中医药治疗克罗恩病研究新况
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摘要
目前克罗恩病的研究正处于摸索阶段,本文厘清中医病因病机,概述了近年关于此病在中医理论指导下进行实验研究、临床研究的最新进展,提出需要发挥中医药的独特优势,与西医治疗有机结合,在病理研究、发掘新药物、减低副作用、缩短疗程、减少复发率、避免炎症及溃疡恶化等方面更加深入研究,才能提高患者生存质量。
The current study of Crohn's disease is in the exploratory stage.This article clarifies the etiology and pathogenesis of traditional Chinese medicine, outlines the new progress of experimental research and clinical research of this disease in these several years under the guidance of traditional Chinese medicine theory and puts forward the need to play the unique advantages of Chinese medicine which is combined with western medicine treatment.We should make more in-depth studies in the pathology research,to explore new drugs,reducing side effects, shortening the course of treatment,reducing the recurrence rate,to avoid inflammation,ulcer deterioration and so on to improve patients' quality of life.
The current study of Crohn's disease is in the exploratory stage.This article clarifies the etiology and pathogenesis of traditional Chinese medicine, outlines the new progress of experimental research and clinical research of this disease in these several years under the guidance of traditional Chinese medicine theory and puts forward the need to play the unique advantages of Chinese medicine which is combined with western medicine treatment.We should make more in-depth studies in the pathology research,to explore new drugs,reducing side effects, shortening the course of treatment,reducing the recurrence rate,to avoid inflammation,ulcer deterioration and so on to improve patients' quality of life.
引文
[1]Gomollón F,Dignass A,Annese V,et al.3rd European Evidence-based Consensus on the Diagnosis and Management of Crohn's Disease 2016:Part 1:Diagnosis and Medical Management[J].Journal of Crohn's and Colitis,2017,11(1):3-25.
[2]Fumery M,Dulai PS,Meirick P,et al.Systematic review with meta-analysis:recurrence of Crohn’s disease after total colectomy with permanent ileostomy[J].Aliment Pharmacol Ther,2017,45(3):381-390.
[3]Saowaluck meesin,谢建群.中医药对炎症性肠病免疫调节的研究[J].中国当代医药,2014,21(19):181-183.
[4]邹颖.黄芩汤对TNBS诱导的结肠炎大鼠Th1/Th2和Th17/Treg细胞平衡的影响[D].南方医科大学,2012.
[5]程滢瑞.黄葵总黄酮对克罗恩病小鼠模型作用的实验研究[D].南京中医药大学,2015.
[6]王倩,范文涛.马齿苋对炎症性肠病癌变的影响[J].中医学报,2014,29(2):180-181.
[7]赵敏.炎症性肠病患者临床资料回顾性分析[D].南京中医药大学,2017.
[8]陈延,黄智斌,刘奇,等.补土方案维持克罗恩病缓解期及生存质量研究[J].中国中西医结合消化杂志,2015,23(12):888-890.
[9]史佳宁,郝微微,温红珠,等.健脾化湿法治疗克罗恩病1例[J].中医杂志,2017,58(1):84-85.
[10]贾怡维.中医药治疗克罗恩病肛瘘临床观察[J].中医药临床杂志,2017,29(8):1316-1318.
[11]陈锦锋.克罗恩病中医证治探讨[J].中医药导报,2017,23(5):9-11.
[12]李妩玲.窦金发主任的学术思想和临床经验总结及运化分利汤治疗腹泻脾虚湿盛证的疗效观察[D].安徽中医药大学,2016.
[13]张建宁.沈继泽临证治疗克罗恩病的经验[J].江苏中医药,2013,45(11):16-17.
[14]施茵,包春辉.吴焕淦温养脾胃补肾通络辨治克罗恩病验案举隅[J].中华中医药杂志,2016,31(3):878-880.
[15]范钦梅.行气活血法治疗气滞血瘀型克罗恩病的疗效研究[D].南京中医药大学,2014.
[16]吉新强.克罗恩病中医证型分布规律及与体质分类关系的研究[D].南京中医药大学,2012.
[17]燕淑璇,姜树民.姜树民从痈论治克罗恩病经验[J].湖南中医杂志,2015,9(31):27-29.
[18]史涛,危北海.危北海治疗克罗恩病经验介绍[J].山西中医,2014,30(7):4-5,7.
[19]陈欣然,严季澜,李柳骥,等.严季澜教授治疗克罗恩病验案1则[J].河北中医,2014,36(7):972,975.
[20]欧阳博文,陈延.从“疮全赖脾土”理论探讨克罗恩病的中医治疗[J].广州中医药大学学报,2013,30(4):583-585.
