银屑病复发相关的免疫学研究进展
|
摘要
银屑病可由多种因素诱导产生,其病因及致病机理目前尚未完全明确,虽然治疗方法多样,但是大部分只能取得临床缓解,且复发率较高。银屑病反复发作成为困扰患者及医学的一大难题,其发病与固有免疫系统和获得性免疫系统相关,涉及多个信号通路及抗原呈递等方面。目前临床上已有如拮抗IL-23、IL-17、TNF-α等生物靶向治疗,并取得了很好的疗效,证实了这些炎症介质在临床治疗中的重要性。准确地识别导致复发的炎症介质以及如何抑制其发生、发展非常重要,因此为了进一步了解银屑病复发的免疫学机制,减少复发,指导临床治疗,本文就与银屑病复发相关的免疫学研究进展进行综述。
引文
[1]GREB J E,GOLDMINZ A M,ELDER J T,et al.Psoriasis[J].Nat Rev Dis Primers,2016,2:16082.doi:10.1038/nrdp.2016.82.
[2]REICH K,ARMSTRONG A W,FOLEY P,et al.Efficacy and safety of guselkumab,an anti-interleukin-23 monoclonal antibody,compared with adalimumab for the treatment of patients with moderate to severe psoriasis with randomized withdrawal and retreatment:Results from the phase III,double-blind,placebo-and active comparatorcontrolled VOYA-GE 2 trial[J].J Am Acad Dermatol,2017,76(3):418-431.
[3]BALAK D M,VAN DOORN M B,ARBEIT R D,et al.IMO-8400,a toll-like receptor 7,8,and 9 antagonist,demonstrates clinical activity in a phase 2a,randomized,placebo-controlled trial in patients with mode-rate-to-severe plaque psoriasis[J].Clin Immunol,2017,174:63-72.
[4]JOHNSON-HUANG L M,PENSABENE C A,SHAH KR,et al.Post-therapeutic relapse of psoriasis after CD11a blockade is associated with T cells and inflammatory myeloid DCs[J].Plos One,2012,7(2):e30308.
[5]BOUTET M A,NERVIANI A,GALLO AFFLITTO G,et al.Role of the IL-23/IL-17 axis in psoriasis and psoriatic arthritis:the clinical importance of its divergence in skin and joints[J].Int J Mol Sci,2018,19(2):pii:E530.
[6]LOWES M A,SU REZ-FARIFIAS M,KRUEGER J G.Immunology of psoriasis[J].Annu Rev Immunol,2014,32:227-255.
[7]CHEUK S,WIK N M,BLOMQVIST L,et al.Epidermal Th22 and Tc17 cells form a localized disease memory in clinically healed psoriasis[J].J Immunol,2014,192(7):3111-3120.
[8]MATOS T R,O'MALLEY J T,LOWRY E L,et al.Clinically resolved psoriatic lesions contain psoriasis-specific IL-17-producingαβT cell clones[J].J Cli Invest,2017,127(11):4031-4041.
[9]REICH K,WOZEL G,ZHENG H,et al.Efficacy and safety of infliximab as continuous or intermittent therapy in patients with moderate-to-severe plaque psoriasis:results of a randomized,long-term extension trial(RESTORE2)[J].Br J Dermatol,2013,168(6):1325-1334.
[10]SINGH T P,ZHANG H H,BOREK I,et al.Monocyte-derived inflammatory Langerhans cells and dermal dendritic cells mediate psoriasis-like inflammation[J].Nat Commun,2016,7:13581.
[11]MALISSEN B,TAMOUTOUNOUR S,HENRI S.The origins and functions of dendritic cells and macrophages in the skin[J].Nat Rev Immunol,2014,14(6):417-428.
[12]LOWES M A,SU REZ-FARI AS M,KRUEGER J G.Immunology of psoriasis[J].Annu Rev Immunol,2014,32:227-255.
