基于“体质土壤学说”的调体防控痰湿体质相关代谢性疾病的研究思路
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摘要
目前糖尿病、高脂血症、高血压病等慢性病的高发病率、高致残率、高病死率成为困扰人类健康的主要问题。实现慢性病防治关口前移亟需找到新途径。本研究基于国医大师王琦教授"体质土壤"学说,提出"痰湿体质是许多代谢性疾病的共同土壤,其机制可能与免疫炎症进程、胰岛素抵抗及氧化应激反应失调有关"的假说。对平和体质及痰湿体质的"未病人群"、高脂血症边缘升高人群、2型糖尿病临床前期3类人群的共同分子通路表达进行检测分析对比,并观察王琦教授"化痰祛湿方"对其表达的调控效应及机制。本研究对于揭示中医痰湿体质的现代内涵,指导实施防控代谢紊乱性疾病,实现慢性病防治关口前移,具有重要的理论和实践意义。
Nowadays, the increasing morbidity, disability rate and mortality of many chronic diseases such as diabetes, hyperlipidemia and hypertension have become major problems that threatened public health. New approaches need to be found to move forward the critical pass of the chronic diseases' prevention. Based on the theory of body constitution soil of master of TCM WANG Qi, this research proposed the hypothesis that the phlegm-dampness constitution is the common basis of metabolic diseases. The mechanism may be related to the immune inflammation process, imbalance of insulin resistance and oxidative stress reaction. This research will detect the peripheral blood mononuclear cell(PBMC) and serum protein expression of phlegmdampness constitution individuals among pre-disease populations, hyperlipidemia populations and type 2 diabetes populations of preclinical stage to comparing the molecular pathways expression, and further observe the regulating effects and mechanisms that Huatan Qushi Decoction(invented by professor WANG Qi) has on the common expression proteins. This research has important theoretical and practical significance on revealing the modern connotation of same treatment to different diseases of the phlegmdampness constitution, achieving the goal of better prevention and control of chronic diseases and promoting the wide application of the nine body constitution medical health plan.
Nowadays, the increasing morbidity, disability rate and mortality of many chronic diseases such as diabetes, hyperlipidemia and hypertension have become major problems that threatened public health. New approaches need to be found to move forward the critical pass of the chronic diseases' prevention. Based on the theory of body constitution soil of master of TCM WANG Qi, this research proposed the hypothesis that the phlegm-dampness constitution is the common basis of metabolic diseases. The mechanism may be related to the immune inflammation process, imbalance of insulin resistance and oxidative stress reaction. This research will detect the peripheral blood mononuclear cell(PBMC) and serum protein expression of phlegmdampness constitution individuals among pre-disease populations, hyperlipidemia populations and type 2 diabetes populations of preclinical stage to comparing the molecular pathways expression, and further observe the regulating effects and mechanisms that Huatan Qushi Decoction(invented by professor WANG Qi) has on the common expression proteins. This research has important theoretical and practical significance on revealing the modern connotation of same treatment to different diseases of the phlegmdampness constitution, achieving the goal of better prevention and control of chronic diseases and promoting the wide application of the nine body constitution medical health plan.
