序贯疗法与三联疗法治疗幽门螺杆菌阳性胃溃疡观察
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摘要
目的探讨序贯疗法与标准三联疗法治疗幽门螺杆菌阳性胃溃疡的临床效果。方法选取我院2015年1月—2017年1月收治的幽门螺杆菌阳性胃溃疡患者98例为研究对象,随机分为两组,观察组(n=49)给予序贯疗法治疗,对照组(n=49)给予标准三联疗法治疗,对比两组患者临床疗效和胃溃疡愈合情况以及不良反应发生率。结果两组患者临床疗效(95.92%/83.67%)对比差异具有统计学意义(P <0.05)。两组患者胃溃疡愈合率(93.88%/75.51%)对比差异具有统计学意义(P<0.05)。两组患者不良反应发生率(10.20%/12.24%)对比差异无统计学意义(P> 0.05)。结论序贯疗法治疗幽门螺杆菌阳性胃溃疡效果优于标准三联法,能有效清除幽门螺杆菌,促进胃溃疡愈合,安全性高。
Objective To compare the clinical effects of sequential therapy and standard triple therapy in the treatment of helicobacter pylori positive gastric ulcer. Methods From January 2015 to January 2017, 98 patients with helicobacter pylori-positive gastric ulcer were randomly divided into two groups. The observation group(n=49) was treated with sequential therapy, and the control group(n=49) was treated with standard triple therapy. The clinical efficacy, gastric ulcer healing and the incidence of adverse reactions were compared between the two groups. Results The clinical efficacy of the two groups(95.92%/83.67%) was compared, the difference was statistically significant(P < 0.05). The healing rate of gastric ulcer in the two groups(93.88%/75.51%) was compared, the difference was statistically significant(P < 0.05). The incidence of adverse reactions(10.20%/12.24%) was compared between the two groups, there was no significant difference(P > 0.05). Conclusion Sequential therapy is better than standard triple therapy in the treatment of helicobacter pylori positive gastric ulcer. It can effectively eliminate helicobacter pylori and promote the healing of gastric ulcer.
Objective To compare the clinical effects of sequential therapy and standard triple therapy in the treatment of helicobacter pylori positive gastric ulcer. Methods From January 2015 to January 2017, 98 patients with helicobacter pylori-positive gastric ulcer were randomly divided into two groups. The observation group(n=49) was treated with sequential therapy, and the control group(n=49) was treated with standard triple therapy. The clinical efficacy, gastric ulcer healing and the incidence of adverse reactions were compared between the two groups. Results The clinical efficacy of the two groups(95.92%/83.67%) was compared, the difference was statistically significant(P < 0.05). The healing rate of gastric ulcer in the two groups(93.88%/75.51%) was compared, the difference was statistically significant(P < 0.05). The incidence of adverse reactions(10.20%/12.24%) was compared between the two groups, there was no significant difference(P > 0.05). Conclusion Sequential therapy is better than standard triple therapy in the treatment of helicobacter pylori positive gastric ulcer. It can effectively eliminate helicobacter pylori and promote the healing of gastric ulcer.
引文
[1]歧红阳.序贯疗法与三联疗法治疗幽门螺杆菌感染的效果研究[J].北方药学,2018,15(8):90-91.
[2]郁燕.标准四联疗法及序贯疗法治疗Hp阳性消化性溃疡的效果分析[J].中外医疗,2018,37(14):112-114.
[3]向仍运,李凯,欧廷宏.幽门螺杆菌感染的各种治疗方案对幽门螺杆菌根除率的对比分析[J].实用医院临床杂志,2018,15(3):159-161.
[4]欧廷宏,向平,周卫华.幽门螺杆菌感染现状及临床治疗研究进展[J].中国当代医药,2018,25(5):28-31.
[5]陈侃.雷贝拉唑三联不同疗法对幽门螺杆菌致消化性溃疡患者的疗效及其对胃泌素水平的影响[J].抗感染药学,2017,14(8):1630-1633.
