摘要
<正>目前认为克雅病(Creutzfeldt-Jakob disease,CJD)是一种罕见致命的神经退行性疾病,是由中枢系统内致病型朊蛋白(scrapie prion protein,PrP~(Sc))异常沉积所致。本文就CJD的病理及分子生物学基础,从体液、外周免疫器官、神经影像学等方面临床前生物标志物的研究进展进行综述。随着其分子生物学基础和病理生理学研究不断深入,目前其临床前
引文
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