引文
[1]WANG J,LI Y S,NI C,et al.Cognition research and constitutional classification in Chinese medicine.The American Journal of Chinese Medicine,2011,39(4):651-660
[2]王琦.论中医体质研究的3个关键问题(上).中医杂志,2006,47(4):250-252
[3]梁雪,王琦,沈昆,等.痰湿体质人群易发代谢综合征相关危险因素的调查研究.中华中医药杂志,2017,32(4):1500-1503
[4]董伟,倪诚,英孝.基于“体质土壤”学说的痰湿体质异病同治学术传承研究.中华中医药杂志,2014,29(6):1771-1774
[5]王琦.中医体质学2008.北京:人民卫生出版社,2009:279,237-238
[6]陈光美,唐平,宋丽娟.焦虑障碍的蛋白组学与社会文化病因学研究(对31例焦虑障碍患者人格特点进行分析).中国健康心理学杂志,2011,19(3):262-265
[7]牟君.抑郁症的脑功能磁共振和蛋白组学研究.重庆:重庆医科大学,2007
[8]王琦,卫东.中医体质学说的基本原理.北京中医学院学报,1989,12(1):8-10
[9]郭刚,吕雅郁,郑燕飞,等.中医体质学原理的复杂性解读.北京中医药大学学报,2015,38(7):437-440
[10]王琦,董静,吴宏东,等.痰湿体质的分子生物学特征.中国工程科学,2008,10(7):100-103
[11]GONG H Y,GAO J H,WANG Q.Peripheral blood gene expression profile of Chinese adult obesities by gene chip technique.Journal of Clinical Rehabilitative Tissue Engineering Research,2008,12(24):4797-4800
[12]WANG J,WANG Q,LI L R,et al.Phlegm-dampness constitution:genomics,susceptibility adjustment and treatment with traditional Chinese medicine.The American Journal of Chinese Medicine,2013,41(2):253-262
[13]姚海强.痰湿体质DNA甲基化、mi RNA及Inc RNA表达谱研究.北京:北京中医药大学,2016
[14]杨玲玲,王琦,王济,等.肥胖痰湿体质、非痰湿体质与代谢综合征人群胰岛素抵抗相关指数的比较研究.中华中医药学刊,2014,32(4):763-765
[15]郑璐玉,杨玲玲,李玲孺,等.液相芯片技术检测痰湿体质人群TNF-α、IL-6、CRP及MCP-1的表达研究.中国中西医结合杂志,2013,33(7):920-923
[16]李玲孺.痰湿体质与肥胖亚型的相关性及其易发代谢综合征的氧化应激机制研究.北京:北京中医药大学,2012
[17]许璇璇.调理痰湿体质干预空腹血糖受损的临床研究.北京:北京中医药大学,2015
[18]钱彦方,王琦.轻健胶囊改善单纯性肥胖痰湿体质疗效观察.中医杂志,1993,34(4):232-235
[19]钱彦方,王琦.轻健胶囊的降脂减肥动物实验研究.实用中西医结合杂志,1994,7(10):592-595
[20]郑璐玉.痰湿体质人群炎症相关机制研究.北京:北京中医药大学,2013
[21]杨玲玲.痰湿体质人群胰岛素抵抗相关因子表达研究.北京:北京中医药大学,2013
[2]王琦.论中医体质研究的3个关键问题(上).中医杂志,2006,47(4):250-252
[3]梁雪,王琦,沈昆,等.痰湿体质人群易发代谢综合征相关危险因素的调查研究.中华中医药杂志,2017,32(4):1500-1503
[4]董伟,倪诚,英孝.基于“体质土壤”学说的痰湿体质异病同治学术传承研究.中华中医药杂志,2014,29(6):1771-1774
[5]王琦.中医体质学2008.北京:人民卫生出版社,2009:279,237-238
[6]陈光美,唐平,宋丽娟.焦虑障碍的蛋白组学与社会文化病因学研究(对31例焦虑障碍患者人格特点进行分析).中国健康心理学杂志,2011,19(3):262-265
[7]牟君.抑郁症的脑功能磁共振和蛋白组学研究.重庆:重庆医科大学,2007
[8]王琦,卫东.中医体质学说的基本原理.北京中医学院学报,1989,12(1):8-10
[9]郭刚,吕雅郁,郑燕飞,等.中医体质学原理的复杂性解读.北京中医药大学学报,2015,38(7):437-440
[10]王琦,董静,吴宏东,等.痰湿体质的分子生物学特征.中国工程科学,2008,10(7):100-103
[11]GONG H Y,GAO J H,WANG Q.Peripheral blood gene expression profile of Chinese adult obesities by gene chip technique.Journal of Clinical Rehabilitative Tissue Engineering Research,2008,12(24):4797-4800
[12]WANG J,WANG Q,LI L R,et al.Phlegm-dampness constitution:genomics,susceptibility adjustment and treatment with traditional Chinese medicine.The American Journal of Chinese Medicine,2013,41(2):253-262
[13]姚海强.痰湿体质DNA甲基化、mi RNA及Inc RNA表达谱研究.北京:北京中医药大学,2016
[14]杨玲玲,王琦,王济,等.肥胖痰湿体质、非痰湿体质与代谢综合征人群胰岛素抵抗相关指数的比较研究.中华中医药学刊,2014,32(4):763-765
[15]郑璐玉,杨玲玲,李玲孺,等.液相芯片技术检测痰湿体质人群TNF-α、IL-6、CRP及MCP-1的表达研究.中国中西医结合杂志,2013,33(7):920-923
[16]李玲孺.痰湿体质与肥胖亚型的相关性及其易发代谢综合征的氧化应激机制研究.北京:北京中医药大学,2012
[17]许璇璇.调理痰湿体质干预空腹血糖受损的临床研究.北京:北京中医药大学,2015
[18]钱彦方,王琦.轻健胶囊改善单纯性肥胖痰湿体质疗效观察.中医杂志,1993,34(4):232-235
[19]钱彦方,王琦.轻健胶囊的降脂减肥动物实验研究.实用中西医结合杂志,1994,7(10):592-595
[20]郑璐玉.痰湿体质人群炎症相关机制研究.北京:北京中医药大学,2013
[21]杨玲玲.痰湿体质人群胰岛素抵抗相关因子表达研究.北京:北京中医药大学,2013