[6]顾维凤,顾卓珺.奥美拉唑三联疗法与序贯疗法治疗老年幽门螺杆菌感染消化性溃疡患者成本-效果比较[J].世界华人消化杂志,2018,26(1):47-52.
[7]唐耀华.序贯疗法治疗幽门螺旋杆菌(HP)感染性胃溃疡的临床疗效及其安全性[J].药品评价,2017,14(24):55-57.
[8]龙绍明,赵晓亮.雷贝拉唑联合抗生素序贯疗法治疗Hp阳性消化性溃疡的临床效果[J].中外医学研究,2017,15(35):187-188.
[9]洪宇,吴洁琼,李熠雯.左氟沙星与阿莫西林序贯疗法对消化道溃疡患者抗幽门螺旋杆菌感染的临床疗效评价[J].抗感染药学,2017,14(7):1352-1355.
[10]刘鹏,胡阳黔,何旭东,等.序贯与标准的三联疗法对幽门螺杆菌阳性的消化性溃疡治疗效果的分析[J].临床消化病杂志,2017,29(5):287-290.
[11]李欣,马艳,陈小玉.新序贯疗法治疗难治性Hp感染的效果分析[J].湖南师范大学学报(医学版),2017,14(4):123-126.
[12]杨景福.清胃汤剂联合西药三联治疗耐药幽门螺杆菌感染相关胃病[J].中国卫生标准管理,2018,9(1):94-95.
[13]曾豪杰.三联疗法与序贯疗法治疗幽门螺杆菌阳性胃溃疡的疗效对比[J].现代消化及介入诊疗,2017,22(4):541-543.
[2]郁燕.标准四联疗法及序贯疗法治疗Hp阳性消化性溃疡的效果分析[J].中外医疗,2018,37(14):112-114.
[3]向仍运,李凯,欧廷宏.幽门螺杆菌感染的各种治疗方案对幽门螺杆菌根除率的对比分析[J].实用医院临床杂志,2018,15(3):159-161.
[4]欧廷宏,向平,周卫华.幽门螺杆菌感染现状及临床治疗研究进展[J].中国当代医药,2018,25(5):28-31.
[5]陈侃.雷贝拉唑三联不同疗法对幽门螺杆菌致消化性溃疡患者的疗效及其对胃泌素水平的影响[J].抗感染药学,2017,14(8):1630-1633.
[6]顾维凤,顾卓珺.奥美拉唑三联疗法与序贯疗法治疗老年幽门螺杆菌感染消化性溃疡患者成本-效果比较[J].世界华人消化杂志,2018,26(1):47-52.
[7]唐耀华.序贯疗法治疗幽门螺旋杆菌(HP)感染性胃溃疡的临床疗效及其安全性[J].药品评价,2017,14(24):55-57.
[8]龙绍明,赵晓亮.雷贝拉唑联合抗生素序贯疗法治疗Hp阳性消化性溃疡的临床效果[J].中外医学研究,2017,15(35):187-188.
[9]洪宇,吴洁琼,李熠雯.左氟沙星与阿莫西林序贯疗法对消化道溃疡患者抗幽门螺旋杆菌感染的临床疗效评价[J].抗感染药学,2017,14(7):1352-1355.
[10]刘鹏,胡阳黔,何旭东,等.序贯与标准的三联疗法对幽门螺杆菌阳性的消化性溃疡治疗效果的分析[J].临床消化病杂志,2017,29(5):287-290.
[11]李欣,马艳,陈小玉.新序贯疗法治疗难治性Hp感染的效果分析[J].湖南师范大学学报(医学版),2017,14(4):123-126.
[12]杨景福.清胃汤剂联合西药三联治疗耐药幽门螺杆菌感染相关胃病[J].中国卫生标准管理,2018,9(1):94-95.
[13]曾豪杰.三联疗法与序贯疗法治疗幽门螺杆菌阳性胃溃疡的疗效对比[J].现代消化及介入诊疗,2017,22(4):541-543.