慢性阻塞性肺疾病病证结合动物模型建立方法研究进展及思考
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摘要
对稳定期及急性加重期慢性阻塞性肺疾病(COPD)常见证型模型的建立方法及研究现状进行概述,并从不同证型病证结合动物模型的诱导因素及检测指标2个方面提出思考,为COPD病证结合动物模型的建立方法提供相关参考,同时为病证结合动物模型评价标准的不断完善提供一定思路。
The paper summarizes the establishment method for the main syndroms of chronic obstructive pulmonary disease( COPD) at stable phase and acute exacerbation. Based on the reflection of inducing factors and testing indexes,it also provides a reference for establishing animal models by combining COPD with different syndroms as well as new ideas for improving the evaluation of the establishment.
The paper summarizes the establishment method for the main syndroms of chronic obstructive pulmonary disease( COPD) at stable phase and acute exacerbation. Based on the reflection of inducing factors and testing indexes,it also provides a reference for establishing animal models by combining COPD with different syndroms as well as new ideas for improving the evaluation of the establishment.
引文
[1]中华医学会呼吸病学会慢性阻塞性肺疾病学组.慢性阻塞性肺疾病诊治指南(2013年修订版)(二)[J].全科医学临床与教育,2013,6(6):603-607.
[2]Vestbo J,Hurd S S,Agusti A G,et al.Global strategy for the diagnosis,management,and prevention of chronic obstructive pulmonary disease:gold executive summary[J].Am J Respir Crit Care Med,2013,187(4):347-365.
[3]Zhong N S,Wang C,Ran P X.Prevalence of chronic obstructive pulmonary disease in China[J].Am J Respir Crit Care Med,2007,176(8):753-760.
[4]王至婉,李建生,王明航,等.慢性阻塞性肺疾病稳定期肺功能与证候分布规律的相关性[J].中医杂志,2011,52(16):1376-1378.
[5]王至婉,李建生,李素云,等.慢性阻塞性肺疾病稳定期证素分布及组合规律[J].南京中医药大学学报,2010,26(4):252-254.
[6]王至婉,李建生,王明航,等.慢性阻塞性肺疾病急性加重期中医证候分布规律的文献研究[J].中医杂志,2008,49(8):727-730.
[7]程惠娟,汪长中,王艳,等.呼吸道生物被膜菌致肺气虚证大鼠模型的研制[J].上海中医药大学学报,2009,23(3):38-41.
[8]张伟,邵雨萌,张心月.辨证施治经典方剂对慢性阻塞性肺疾病大鼠细胞因子及Th1/Th2失衡的干预效应[J].中国组织工程研究与临床康复,2007,11(12):2363-2367.
[9]张伟,宫静,肖惠珍,等.一种肺脾两虚型慢阻肺动物模型的建立[J].辽宁中医杂志,2009,36(1):142-143.
[10]何嘉,郭建辉,梁栋,等.健脾益肺口服液对慢阻肺“肺脾气虚证”大鼠脾脏指数和胸腺指数的影响[J].海南医学,2014,25(10):1412-1414.
[11]孙广仁,王洪武,高博,等.COPD寒饮蕴肺证大鼠病证结合模型的建立[J].山东中医药大学学报,2007,31(3):242-244.
[12]李泽庚,王传博,彭波,等.慢性阻塞性肺疾病痰瘀阻肺证大鼠模型的建立[J].中华中医药学刊,2011,27(10):2161-2163.
[13]金朝晖,彭芝配,滕久祥,等.慢性阻塞性肺疾病痰热郁肺证大鼠模型建立的研究[J].湖南中医药大学学报,2008,28(4):17-19.
[14]李建生,周红艳,乔翠霞,等.慢性阻塞性肺疾病急性加重期痰热证模型的建立与评价[J].中国中医基础医学,2010,16(7):553-556.
[15]李素云,乔翠霞,李建生,等.慢性阻塞性肺疾病急性加重期痰湿证模型的建立与评价[J].中华中医药杂志,2012,27(3):585-590.
