白细胞介素22在哮喘中的研究进展
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摘要
支气管哮喘(哮喘)是由多种细胞及细胞组分共同参与的慢性气道炎症疾病。白细胞介素22(IL-22)是IL-10家族的新成员,它能通过结合特异性受体IL-22R发挥其生物学效应。IL-22在哮喘的发病机制中起着一定的调控作用。IL-22在哮喘患者外周血中或者哮喘动物模型中表达增高。目前,IL-22在不同的实验中得出的结果对于哮喘炎症是促进还是抑制仍有争议。此外,IL-22如何在哮喘中发挥调控作用仍是未知的。
Bronchial asthma( asthma) is a common chronic inflammatory disease involved with a variety of cells and cellular components. Interleukin 22( IL-22) is a new member of the IL-10 family,which can exert its biological effects through combining the specific receptors of IL-22( IL-22R). IL-22 plays a regulatory role in the pathogenesis of asthma. The expression of IL-22 is increased in peripheral blood of asthma patients or in asthma animal model. It is still a controversial problem whether IL-22 promotes inflammation or suppresses inflammation in different studies,and it remains unknown how IL-22 plays its regulatory role in asthma.
Bronchial asthma( asthma) is a common chronic inflammatory disease involved with a variety of cells and cellular components. Interleukin 22( IL-22) is a new member of the IL-10 family,which can exert its biological effects through combining the specific receptors of IL-22( IL-22R). IL-22 plays a regulatory role in the pathogenesis of asthma. The expression of IL-22 is increased in peripheral blood of asthma patients or in asthma animal model. It is still a controversial problem whether IL-22 promotes inflammation or suppresses inflammation in different studies,and it remains unknown how IL-22 plays its regulatory role in asthma.
引文
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[24]Martin JC,Beriou G,Heslan M,et al.Interleukin-22 binding protein(IL-22BP)is constitutively expressed by a subset of conventional dendritic cells and is strongly induced by retinoic acid[J].Mucosal Immunol,2014,7(1):101-113.
[25]Logsdon NJ,Jones BC,Josephson K,et al.Comparison of interleukin-22 and interleukin-10 soluble receptor complexes[J].J Interferon Cytokine Res,2002,22(11):1099-1112.
[26]Wolk K,Kunz S,Witte E,et al.IL-22 increases the innate immunity of tissues[J].Immunity,2004,21(2):241-254.
[27]Wawrzyniak M,Ochsner U,Wirz O,et al.A novel,dual cytokinesecretion assay for the purification of human Th22 cells that do not co-produce IL-17A[J].Allergy,2016,71(1):47-57.
[28]Lambrecht BN,Hammad H.Asthma:the importance of dysregulated barrier immunity[J].Eur J Immunol,2013,43(12):3125-3137.
[29]Chang H,Hanawa H,Liu H,et al.Hydrodynamic-based delivery of an interleukin-22-Ig fusion gene ameliorates experimental autoimmune myocarditis in rats[J].J Immunol,2006,177(6):3635-3643.
[30]Nakagome K,Imamura M,Kawahata K,et al.High expression of IL-22 suppresses antigen-induced immune responses and eosinophilic airway inflammation via an IL-10-associated mechanism[J].J Immunol,2011,187(10):5077-5089.
[31]Besnard AG,Sabat R,Dumoutier L,et al.Dual Role of IL-22 in allergic airway inflammation and its cross-talk with IL-17A[J].Am J Respir Crit Care Med,2011,183(9):1153-1163.
[32]Sonnenberg GF,Nair MG,Kirn TJ,et al.Pathological versus protective functions of IL-22 in airway inflammation are regulated by IL-17A[J].J Exp Med,2010,207(6):1293-1305.
[33]Liang SC,Long AJ,Bennett F,et al.An IL-17F/A heterodimer protein is produced by mouse Th17 cells and induces airway neutrophil recruitment[J].J Immunol,2007,179(11):7791-7799.
[34]Pennino D,Bhavsar PK,Effner R,et al.IL-22 suppresses IFNgamma-mediated lung inflammation in asthmatic patients[J].J Allergy Clin Immunol,2013,131(2):562-570.
[35]Halwani R,Sultana A,Al-Kufaidy R,et al.Th-17 regulatory cytokines inhibit corticosteroid induced airway structural cells apoptosis[J].Respir Res,2016,17:6.
