维生素D_3不同补充时期对早产儿骨密度和身长的影响
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摘要
目的:探究维生素D3不同补充时期对早产儿骨密度和身长的影响。方法:选取2017年1月至2017年12月入住我院新生儿监护病房的早产儿为研究对象,随机分为早期维生素D_3干预组、常规儿童保健组,每组30例;干预组患儿生后第3 d起每日口服维生素D_3剂量为400IU。结果:常规儿童保健组与早期维生素D_3干预组早产儿相比,纠正月龄在1月龄、2月龄、3月龄以及6月龄四个月龄阶段的骨密度较低及身长较短,差异具有统计学差异(P<0.05);纠正月龄在6月龄时,25-羟基维生素D含量较低,而碱性磷酸酶活性较高,差异具有统计学差异(P<0.05)。结论:早产儿尽早添加适量的维生素D_3,可以提高早产儿的维生素D水平,增强骨密度;对提高早产儿健康水平具有重要意义。
Objective:To investigate the effect of vitamin D3 supplementation periods on bone mineral density(BMD) and body length of premature infants. Methods: Preterm infants admitted to the neonatal care unit of our hospital from January 2017 to December 2017 were selected as the research objects. They were randomly divided into the early vitamin D3 intervention group and the conventional child care group, with 30 cases in each group. The daily oral dose of vitamin D3 in the intervention group was 400 IU from the third day after birth. Results: Compared with the early vitamin D3 intervention group, the preterm infants in the conventional child care group had lower BMD and shorter body length at the age of 1 month, 2 months, 3 months and 6 months, with statistically significant differences(P<0.05). At the age of 6 months after correction, 25-hydroxy vitamin D content was lower, while alkaline phosphatase activity was higher, and the difference was statistically significant(P<0.05). Conclusion: The vitamin D level and bone mineral density of premature infants can be improved by adding adequate vitamin D3 as early as possible. It is of great significance to improve the health of premature infants.
Objective:To investigate the effect of vitamin D3 supplementation periods on bone mineral density(BMD) and body length of premature infants. Methods: Preterm infants admitted to the neonatal care unit of our hospital from January 2017 to December 2017 were selected as the research objects. They were randomly divided into the early vitamin D3 intervention group and the conventional child care group, with 30 cases in each group. The daily oral dose of vitamin D3 in the intervention group was 400 IU from the third day after birth. Results: Compared with the early vitamin D3 intervention group, the preterm infants in the conventional child care group had lower BMD and shorter body length at the age of 1 month, 2 months, 3 months and 6 months, with statistically significant differences(P<0.05). At the age of 6 months after correction, 25-hydroxy vitamin D content was lower, while alkaline phosphatase activity was higher, and the difference was statistically significant(P<0.05). Conclusion: The vitamin D level and bone mineral density of premature infants can be improved by adding adequate vitamin D3 as early as possible. It is of great significance to improve the health of premature infants.
引文
[1] 刘阳洋.低血磷性佝偻病的诊治进展[J].中国儿童保健杂志,2015,23( 5):486-488.
[2] 仰曙芬,吴光驰.维生素D缺乏及维生素D缺乏性佝偻病防治建议解读[J].中国儿童保健杂志,2015,23( 7) :680-683.
[3] 刘旭,赵琳.104例早产儿骨密度结果分析[J].湖北科技学院学报(医学版),2017,31(3):195-197.
[4] 李源斌,陆妹.早产儿血清25羟基维生素D3水平与超声骨密度的相关性研究[J].中国当代医药,2017,24(13):106-108.
[5] 李琳霞,赵琳,李艳红,等.不同喂养方式对早产儿骨密度的影响[J].中国新生儿科杂志,2015,30(2):104-107.
[6] 焦蓉,杨文健,温晓敏,等.早期补充维生素D3对早产儿IL-2、免疫球蛋白的影响[J].贵州医药,2017,41(5):479-480.
[7] 李红,肖义峰,曾俊杰,等.早期补充维生素D对早产儿钙磷代谢及白细胞介素2的影响[J].中华新生儿科杂志,2016,31(1):36-39.
[8] Backstrom MC ,Maki R ,Kuusela AL ,et al.Randomised controlled trial of vitamin D supplementation on bone density and biochemical indices in preterm infants[J].Archives of Disease in Childhood - Fetal and Neonatal Edition,1999,80(3):F161-F166.
[9] Joung KE,Burris HH,Marter LJV,et al.Vitamin D and bronchopulmonary dysplasia in preterm infants[J].Journal of Perinatology,2016,36(10):878-882.
[10] Yang Y,Feng Y,Chen X,et al.Is there a potential link between vitamin D and pulmonary morbidities in preterm infants?[J].Journal of the Chinese Medical Association,2017,81(5):482-486.
[11] Giapros VI ,Schiza V ,Challa AS ,et al.Vitamin D and parathormone levels of late-preterm formula fed infants during the first year of life[J].European Journal of Clinical Nutrition,2012,66(2):224-230.
[2] 仰曙芬,吴光驰.维生素D缺乏及维生素D缺乏性佝偻病防治建议解读[J].中国儿童保健杂志,2015,23( 7) :680-683.
[3] 刘旭,赵琳.104例早产儿骨密度结果分析[J].湖北科技学院学报(医学版),2017,31(3):195-197.
[4] 李源斌,陆妹.早产儿血清25羟基维生素D3水平与超声骨密度的相关性研究[J].中国当代医药,2017,24(13):106-108.
[5] 李琳霞,赵琳,李艳红,等.不同喂养方式对早产儿骨密度的影响[J].中国新生儿科杂志,2015,30(2):104-107.
[6] 焦蓉,杨文健,温晓敏,等.早期补充维生素D3对早产儿IL-2、免疫球蛋白的影响[J].贵州医药,2017,41(5):479-480.
[7] 李红,肖义峰,曾俊杰,等.早期补充维生素D对早产儿钙磷代谢及白细胞介素2的影响[J].中华新生儿科杂志,2016,31(1):36-39.
[8] Backstrom MC ,Maki R ,Kuusela AL ,et al.Randomised controlled trial of vitamin D supplementation on bone density and biochemical indices in preterm infants[J].Archives of Disease in Childhood - Fetal and Neonatal Edition,1999,80(3):F161-F166.
[9] Joung KE,Burris HH,Marter LJV,et al.Vitamin D and bronchopulmonary dysplasia in preterm infants[J].Journal of Perinatology,2016,36(10):878-882.
[10] Yang Y,Feng Y,Chen X,et al.Is there a potential link between vitamin D and pulmonary morbidities in preterm infants?[J].Journal of the Chinese Medical Association,2017,81(5):482-486.
[11] Giapros VI ,Schiza V ,Challa AS ,et al.Vitamin D and parathormone levels of late-preterm formula fed infants during the first year of life[J].European Journal of Clinical Nutrition,2012,66(2):224-230.