IL-22在免疫相关性疾病中的研究进展
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摘要
IL-22是IL-10家族的细胞因子,具有多种生物学功能。IL-22参与多种免疫相关性疾病的发生发展,但在不同的疾病中发挥不同作用。本文通过研究IL-22在不同的免疫相关性疾病中的作用机制,探讨IL-22在这些疾病中的靶向作用。
引文
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[20]Yamamoto-Furusho JK,Miranda-pérez E,Fonseca-camarillo G,et al.Colonic epithelial upregulation of interleukin 22(IL-22)in patients with ulcerative colitis[J].Inflammatory bowel diseases,2010,16(11):1823.
[21]Sugimoto K,Ogawa A,Mizoguchi E,et al.IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis[J].The Journal of clinical investigation,2008,118(2):534-544.
[2]张保龙,尤笑迎,尹万乐,等.Th22细胞和血清白细胞介素-22在胶原诱导的关节炎大鼠模型外周血的表达水平及其机制[J].中国现代医学杂志,2016,26(2):1-5.
[3]岳利环,林进.系统性红斑狼疮患者血浆IL-22水平下降[J].基础医学与临床,2017,37(2):243-244.
[4]鄢海波,赵令,马宁,等.汉族人系统性红斑狼疮和狼疮肾炎与IL-22受体基因多态性的关系[J].中国现代医学杂志,2017,27(9):44-48.
[5]Meephansan J,Ruchusatsawat K,Sindhupak W,et al.Effect of methotrexate on serum levels of IL-22 in patients with psoriasis[J].European journal of dermatology:EJD,2011,21(4):501-504.
[6]Jabbari A,Johnson-Huang LM.Role ofthe immune systemand immunological circuits in psoriasis[J].Giornale italiano di dermatologia e venereologia:organo ufficiale,Societa?italiana di dermatologia e sifilografia,2011,146(1):17-30.
[7]Cochez PM,Michiels C,Hendrickx E,et al.Ah R modulates the IL-22producing cell proliferation/recruitment in imiquimod-induced psoriasis mouse model[J].European journal of immunology,2016,46(6):1449-1459.
[8]Zhang L,Cheng Z,Liu W.Expression of interleukin(IL)-10,IL-17A and IL-22 in serum and sputum of stable chronic obstructive pulmonary disease patients[J].COPD,2013,10(4):459-465.
[9]Di Stefano A,Caramori G,Gnemmi I,et al.T helper type 17-related cytokine expression is increased in the bronchial mucosa of stable chronic obstructive pulmonary disease patients[J].Clinical and experimental immunology,2009,157(2):316-324.
[10]Sharan R,Perez-Cruz M,Kervoaze G,et al.Interleukin-22 protects against non-typeable Haemophilus influenzae infection:alteration during chronic obstructive pulmonary disease[J].Mucosal immunology,2017,10(1):139-149.
[11]Wang YH,Voo KS,Liu B,et al.Anovel subset of CD4(+)T(H)2 memory/effector cells that produce inflammatory IL-17 cytokine and promote the exacerbation of chronic allergic asthma[J].The Journal of experimental medicine,2010,207(11):2479-2491.
[12]Taube C,Tertilt C,G Gabor1lveszi G,et al.IL-22 is produced by innate lymphoid cells and limits inflammation in allergic airway disease[J].Plo S one,2011,6(7):e21799.
[13]Takahashi K,Hirose K,Kawashima S,et al.IL-22 attenuates IL-25 production by lung epithelial cells and inhibits antigen-induced eosinophilic airway inflammation[J].The Journal of allergy and clinical immunology,2011,128(5):1067.
[14]Lin YZ,Wu BW,Lu ZD,et al.Circulating Th22 and Th9 levels in patients with acute coronary syndrome[J].Mediators of inflammation,2013,2013(1):635672.
[15]王晓琦.Th17、Th17/Th1细胞与急性冠状动脉综合征相关性及临床意义的研究[D].济南:山东大学,2013.
[16]Hu Y,Li H,Zhang L,et al.Elevated profiles of Th22 cells and correlations with Th17 cells in patients with immune thrombocytopenia[J].Human immunology,2012,73(6):629-635.
[17]Liu LM,Zhang XX,Zhao GS,et al.Change of Th22 cells in peripheral blood of patients with primary immune thrombocytopenia and clinical implication[J].Chinese journal of cellular and molecular immunology,2012,28(12):1314-1316.
[18]Cao J,Chen C,Li L,et al.Effects of high-dose dexamethasone on regulating interleukin-22 production and correcting Th1 and Th22 polarization in immune thrombocytopenia[J].Journal of clinical immunology,2012,32(3):523-529.
[19]Wolk K,Witte E,Hoffmann U,et al.IL-22 induces lipopolysaccharidebinding protein in hepatocytes:a potential systemic role of IL-22 in Crohn's disease[J].Journal of immunology,2007,178(9):5973-5981.
[20]Yamamoto-Furusho JK,Miranda-pérez E,Fonseca-camarillo G,et al.Colonic epithelial upregulation of interleukin 22(IL-22)in patients with ulcerative colitis[J].Inflammatory bowel diseases,2010,16(11):1823.
[21]Sugimoto K,Ogawa A,Mizoguchi E,et al.IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis[J].The Journal of clinical investigation,2008,118(2):534-544.