手术联合氨基酮戊酸光动力疗法治疗皮肤肿瘤临床研究
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摘要
目的:观察手术联合氨基酮戊酸光动力疗法治疗皮肤肿瘤的临床疗效,为临床进一步研究提供有效参考。方法:选取2015年8月-2017年2月于笔者医院进行治疗的118例皮肤肿瘤患者为研究对象,根据随机数字表法分为联合组和手术组,每组59例。手术组使用外科手术进行治疗,联合组在手术组的基础上联合应用氨基酮戊酸光动力疗法,对两组患者治疗后的临床疗效进行研究与分析。结果:联合组完全恢复者49例,总有效率为96.61%,明显优于单纯组的84.74%,差异有统计学意义(P<0.05);联合组的不良反应发生率为6.78%,明显的低于单纯组的16.95%,差异有统计学意义(P<0.05);联合组的满意率和复发率均明显优于手术组,差异有统计学意义(P<0.05)。结论:手术联合氨基酮戊酸光动力疗法治疗皮肤肿瘤,提高了临床疗效,降低不良反应发生率和复发率,大大提升了患者满意率,适合在临床上广泛的应用。
Objective To observe the clinical effect of surgery combined with aminolevulinic acid photodynamic therapy in the treatment of skin tumors, and to provide an effective reference for further clinical study. Methods From August 2015 to February 2017, 118 patients with skin tumor were divided into combined group and simple group, 59 cases in each group. The simple group was treated by surgical operation, the combined group was treated with aminolevulinic acid photodynamic therapy on the basis of simple group, and the clinical effect of the two groups after treatment was studied and analyzed. Results The total effective rate of the combined group was 96.61, which was significantly better than that of the simple group(84.74%,P<0.05). The incidence of adverse reactions in the combined group was 6.78, which was significantly lower than that in the simple group(16.95,P<0.05). The satisfaction rate and recurrence rate of the combined group were significantly better than that of the simple group(P<0.05). Conclusion Aminolevulinic acid photodynamic therapy combined with surgery has improved the clinical efficacy, reduced the incidence and recurrence rate of adverse reactions, and greatly improved the satisfaction rate of patients.
Objective To observe the clinical effect of surgery combined with aminolevulinic acid photodynamic therapy in the treatment of skin tumors, and to provide an effective reference for further clinical study. Methods From August 2015 to February 2017, 118 patients with skin tumor were divided into combined group and simple group, 59 cases in each group. The simple group was treated by surgical operation, the combined group was treated with aminolevulinic acid photodynamic therapy on the basis of simple group, and the clinical effect of the two groups after treatment was studied and analyzed. Results The total effective rate of the combined group was 96.61, which was significantly better than that of the simple group(84.74%,P<0.05). The incidence of adverse reactions in the combined group was 6.78, which was significantly lower than that in the simple group(16.95,P<0.05). The satisfaction rate and recurrence rate of the combined group were significantly better than that of the simple group(P<0.05). Conclusion Aminolevulinic acid photodynamic therapy combined with surgery has improved the clinical efficacy, reduced the incidence and recurrence rate of adverse reactions, and greatly improved the satisfaction rate of patients.
引文
[1]伍金祥.单纯外科手术及联合氨基酮戊酸光动力疗法治疗皮肤肿瘤的临床预后观察[J].浙江创伤外科,2016,21(5):971-973.
[2]邓玲俐.单纯外科手术及联合5-氨基酮戊酸光动力疗法治疗皮肤肿瘤的临床预后观察[J].中西医结合心血管病电子杂志,2017,5(27):170-171.
[3]Cosgarea R,Susan M,Crisan M,et al.Photodynamic therapy using topical 5-aminolaevulinic acid vs.surgery for basal cell carcinoma[J].J Eur Acad Dermatol Venereol,2013,27(8):980-984.
[4]黄毅宗.5-氨基酮戊酸光动力疗法治疗皮肤肿瘤的临床疗效观察[J].皮肤病与性病,2018,40(1):134-135.
[5]赵英,陈蕾,贾艳辉,等.5-氨基酮戊酸光动力疗法治疗皮肤癌及皮肤癌前病变疗效观察[J].中国卫生标准管理,2016,7(18):107-108.
