Modulatory effect of International standard Scalp Acupuncture on brain activation in the elderly as revealed by resting-state fMRI
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摘要
The specific mechanisms by which acupuncture affects the central nervous system are unclear. In the International Standard Scalp Acupuncture system, acupuncture needles are applied at the middle line of the vertex, anterior parietal-temporal oblique line, and the posterior parietal-temporal oblique line. We conducted a single-arm prospective clinical trial in which seven healthy elderly volunteers(three men and four women; 50–70 years old) received International Standard Scalp Acupuncture at MS5(the mid-sagittal line between Baihui(DU20) and Qianding(DU21)), the left MS6(line joining Sishencong(EX-HN1) and Xuanli(GB6)), and the left MS7(line joining DU20 and Qubin(GB7)).After acupuncture, resting-state functional magnetic resonance imaging demonstrated changes in the fractional amplitude of low frequency fluctuations and regional homogeneity in various areas, showing remarkable enhancement of regional homogeneity in the bilateral anterior cingulate, left medial frontal gyrus, supramarginal gyrus, right middle frontal gyrus, and inferior frontal gyrus. Functional connectivity based on a seed region at the right middle frontal gyrus(42, 51, 9) decreased at the bilateral medial superior frontal gyrus. Our data preliminarily indicates that the international standard scalp acupuncture in healthy elderly participants specifcally enhances the correlation between the brain regions involved in cognition and implementation of the brain network regulation system and the surrounding adjacent brain regions.The study was approved by the Ethics Committee of the China-Japan Union Hospital at Jilin University, China, on July 18, 2016(approval No.2016 ks043).
The specific mechanisms by which acupuncture affects the central nervous system are unclear. In the International Standard Scalp Acupuncture system, acupuncture needles are applied at the middle line of the vertex, anterior parietal-temporal oblique line, and the posterior parietal-temporal oblique line. We conducted a single-arm prospective clinical trial in which seven healthy elderly volunteers(three men and four women; 50–70 years old) received International Standard Scalp Acupuncture at MS5(the mid-sagittal line between Baihui(DU20) and Qianding(DU21)), the left MS6(line joining Sishencong(EX-HN1) and Xuanli(GB6)), and the left MS7(line joining DU20 and Qubin(GB7)).After acupuncture, resting-state functional magnetic resonance imaging demonstrated changes in the fractional amplitude of low frequency fluctuations and regional homogeneity in various areas, showing remarkable enhancement of regional homogeneity in the bilateral anterior cingulate, left medial frontal gyrus, supramarginal gyrus, right middle frontal gyrus, and inferior frontal gyrus. Functional connectivity based on a seed region at the right middle frontal gyrus(42, 51, 9) decreased at the bilateral medial superior frontal gyrus. Our data preliminarily indicates that the international standard scalp acupuncture in healthy elderly participants specifcally enhances the correlation between the brain regions involved in cognition and implementation of the brain network regulation system and the surrounding adjacent brain regions.The study was approved by the Ethics Committee of the China-Japan Union Hospital at Jilin University, China, on July 18, 2016(approval No.2016 ks043).
The specific mechanisms by which acupuncture affects the central nervous system are unclear. In the International Standard Scalp Acupuncture system, acupuncture needles are applied at the middle line of the vertex, anterior parietal-temporal oblique line, and the posterior parietal-temporal oblique line. We conducted a single-arm prospective clinical trial in which seven healthy elderly volunteers(three men and four women; 50–70 years old) received International Standard Scalp Acupuncture at MS5(the mid-sagittal line between Baihui(DU20) and Qianding(DU21)), the left MS6(line joining Sishencong(EX-HN1) and Xuanli(GB6)), and the left MS7(line joining DU20 and Qubin(GB7)).After acupuncture, resting-state functional magnetic resonance imaging demonstrated changes in the fractional amplitude of low frequency fluctuations and regional homogeneity in various areas, showing remarkable enhancement of regional homogeneity in the bilateral anterior cingulate, left medial frontal gyrus, supramarginal gyrus, right middle frontal gyrus, and inferior frontal gyrus. Functional connectivity based on a seed region at the right middle frontal gyrus(42, 51, 9) decreased at the bilateral medial superior frontal gyrus. Our data preliminarily indicates that the international standard scalp acupuncture in healthy elderly participants specifcally enhances the correlation between the brain regions involved in cognition and implementation of the brain network regulation system and the surrounding adjacent brain regions.The study was approved by the Ethics Committee of the China-Japan Union Hospital at Jilin University, China, on July 18, 2016(approval No.2016 ks043).
