复方玄驹胶囊联合他达拉非对中老年男性继发性ED的疗效观察
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摘要
目的:探讨复方玄驹胶囊联合他达拉非对中老年男性继发性勃起功能障碍(erectile dysfunction,ED)的疗效。方法:选取衡水市哈励逊国际和平医院老年病科和男科门诊55岁以上男性,确诊为继发性ED,排除严重心血管疾病病史,且坚持相应治疗半年的72例患者为研究对象,将其分为A、B、C组。A组:28例患者,给予复方玄驹胶囊(口服,3粒/次,tid,24d一个疗程)+他达拉非(性交前1～2h,10mg～20mg/次); B组,20例患者,单纯给予复方玄驹胶囊(口服,3粒/次,tid,24d一个疗程); C组,24例患者,单纯给予希爱力(他达拉非)(性交前1～2h,10mg～20mg/次)。要求三组患者每7～11d进行一次性生活,治疗时间6个月,此间与治疗血脂、血糖的药物至少隔开1h服用,对治疗前后患者的勃起功能采用国际勃起功能指数问卷-5(International Index of Erectile Function-5,IIEF-5)问卷评分进行对比分析,并比较各组患者治疗后平均分和治疗有效率。所有患者对本研究充分知情同意,为其做好隐私保护。结果:治疗半年后,A组患者的治愈率为85. 7%,治疗后IIEF-5平均分显著高于B组和C组; B组患者治愈率为65. 0%; C组患者治愈率70. 8%。IIEF-5平均评分:B组 Objective: To explore the curative effect of combination therapy with Xuanju capsule and tadalafil on secondary ED( Erectile dysfunction) of middle-aged and elderly males. Methods: Geriatrics and andrology clinic of our hospital,aged above 55 years old,male patients diagnosed with secondary ED,excluding serious cardiovascular diseases,72 patients who accepted the treatment half a year were selected and divided into A,B,C group: A group: given Fu Fangxuanju capsule( oral,3 tablets once,Tid,24 days a course + tadalafil 10 mg-20 mg,oral,1-2 hours before sex),28 people; group B,treated with Fu Fangxuanju capsule( oral,3 tablets once,Tid,24 days a course),20 people; group C,treated with cialis( tadalafil)( 1-2 hours before sex,10 mg-20 mg,oral),24 people. Three groups of patients were asked to arrange sex life every 7-11 days,6 months of treatment,and at least 1 hours interval to take the other drugs. ED patients before and after treatment,assessed with IIEF-5( International Index of Erectile Function-5). Average scores and efficiency were analyzed and compared with each group after treatment,fully informed consent well,a tight privacy protection. Results: Half a year later,the cure rate of group A was 85. 7%. The average score of IIEF-5 was significantly higher than that of group B and C; the cure rate in B group was 65. 0%,and the cure rate of group C was 70. 8%. IIEF-5 average score: group B < group C
引文
[1]戚龙,董碧蓉.老年多病共存临床治疗决策新视角.现代临床医学,2014,40(2):150-153.
[2]金重睿,徐月敏.中老年男性勃起功能障碍的危险因素及研究进展.中国男科学杂志,2008,22(4):69-72.
[3] Cynthia M. Boyd,Bruce Leff,Jennifer L. Wolff,et al. Informing clinical practice guideline development and implementation:Prevalence of coexisting conditions among adults with coronary heartdisease. J Am Geriatr Soc,2011,59(5):797-805.
[4]石亮,朱磊磊.他达拉非按时或按需治疗中老年男性勃起功能障碍的研究.实用老年医学,2017,31(11):1032-1035.
[5]王俊龙,江专新,杨念钦,等.他达拉非按需与按时治疗勃起功能障碍前瞻性、多中心研究.中华男科学杂志,2014,20(1):14-18.
[6]孙倩倩,王双.老年综合评估的临床应用及研究进展.中国老年学杂志,2012,32(3):660-662
[7]高学勇,王玮.淫羊藿苷对环磷酰胺诱导生精障碍大鼠睾丸的影响.中外医疗,2009,28(17):18,20.
[8]辛军,李培勇,辛明华,等.复方玄驹胶囊联合十一酸睾酮治疗男性勃起功能障碍疗效观察.中国男科学杂志,2014,28(3):59-61.
[9]马渊,李纪夫.复方玄驹胶囊联合美国安诺治疗仪治疗2型糖尿病引起的勃起功能障碍54例.健康必读(中旬刊),2012,11(4):242-242.
