. Effect of Melatonin on the Outcome of Assisted Reproductive Technique Cycles in Women with Diminished Ovarian Reserve:A Double-Blinded Randomized Clinical Trial[J]. Iran J Med Sci,2017,42(1):73-78.
[12] Song C,Peng W,Yin S,et al. Melatonin improves age-induced fertility decline and attenuates ovarian mitochondrial oxidative stress in mice[J]. SCI REP-UK,2016,6(1).
[13] Wurfel W. Treatment with granulocyte colony-stimulating factor in patients with repetitiveimplantation failures and/or recurrent spontaneous abortions[J]. J REPROD IMMUNOL,2015,108:123-135.
[14] Li C,Zhao Y,Hao H,et al. Resveratrol significantly improves the fertilisation capacity of bovine sex-sorted semen by inhibiting apoptosis and lipid peroxidation[J]. SCI REP-UK,2018,8(1).
[15] Kwak S S,Cheong S A,Jeon Y,et al. The effects of resveratrol on porcine oocyte in vitro maturation and subsequent embryonic development after parthenogenetic activation and in vitro fertilization[J]. THERIOGENOLOGY,2012,78(1):86-101.
[16] Keane K N,Hinchliffe P M,Rowlands P K,et al. DHEA Supplementation Confers No Additional Benefit to that of Growth Hormone on Pregnancy and Live Birth Rates in IVF Patients Categorized as Poor Prognosis[J]. FRONT ENDOCRINOL,2018,9.
[17] Gat I,Blanco Mejia S,Balakier H,et al. The use of coenzyme Q10 and DHEA during IUI and IVF cycles in patients with decreased ovarian reserve[J]. Gynecological endocrinology:the official journal of the International Society of Gynecological Endocrinology,2016,32(7):534-537.
[18] Teng B,Peng J,Ong M,et al. Successful Pregnancy after Treatment with Chinese Herbal Medicine in a 43-Year-Old Woman with Diminished Ovarian Reserve and Multiple Uterus Fibrosis:A Case Report[J]. Medicines(Basel),2017,4(1).
[19] Zhang C,Xu X. Advancement in the treatment of diminished ovarian reserve by traditional Chinese and Western medicine[J].EXP THER MED,2016,11(4):1173-1176.
[20] Wang Y,Li Y,Chen R,et al. Electroacupuncture for reproductive hormone levels in patients with diminished ovarian reserve:a prospective observational study[J]. ACUPUNCT MED,2016,34(5):386-391.