3例毒蕈中毒致肝损伤型患者临床分析
摘要
<正>毒蕈又称毒蘑菇,是指食用后会使人或畜禽产生中毒反应的某些大型真菌的子实体[1]。毒蕈中毒是临床上常见的急危重症之一,其引起的死亡是造成食物中毒死亡的主要原因之一[2],其发病率和病死率呈上升趋势[3-4]。毒蕈中毒事件的发生有明显的季节性,6-9月是毒蕈中毒事件的高发期。毒蕈中毒报告事件数较多的省份多集中在我国西南及华南地区,其中广西是毒蕈中毒的高发省份之一[5]。毒蕈中毒临床表现复杂多样,缺乏特异性,轻症者仅表现为胃肠道症状,严重者可引起肝、肾、脑等重要器官损伤,甚至多器官功能衰竭而死亡[6-7]。因此,动态观察毒蕈中毒患者多系统功能指标对诊断及预后判定有重要指导意义。
引文
[1]余思洋,王晓雯,赵江,等.云南省2004-2010年野生蕈食物中毒分析[J].中国食品卫生杂志,2012,24(1):71-73.
[2]BRANDENBURG W E,WARD K J.Mushroom poisoning epidemiology in the United States[J].Mycologia,2018,110(4):637-641.
[3]CHO J T,HAN J H.A case of mushroom poisoning with russula subnigricans:development of rhabdomyolysis,acute kidney injury,cardiogenic shock,and death[J].J Korean Med Sci,2016,31(7):1164-1167.
[4]EREN S H,KORKMAZ I,GUVEN F M K,et al.Serum paraoxonase,arylesterase,and glutathione-s-transferase activities and oxidative stress levels in patients with mushroom poisoning[J].Clinics(Sao Paulo),2018,10(73):e16550.
[5]王锐,高永军,丁凡,等.中国2004-2011年毒蕈中毒事件分析[J].中国公共卫生,2014,30(2):158-161.
[6]BASKIRAN A,DIRICAN A,OZGOR D,et al.Significance and outcome of living-donor liver transplantation in acute mushroom intoxication[J].Niger J Clin Pract,2018,21(7):888-893.
[7]KRENOV M,PELCLOV D,NAVRTIL T.Survey of amanita phalloides poisoning:clinical findings and follow-upevaluation[J].Hum Exp Toxicol,2007,26(12):955.
[8]梁进军,史文佩,段宏波,等.2016年湖南省毒蕈中毒的疾病经济负担研究[J].中国食品卫生杂志,2018,30(2):139-142.
[9]KIESLICHOVA E,FRANKOVA S,PROTUS M,et al.Acute liver failure due to amanita phalloides poisoning:therapeutic approach and outcome[J].Transplant Proc,2018,50(1):192-197.
[10]KANTOLA T,KANTOLA T,KOIVUSALO A M,et al.Early molecular adsorbents recirculating system treatment of amanita mushroom poisoning[J].Ther Apher Dial,2009,13:399403.
[11]FERENC T,LUKASIEWICZ B,CIECWIERZ J,et al.Poisonings with Amanita phalloides[J].Med Pr,2009,60(5):415-426.
[12]潘洁,刘薇薇,黄建伟,等.白毒伞中毒致肝损伤的酶学与凝血指标变化规律及其对预后的影响[J].胃肠病学和肝病学杂志,2016,25(5):566-569.
[13]JANSSON D,FREDRIKSSON S A,HERRMANN A A.A concept study on identification and attribution profiling of chemical threat agents using liquid chromatographymass spectrometry applied to Amanita toxins in food[J].Forensic Sci Int,2012,221(1/3):44-49.
[2]BRANDENBURG W E,WARD K J.Mushroom poisoning epidemiology in the United States[J].Mycologia,2018,110(4):637-641.
[3]CHO J T,HAN J H.A case of mushroom poisoning with russula subnigricans:development of rhabdomyolysis,acute kidney injury,cardiogenic shock,and death[J].J Korean Med Sci,2016,31(7):1164-1167.
[4]EREN S H,KORKMAZ I,GUVEN F M K,et al.Serum paraoxonase,arylesterase,and glutathione-s-transferase activities and oxidative stress levels in patients with mushroom poisoning[J].Clinics(Sao Paulo),2018,10(73):e16550.
[5]王锐,高永军,丁凡,等.中国2004-2011年毒蕈中毒事件分析[J].中国公共卫生,2014,30(2):158-161.
[6]BASKIRAN A,DIRICAN A,OZGOR D,et al.Significance and outcome of living-donor liver transplantation in acute mushroom intoxication[J].Niger J Clin Pract,2018,21(7):888-893.
[7]KRENOV M,PELCLOV D,NAVRTIL T.Survey of amanita phalloides poisoning:clinical findings and follow-upevaluation[J].Hum Exp Toxicol,2007,26(12):955.
[8]梁进军,史文佩,段宏波,等.2016年湖南省毒蕈中毒的疾病经济负担研究[J].中国食品卫生杂志,2018,30(2):139-142.
[9]KIESLICHOVA E,FRANKOVA S,PROTUS M,et al.Acute liver failure due to amanita phalloides poisoning:therapeutic approach and outcome[J].Transplant Proc,2018,50(1):192-197.
[10]KANTOLA T,KANTOLA T,KOIVUSALO A M,et al.Early molecular adsorbents recirculating system treatment of amanita mushroom poisoning[J].Ther Apher Dial,2009,13:399403.
[11]FERENC T,LUKASIEWICZ B,CIECWIERZ J,et al.Poisonings with Amanita phalloides[J].Med Pr,2009,60(5):415-426.
[12]潘洁,刘薇薇,黄建伟,等.白毒伞中毒致肝损伤的酶学与凝血指标变化规律及其对预后的影响[J].胃肠病学和肝病学杂志,2016,25(5):566-569.
[13]JANSSON D,FREDRIKSSON S A,HERRMANN A A.A concept study on identification and attribution profiling of chemical threat agents using liquid chromatographymass spectrometry applied to Amanita toxins in food[J].Forensic Sci Int,2012,221(1/3):44-49.