[13]SU REZ-FARI AS M,LOWES M A,et al.Evaluation of the psoriasis transcriptome across different studies by gene set enrichment analysis(GSEA)[J].PLo S One,2010,5(4):e10247.
[14]GUTTMAN-YASSKY E,SU REZ-FARI AS M,CHIRI-COZZI A,et al.Broad defects in epidermal cornification in atopic dermatitis identified through genomic analysis[J].JAllergy Clin Immunol,2009,124(6):1235-1244.
[15]KRYCZEK I,BRUCE A T,GUDJONSSON J E,et al.Induction of IL-17+T cell trafficking and development by IFN-gamma:mechanism and patho-logical relevance in psoriasis[J].J Immunol,2008,181(7):4733-4741.
[16]AUFFRAY C,SIEWEKE M H,GEISSMANN F.Blood monocytes:development,heterogeneity,and relationship with dendritic cells[J].Annu Rev Immunol,2009,27:669-692.
[17]NOGRALES K E,KRUEGER J G.Anti-cytokine therapies for psoriasis[J].Exp Cell Res,2011,317(9):1293-1300.
[18]FERRAN M,GALVN A B,RINCN C,et al.Streptococcus induces circulating CLA(+)memory T-cell-dependent epidermal cell activation in psoriasis[J].J Invest Dermatol,2013,133(4):999-1007.
[19]CARBONE S,LEE P J,MAURO A G,et al.Interleukin-18 mediates cardiac dysfunction induced by western diet independent of obesity and hyperglycemia in the mouse[J].Nutr Diabetes,2017,7(4):e258.
[20]NAIK S,LARSEN S B,GOMEZ N C,et al.Inflammatory memory sensitizes skin epithelial stem cells to tissue damage[J].Nature,2017,550(7677):475-480.
[21]LUO Q,ZENG J,LI W,et al.Silencing of miR155 suppresses inflammatory responses in psoriasis through inflammasome NLRP3 regulation[J].Int J Mol Med,2018,42(2):1086-1095.
[22]LOWES M A,RUSSELL C B,MARTIN D A,et al.The IL-23/Th17 pathogenic axis in psoriasis is amplified by keratinocyte responses[J].Trends Immunol,2013,34(4):174-181.
[23]TOWNE J E,SIMS J E.IL-36 in psoriasis[J].Curr Opin Pharmacol,2012,12(4):486-490.
[24]WEAVER C T,ELSON C O,FOUSER L A,et al.The Th17 pathway and inflammatory diseases of the intestines,lungs,and skin[J].Annu Rev Pathol,2013,8:477-512.
[2]REICH K,ARMSTRONG A W,FOLEY P,et al.Efficacy and safety of guselkumab,an anti-interleukin-23 monoclonal antibody,compared with adalimumab for the treatment of patients with moderate to severe psoriasis with randomized withdrawal and retreatment:Results from the phase III,double-blind,placebo-and active comparatorcontrolled VOYA-GE 2 trial[J].J Am Acad Dermatol,2017,76(3):418-431.
[3]BALAK D M,VAN DOORN M B,ARBEIT R D,et al.IMO-8400,a toll-like receptor 7,8,and 9 antagonist,demonstrates clinical activity in a phase 2a,randomized,placebo-controlled trial in patients with mode-rate-to-severe plaque psoriasis[J].Clin Immunol,2017,174:63-72.
[4]JOHNSON-HUANG L M,PENSABENE C A,SHAH KR,et al.Post-therapeutic relapse of psoriasis after CD11a blockade is associated with T cells and inflammatory myeloid DCs[J].Plos One,2012,7(2):e30308.
[5]BOUTET M A,NERVIANI A,GALLO AFFLITTO G,et al.Role of the IL-23/IL-17 axis in psoriasis and psoriatic arthritis:the clinical importance of its divergence in skin and joints[J].Int J Mol Sci,2018,19(2):pii:E530.
[6]LOWES M A,SU REZ-FARIFIAS M,KRUEGER J G.Immunology of psoriasis[J].Annu Rev Immunol,2014,32:227-255.
