标准四联疗法与序贯疗法在胃溃疡幽门螺杆菌阳性患者中的应用评价
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摘要
目的分析标准四联疗法与序贯疗法在胃溃疡幽门螺杆菌(Hp)阳性患者中的应用效果。方法 71例胃溃疡Hp阳性患者,采用随机数字表法分为试验组(35例,采用序贯疗法治疗)和对照组(36例,采用标准四联疗法治疗)。比较两组患者的临床疗效及Hp清除率。结果试验组患者治疗总有效率为97.14%,显著高于对照组的72.22%,差异有统计学意义(P<0.05)。试验组34例患者Hp清除, Hp清除率为97.14%(34/35);对照组25例患者Hp清除, Hp清除率为69.44%(25/36);试验组Hp清除率显著高于对照组,差异有统计学意义(P<0.05)。结论序贯疗法可有效改善胃溃疡Hp阳性患者病情,提高Hp清除率,促进胃溃疡愈合,效果显著,值得借鉴。
Objective To analyze the effect of standard quadruple therapy and sequential therapy in Helicobacter pylori(Hp) positive patients with gastric ulcer. Methods A total of 71 Hp positive patients with gastric ulcer were divided by random number table into experimental group(35 cases, receiving sequential therapy) and control group(36 cases, receiving standard quadruple therapy). The clinical efficacy and Hp clearance rate between the two groups was compared. Results The experimental group had significantly higher total treatment effective rate as 97.14% than 72.22% in the control group, and the difference was statistically significant(P<0.05). The experimental group had 34 cases with Hp clearance, with Hp clearance rate as 97.14%(34/35), while the control group had 25 cases with Hp clearance, with Hp clearance rate as 69.44%(25/36). The experimental group had significantly higher Hp clearance rate than the control group, and the difference was statistically significant(P<0.05). Conclusion Sequential therapy shows remarkable effect, and it can effectively improve condition of patients with Hp positive gastric ulcer, improve Hp clearance rate, and promote the healing of gastric ulcer. It is worth reference.
Objective To analyze the effect of standard quadruple therapy and sequential therapy in Helicobacter pylori(Hp) positive patients with gastric ulcer. Methods A total of 71 Hp positive patients with gastric ulcer were divided by random number table into experimental group(35 cases, receiving sequential therapy) and control group(36 cases, receiving standard quadruple therapy). The clinical efficacy and Hp clearance rate between the two groups was compared. Results The experimental group had significantly higher total treatment effective rate as 97.14% than 72.22% in the control group, and the difference was statistically significant(P<0.05). The experimental group had 34 cases with Hp clearance, with Hp clearance rate as 97.14%(34/35), while the control group had 25 cases with Hp clearance, with Hp clearance rate as 69.44%(25/36). The experimental group had significantly higher Hp clearance rate than the control group, and the difference was statistically significant(P<0.05). Conclusion Sequential therapy shows remarkable effect, and it can effectively improve condition of patients with Hp positive gastric ulcer, improve Hp clearance rate, and promote the healing of gastric ulcer. It is worth reference.
引文
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[4]杨智超,史晓筠,孙晓丹.四联疗法在胃溃疡幽门螺旋杆菌阳性患者中的应用效果探讨.社区医学杂志, 2017, 15(12):29-30.
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[7]高花.四联疗法和序贯疗法治疗幽门螺杆菌(HP)感染所致胃溃疡的临床效果.医药卫生(文摘版), 2016, 9(5):00268.
[8]陈平,江明万,于双,等.标准四联疗法及序贯疗法治疗胃溃疡幽门螺杆菌阳性患者疗效分析.胃肠病学和肝病学杂志,2015. 24(4):402-405.
[2]徐欣昌,田晓云.消化系统疾病.北京:人民卫生出版社,2015:52.
[3]冯朝晖.序贯疗法与常规四联疗法在幽门螺杆菌阳性胃溃疡患者的疗效比较.中国医师杂志, 2016, 18(2):275-276.
[4]杨智超,史晓筠,孙晓丹.四联疗法在胃溃疡幽门螺旋杆菌阳性患者中的应用效果探讨.社区医学杂志, 2017, 15(12):29-30.
[5]李文金,段国安.标准四联疗法及序贯疗法治疗胃溃疡幽门螺杆菌阳性患者疗效分析.临床医药文献电子杂志, 2018, 5(7):34.
[6]马健.标准四联疗法及序贯疗法治疗胃溃疡幽门螺杆菌阳性患者的疗效分析.中国药物经济学, 2017, 12(10);85-87.
[7]高花.四联疗法和序贯疗法治疗幽门螺杆菌(HP)感染所致胃溃疡的临床效果.医药卫生(文摘版), 2016, 9(5):00268.
[8]陈平,江明万,于双,等.标准四联疗法及序贯疗法治疗胃溃疡幽门螺杆菌阳性患者疗效分析.胃肠病学和肝病学杂志,2015. 24(4):402-405.