除草剂阿特拉津对大鼠神经内分泌功能的影响
摘要
<正>阿特拉津(atrazine,ATR)又名莠去津,化学名:2-氯-4-二乙胺基-6-异丙胺基-1,3,5-三嗪,是一种低毒性农用除草剂,广泛应用于玉米、高粱、甘蔗、小麦等农作物种植~([1-3])。由于良好的水溶性、土壤流动性以及较长的半衰期,ATR常常导致地表饮用水源污染并超出美国环保局(EPA)设定的最大污染限制(3/109 ppb)~([4,5])。欧盟于2003年全面禁用ATR~([6]),但在美国中西部及我国部分地区ATR仍
引文
[1]Barr DB,Needham LL.Assessing Exposure to Atrazine and Its Metabolites Using Biomonitoring[J].Environmental Health Perspectives,2007,115(10):1474.
[2]Eldridge JC,Stevens JT,Breckenridge CB.Atrazine Interaction with Estrogen Expression Systems,2008.
[3]Solomon K,Carr JP,Lh,Giesy J,et al.Effects of atrazine on fish,amphibians,and aquatic reptiles:a critical review[J].Critical Reviews in Toxicology,2008,38(9):721.
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[6]Bethsass J,Colangelo A.European Union Bans Atrazine,While the United States Negotiates Continued Use[J].International Journal of Occupational&Environmental Health,2016,12(3):260.
[7]Swedenborg E,Rüegg J,MkelS,et al.Endocrine disruptive chemicals:mechanisms of action and involvement in metabolic disorders[J].Journal of Molecular Endocrinology,2009,43(1):1.
[8]Wetzel LT,Luempert LG,Breckenridge CB,et al.Chronic effects of atrazine on estrus and mammary tumor formation in female Sprague-Dawley and Fischer 344 rats[J].J Toxicol Environ Health,1994,43(2):169.
[9]Birnbaum LS,Fenton SE.Cancer and developmental exposure to endocrine disruptors[J].Environmental Health Perspectives,2003,111(4):389.
[10]Ma Y,Zhang P,Wang F,et al.The relationship between early embryo development and tumourigenesis[J].Journal of Cellular&Molecular Medicine,2010,14(12):2697.
[11]Prins GS,Birch L,Tang WY,et al.Developmental estrogen exposures predispose to prostate carcinogenesis with aging[J].Reproductive Toxicology,2007,23(3):374.
[12]Cocco P.On the rumors about the silent spring:review of the scientific evidence linking occupational and environmental pesticide exposure to endocrine disruption health effects Rumores de uma primavera silenciosa:uma revis2o das evidências científicas sobrea[J].Cadernos De Saúde Pública,2002,18(2):379.
[13]Mnif W,Pillon A,Balaguer P,et al.Endocrine xenoestrogenics disrupters:molecular mechanisms and detection methods[J].Therapie,2007,62(5):369.
[14]Goldman L,Falk H,Landrigan PJ,et al.Environmental pediatrics and its impact on government health policy[J].Pediatrics,2004,113(Suppl 4):1146.
[15]Sharpe RM.Pathways of endocrine disruption during male sexual differentiation and masculinisation[J].Best Pract Res Clin Endocrinol Metab,2006,20(1):91.
[16]Pakkenberg B,Mller A,Gundersen HJ,et al.The absolute number of nerve cells in substantia nigra in normal subjects and in patients with Parkinson's disease estimated with an unbiased stereological method[J].Journal of Neurology Neurosurgery&Psychiatry,1991,54(1):30.
[17]张宁,侯钢,方群.抑郁症的神经内分泌学初步研究[J].临床精神医学杂志,2002,12(4):208.
[18]孟瑶,陈莅蓉,周仁来.皮质醇分泌缓解负性情绪的证据及其机制[J].中国临床心理学杂志,2019,1:28.
[19]Vandenberg LN,Colborn T,Hayes TB,et al.Hormones and endocrine-disrupting chemicals:low-dose effects and nonmonotonic dose responses[J].Endocrine reviews,2012,33(3):378.
[2]Eldridge JC,Stevens JT,Breckenridge CB.Atrazine Interaction with Estrogen Expression Systems,2008.
[3]Solomon K,Carr JP,Lh,Giesy J,et al.Effects of atrazine on fish,amphibians,and aquatic reptiles:a critical review[J].Critical Reviews in Toxicology,2008,38(9):721.
[4]Fraites MJP,Cooper RL,Buckalew A,et al.Characterization of the Hypothalamic-Pituitary-Adrenal Axis Response to Atrazine and Metabolites in the Female Rat[J].Toxicological Sciences,2009,112(1):88.
[5]Rohr JR,Mccoy KA.A Qualitative Meta-Analysis Reveals Consistent Effects of Atrazine on Freshwater Fish and Amphibians[J].Environmental Health Perspectives,2010,118(1):20.
[6]Bethsass J,Colangelo A.European Union Bans Atrazine,While the United States Negotiates Continued Use[J].International Journal of Occupational&Environmental Health,2016,12(3):260.
[7]Swedenborg E,Rüegg J,MkelS,et al.Endocrine disruptive chemicals:mechanisms of action and involvement in metabolic disorders[J].Journal of Molecular Endocrinology,2009,43(1):1.
[8]Wetzel LT,Luempert LG,Breckenridge CB,et al.Chronic effects of atrazine on estrus and mammary tumor formation in female Sprague-Dawley and Fischer 344 rats[J].J Toxicol Environ Health,1994,43(2):169.
[9]Birnbaum LS,Fenton SE.Cancer and developmental exposure to endocrine disruptors[J].Environmental Health Perspectives,2003,111(4):389.
[10]Ma Y,Zhang P,Wang F,et al.The relationship between early embryo development and tumourigenesis[J].Journal of Cellular&Molecular Medicine,2010,14(12):2697.
[11]Prins GS,Birch L,Tang WY,et al.Developmental estrogen exposures predispose to prostate carcinogenesis with aging[J].Reproductive Toxicology,2007,23(3):374.
[12]Cocco P.On the rumors about the silent spring:review of the scientific evidence linking occupational and environmental pesticide exposure to endocrine disruption health effects Rumores de uma primavera silenciosa:uma revis2o das evidências científicas sobrea[J].Cadernos De Saúde Pública,2002,18(2):379.
[13]Mnif W,Pillon A,Balaguer P,et al.Endocrine xenoestrogenics disrupters:molecular mechanisms and detection methods[J].Therapie,2007,62(5):369.
[14]Goldman L,Falk H,Landrigan PJ,et al.Environmental pediatrics and its impact on government health policy[J].Pediatrics,2004,113(Suppl 4):1146.
[15]Sharpe RM.Pathways of endocrine disruption during male sexual differentiation and masculinisation[J].Best Pract Res Clin Endocrinol Metab,2006,20(1):91.
[16]Pakkenberg B,Mller A,Gundersen HJ,et al.The absolute number of nerve cells in substantia nigra in normal subjects and in patients with Parkinson's disease estimated with an unbiased stereological method[J].Journal of Neurology Neurosurgery&Psychiatry,1991,54(1):30.
[17]张宁,侯钢,方群.抑郁症的神经内分泌学初步研究[J].临床精神医学杂志,2002,12(4):208.
[18]孟瑶,陈莅蓉,周仁来.皮质醇分泌缓解负性情绪的证据及其机制[J].中国临床心理学杂志,2019,1:28.
[19]Vandenberg LN,Colborn T,Hayes TB,et al.Hormones and endocrine-disrupting chemicals:low-dose effects and nonmonotonic dose responses[J].Endocrine reviews,2012,33(3):378.