[6]Nissen CV,Philipsen PA,Wulf HC.Protoporphyrin IX formation after topical application of methyl aminolaevulinate and BF-200 aminolaevulinic acid declines with age[J].Br J Dermatol,2015,173(3):760-766.
[7]丁鹏,陈晓栋,吴晓琰.手术联合5-氨基酮戊酸光动力疗法治疗面部非黑色素皮肤癌效果观察[J].南通大学学报(医学版),2015,35(6):623-624.
[8]张鑫,郝玉琴.5-氨基酮戊酸光动力疗法在皮肤科治疗的研究进展[J].中华临床医师杂志(电子版),2016,10(20):3103-3106.
[9]周萌,刘保国,顾静.5-氨基酮戊酸光动力疗法治疗皮肤恶性肿瘤及癌前病变的研究进展[J].中国激光医学杂志,2016,25(3):160-164.
[10]Morton C A,Birnie A J,Eedy D J.British Association of Dermatologists'guidelines for the management of squamous cell carcinoma in situ(B owen's disease)2014[J].Bri J Dermatol,2014,170(2):245-260.
[11]许云鹏.氨基酮戊酸光动力疗法在面部皮肤癌治疗中的临床效果及不良反应分析[J].中国农村卫生,2016,9(11):52-53.
[12]张黎峰,陈龙,杨光艳,等.ALA-PDT治疗皮肤肿瘤的长期疗效分析[J].中国皮肤性病学杂志,2017,31(11):1202-1204.
[13]段宝学.皮肤癌前病变及浅表皮肤肿瘤采用5-氨基酮戊酸光动力疗法治疗的效果评价[J].中外医学研究,2018,16(8):155-156.
[2]邓玲俐.单纯外科手术及联合5-氨基酮戊酸光动力疗法治疗皮肤肿瘤的临床预后观察[J].中西医结合心血管病电子杂志,2017,5(27):170-171.
[3]Cosgarea R,Susan M,Crisan M,et al.Photodynamic therapy using topical 5-aminolaevulinic acid vs.surgery for basal cell carcinoma[J].J Eur Acad Dermatol Venereol,2013,27(8):980-984.
[4]黄毅宗.5-氨基酮戊酸光动力疗法治疗皮肤肿瘤的临床疗效观察[J].皮肤病与性病,2018,40(1):134-135.
[5]赵英,陈蕾,贾艳辉,等.5-氨基酮戊酸光动力疗法治疗皮肤癌及皮肤癌前病变疗效观察[J].中国卫生标准管理,2016,7(18):107-108.
[6]Nissen CV,Philipsen PA,Wulf HC.Protoporphyrin IX formation after topical application of methyl aminolaevulinate and BF-200 aminolaevulinic acid declines with age[J].Br J Dermatol,2015,173(3):760-766.
[7]丁鹏,陈晓栋,吴晓琰.手术联合5-氨基酮戊酸光动力疗法治疗面部非黑色素皮肤癌效果观察[J].南通大学学报(医学版),2015,35(6):623-624.
[8]张鑫,郝玉琴.5-氨基酮戊酸光动力疗法在皮肤科治疗的研究进展[J].中华临床医师杂志(电子版),2016,10(20):3103-3106.
[9]周萌,刘保国,顾静.5-氨基酮戊酸光动力疗法治疗皮肤恶性肿瘤及癌前病变的研究进展[J].中国激光医学杂志,2016,25(3):160-164.
[10]Morton C A,Birnie A J,Eedy D J.British Association of Dermatologists'guidelines for the management of squamous cell carcinoma in situ(B owen's disease)2014[J].Bri J Dermatol,2014,170(2):245-260.
[11]许云鹏.氨基酮戊酸光动力疗法在面部皮肤癌治疗中的临床效果及不良反应分析[J].中国农村卫生,2016,9(11):52-53.
[12]张黎峰,陈龙,杨光艳,等.ALA-PDT治疗皮肤肿瘤的长期疗效分析[J].中国皮肤性病学杂志,2017,31(11):1202-1204.
[13]段宝学.皮肤癌前病变及浅表皮肤肿瘤采用5-氨基酮戊酸光动力疗法治疗的效果评价[J].中外医学研究,2018,16(8):155-156.