引文
Bai L,Tao Y,Wang D,Wang J,Sun C,Hao N,Chen S,Lao L(2014)Acupuncture induces time-dependent remodelling brain network on the stable somatosensory first-ever stroke patients:combining diffusion tensor and functional MR imaging.Evid Based Complement Alternat Med 2014:740480.
Baldassarre A,Ramsey LE,Siegel JS,Shulman GL,Corbetta M(2016)Brain connectivity and neurological disorders after stroke.Curr Opin Neurol 29:706-713.
Bogousslavsky J,Miklossy J,Deruaz JP,Assal G,Regli F(1987)Lingual and fusiform gyri in visual processing:a clinico-pathologic study of superior altitudinal hemianopia.J Neurol Neurosurg Psychiatry50:607-614.
Brakowski J,Spinelli S,Dorig N,Bosch OG,Manoliu A,Holtforth MG,Seifritz E(2017)Resting state brain network function in major depression-Depression symptomatology,antidepressant treatment effects,future research.J Psychiatr Res 92:147-159.
Cai RL,Shen GM,Wang H,Guan YY(2018)Brain functional connectivity network studies of acupuncture:a systematic review on resting-state fMRI.J Integr Med 16:26-33.
Cavanna AE,Trimble MR(2006)The precuneus:a review of its functional anatomy and behavioural correlates.Brain 129:564-583.
Cerasa A,Novellino F,Quattrone A(2016)Connectivity changes in Parkinson’s disease.Curr Neurol Neurosci Rep 16:91.
Deng D,Liao H,Duan G,Liu Y,He Q,Liu H,Tang L,Pang Y,Tao J(2016)Modulation of the default mode network in first-episode,drug-naive major depressive disorder via acupuncture at Baihui(GV20)Acupoint.Front Hum Neurosci 10:230.
Frascarelli M,Tognin S,Mirigliani A,Parente F,Buzzanca A,Torti MC,Tinelli E,Caramia F,Di Fabio F,Biondi M,Fusar-Poli P(2015)Medial frontal gyrus alterations in schizophrenia:relationship with duration of illness and executive dysfunction.Psychiatry Res231:103-110.
Goffaux P,Girard-Tremblay L,Marchand S,Daigle K,Whittingstall K(2014)Individual differences in pain sensitivity vary as a function of precuneus reactivity.Brain Topogr 27:366-374.
Golestani AM,Kwinta JB,Khatamian YB,Chen JJ(2017)The effect of low-frequency physiological correction on the reproducibility and specificity of resting-state fMRI metrics:functional connectivity,ALFF,and ReHo.Front Neurosci 11:546.
He T,Zhu W,Du SQ,Yang JW,Li F,Yang BF,Shi GX,Liu CZ(2015)Neural mechanisms of acupuncture as revealed by fMRI studies.Auton Neurosci 190:1-9.
Koike S,Takizawa R,Nishimura Y,Marumo K,Kinou M,Kawakubo Y,Rogers MA,Kasai K(2011)Association between severe dorsolateral prefrontal dysfunction during random number generation and earlier onset in schizophrenia.Clin Neurophysiol 122:1533-1540.
Króliczak G,Piper BJ,Frey SH(2016)Specialization of the left supramarginal gyrus for hand-independent praxis representation is not related to hand dominance.Neuropsychologia 93:501-512.
Lai XS,Huang Y(2007)A cerebral functional definition on the specificity of acupoints,needling sensation and association of acupoints based on the“acupoints-brain relation hypothesis?Zhongguo Zhen Jiu 27:777-780.
Li W,Qin W,Liu H,Fan L,Wang J,Jiang T,Yu C(2013)Subregions of the human superior frontal gyrus and their connections.Neuroimage 78:46-58.
Lichteim L(1885)On Aphasia.Brain 7:433-484.
Lu YJ,Huang Y,Chen JQ,Lin RY,Xiao HL(2011)Thinkings on the key brain region activated by needling with the baseline state fMRI.Zhongguo Zhen Jiu 31:367-370.
Myung W,Na KS,Ham BJ,Oh SJ,Ahn HW,Jung HY(2016)Decreased medial frontal gyrus in patients with adjustment disorder.JAffect Disord 191:36-40.
No authors listed(1990)A standard international acupuncture nomenclature:memorandum from a WHO meeting.Bull World Health Organ 68:165-169.
Olivetti Belardinelli M,Palmiero M,Sestieri C,Nardo D,Di Matteo R,Londei A,D’Ausilio A,Ferretti A,Del Gratta C,Romani GL(2009)An fMRI investigation on image generation in different sensory modalities:the influence of vividness.Acta Psychol(Amst)132:190-200.
