葡萄糖酸氯己定含漱液过敏一例并文献复习
摘要
<正>葡萄糖酸氯已定含漱液为无色澄明、有香味的液体,作为口腔科常用药物,临床上用于牙龈炎[1]、口腔黏膜炎、冠周炎局部冲洗[2]及口腔内术后控制口腔感染[3]。国内对于其过敏反应罕有报道,本文报告1例在应用葡萄糖酸氯已定含漱液后出现局部过敏反应患者的临床症状、处理方法及过程,并查阅相关文献进行总结,为临床安全应用葡萄糖酸氯已定含漱液提供
引文
[1]杨适宜.复方氯已定含漱液治疗牙周病的疗效评价[J].中国城乡企业卫生,2018,33(10):19-20.
[2]朱雅琦.复方氯己定含漱液治疗孕妇下颌智齿冠周炎的疗效观察[J].全科口腔医学电子杂志,2017,4(16):29-30.
[3]纪张磊,宋毅果,许广杰.复方氯己定含漱液在颌骨骨折患者口腔护理中的应用探讨[J].全科口腔医学电子杂志,2016,3(12):38-39.
[4]于林祥,张国.葡萄糖酸氯已定含漱液对口腔黏膜刺激性的研究察[J].吉林医学,2012,33(7):1422-1423.
[5]陈立.葡萄糖酸氯己定含漱液的制备、含量测定及效期观察[J].海峡药学,2016,28(5):14-15.
[6]LIU JX,WERNER J,KIRSCH T.Cytotoxicity evaluation of chlorhexidine gluconate on human fibroblasts,myoblasts,and osteoblasts[J].JBone Jt Infect,2018,10,3(4):165-172.
[7]Takenaka S,Ohsumi T,Noiri Y.Evidence-based strategy for dental biofilms:Current evidence of mouthwashes on dental biofilm and gingivitis[J].Jpn Dent Sci Rev,2019,55(1):33-40.
[8]OKANO M,NOMURA M,HATA S,et al.Anaphylactic symptoms due to chlorhexidine gluconate[J].Arch Dermatol,1989,125:50-52.
[9]MOGHADAM BK,DRISKO CL,GIER RE.Chlorhexidine mouthwash-induced fixed drug eruption:Case report and review of the literature[J].Oral Surg Oral Med Oral Pathol,1991,1(4):431-434.
[10]KOW RY,LOW CL,RUBEN JK,Zaharul-Azri MZ,et al.Life-threatening Chlorhexidine Anaphylaxis:A Case Report[J].Malays Orthop J,2017,11(2):72-74.
[11]EGNER W,HELBERT M,SARGUR R,et al.Chlorhexidine allergy in four specialist allergy centres in the United Kingdom,2009-13:clinical features and diagnostic tests[J].Clin Exp Immunol,2017,188(3):380-386.
[12]PEMBERTON MN,GIBSON J.Chlorhexidine and hypersensitivity reactions in dentistry[J].Br Dent J,2012,213(11):547-550.
[13]GU JQ,LIU S,ZHI YX.Provocation Test-Confirmed Chlorhexidine-Induced Anaphylaxis in Dental Procedure[J].Chin Med J.2018,131:2893-2894.
[14]KENI NN,ARAS MA,CHITRE V.Chlorhexidine allergy due to topical application[J].Indian J Dent Res,2012,23(5):674-676.
[15]FDA Drug Safety Communications:FDA warns about rare but serious allergic reactions with the skin antiseptic chlorhexidine gluconate.2017,https://www.fda.gov/Drugs/DrugSafety/ucm530975.htm
[2]朱雅琦.复方氯己定含漱液治疗孕妇下颌智齿冠周炎的疗效观察[J].全科口腔医学电子杂志,2017,4(16):29-30.
[3]纪张磊,宋毅果,许广杰.复方氯己定含漱液在颌骨骨折患者口腔护理中的应用探讨[J].全科口腔医学电子杂志,2016,3(12):38-39.
[4]于林祥,张国.葡萄糖酸氯已定含漱液对口腔黏膜刺激性的研究察[J].吉林医学,2012,33(7):1422-1423.
[5]陈立.葡萄糖酸氯己定含漱液的制备、含量测定及效期观察[J].海峡药学,2016,28(5):14-15.
[6]LIU JX,WERNER J,KIRSCH T.Cytotoxicity evaluation of chlorhexidine gluconate on human fibroblasts,myoblasts,and osteoblasts[J].JBone Jt Infect,2018,10,3(4):165-172.
[7]Takenaka S,Ohsumi T,Noiri Y.Evidence-based strategy for dental biofilms:Current evidence of mouthwashes on dental biofilm and gingivitis[J].Jpn Dent Sci Rev,2019,55(1):33-40.
[8]OKANO M,NOMURA M,HATA S,et al.Anaphylactic symptoms due to chlorhexidine gluconate[J].Arch Dermatol,1989,125:50-52.
[9]MOGHADAM BK,DRISKO CL,GIER RE.Chlorhexidine mouthwash-induced fixed drug eruption:Case report and review of the literature[J].Oral Surg Oral Med Oral Pathol,1991,1(4):431-434.
[10]KOW RY,LOW CL,RUBEN JK,Zaharul-Azri MZ,et al.Life-threatening Chlorhexidine Anaphylaxis:A Case Report[J].Malays Orthop J,2017,11(2):72-74.
[11]EGNER W,HELBERT M,SARGUR R,et al.Chlorhexidine allergy in four specialist allergy centres in the United Kingdom,2009-13:clinical features and diagnostic tests[J].Clin Exp Immunol,2017,188(3):380-386.
[12]PEMBERTON MN,GIBSON J.Chlorhexidine and hypersensitivity reactions in dentistry[J].Br Dent J,2012,213(11):547-550.
[13]GU JQ,LIU S,ZHI YX.Provocation Test-Confirmed Chlorhexidine-Induced Anaphylaxis in Dental Procedure[J].Chin Med J.2018,131:2893-2894.
[14]KENI NN,ARAS MA,CHITRE V.Chlorhexidine allergy due to topical application[J].Indian J Dent Res,2012,23(5):674-676.
[15]FDA Drug Safety Communications:FDA warns about rare but serious allergic reactions with the skin antiseptic chlorhexidine gluconate.2017,https://www.fda.gov/Drugs/DrugSafety/ucm530975.htm