[16]李勇铭,张永生,吴巧敏,等.慢性阻塞性肺疾病动物模型的研究进展[J].山西中医,2017,33(2):56-57.
[17]Leberl M,Kratzer A,Taraseviciene-Stewart L.Tobacco smoke induced COPD/emphysema in the animal model-are we all on the same page?[J].Frontiers in Physiology,2013,4:91.
[18]Garcha D S,Thurston S J,Patel A R,et al.Changes in prevalence and load of airway bacteria using quantitative PCR in stable and exacerbated COPD[J].Thorax,2012,67(12):1075-1080.
[2]Vestbo J,Hurd S S,Agusti A G,et al.Global strategy for the diagnosis,management,and prevention of chronic obstructive pulmonary disease:gold executive summary[J].Am J Respir Crit Care Med,2013,187(4):347-365.
[3]Zhong N S,Wang C,Ran P X.Prevalence of chronic obstructive pulmonary disease in China[J].Am J Respir Crit Care Med,2007,176(8):753-760.
[4]王至婉,李建生,王明航,等.慢性阻塞性肺疾病稳定期肺功能与证候分布规律的相关性[J].中医杂志,2011,52(16):1376-1378.
[5]王至婉,李建生,李素云,等.慢性阻塞性肺疾病稳定期证素分布及组合规律[J].南京中医药大学学报,2010,26(4):252-254.
[6]王至婉,李建生,王明航,等.慢性阻塞性肺疾病急性加重期中医证候分布规律的文献研究[J].中医杂志,2008,49(8):727-730.
[7]程惠娟,汪长中,王艳,等.呼吸道生物被膜菌致肺气虚证大鼠模型的研制[J].上海中医药大学学报,2009,23(3):38-41.
[8]张伟,邵雨萌,张心月.辨证施治经典方剂对慢性阻塞性肺疾病大鼠细胞因子及Th1/Th2失衡的干预效应[J].中国组织工程研究与临床康复,2007,11(12):2363-2367.
[9]张伟,宫静,肖惠珍,等.一种肺脾两虚型慢阻肺动物模型的建立[J].辽宁中医杂志,2009,36(1):142-143.
[10]何嘉,郭建辉,梁栋,等.健脾益肺口服液对慢阻肺“肺脾气虚证”大鼠脾脏指数和胸腺指数的影响[J].海南医学,2014,25(10):1412-1414.
[11]孙广仁,王洪武,高博,等.COPD寒饮蕴肺证大鼠病证结合模型的建立[J].山东中医药大学学报,2007,31(3):242-244.
[12]李泽庚,王传博,彭波,等.慢性阻塞性肺疾病痰瘀阻肺证大鼠模型的建立[J].中华中医药学刊,2011,27(10):2161-2163.
[13]金朝晖,彭芝配,滕久祥,等.慢性阻塞性肺疾病痰热郁肺证大鼠模型建立的研究[J].湖南中医药大学学报,2008,28(4):17-19.
[14]李建生,周红艳,乔翠霞,等.慢性阻塞性肺疾病急性加重期痰热证模型的建立与评价[J].中国中医基础医学,2010,16(7):553-556.
[15]李素云,乔翠霞,李建生,等.慢性阻塞性肺疾病急性加重期痰湿证模型的建立与评价[J].中华中医药杂志,2012,27(3):585-590.
[16]李勇铭,张永生,吴巧敏,等.慢性阻塞性肺疾病动物模型的研究进展[J].山西中医,2017,33(2):56-57.
[17]Leberl M,Kratzer A,Taraseviciene-Stewart L.Tobacco smoke induced COPD/emphysema in the animal model-are we all on the same page?[J].Frontiers in Physiology,2013,4:91.
[18]Garcha D S,Thurston S J,Patel A R,et al.Changes in prevalence and load of airway bacteria using quantitative PCR in stable and exacerbated COPD[J].Thorax,2012,67(12):1075-1080.