[7]CHEUK S,WIK N M,BLOMQVIST L,et al.Epidermal Th22 and Tc17 cells form a localized disease memory in clinically healed psoriasis[J].J Immunol,2014,192(7):3111-3120.
[8]MATOS T R,O'MALLEY J T,LOWRY E L,et al.Clinically resolved psoriatic lesions contain psoriasis-specific IL-17-producingαβT cell clones[J].J Cli Invest,2017,127(11):4031-4041.
[9]REICH K,WOZEL G,ZHENG H,et al.Efficacy and safety of infliximab as continuous or intermittent therapy in patients with moderate-to-severe plaque psoriasis:results of a randomized,long-term extension trial(RESTORE2)[J].Br J Dermatol,2013,168(6):1325-1334.
[10]SINGH T P,ZHANG H H,BOREK I,et al.Monocyte-derived inflammatory Langerhans cells and dermal dendritic cells mediate psoriasis-like inflammation[J].Nat Commun,2016,7:13581.
[11]MALISSEN B,TAMOUTOUNOUR S,HENRI S.The origins and functions of dendritic cells and macrophages in the skin[J].Nat Rev Immunol,2014,14(6):417-428.
[12]LOWES M A,SU REZ-FARI AS M,KRUEGER J G.Immunology of psoriasis[J].Annu Rev Immunol,2014,32:227-255.
[13]SU REZ-FARI AS M,LOWES M A,et al.Evaluation of the psoriasis transcriptome across different studies by gene set enrichment analysis(GSEA)[J].PLo S One,2010,5(4):e10247.
[14]GUTTMAN-YASSKY E,SU REZ-FARI AS M,CHIRI-COZZI A,et al.Broad defects in epidermal cornification in atopic dermatitis identified through genomic analysis[J].JAllergy Clin Immunol,2009,124(6):1235-1244.
[15]KRYCZEK I,BRUCE A T,GUDJONSSON J E,et al.Induction of IL-17+T cell trafficking and development by IFN-gamma:mechanism and patho-logical relevance in psoriasis[J].J Immunol,2008,181(7):4733-4741.
[16]AUFFRAY C,SIEWEKE M H,GEISSMANN F.Blood monocytes:development,heterogeneity,and relationship with dendritic cells[J].Annu Rev Immunol,2009,27:669-692.
[17]NOGRALES K E,KRUEGER J G.Anti-cytokine therapies for psoriasis[J].Exp Cell Res,2011,317(9):1293-1300.
[18]FERRAN M,GALVN A B,RINCN C,et al.Streptococcus induces circulating CLA(+)memory T-cell-dependent epidermal cell activation in psoriasis[J].J Invest Dermatol,2013,133(4):999-1007.
[19]CARBONE S,LEE P J,MAURO A G,et al.Interleukin-18 mediates cardiac dysfunction induced by western diet independent of obesity and hyperglycemia in the mouse[J].Nutr Diabetes,2017,7(4):e258.
[20]NAIK S,LARSEN S B,GOMEZ N C,et al.Inflammatory memory sensitizes skin epithelial stem cells to tissue damage[J].Nature,2017,550(7677):475-480.
[21]LUO Q,ZENG J,LI W,et al.Silencing of miR155 suppresses inflammatory responses in psoriasis through inflammasome NLRP3 regulation[J].Int J Mol Med,2018,42(2):1086-1095.
[22]LOWES M A,RUSSELL C B,MARTIN D A,et al.The IL-23/Th17 pathogenic axis in psoriasis is amplified by keratinocyte responses[J].Trends Immunol,2013,34(4):174-181.
[23]TOWNE J E,SIMS J E.IL-36 in psoriasis[J].Curr Opin Pharmacol,2012,12(4):486-490.
[24]WEAVER C T,ELSON C O,FOUSER L A,et al.The Th17 pathway and inflammatory diseases of the intestines,lungs,and skin[J].Annu Rev Pathol,2013,8:477-512.