青年女性分泌性乳腺癌1例并文献复习
摘要
目的:探讨青年女性分泌性乳腺癌临床病理特征、诊断、治疗及预后。方法:对1例25岁女性乳腺分泌性癌病人临床症状、体征及辅助检查进行判断,手术方式、术后病理免疫组织化学染色及术后是否行放化疗进行分析,并复习相关文献。结果:病人术前彩超提示双侧乳腺囊性增生、右乳低回声结节。术后病理提示右侧乳腺腺病伴小区导管扩张,局部导管上皮增生伴实性、微囊性生长。免疫组织化学:雌激素受体-、孕激素受体-、Cerb B-2-、S-100+、CK5/6部分+、CD10局灶+、Calponin-、P63-、Action-、Ki-67+,5%。结论:分泌性乳腺癌较少见,免疫表型将其归为三阴性乳腺癌类型中,诊断需结合术后组织学病理及免疫组织化学。
引文
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[9]MUN SH,KO EY,HAN BK,et al.Secretory carcinoma of the breast:sonographic features[J].J Ultrasound Med,2008,27(6):947.
[10]HERZ H,COOKE B,GOLDSTEIN D.Metastatic secretory breastcancer.Non responsive to chemotherapy:case report and review of the literature[J].Ann Oncol,2000,11(10):1343.
[11]DEL CASTILLO M,CHIBON F,ARNOULD L,et al.Secretory Breast Carcinoma:A Histopathologic and Genomic Spectrum Characterized by a Joint Specific ETV6-NTRK3 Gene Fusion[J].Am J Surg Pathol,2015,39(11):1458.
[12]LI G,ZHONG X,YAO J,et al.Secretory breast carcinoma in a41-year-old man with long-term follow-up:a special report[J].Future Oncol,2015,11(12):1767.
[13]WONG M,JARA-LAZARO AR,HUI NG RC,et al.ETV6disruption doesnot predict indolent clinical behavior in secretory breast carcinoma[J].Breast J,2012,18(6):604.
[14]CADOO KA,MC ARDLE O,O'SHEA AM,et al.Management of unusual histological types of breast cancer[J].Oncologist,2012,17(9):1135.
[2]BREE ED,ASKOXYLAKIS J,GIANNIKAKI E,et al.Secretory carcinoma of the male breast[J].Ann Surg Oncol,2002,57(7):894.
[3]WANG YQ,WANG Y,ZHANG JH,et al.Secretory breast carcinoma in a 12-year-old girl:a case report[J].Oncol Lett,2014,8(4):1635.
[4]VASUDEY P,ONUMA K.Secretory breast carcinoma:unique,triple-negative carcinoma with a favorable prognosis and characteristic molecular expression[J].Arch Pathol Lab Med,2011,135(12):1606.
[5]WOTO-GAYE G,KASSE AA,DIEYE Y,et al.Secretory breast carcinoma in a man:a case report with rapid evolution unfavorable[J].Ann Pathol,2004,24(5):432.
[6]魏晓龙,付丽,郎荣刚.乳腺分泌性癌的研究进展[J/CD].中华乳腺病杂志(电子版),2014,8(4):273.
[7]HOROWITZ DP,SHARMA CS,CONNOLLY E,et al.Secretory carcinoma of the breast:results from the survival,epidemiology and end results database[J].Breast,2012,21(3):350.
[8]SOYER T,YAMAN BAJIN,ORHAN D,et al.Secretory breast carcinoma in a 6-year-old girl:mastectomy with sentinel lymph node dissection[J].Pediatr Surg Int,2015,31(7):677.
[9]MUN SH,KO EY,HAN BK,et al.Secretory carcinoma of the breast:sonographic features[J].J Ultrasound Med,2008,27(6):947.
[10]HERZ H,COOKE B,GOLDSTEIN D.Metastatic secretory breastcancer.Non responsive to chemotherapy:case report and review of the literature[J].Ann Oncol,2000,11(10):1343.
[11]DEL CASTILLO M,CHIBON F,ARNOULD L,et al.Secretory Breast Carcinoma:A Histopathologic and Genomic Spectrum Characterized by a Joint Specific ETV6-NTRK3 Gene Fusion[J].Am J Surg Pathol,2015,39(11):1458.
[12]LI G,ZHONG X,YAO J,et al.Secretory breast carcinoma in a41-year-old man with long-term follow-up:a special report[J].Future Oncol,2015,11(12):1767.
[13]WONG M,JARA-LAZARO AR,HUI NG RC,et al.ETV6disruption doesnot predict indolent clinical behavior in secretory breast carcinoma[J].Breast J,2012,18(6):604.
[14]CADOO KA,MC ARDLE O,O'SHEA AM,et al.Management of unusual histological types of breast cancer[J].Oncologist,2012,17(9):1135.