Rong PJ,Zhao JJ,Gao JH,Li X,Li SY,Ben H,Pearson B(2013)Progress of research on specificity of meridian acupoint efficacy.Chin JIntegr Med 19:889-893.
Shi Y,Zhang S,Li Q,Liu Z,Guo S,Yang J,Wu W(2016)A study of the brain functional network of Deqi via acupuncturing stimulation at BL40 by rs-fMRI.Complement Ther Med 25:71-77.
Tahmasian M,Eickhoff SB,Giehl K,Schwartz F,Herz DM,Drzezga A,van Eimeren T,Laird AR,Fox PT,Khazaie H,Zarei M,Eggers C,Eickhoff CR(2017)Resting-state functional reorganization in Parkinson’s disease:An activation likelihood estimation meta-analysis.Cortex 92:119-138.
Talati A,Hirsch J(2005)Functional specialization within the medial frontal gyrus for perceptual go/no-go decisions based on“what,”“when,”and“where”related information:an fMRI study.J Cogn Neurosci 17:981-993.
Thiel A,Vahdat S(2015)Structural and resting-state brain connectivity of motor networks after stroke.Stroke 46:296-301.
Tomoda A,Kinoshita S,Korenaga Y,Mabe H(2012)Pseudohypacusis in childhood and adolescence is associated with increased gray matter volume in the medial frontal gyrus and superior temporal gyrus.Cortex 48:492-503.
Vincent JL,Kahn I,Snyder AZ,Raichle ME,Buckner RL(2008)Evidence for a frontoparietal control system revealed by intrinsic functional connectivity.J Neurophysiol 100:3328-3342.
Wang HQ,Dong GR,Bao CL,Jiao ZH(2018)Immediate effect of scalp acupuncture on the gait of patients with subacute intracerebral haemorrhage analysed by three-dimensional motion:secondary analysis of a randomised controlled trial.Acupunct Med 36:71-79.
Wang J,Pei J,Cui X,Sun K,Fu Q,Xing C,Jiang C,Zhou C,Chen Y,Yan M(2017)Individualized scalp acupuncture for motor dysfunction in stroke:a randomized controlled trial.Zhongguo Zhen Jiu37:918-924.
Wang X,Wang Z,Liu J,Chen J,Liu X,Nie G,Byun JS,Liang Y,Park J,Huang R,Liu M,Liu B,Kong J(2016)Repeated acupuncture treatments modulate amygdala resting state functional connectivity of depressive patients.Neuroimage Clin 12:746-752.
Yin S,Chen Y,Lei D,Sun RR,Ma TT,Feng PM,He ZX,Suo XL,Ma PH,Qu YZ,Qiu K,Jing MM,Gong QY,Liang FR,Chen J,Zeng F(2017)Cerebral mechanism of puncturing at He-Mu point combination for functional dyspepsia:study protocol for a randomized controlled parallel trial.Neural Regen Res 12:831-840.
You YN,Cho MR,Kim JH,Park JH,Park GC,Song MY,Choi JB,Han JY(2017)Assessing the quality of reports about randomized controlled trials of scalp acupuncture combined with another treatment for stroke.BMC Complement Altern Med 17:452.
Zhang J,Zheng Y,Wang Y,Qu S,Zhang S,Wu C,Chen J,Ouyang H,Tang C,Huang Y(2016)Evidence of a synergistic effect of acupoint combination:a resting-state functional magnetic resonance imaging study.J Altern Complement Med 22:800-809.
Zhang JX,Leung HC,Johnson MK(2003)Frontal activations associated with accessing and evaluating information in working memory:an fMRI study.Neuroimage 20:1531-1539.
Zhang Y,Li K,Ren Y,Cui F,Xie Z,Shin JY,Tan Z,Tang L,Bai L,Zou Y(2014)Acupuncture modulates the functional connectivity of the default mode network in stroke patients.Evid Based Complement Alternat Med 2014:765413.
Zhao L,Chen J,Liu CZ,Li Y,Cai DJ,Tang Y,Yang J,Liang FR(2012)A review of acupoint specificity research in china:status quo and prospects.Evid Based Complement Alternat Med 2012:543943.
Zheng J,Chen B,Guo Y,Guo Y(2015)Analysis on the factors that cause the difference of acupoints synergy effect.Zhongguo Zhen Jiu35:719-722.