[21]崔成成.叶柏教授治疗克罗恩病经验[J].长春中医药大学学报,2016,32(5):938-940.
[22]徐民民,王浩.谷云飞教授治疗肛周克罗恩病的经验[J].光明中医,2014,29(12):2503-2505.
[23]包春辉,吴璐一,吴焕淦,等.针灸治疗活动期克罗恩病:随机对照研究[J].中国针灸,2016,36(7):683-688.
[24]黄傲霜,史琲,郭圆,等.超声内镜在结肠克罗恩病微观辨证中的应用[J].中国中西医结合消化杂志,2016,24(5):367-369,373.
[25]顾沐恩,吴焕淦,刘雅楠,等.从长链非编码R NA角度探讨针灸治疗IBD的效应及调节机制[J].世界中医药,2017,12(2):417-423.
[26]张建宁.《金匮要略》人参汤合肾气丸治疗克罗恩病的研究[D].南京中医药大学,2013.
[2]Fumery M,Dulai PS,Meirick P,et al.Systematic review with meta-analysis:recurrence of Crohn’s disease after total colectomy with permanent ileostomy[J].Aliment Pharmacol Ther,2017,45(3):381-390.
[3]Saowaluck meesin,谢建群.中医药对炎症性肠病免疫调节的研究[J].中国当代医药,2014,21(19):181-183.
[4]邹颖.黄芩汤对TNBS诱导的结肠炎大鼠Th1/Th2和Th17/Treg细胞平衡的影响[D].南方医科大学,2012.
[5]程滢瑞.黄葵总黄酮对克罗恩病小鼠模型作用的实验研究[D].南京中医药大学,2015.
[6]王倩,范文涛.马齿苋对炎症性肠病癌变的影响[J].中医学报,2014,29(2):180-181.
[7]赵敏.炎症性肠病患者临床资料回顾性分析[D].南京中医药大学,2017.
[8]陈延,黄智斌,刘奇,等.补土方案维持克罗恩病缓解期及生存质量研究[J].中国中西医结合消化杂志,2015,23(12):888-890.
[9]史佳宁,郝微微,温红珠,等.健脾化湿法治疗克罗恩病1例[J].中医杂志,2017,58(1):84-85.
[10]贾怡维.中医药治疗克罗恩病肛瘘临床观察[J].中医药临床杂志,2017,29(8):1316-1318.
[11]陈锦锋.克罗恩病中医证治探讨[J].中医药导报,2017,23(5):9-11.
[12]李妩玲.窦金发主任的学术思想和临床经验总结及运化分利汤治疗腹泻脾虚湿盛证的疗效观察[D].安徽中医药大学,2016.
[13]张建宁.沈继泽临证治疗克罗恩病的经验[J].江苏中医药,2013,45(11):16-17.
[14]施茵,包春辉.吴焕淦温养脾胃补肾通络辨治克罗恩病验案举隅[J].中华中医药杂志,2016,31(3):878-880.
[15]范钦梅.行气活血法治疗气滞血瘀型克罗恩病的疗效研究[D].南京中医药大学,2014.
[16]吉新强.克罗恩病中医证型分布规律及与体质分类关系的研究[D].南京中医药大学,2012.
[17]燕淑璇,姜树民.姜树民从痈论治克罗恩病经验[J].湖南中医杂志,2015,9(31):27-29.
[18]史涛,危北海.危北海治疗克罗恩病经验介绍[J].山西中医,2014,30(7):4-5,7.
[19]陈欣然,严季澜,李柳骥,等.严季澜教授治疗克罗恩病验案1则[J].河北中医,2014,36(7):972,975.
[20]欧阳博文,陈延.从“疮全赖脾土”理论探讨克罗恩病的中医治疗[J].广州中医药大学学报,2013,30(4):583-585.
[21]崔成成.叶柏教授治疗克罗恩病经验[J].长春中医药大学学报,2016,32(5):938-940.
[22]徐民民,王浩.谷云飞教授治疗肛周克罗恩病的经验[J].光明中医,2014,29(12):2503-2505.
[23]包春辉,吴璐一,吴焕淦,等.针灸治疗活动期克罗恩病:随机对照研究[J].中国针灸,2016,36(7):683-688.
[24]黄傲霜,史琲,郭圆,等.超声内镜在结肠克罗恩病微观辨证中的应用[J].中国中西医结合消化杂志,2016,24(5):367-369,373.
[25]顾沐恩,吴焕淦,刘雅楠,等.从长链非编码R NA角度探讨针灸治疗IBD的效应及调节机制[J].世界中医药,2017,12(2):417-423.
[26]张建宁.《金匮要略》人参汤合肾气丸治疗克罗恩病的研究[D].南京中医药大学,2013.