麦杏补肺汤治疗慢性阻塞性肺疾病稳定期的效果及其对中医临床症状评分及痰液指标的影响
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摘要
目的探讨麦杏补肺汤治疗慢性阻塞性肺疾病(COPD)稳定期的效果及其对患者中医临床症状评分及痰液指标的影响。方法选取我院收治的128例COPD稳定期患者为研究对象,按照随机数表法将其分为对照组(64例,沙美特罗替卡松粉吸入剂治疗)与观察组(64例,沙美特罗替卡松粉吸入剂+麦杏补肺汤治疗),对比两组患者治疗前、后的中医临床症状评分、肺功能指标及痰液指标。结果治疗后,两组患者的各项中医临床症状评分均明显降低,FEV_1、FVC及FEV1/FVC均明显升高,HDACs、TGF-β1、IL-8水平均明显改善,且观察组优于对照组(P<0.05)。结论麦杏补肺汤可以改善COPD稳定期患者中医临床症状评分、肺功能指标及痰液指标,值得临床推广与应用。
Objective To investigate the effect of Maixing Bufei decoction on clinical symptom score and phlegm indexes of TCM in stable stage of chronic obstructive pulmonary disease(COPD). Methods A total of 128 patients with COPD in stable phase in our hospital were selected and divided into control group(64 cases, treated with salmeterol and fluticasone powder inhalation) and observation group(64 cases, treated with salmeterol and fluticasone powder inhalation combined with Maixing Bufei decoction) according to random number table method. The clinical symptom scores, pulmonary function indexes and sputum indexes of the two groups before and after treatment were compared. Results After treatment, the scores of TCM clinical symptoms in both groups significantly decreased, the FEV_1, FVC and FEV_1/FVC significantly increased, the levels of HDACs, TGF-β1 and IL-8 significantly improved, and those in the observation group were better than the control group(P<0.05). Conclusion Maixing Bufei decoction can improve the TCM clinical symptom score, lung function indexes and sputum indexes of COPD patients in stable phase, which is worthy of clinical promotion and application.
Objective To investigate the effect of Maixing Bufei decoction on clinical symptom score and phlegm indexes of TCM in stable stage of chronic obstructive pulmonary disease(COPD). Methods A total of 128 patients with COPD in stable phase in our hospital were selected and divided into control group(64 cases, treated with salmeterol and fluticasone powder inhalation) and observation group(64 cases, treated with salmeterol and fluticasone powder inhalation combined with Maixing Bufei decoction) according to random number table method. The clinical symptom scores, pulmonary function indexes and sputum indexes of the two groups before and after treatment were compared. Results After treatment, the scores of TCM clinical symptoms in both groups significantly decreased, the FEV_1, FVC and FEV_1/FVC significantly increased, the levels of HDACs, TGF-β1 and IL-8 significantly improved, and those in the observation group were better than the control group(P<0.05). Conclusion Maixing Bufei decoction can improve the TCM clinical symptom score, lung function indexes and sputum indexes of COPD patients in stable phase, which is worthy of clinical promotion and application.
引文
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[3]郑筱萸.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:532-533.
[4]中华医学会呼吸病学分会慢性阻塞性肺疾病学组.慢性阻塞性肺疾病诊治指南(2013年修订版)[J].中华结核和呼吸杂志,2014,36(2):255-264.
[5]利君,陈陶甫,徐权胜,等.舒利迭吸入治疗中重度慢性阻塞性肺疾病82例临床观察[J].赣南医学院学报,2015,35(1):78-80.
[6]冯祥兴.中医综合疗法联合无创正压通气治疗COPD并呼吸衰竭98例临床疗效观察[J].中医临床研究,2013,5(10):41-42.