麻黄汤加减治疗急性喘息型支气管炎临床观察
|
摘要
目的探讨麻黄汤加减治疗急性喘息型支气管炎的临床疗效。方法选取2016年1月—2018年12月收治的196例急性喘息型支气管炎患者为研究对象,随机分为治疗组和对照组,各98例。对照组采取常规治疗,治疗组在对照组的基础上采用麻黄汤加减方进行治疗。比较2组患者临床症状缓解情况;检测并比较2组患者治疗前后血清炎性因子及肺功能指标水平。结果治疗组患者咳嗽、憋喘、湿啰音及喘鸣音消失时间及住院时间均较对照组显著缩短(P <0. 05或P <0. 01)。治疗后2组患者咳嗽咳痰、喘息、哮鸣等症状积分均较治疗前显著下降(P <0. 01),且治疗组各积分较对照组下降更多(P <0. 01)。治疗后2组患者血清中hs-CRP、NE水平均较治疗前显著下降,FEV_1、FEV_1/FVC水平则显著升高,且治疗组改善程度较对照组更为明显(P <0. 05或P <0. 01)。结论麻黄汤加减治疗急性喘息型支气管炎,对患者临床症状的改善效果更为显著,且有效调控炎性因子水平,改善患者肺功能,值得在临床进行推广。
Objective To explore the clinical effect of modified Mahuang decoction on acute asthmatic bronchitis. Methods 196 patients with acute asthmatic bronchitis admitted to our hospital from January 2016 to December 2018 were randomly divided into the treatment group(n = 98) and the control group(n = 98). The control group was treated with routine therapy,and the treatment group was treated with modified Mahuang decoction on the basis of the control group. The clinical symptoms of the 2 groups were compared,and the levels of serum inflammatory factors and pulmonary function indexes of the 2 groups were detected and compared before and after treatment. Results The disappearing time of cough,wheezing,moist rales and wheezing sounds and hospitalization time in the treatment group were significantly shorter than those in the control group(P < 0. 05 or P < 0. 01). After treatment,the scores of cough,expectoration and wheezing in the 2 groups were significantly lower than those before treatment(P < 0. 01),and the scores in the treatment group were lower than those in the control group(P < 0. 01). After treatment,the serum levels of hs-CRP,NE in the 2 groups significantly decreased than those before treatment,and the level of FEV1,FEV1/FVC significantly increased,and the improvement degree of the treatment group was more obvious than those of the control group(P < 0. 05 or P < 0. 01). Conclusion Modified Mahuang decoction in the treatment of acute wheezing bronchitis is more effective,and it can improve the clinical symptoms of patients,effectively regulate the level of inflammatory factors and improve the pulmonary function of patients,so it is worth popularizing in clinical practice.
Objective To explore the clinical effect of modified Mahuang decoction on acute asthmatic bronchitis. Methods 196 patients with acute asthmatic bronchitis admitted to our hospital from January 2016 to December 2018 were randomly divided into the treatment group(n = 98) and the control group(n = 98). The control group was treated with routine therapy,and the treatment group was treated with modified Mahuang decoction on the basis of the control group. The clinical symptoms of the 2 groups were compared,and the levels of serum inflammatory factors and pulmonary function indexes of the 2 groups were detected and compared before and after treatment. Results The disappearing time of cough,wheezing,moist rales and wheezing sounds and hospitalization time in the treatment group were significantly shorter than those in the control group(P < 0. 05 or P < 0. 01). After treatment,the scores of cough,expectoration and wheezing in the 2 groups were significantly lower than those before treatment(P < 0. 01),and the scores in the treatment group were lower than those in the control group(P < 0. 01). After treatment,the serum levels of hs-CRP,NE in the 2 groups significantly decreased than those before treatment,and the level of FEV1,FEV1/FVC significantly increased,and the improvement degree of the treatment group was more obvious than those of the control group(P < 0. 05 or P < 0. 01). Conclusion Modified Mahuang decoction in the treatment of acute wheezing bronchitis is more effective,and it can improve the clinical symptoms of patients,effectively regulate the level of inflammatory factors and improve the pulmonary function of patients,so it is worth popularizing in clinical practice.
引文
[1]徐建辉,黄祖辉.IL-12、IL-4、IL-8、转化生长因子-β1及1,25-二羟基维生素D3在婴幼儿喘息性支气管炎表达水平及其临床意义[J].贵州医药,2016,40(11):1138-1140.
[2]王晓敏,蔡建新,徐和祥,等.小儿宣肺止咳颗粒治疗小儿急性支气管炎的理论发微[J].世界中医药,2016,11(5):917-918.
[3]殷凯生.呼吸疾病诊断流程与治疗策略[M].北京:科学出版社,2008:112-114.
[4]郑筱萸.中药新药临床研究指导原则(试行)[S].北京:中国医药科技出版社,2002:75-79.
[5]郭宏亮.中西医联合治疗喘息型支气管炎80例临床疗效观察[J].光明中医,2017,32(3):417-419.
[6]YATSENKO O,PIZANO J,NIKOLAIDIS A,et al.Revisiting maternal-infant bonding’s effects on asthma:A brief history[J].Cogent Psychology,2016,3(1):1161267.
[7]张芳.温肺化痰汤加减治疗慢性喘息型支气管炎急性发作期临床观察[J].陕西中医,2017,38(5):590-592.
[8]张月峰.麻黄汤加减对慢性支气管炎急性发作患者炎症细胞因子的影响及临床疗效观察[J].四川中医,2017,35(8):68-71.
[9]胡纯娴.麻黄汤治疗慢性支气管炎合并肺气肿的临床效果分析[J].中西医结合心血管病电子杂志,2017,5(21):126-127.
[10]刘立弘.麻黄汤治疗尘肺并发支气管炎与西药等效性随机平行对照研究[J].实用中医内科杂志,2017,31(10):65-67.
[11]杨正腾,王力宁,张明.麻黄汤其饮片汤剂与煮散剂止咳和抗炎药效比较研究[J].中医药导报,2017,23(4):50-52.
[2]王晓敏,蔡建新,徐和祥,等.小儿宣肺止咳颗粒治疗小儿急性支气管炎的理论发微[J].世界中医药,2016,11(5):917-918.
[3]殷凯生.呼吸疾病诊断流程与治疗策略[M].北京:科学出版社,2008:112-114.
[4]郑筱萸.中药新药临床研究指导原则(试行)[S].北京:中国医药科技出版社,2002:75-79.
[5]郭宏亮.中西医联合治疗喘息型支气管炎80例临床疗效观察[J].光明中医,2017,32(3):417-419.
[6]YATSENKO O,PIZANO J,NIKOLAIDIS A,et al.Revisiting maternal-infant bonding’s effects on asthma:A brief history[J].Cogent Psychology,2016,3(1):1161267.
[7]张芳.温肺化痰汤加减治疗慢性喘息型支气管炎急性发作期临床观察[J].陕西中医,2017,38(5):590-592.
[8]张月峰.麻黄汤加减对慢性支气管炎急性发作患者炎症细胞因子的影响及临床疗效观察[J].四川中医,2017,35(8):68-71.
[9]胡纯娴.麻黄汤治疗慢性支气管炎合并肺气肿的临床效果分析[J].中西医结合心血管病电子杂志,2017,5(21):126-127.
[10]刘立弘.麻黄汤治疗尘肺并发支气管炎与西药等效性随机平行对照研究[J].实用中医内科杂志,2017,31(10):65-67.
[11]杨正腾,王力宁,张明.麻黄汤其饮片汤剂与煮散剂止咳和抗炎药效比较研究[J].中医药导报,2017,23(4):50-52.