摘要
目的:探讨急性缺血性中风血瘀证与血浆Hcy水平、颈动脉粥样硬化的关系。方法:将70例首次发作急性缺血性中风患者作为观察组,其中血瘀证组37例、非血瘀证组33例;将40例健康体检者作为对照组;观测并比较三组的血浆Hcy水平、颈动脉内中膜厚度(IMT)及粥样斑块分型、发生率。结果:观察组两组的血浆Hcy水平均显著高于对照组(P <0.01),且血瘀证组血浆Hcy水平较非血瘀证组高(P <0.01);观察组两组颈动脉IMT、斑块发生率均高于对照组(P <0.01),其中血瘀证组较非血瘀证组的颈动脉IMT、斑块发生率高(P <0.05);观察组两组不同分型的Hcy水平均高于对照组(P <0.05),且观察组两组稳定斑块及不稳定斑块分型的血浆HCY水平均显著高于同组无斑块分型的血浆Hcy水平(P <0.05)。结论:血浆Hcy水平、颈动脉粥样硬化与缺血性中风血瘀证密切相关。
Objective: To investigate the relationship between blood stasis syndrome of acute ischemic stroke and plasma homocysteine(Hcy) level and carotid atherosclerosis(CAS). Method: 70 cases of the first attack of acute ischemic stroke were selected as the observation group, including 37 cases of blood stasis syndrome group and 33 cases of non blood stasis syndrome group; 40 healthy subjects were selected as control group; Plasma Hcy level, carotid artery intima-media thickness(IMT) and atheromatous plaque typing and incidence were observed and compared between the 3 groups. Results: The plasma Hcy level in the 2 groups of the observation group was significantly higher than that of the control group(P<0.01), and the plasma Hcy level of the blood stasis syndrome group was higher than that of the non blood stasis syndrome group(P<0.01); The carotid artery IMT and incidence of plaque in the 2 groups of the observation group was higher than that of the control group(P<0.01), and the carotid artery IMT and incidence of plaque in the blood stasis syndrome group was higher than that of the non blood stasis syndrome group(P<0.05); The plasma Hcy level of the 2 groups in the observation group was both higher than that of the control group(P<0.05), and the level of plasma Hcy in the two groups of stable plaques and unstable plaques was significantly higher than that of the same group without plaques(P<0.05). Conclusion: Plasma Hcy level and CAS were closely related to blood stasis syndrome of ischemic stroke.
引文
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