消鼾利气颗粒治疗阻塞性睡眠呼吸暂停低通气综合征的临床疗效评价
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摘要
目的:评价消鼾利气颗粒治疗阻塞性睡眠呼吸暂停低通气综合征(OSAHS)的临床疗效。方法:将60例轻/中度OSAHS患者按照随机对照试验(RCT)原则分为治疗组与对照组各30例,治疗组采用口服消鼾利气颗粒加基础干预措施,对照组采用单纯基础干预措施,疗程1个月。观察两组治疗前后痰湿体质积分、中医证候积分、睡眠呼吸暂停低通气指数(AHI)、Epworth嗜睡量表(ESS)、夜间最低末梢血氧饱和度(LSPO2)及SpO2<90%占总睡眠时间比例(%)等的变化。结果:治疗后治疗组痰湿体质积分、中医证候积分、AHI、ESS、SpO2<90%占总睡眠时间比例较本组治疗前下降,LSPO2升高,且与对照组同期比较均有极显著性差异(P<0.01)。相关性分析显示痰湿体质积分与中医证侯积分、AHI、ESS及SpO2<90%占总睡眠时间比例均成正相关;与LSPO2成负相关。结论:消鼾利气颗粒通过调理OSAHS患者痰湿体质,从而减轻其临床症状,改善通气功能,提高患者生活质量。
Objective: To evaluate the clinical efficacy of Xiaohan Liqi Granules in treating obstructive sleep apneahypopnea syndrome(OSAHS). Methods: A total of 60 patients with mild or moderate OSAHS were divided into treatment group and control group according to RCT principle, and 30 cases were included in each group. The treatment group was treated with oral Xiaohan Liqi Granules and basic intervention measures, while the control group received only basic intervention. The whole treatment lasted for one months. The changes of phlegm-dampness constitution score, TCM syndrome score, sleeprelated apnea-hypopnea index(AHI), Epworth sleepiness scale(ESS), the lowest peripheral vascular oxygen saturation(LSPO2) at night and the proportion of SpO2<90% in total sleep time(%) before and after treatment were observed. Results: The phlegmdampness constitution scores, TCM syndrome score, AHI, ESS, SpO2<90% accounted for total sleep time in the treatment group were significantly decreased compared with that before treatment, while the LSPO2 was increased. The results had significant differences compared with that of the control group(P<0.01). The correlation analysis showed that phlegm-dampness constitution scores were positively correlated with TCM syndromes, AHI, ESS and SpO2<90% of total sleep time, and negatively correlated with LSPO2. Conclusion: Xiaohan Liqi Granules can alleviate the clinical symptoms, improve the ventilation function and the quality of life of OSAHS patients by regulating their phlegm-dampness constitution.
Objective: To evaluate the clinical efficacy of Xiaohan Liqi Granules in treating obstructive sleep apneahypopnea syndrome(OSAHS). Methods: A total of 60 patients with mild or moderate OSAHS were divided into treatment group and control group according to RCT principle, and 30 cases were included in each group. The treatment group was treated with oral Xiaohan Liqi Granules and basic intervention measures, while the control group received only basic intervention. The whole treatment lasted for one months. The changes of phlegm-dampness constitution score, TCM syndrome score, sleeprelated apnea-hypopnea index(AHI), Epworth sleepiness scale(ESS), the lowest peripheral vascular oxygen saturation(LSPO2) at night and the proportion of SpO2<90% in total sleep time(%) before and after treatment were observed. Results: The phlegmdampness constitution scores, TCM syndrome score, AHI, ESS, SpO2<90% accounted for total sleep time in the treatment group were significantly decreased compared with that before treatment, while the LSPO2 was increased. The results had significant differences compared with that of the control group(P<0.01). The correlation analysis showed that phlegm-dampness constitution scores were positively correlated with TCM syndromes, AHI, ESS and SpO2<90% of total sleep time, and negatively correlated with LSPO2. Conclusion: Xiaohan Liqi Granules can alleviate the clinical symptoms, improve the ventilation function and the quality of life of OSAHS patients by regulating their phlegm-dampness constitution.
引文
[1]中华医学会呼吸病学分会睡眠呼吸障碍学组.阻塞性睡眠呼吸暂停低通气综合征患者持续气道正压通气临床应用专家共识(草案).中华结核和呼吸杂志,2012,35(1):13-18
[2]Freedman N.Treatment of obstructive sleep apnea syndrome.Clinics in Chest Medicine,2010,31(2):187-201
[3]中华医学会耳鼻咽喉头颈外科学分会咽喉学组.阻塞性睡眠呼吸暂停低通气综合征诊断和外科治疗指南.中华耳鼻咽喉头颈外科杂志,2009,44(2):95-96
[4]姚海强,崔红生,王琦.国医大师王琦教授论治睡眠呼吸暂停低通气综合征经验.中华中医药杂志,2015,30(10):168-170
[5]张元兵,徐超,刘良徛.半夏厚朴汤治疗阻塞型睡眠呼吸暂停降低通气综合征相关慢性咳嗽初探.中华中医药杂志,2017,32(10):4522-4524
[2]Freedman N.Treatment of obstructive sleep apnea syndrome.Clinics in Chest Medicine,2010,31(2):187-201
[3]中华医学会耳鼻咽喉头颈外科学分会咽喉学组.阻塞性睡眠呼吸暂停低通气综合征诊断和外科治疗指南.中华耳鼻咽喉头颈外科杂志,2009,44(2):95-96
[4]姚海强,崔红生,王琦.国医大师王琦教授论治睡眠呼吸暂停低通气综合征经验.中华中医药杂志,2015,30(10):168-170
[5]张元兵,徐超,刘良徛.半夏厚朴汤治疗阻塞型睡眠呼吸暂停降低通气综合征相关慢性咳嗽初探.中华中医药杂志,2017,32(10):4522-4524