Zhong ZP,Wu SS,Chen ZG,Bo L(2011)Study on response of resting-state functional magnetic resonance imaging induced by abdominal acupuncture with invigorating the kidney and nourishing marrow method.Zhongguo Zhen Jiu 31:139-143.
Baldassarre A,Ramsey LE,Siegel JS,Shulman GL,Corbetta M(2016)Brain connectivity and neurological disorders after stroke.Curr Opin Neurol 29:706-713.
Bogousslavsky J,Miklossy J,Deruaz JP,Assal G,Regli F(1987)Lingual and fusiform gyri in visual processing:a clinico-pathologic study of superior altitudinal hemianopia.J Neurol Neurosurg Psychiatry50:607-614.
Brakowski J,Spinelli S,Dorig N,Bosch OG,Manoliu A,Holtforth MG,Seifritz E(2017)Resting state brain network function in major depression-Depression symptomatology,antidepressant treatment effects,future research.J Psychiatr Res 92:147-159.
Cai RL,Shen GM,Wang H,Guan YY(2018)Brain functional connectivity network studies of acupuncture:a systematic review on resting-state fMRI.J Integr Med 16:26-33.
Cavanna AE,Trimble MR(2006)The precuneus:a review of its functional anatomy and behavioural correlates.Brain 129:564-583.
Cerasa A,Novellino F,Quattrone A(2016)Connectivity changes in Parkinson’s disease.Curr Neurol Neurosci Rep 16:91.
Deng D,Liao H,Duan G,Liu Y,He Q,Liu H,Tang L,Pang Y,Tao J(2016)Modulation of the default mode network in first-episode,drug-naive major depressive disorder via acupuncture at Baihui(GV20)Acupoint.Front Hum Neurosci 10:230.
Frascarelli M,Tognin S,Mirigliani A,Parente F,Buzzanca A,Torti MC,Tinelli E,Caramia F,Di Fabio F,Biondi M,Fusar-Poli P(2015)Medial frontal gyrus alterations in schizophrenia:relationship with duration of illness and executive dysfunction.Psychiatry Res231:103-110.
Goffaux P,Girard-Tremblay L,Marchand S,Daigle K,Whittingstall K(2014)Individual differences in pain sensitivity vary as a function of precuneus reactivity.Brain Topogr 27:366-374.
Golestani AM,Kwinta JB,Khatamian YB,Chen JJ(2017)The effect of low-frequency physiological correction on the reproducibility and specificity of resting-state fMRI metrics:functional connectivity,ALFF,and ReHo.Front Neurosci 11:546.
He T,Zhu W,Du SQ,Yang JW,Li F,Yang BF,Shi GX,Liu CZ(2015)Neural mechanisms of acupuncture as revealed by fMRI studies.Auton Neurosci 190:1-9.
Koike S,Takizawa R,Nishimura Y,Marumo K,Kinou M,Kawakubo Y,Rogers MA,Kasai K(2011)Association between severe dorsolateral prefrontal dysfunction during random number generation and earlier onset in schizophrenia.Clin Neurophysiol 122:1533-1540.
Króliczak G,Piper BJ,Frey SH(2016)Specialization of the left supramarginal gyrus for hand-independent praxis representation is not related to hand dominance.Neuropsychologia 93:501-512.
Lai XS,Huang Y(2007)A cerebral functional definition on the specificity of acupoints,needling sensation and association of acupoints based on the“acupoints-brain relation hypothesis?Zhongguo Zhen Jiu 27:777-780.
Li W,Qin W,Liu H,Fan L,Wang J,Jiang T,Yu C(2013)Subregions of the human superior frontal gyrus and their connections.Neuroimage 78:46-58.
Lichteim L(1885)On Aphasia.Brain 7:433-484.
Lu YJ,Huang Y,Chen JQ,Lin RY,Xiao HL(2011)Thinkings on the key brain region activated by needling with the baseline state fMRI.Zhongguo Zhen Jiu 31:367-370.
Myung W,Na KS,Ham BJ,Oh SJ,Ahn HW,Jung HY(2016)Decreased medial frontal gyrus in patients with adjustment disorder.JAffect Disord 191:36-40.
No authors listed(1990)A standard international acupuncture nomenclature:memorandum from a WHO meeting.Bull World Health Organ 68:165-169.
Olivetti Belardinelli M,Palmiero M,Sestieri C,Nardo D,Di Matteo R,Londei A,D’Ausilio A,Ferretti A,Del Gratta C,Romani GL(2009)An fMRI investigation on image generation in different sensory modalities:the influence of vividness.Acta Psychol(Amst)132:190-200.