[36]Taube C,Tertilt C,Gyulveszi G,et al.IL-22 is produced by innate lymphoid cells and limits inflammation in allergic airway disease[J].PLo S One,2011,6(7):e21799.
[37]Schnyder B,Lima C,Schnyder-Candrian S.Interleukin-22 is a negative regulator of the allergic response[J].Cytokine,2010,50(2):220-227.
[38]Takahashi K,Hirose K,Kawashima S,et al.IL-22 attenuates IL-25production by lung epithelial cells and inhibits antigen-induced eosinophilic airway inflammation[J].J Allergy Clin Immunol,2011,128(5):1067-1076.
[39]Farfariello V,Amantini C,Nabissi M,et al.IL-22 mRNA in peripheral blood mononuclear cells from allergic rhinitic and asthmatic pediatric patients[J].Pediatr Allergy Immunol,2011,22(4):419-423.
[40]Zhao Y,Yang J,Gao YD,et al.Th17 immunity in patients with allergic asthma[J].Int Arch Allergy Immunol,2010,151(4):297-307.
[41]Zhu J,Cao Y,Li K,et al.Increased expression of aryl hydrocarbon receptor and interleukin 22 in patients with allergic asthma[J].Asian Pac J Allergy Immunol,2011,29(3):266-272.
[42]Wong CK,Lun SW,Ko FW,et al.Activation of peripheral Th17lymphocytes in patients with asthma[J].Immunol Invest,2009,38(7):652-664.
[43]张旃,罗雅玲,周丽丽,等.IL-22在支气管哮喘患者血清中的表达及其受体IL-22R1在人气道细胞中的表达[J].第二军医大学学报,2010(12):1291-1295.
[44]张旃,蓝海兵,周丽丽,等.IL-22对人气道细胞的作用[J].中国老年学杂志,2011,31(12):2222-2225.
[45]Chang Y,Al-Alwan L,Risse PA,et al.Th17-associated cytokines promote human airway smooth muscle cell proliferation[J].FASEB J,2012,26(12):5152-5160.
[46]Lilly LM,Gessner MA,Dunaway CW,et al.The beta-glucan recepto r dectin-1 promotes lung immunopathology during fungal allergy via IL-22[J].J Immunol,2012,189(7):3653-3660.
[47]Guo H,Topham DJ.Interleukin-22(IL-22)production by pulmonary Natural Killer cells and the potential role of IL-22during primary influenza virus infection[J].J Virol,2010,84(15):7750-7759.
[48]Kim EY,Battaile JT,Patel AC,et al.Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease[J].Nat Med,2008,14(6):633-640.
[49]Djukanovic R,Gadola SD.Virus infection,asthma,and chronic obstructive pulmonary disease[J].N Engl J Med,2008,359(19):2062-2064.
[50]Hirose K,Takahashi K,Nakajima H.Roles of IL-22 in Allergic Airway Inflammation[J].J Allergy(Cairo),2013,2013:260518.
[2]Manni ML,Alcorn JF.The enigmatic role of IL-22 in asthma[J].Expert Rev Respir Med,2016,10(6):619-623.
[3]Dumoutier L,Louahed J,Renauld JC.Cloning and characterization of IL-10-related T cell-derived inducible factor(IL-TIF),a novel cytokine structurally related to IL-10 and inducible by IL-9[J].J Immunol,2000,164(4):1814-1819.
[4]Akdis M,Palomares O,van de Veen W,et al.TH17 and TH22cells:a confusion of antimicrobial response with tissue inflammation versus protection[J].J Allergy Clin Immunol,2012,129(6):1438-1449,z1450-z1451.
[5]Dumoutier L,Van Roost E,Ameye G,et al.IL-TIF/IL-22:genomic organization and mapping of the human and mouse genes[J].Genes Immun,2000,1(8):488-494.
[6]Dubin PJ,Kolls JK.Th17 cytokines and mucosal immunity[J].Immunol Rev,2008,226:160-171.
[7]Perusina LM,Lin Y,Fang J,et al.Biological and pathological activities of interleukin-22[J].J Mol Med(Berl),2016,94(5):523-534.
[8]Mashiko S,Bouguermouh S,Rubio M,et al.Human mast cells are major IL-22 producers in patients with psoriasis and atopic dermatitis[J].J Allergy Clin Immunol,2015,136(2):351-359.
[9]Hansson M,Silverpil E,Linden A,et al.Interleukin-22 produced by alveolar macrophages during activation of the innate immune response[J].Inflamm Res,2013,62(6):561-569.