[10]蒋超,曹志刚,陈其超,等.复方玄驹胶囊联合他达拉非治疗糖尿病勃起功能障碍的疗效观察.蚌埠医学院学报,2016,41(10):1323-1325.
[11] Amany S,Heba K. Effect of pregabalin on erectile function and penile NOS expression in rats with streptozotocin-induced diabetes. Official J,2013,121(4):230-233.
[12] Echeverri Tirado LC,Ferrer JE,Herrera AM. Aging and erectile dysfunction. Sex Med Rev,2016,4(1):63-73.
[13]刘子明,白培明,罗广承,等.他达拉非每日按时治疗和按需治疗勃起功能障碍的近期临床疗效.第三军医大学学报,2014,36(16):1769-1770.
[14]蔡健,邓哲献,蒋海波,等.复方玄驹胶囊治疗勃起功能障碍的疗效观察.中华男科学杂志,2006,12(6):568-569.
[15]罗昌春,邓宝凤,李海芳,等.老年综合评估的应用与研究现状.实用老年医学,2015,29(2):160-162.
[16] Deschodt M,Devriendt E,Sabbe M,et al. Characteristics of older adults admitted to the emergency department(ED)and their risk factors for ED readmission based on comprehensive geriatric assessment:A prospective cohort study. BMC Geriatrics,2015,15(1):54.
[17] Van CK,Braes T,Wellens N,et al. The effectiveness of inpatient geriatric evaluation and management units:A systematic review and meta-analysis. J Am Geriatr Soc,2010,58(1):83-92.
[2]金重睿,徐月敏.中老年男性勃起功能障碍的危险因素及研究进展.中国男科学杂志,2008,22(4):69-72.
[3] Cynthia M. Boyd,Bruce Leff,Jennifer L. Wolff,et al. Informing clinical practice guideline development and implementation:Prevalence of coexisting conditions among adults with coronary heartdisease. J Am Geriatr Soc,2011,59(5):797-805.
[4]石亮,朱磊磊.他达拉非按时或按需治疗中老年男性勃起功能障碍的研究.实用老年医学,2017,31(11):1032-1035.
[5]王俊龙,江专新,杨念钦,等.他达拉非按需与按时治疗勃起功能障碍前瞻性、多中心研究.中华男科学杂志,2014,20(1):14-18.
[6]孙倩倩,王双.老年综合评估的临床应用及研究进展.中国老年学杂志,2012,32(3):660-662
[7]高学勇,王玮.淫羊藿苷对环磷酰胺诱导生精障碍大鼠睾丸的影响.中外医疗,2009,28(17):18,20.
[8]辛军,李培勇,辛明华,等.复方玄驹胶囊联合十一酸睾酮治疗男性勃起功能障碍疗效观察.中国男科学杂志,2014,28(3):59-61.
[9]马渊,李纪夫.复方玄驹胶囊联合美国安诺治疗仪治疗2型糖尿病引起的勃起功能障碍54例.健康必读(中旬刊),2012,11(4):242-242.
[10]蒋超,曹志刚,陈其超,等.复方玄驹胶囊联合他达拉非治疗糖尿病勃起功能障碍的疗效观察.蚌埠医学院学报,2016,41(10):1323-1325.
[11] Amany S,Heba K. Effect of pregabalin on erectile function and penile NOS expression in rats with streptozotocin-induced diabetes. Official J,2013,121(4):230-233.
[12] Echeverri Tirado LC,Ferrer JE,Herrera AM. Aging and erectile dysfunction. Sex Med Rev,2016,4(1):63-73.
[13]刘子明,白培明,罗广承,等.他达拉非每日按时治疗和按需治疗勃起功能障碍的近期临床疗效.第三军医大学学报,2014,36(16):1769-1770.
[14]蔡健,邓哲献,蒋海波,等.复方玄驹胶囊治疗勃起功能障碍的疗效观察.中华男科学杂志,2006,12(6):568-569.
[15]罗昌春,邓宝凤,李海芳,等.老年综合评估的应用与研究现状.实用老年医学,2015,29(2):160-162.
[16] Deschodt M,Devriendt E,Sabbe M,et al. Characteristics of older adults admitted to the emergency department(ED)and their risk factors for ED readmission based on comprehensive geriatric assessment:A prospective cohort study. BMC Geriatrics,2015,15(1):54.
[17] Van CK,Braes T,Wellens N,et al. The effectiveness of inpatient geriatric evaluation and management units:A systematic review and meta-analysis. J Am Geriatr Soc,2010,58(1):83-92.