血清同型半胱氨酸和尿液微量白蛋白水平在2型糖尿病诊治中的临床价值研究
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摘要
目的探究血清同型半胱氨酸(Hcy)和尿液微量白蛋白(U-mAlb)水平与2型糖尿病的关系。方法选择北京市海淀医院2018年1月至2018年10月收治的220例2型糖尿病患者为观察组,另选取同时期120例健康体检者为对照组,检测并分析两组受试者血清中Hcy和尿液U-mAlb水平。结果观察组血清Hcy和尿液U-mAlb水平均较对照组高,差异有统计学意义(P <0. 05); U-mAlb检测阳性的2型糖尿病患者,与U-mAlb检测阴性的患者比较,血清Hcy水平明显增高,差异有统计学意义(P<0.05)。结论 2型糖尿病患者血清Hcy、U-mAlb水平均高于正常人,高Hcy血症和糖尿病早期肾损伤有着密切的关系,对糖尿病早期肾损伤诊断具有重要意义。
Objective To investigate the relationship between serum homocysteine( Hey) and urinary microalbumin(u-malb) levels and type 2 diabetes mellitus. Methods 220 patients with type 2 diabetes admitted to Beijing HaiDian hospital from January,2018 to October,2018 were selected as the observation group,while 120 healthy subjects in the same period were selected as the control group. Serum Hey,Urinary Micro-Albumin(u-mAlb)levels in the two groups were detected. Results Serum Hey,urine u-mAlb levels in the observation group were higher than those in the control group,(P < 0. 05). The serum Hey level of patients with type 2 diabetes who had a positive urine u-malb test was significantly higher than that of patients with a negative urine u-malb test(P <0.05). Conclusion Hey and u-mAlb levels of type 2 diabetes patients are higher than that of normal people. High Hey is closely related to the early renal injury of diabetes, which is of great significance for the early detection of renal injury of diabetes.
Objective To investigate the relationship between serum homocysteine( Hey) and urinary microalbumin(u-malb) levels and type 2 diabetes mellitus. Methods 220 patients with type 2 diabetes admitted to Beijing HaiDian hospital from January,2018 to October,2018 were selected as the observation group,while 120 healthy subjects in the same period were selected as the control group. Serum Hey,Urinary Micro-Albumin(u-mAlb)levels in the two groups were detected. Results Serum Hey,urine u-mAlb levels in the observation group were higher than those in the control group,(P < 0. 05). The serum Hey level of patients with type 2 diabetes who had a positive urine u-malb test was significantly higher than that of patients with a negative urine u-malb test(P <0.05). Conclusion Hey and u-mAlb levels of type 2 diabetes patients are higher than that of normal people. High Hey is closely related to the early renal injury of diabetes, which is of great significance for the early detection of renal injury of diabetes.
引文
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[9]陈薇,童秀峰,黎安玲,等.血FFA,Hcy和Cys-C测定在糖尿病肾病早期诊断中的应用价值[J].海南医学,2015,26(3):375-377.
[2]金海英,张敏. VCAM-1、AOPP、HbA1c和FBG在二甲双胍治疗糖尿病肾病患者中的意义[J].标记免疫分析与临床,2018,25(1):50-53.
[3]董闪闪,刘瑶,李奉,等.硫辛酸对糖尿病肾病III期患者PCX和VEGF的影响[J].中国现代医学杂志,2018,28(5):77-81.
[4]American Diabetes Association. Classification and diagnosis of diabetes:standards of medical care in Diabetes-2018[J]. Diabetes Care,2018,41(Suppl 1):S13-S27.
[5]武春梅,李霞莲,李玲,等.Hcy,Sβ_2-MG,Uβ_2-MG及U-mAlb联合检测对糖尿病肾病的临床诊断价值[J].国际检验医学杂志,2014,35(9):1116-1118.
[6]朱建锋,瞿亚红,陈佳英.尿微量白蛋白和血清胱抑素C检测对糖尿病肾病早期诊断的意义[J].中国基层医药,2010,17(4):419.
[7]王蕾,熊声贺,张俊,等.同型半胱氨酸、血脂、肾功能指标及颈动脉超声在H型高血压中的临床应用价值[J].检验医学,2017,32(12):1109-1113.
[8]刘鹏,高学良,原建华,等.H型高血压患者血清同型半胱氨酸水平与冠状动脉狭窄病变程度的关系[J].中华老年心脑血管病杂志,2017,19(3):245-247.
[9]陈薇,童秀峰,黎安玲,等.血FFA,Hcy和Cys-C测定在糖尿病肾病早期诊断中的应用价值[J].海南医学,2015,26(3):375-377.