[10]Zindl CL,Lai JF,Lee YK,et al.IL-22-producing neutrophils contribute to antimicrobial defense and restitution of colonic epithelial integrity during colitis[J].Proc Natl Acad Sci U S A,2013,110(31):12768-12773.
[11]Ikeuchi H,Kuroiwa T,Hiramatsu N,et al.Expression of interleukin-22 in rheumatoid arthritis:potential role as a proinflammatory cytokine[J].Arthritis Rheum,2005,52(4):1037-1046.
[12]Fang P,Zhou L,Zhou Y,et al.Immune modulatory effects of IL-22on allergen-induced pulmonary inflammation[J].PLo S One,2014,9(9):e107454.
[13]Simonian PL,Wehrmann F,Roark CL,et al.gammadelta T cells protect against lung fibrosis via IL-22[J].J Exp Med,2010,207(10):2239-2253.
[14]Martin B,Hirota K,Cua DJ,et al.Interleukin-17-producing gammadelta T cells selectively expand in response to pathogen products and environmental signals[J].Immunity,2009,31(2):321-330.
[15]Siegemund S,Schutze N,Schulz S,et al.Differential IL-23requirement for IL-22 and IL-17A production during innate immunity against Salmonella enterica serovar Enteritidis[J].Int Immunol,2009,21(5):555-565.
[16]Sutton CE,Lalor SJ,Sweeney CM,et al.Interleukin-1 and IL-23induce innate IL-17 production from gammadelta T cells,amplifying Th17 responses and autoimmunity[J].Immunity,2009,31(2):331-341.
[17]Krner J,Wawrzyniak M,Tankov S,et al.Increased microRNA-323-3p in IL-22/IL-17-producing T cells and asthma:a role in the regulation of the TGF-beta pathway and IL-22 production[J].Allergy,2016.
[18]Wolk K,Witte E,Reineke U,et al.Is there an interaction between interleukin-10 and interleukin-22[J].Genes Immun,2005,6(1):8-18.
[19]Pociask DA,Scheller EV,Mandalapu S,et al.IL-22 is essential for lung epithelial repair following influenza infection[J].Am J Pathol,2013,182(4):1286-1296.
[20]Farahani R,Sherkat R,Hakemi MG,et al.Cytokines(interleukin-9,IL-17,IL-22,IL-25 and IL-33)and asthma[J].Adv Biomed Res,2014,3:127.
[21]Lejeune D,Dumoutier L,Constantinescu S,et al.Interleukin-22(IL-22)activates the JAK/STAT,ERK,JNK,and p38 MAP kinase pathways in a rat hepatoma cell line.Pathways that are shared with and distinct from IL-10[J].J Biol Chem,2002,277(37):33676-33682.
[22]Kotenko SV,Izotova LS,Mirochnitchenko OV,et al.Identification of the functional interleukin-22(IL-22)receptor complex:the IL-10R2 chain(IL-10Rbeta)is a common chain of both the IL-10and IL-22(IL-10-related T cell-derived inducible factor,IL-TIF)receptor complexes[J].J Biol Chem,2001,276(4):2725-2732.
[23]Dumoutier L,Lejeune D,Colau D,et al.Cloning and characterization of IL-22 binding protein,a natural antagonist of IL-10-related T cell-derived inducible factor/IL-22[J].J Immunol,2001,166(12):7090-7095.
[24]Martin JC,Beriou G,Heslan M,et al.Interleukin-22 binding protein(IL-22BP)is constitutively expressed by a subset of conventional dendritic cells and is strongly induced by retinoic acid[J].Mucosal Immunol,2014,7(1):101-113.
[25]Logsdon NJ,Jones BC,Josephson K,et al.Comparison of interleukin-22 and interleukin-10 soluble receptor complexes[J].J Interferon Cytokine Res,2002,22(11):1099-1112.
[26]Wolk K,Kunz S,Witte E,et al.IL-22 increases the innate immunity of tissues[J].Immunity,2004,21(2):241-254.
[27]Wawrzyniak M,Ochsner U,Wirz O,et al.A novel,dual cytokinesecretion assay for the purification of human Th22 cells that do not co-produce IL-17A[J].Allergy,2016,71(1):47-57.
[28]Lambrecht BN,Hammad H.Asthma:the importance of dysregulated barrier immunity[J].Eur J Immunol,2013,43(12):3125-3137.