Rong PJ,Zhao JJ,Gao JH,Li X,Li SY,Ben H,Pearson B(2013)Progress of research on specificity of meridian acupoint efficacy.Chin JIntegr Med 19:889-893.
Shi Y,Zhang S,Li Q,Liu Z,Guo S,Yang J,Wu W(2016)A study of the brain functional network of Deqi via acupuncturing stimulation at BL40 by rs-fMRI.Complement Ther Med 25:71-77.
Tahmasian M,Eickhoff SB,Giehl K,Schwartz F,Herz DM,Drzezga A,van Eimeren T,Laird AR,Fox PT,Khazaie H,Zarei M,Eggers C,Eickhoff CR(2017)Resting-state functional reorganization in Parkinson’s disease:An activation likelihood estimation meta-analysis.Cortex 92:119-138.
Talati A,Hirsch J(2005)Functional specialization within the medial frontal gyrus for perceptual go/no-go decisions based on“what,”“when,”and“where”related information:an fMRI study.J Cogn Neurosci 17:981-993.
Thiel A,Vahdat S(2015)Structural and resting-state brain connectivity of motor networks after stroke.Stroke 46:296-301.
Tomoda A,Kinoshita S,Korenaga Y,Mabe H(2012)Pseudohypacusis in childhood and adolescence is associated with increased gray matter volume in the medial frontal gyrus and superior temporal gyrus.Cortex 48:492-503.
Vincent JL,Kahn I,Snyder AZ,Raichle ME,Buckner RL(2008)Evidence for a frontoparietal control system revealed by intrinsic functional connectivity.J Neurophysiol 100:3328-3342.
Wang HQ,Dong GR,Bao CL,Jiao ZH(2018)Immediate effect of scalp acupuncture on the gait of patients with subacute intracerebral haemorrhage analysed by three-dimensional motion:secondary analysis of a randomised controlled trial.Acupunct Med 36:71-79.
Wang J,Pei J,Cui X,Sun K,Fu Q,Xing C,Jiang C,Zhou C,Chen Y,Yan M(2017)Individualized scalp acupuncture for motor dysfunction in stroke:a randomized controlled trial.Zhongguo Zhen Jiu37:918-924.
Wang X,Wang Z,Liu J,Chen J,Liu X,Nie G,Byun JS,Liang Y,Park J,Huang R,Liu M,Liu B,Kong J(2016)Repeated acupuncture treatments modulate amygdala resting state functional connectivity of depressive patients.Neuroimage Clin 12:746-752.
Yin S,Chen Y,Lei D,Sun RR,Ma TT,Feng PM,He ZX,Suo XL,Ma PH,Qu YZ,Qiu K,Jing MM,Gong QY,Liang FR,Chen J,Zeng F(2017)Cerebral mechanism of puncturing at He-Mu point combination for functional dyspepsia:study protocol for a randomized controlled parallel trial.Neural Regen Res 12:831-840.
You YN,Cho MR,Kim JH,Park JH,Park GC,Song MY,Choi JB,Han JY(2017)Assessing the quality of reports about randomized controlled trials of scalp acupuncture combined with another treatment for stroke.BMC Complement Altern Med 17:452.
Zhang J,Zheng Y,Wang Y,Qu S,Zhang S,Wu C,Chen J,Ouyang H,Tang C,Huang Y(2016)Evidence of a synergistic effect of acupoint combination:a resting-state functional magnetic resonance imaging study.J Altern Complement Med 22:800-809.
Zhang JX,Leung HC,Johnson MK(2003)Frontal activations associated with accessing and evaluating information in working memory:an fMRI study.Neuroimage 20:1531-1539.
Zhang Y,Li K,Ren Y,Cui F,Xie Z,Shin JY,Tan Z,Tang L,Bai L,Zou Y(2014)Acupuncture modulates the functional connectivity of the default mode network in stroke patients.Evid Based Complement Alternat Med 2014:765413.
Zhao L,Chen J,Liu CZ,Li Y,Cai DJ,Tang Y,Yang J,Liang FR(2012)A review of acupoint specificity research in china:status quo and prospects.Evid Based Complement Alternat Med 2012:543943.
Zheng J,Chen B,Guo Y,Guo Y(2015)Analysis on the factors that cause the difference of acupoints synergy effect.Zhongguo Zhen Jiu35:719-722.
Zhong ZP,Wu SS,Chen ZG,Bo L(2011)Study on response of resting-state functional magnetic resonance imaging induced by abdominal acupuncture with invigorating the kidney and nourishing marrow method.Zhongguo Zhen Jiu 31:139-143.