Glyphosate-based herbicide: a risk factor for demyelinating conditions of the peripheral nervous system?
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摘要
<正>Glyphosateisabroad-spectrumherbicideoriginallyintroducedto themarketin1974bytheagrochemicalcompanyMonsanto.More than 40 years down the line, glyphosate has become one of the most economically meaningful herbicides, with a global use of more than1.8 million pounds in 2014 (Benbrook, 2016). In non resistant plants,
引文
Benbrook CM(2016)Trends in glyphosate herbicide use in the United States and globally.Environ Sci Eur 28:3.
Defarge N,Spiroux de Vend?mois J,Séralini GE(2017)Toxicity of formulants and heavy metals in glyphosate-based herbicides and other pesticides.Toxicol Rep 5:156-163.
Hutton EJ,Carty L,LauráM,Houlden H,Lunn MP,Brandner S,Mirsky R,Jessen K,Reilly MM(2011)c-Jun expression in human neuropathies:a pilot study.J Peripher Nerv Syst 16:295-303.
Jessen KR,Mirsky R(2008)Negative regulation of myelination:relevance for development,injury,and demyelinating disease.Glia 56:1552-1565.
Kawagashira Y,Koike H,Kawabata K,Takahashi M,Ohyama K,Hashimoto R,Iijima M,Katsuno M,Sobue G(2017)Vasculitic neuropathy following exposure to a glyphosate-based herbicide.Intern Med 56:1431-1434.
Mesnage R,Defarge N,Spiroux de Vend?mois J,Séralini GE(2015)Potential toxic effects of glyphosate and its commercial formulations below regulatory limits.Food Chem Toxicol 84:133-153.
Niemann L,Sieke C,Pfeil R,Solecki R(2015)A critical review of glyphosate findings in human urine samples and comparison with the exposure of operators and consumers.J Verbr Lebensm 10:3-12.
Stettner M,Lohmann B,Wolffram K,Weinberger JP,Dehmel T,Hartung HP,Mausberg AK,Kieseier BC(2014)Interleukin-17 impedes Schwann cell-mediated myelination.J Neuroinflammation 11:63.
Szepanowski F,Szepanowski LP,Mausberg AK,Albrecht P,Kleinschnitz C,Kieseier BC,Stettner M(2018a)Differential impact of pure glyphosate and glyphosate-based herbicide in a model of peripheral nervous system myelination.Acta Neuropathol 136:979-982.
Szepanowski F,Szepanowski LP,Mausberg AK,Kleinschnitz C,Kieseier BC,Stettner M(2018b)Lysophosphatidic acid propagates post-injury Schwann cell dedifferentiation through LPA1 signaling.Neurosci Lett662:136-141.
Wagner M,Klein CL,van Kooten TG,Kirkpatrick CJ(1998)Mechanisms of cell activation by heavy metal ions.J Biomed Mater Res 42:443-452.
Ydens E,Lornet G,Smits V,Goethals S,Timmerman V,Janssens S(2013)The neuroinflammatory role of Schwann cells in disease.Neurobiol Dis55:95-103.
Defarge N,Spiroux de Vend?mois J,Séralini GE(2017)Toxicity of formulants and heavy metals in glyphosate-based herbicides and other pesticides.Toxicol Rep 5:156-163.
Hutton EJ,Carty L,LauráM,Houlden H,Lunn MP,Brandner S,Mirsky R,Jessen K,Reilly MM(2011)c-Jun expression in human neuropathies:a pilot study.J Peripher Nerv Syst 16:295-303.
Jessen KR,Mirsky R(2008)Negative regulation of myelination:relevance for development,injury,and demyelinating disease.Glia 56:1552-1565.
Kawagashira Y,Koike H,Kawabata K,Takahashi M,Ohyama K,Hashimoto R,Iijima M,Katsuno M,Sobue G(2017)Vasculitic neuropathy following exposure to a glyphosate-based herbicide.Intern Med 56:1431-1434.
Mesnage R,Defarge N,Spiroux de Vend?mois J,Séralini GE(2015)Potential toxic effects of glyphosate and its commercial formulations below regulatory limits.Food Chem Toxicol 84:133-153.
Niemann L,Sieke C,Pfeil R,Solecki R(2015)A critical review of glyphosate findings in human urine samples and comparison with the exposure of operators and consumers.J Verbr Lebensm 10:3-12.
Stettner M,Lohmann B,Wolffram K,Weinberger JP,Dehmel T,Hartung HP,Mausberg AK,Kieseier BC(2014)Interleukin-17 impedes Schwann cell-mediated myelination.J Neuroinflammation 11:63.
Szepanowski F,Szepanowski LP,Mausberg AK,Albrecht P,Kleinschnitz C,Kieseier BC,Stettner M(2018a)Differential impact of pure glyphosate and glyphosate-based herbicide in a model of peripheral nervous system myelination.Acta Neuropathol 136:979-982.
Szepanowski F,Szepanowski LP,Mausberg AK,Kleinschnitz C,Kieseier BC,Stettner M(2018b)Lysophosphatidic acid propagates post-injury Schwann cell dedifferentiation through LPA1 signaling.Neurosci Lett662:136-141.
Wagner M,Klein CL,van Kooten TG,Kirkpatrick CJ(1998)Mechanisms of cell activation by heavy metal ions.J Biomed Mater Res 42:443-452.
Ydens E,Lornet G,Smits V,Goethals S,Timmerman V,Janssens S(2013)The neuroinflammatory role of Schwann cells in disease.Neurobiol Dis55:95-103.