[29]Chang H,Hanawa H,Liu H,et al.Hydrodynamic-based delivery of an interleukin-22-Ig fusion gene ameliorates experimental autoimmune myocarditis in rats[J].J Immunol,2006,177(6):3635-3643.
[30]Nakagome K,Imamura M,Kawahata K,et al.High expression of IL-22 suppresses antigen-induced immune responses and eosinophilic airway inflammation via an IL-10-associated mechanism[J].J Immunol,2011,187(10):5077-5089.
[31]Besnard AG,Sabat R,Dumoutier L,et al.Dual Role of IL-22 in allergic airway inflammation and its cross-talk with IL-17A[J].Am J Respir Crit Care Med,2011,183(9):1153-1163.
[32]Sonnenberg GF,Nair MG,Kirn TJ,et al.Pathological versus protective functions of IL-22 in airway inflammation are regulated by IL-17A[J].J Exp Med,2010,207(6):1293-1305.
[33]Liang SC,Long AJ,Bennett F,et al.An IL-17F/A heterodimer protein is produced by mouse Th17 cells and induces airway neutrophil recruitment[J].J Immunol,2007,179(11):7791-7799.
[34]Pennino D,Bhavsar PK,Effner R,et al.IL-22 suppresses IFNgamma-mediated lung inflammation in asthmatic patients[J].J Allergy Clin Immunol,2013,131(2):562-570.
[35]Halwani R,Sultana A,Al-Kufaidy R,et al.Th-17 regulatory cytokines inhibit corticosteroid induced airway structural cells apoptosis[J].Respir Res,2016,17:6.
[36]Taube C,Tertilt C,Gyulveszi G,et al.IL-22 is produced by innate lymphoid cells and limits inflammation in allergic airway disease[J].PLo S One,2011,6(7):e21799.
[37]Schnyder B,Lima C,Schnyder-Candrian S.Interleukin-22 is a negative regulator of the allergic response[J].Cytokine,2010,50(2):220-227.
[38]Takahashi K,Hirose K,Kawashima S,et al.IL-22 attenuates IL-25production by lung epithelial cells and inhibits antigen-induced eosinophilic airway inflammation[J].J Allergy Clin Immunol,2011,128(5):1067-1076.
[39]Farfariello V,Amantini C,Nabissi M,et al.IL-22 mRNA in peripheral blood mononuclear cells from allergic rhinitic and asthmatic pediatric patients[J].Pediatr Allergy Immunol,2011,22(4):419-423.
[40]Zhao Y,Yang J,Gao YD,et al.Th17 immunity in patients with allergic asthma[J].Int Arch Allergy Immunol,2010,151(4):297-307.
[41]Zhu J,Cao Y,Li K,et al.Increased expression of aryl hydrocarbon receptor and interleukin 22 in patients with allergic asthma[J].Asian Pac J Allergy Immunol,2011,29(3):266-272.
[42]Wong CK,Lun SW,Ko FW,et al.Activation of peripheral Th17lymphocytes in patients with asthma[J].Immunol Invest,2009,38(7):652-664.
[43]张旃,罗雅玲,周丽丽,等.IL-22在支气管哮喘患者血清中的表达及其受体IL-22R1在人气道细胞中的表达[J].第二军医大学学报,2010(12):1291-1295.
[44]张旃,蓝海兵,周丽丽,等.IL-22对人气道细胞的作用[J].中国老年学杂志,2011,31(12):2222-2225.
[45]Chang Y,Al-Alwan L,Risse PA,et al.Th17-associated cytokines promote human airway smooth muscle cell proliferation[J].FASEB J,2012,26(12):5152-5160.
[46]Lilly LM,Gessner MA,Dunaway CW,et al.The beta-glucan recepto r dectin-1 promotes lung immunopathology during fungal allergy via IL-22[J].J Immunol,2012,189(7):3653-3660.
[47]Guo H,Topham DJ.Interleukin-22(IL-22)production by pulmonary Natural Killer cells and the potential role of IL-22during primary influenza virus infection[J].J Virol,2010,84(15):7750-7759.
[48]Kim EY,Battaile JT,Patel AC,et al.Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease[J].Nat Med,2008,14(6):633-640.
[49]Djukanovic R,Gadola SD.Virus infection,asthma,and chronic obstructive pulmonary disease[J].N Engl J Med,2008,359(19):2062-2064.
[50]Hirose K,Takahashi K,Nakajima H.Roles of IL-22 in Allergic Airway Inflammation[J].J Allergy(Cairo),2013,2013:260518.