酒精性肝硬化患者CPTⅠα表达水平及其临床意义
摘要
目的观察酒精性肝硬化患者的肉碱转移酶Ⅰα(CPTⅠα)表达水平,并分析其临床意义。方法选取2017年3月-2018年3月在我院接受治疗的酒精性肝硬化患者为研究对象,同时选取同期在我院接受体检的健康成年人作为对照,观察两组研究对象CPTⅠα表达水平、肝功能指标和细胞因子水平的差异,分析酒精性肝硬化患者的CPTⅠα表达水平与肝功能指标和细胞因子水平的相关性。结果酒精性肝硬化患者的CPTⅠα表达水平和胃泌素-17(G-17)水平高于对照组(t=-33.031、-18.786,P<0.001);酒精性肝硬化患者的谷丙转氨酶(ALT)、天门冬氨酸氨基转移酶(AST)、直接胆红素(DBil)、总胆红素(TBil)和白蛋白(Alb)水平高于对照组(t=-31.460、-15.451、-21.106、-12.646、15.799,P<0.001);酒精性肝硬化患者的IL-10、IL-6、IL-12水平均高于对照组(t=-28.845、-49.270、-29.824,P<0.001);酒精性肝硬化患者的CPTⅠα表达水平与ALT、AST、DBil、TBil、Alb、IL-10、IL-6、IL-12水平正相关。结论酒精性肝硬化患者的CPTⅠα表达水平较高,且与肝功能和炎性因子水平密切相关,可作为临床监测酒精性肝硬化的重要指标。
引文
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[ 4 ] 吴安燕,邓世康,杨晋辉. 1545例肝硬化患者病因分析. 云南医药,2017,38:109-111.
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[ 8 ] Jiménez-Romero C. Incidence, risk factors and outcome ofde novo tumors in liver transplant recipients focusing on alcoholic cirrhosis. World J Hepatol,2015,7:942-944.
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[10] 何小谷,方向明,陈时,等. 肝炎后肝硬化和酒精性肝硬化患者临床特点分析. 中国综合临床,2015,31:60-62.
[ 2 ] 朱冰,刘鸿凌,刘利敏,等. 4132例酒精性肝病临床特征分析. 中华肝脏病杂志,2015,23:680-683.
[ 3 ] 尚华,张国顺,孟冬梅,等. 乙型肝炎病毒感染合并酒精性肝病的失代偿期肝硬化患者并发肝衰竭的危险因素分析. 中国综合临床,2016,33:504-507.
[ 4 ] 吴安燕,邓世康,杨晋辉. 1545例肝硬化患者病因分析. 云南医药,2017,38:109-111.
[ 5 ] Benjamin J, Shasthry V, Kaal CR, et al. Characterization of body composition and definition of sarcopenia in patients with alcoholic cirrhosis: A computed tomography based study. Liver Int,2017,37:1668-1674.
[ 6 ] 高潇雪,刘立新. 1991至2015年国内外肝硬化患者中酒精病因构成比变化特点Meta分析. 中华消化病与影像杂志(电子版),2016,6:261-266.
[ 7 ] Mellinger J L, Shedden K, Winder GS, et al. The high burden of alcoholic cirrhosis in privately insured persons in the United States. Hepatology,2018,26:67-69.
[ 8 ] Jiménez-Romero C. Incidence, risk factors and outcome ofde novo tumors in liver transplant recipients focusing on alcoholic cirrhosis. World J Hepatol,2015,7:942-944.
[ 9 ] Jeong JH, Park IS, Kim DH, et al. CLIF–SOFA score and SIRS are independent prognostic factors in patients with hepatic encephalopathy due to alcoholic liver cirrhosis. Medicine,2016,95:3935-3937.
[10] 何小谷,方向明,陈时,等. 肝炎后肝硬化和酒精性肝硬化患者临床特点分析. 中国综合临床,2015,31:60-62.