早期诊断非小细胞肺癌相关生物标志物新进展
摘要
早期诊断非小细胞肺癌是减低患者致死率的重要手段。肿瘤相关生物标记物逐渐成为研究热点。本文介绍了主要生物标记物蛋白质、DNA(ctDNA、甲基化DNA)、RNA等应用于非小细胞肺癌早期诊断的最新研究,以期为联合检测诊断非小细胞肺癌的研究提供更多的实验证据和理论基础。
引文
[1]陈婧华,钟文昭,吴一龙.2017年非小细胞肺癌靶向治疗进展[J].循证医学,2018,18(1):3-5.
[2]Lirong W;Wangxi W;Liming H,et al.A quantitative analysis of the potential biomarkers of non-small cell lung cancer by circulating cell-free DNA[J].ONCOLOGY LETTERS,2018,16(4):4353-4360.
[3]Couraud S,Vaca-Paniagua F,Villar S,et a1.Noninvasive diagnosis of actionable mutations by deep sequencing of circulating free DNA in lung cancer from never-smokers:a proof-of-concept study from BioCAST/IFCT-1002[J].Clin Cancer Res,2014,20(17):4613-4624.
[4]封杰,刘文斌,陈洪强,等.肺癌患者MPDZ基因异常甲基化的研究[J].癌变·畸变·突变,2015,27(6):437-440.
[5]赵培革,鲁德玕,姬晓青,等.非小细胞肺癌血清8个抑癌基因启动子Cp G岛甲基化的联合检测及意义[J].检验医学与临床,2014,11(10):1322-1324.
[6]Ding K,Jiang J,Chen L,Xu X.Methylenetetrahydrofolate Dehydrogenase 1 Silencing Expedites the Apoptosis of Non-Small Cell Lung Cancer Cells via Modulating DNA Methylation[J].Med Sci Monit,2018,24(2):7499-7507.
[7]Feng X,Xie X,Zheng B,et al.The more potential performance of nidogen 2 methylation by tissue or plasma DNA over brichoalveolar lavage DNA in diagnosis of nonsmall cell lung cancer[J].J Cancer Res Ther,2018,14(Supplement):S341-S346.
[8]Heller G,Altenberger C,Steiner I,et al.DNA methylation of microRNA-coding genes in non-small-cell lung cancer patients[J].JPathol,2018,245(4):387-398.
[9]Chen X,Hu Z,Wang W,et a1.Identification of ten serum microRNAs from agenome-wide serulTl microRNA expression profile as novel noninvasive biomarkers for nonsmall cell lung cancer diagnosis[J].Im J Cancer,2012,130(7):1620-1628.
[10]Nadal E,Truird A,Nakata A,et a1.A Novel Serum 4-microRNA Signature for Lung Cancer Detection[J].Sci Rep,2015,5(3):12464.
[11]Hu Z,Chen X,Zhao Y,et al,Serum microRNA signatures identified in a genome-wide serum microRNA expression profiling predict survival of non-small-cell lung cancer[J].J Clin Oncol,2010,28(10):1721-1726.
[12]江美林,彭文颖,李佳,陈柏林,邬麟.非小细胞肺癌免疫治疗生物标志物研究进展[J].肿瘤防治研究,2018,45(10):805-810.
[13]支修益.小细胞肺癌生物标志物临床应用进展[J].中国医学前沿杂志(电子版),2017,9(03):1-7+153.
[14]马兴元.非小细胞肺癌治疗性疫苗及相关生物标志物研发进展[J].生物产业技术,2013(05):22-29.
[2]Lirong W;Wangxi W;Liming H,et al.A quantitative analysis of the potential biomarkers of non-small cell lung cancer by circulating cell-free DNA[J].ONCOLOGY LETTERS,2018,16(4):4353-4360.
[3]Couraud S,Vaca-Paniagua F,Villar S,et a1.Noninvasive diagnosis of actionable mutations by deep sequencing of circulating free DNA in lung cancer from never-smokers:a proof-of-concept study from BioCAST/IFCT-1002[J].Clin Cancer Res,2014,20(17):4613-4624.
[4]封杰,刘文斌,陈洪强,等.肺癌患者MPDZ基因异常甲基化的研究[J].癌变·畸变·突变,2015,27(6):437-440.
[5]赵培革,鲁德玕,姬晓青,等.非小细胞肺癌血清8个抑癌基因启动子Cp G岛甲基化的联合检测及意义[J].检验医学与临床,2014,11(10):1322-1324.
[6]Ding K,Jiang J,Chen L,Xu X.Methylenetetrahydrofolate Dehydrogenase 1 Silencing Expedites the Apoptosis of Non-Small Cell Lung Cancer Cells via Modulating DNA Methylation[J].Med Sci Monit,2018,24(2):7499-7507.
[7]Feng X,Xie X,Zheng B,et al.The more potential performance of nidogen 2 methylation by tissue or plasma DNA over brichoalveolar lavage DNA in diagnosis of nonsmall cell lung cancer[J].J Cancer Res Ther,2018,14(Supplement):S341-S346.
[8]Heller G,Altenberger C,Steiner I,et al.DNA methylation of microRNA-coding genes in non-small-cell lung cancer patients[J].JPathol,2018,245(4):387-398.
[9]Chen X,Hu Z,Wang W,et a1.Identification of ten serum microRNAs from agenome-wide serulTl microRNA expression profile as novel noninvasive biomarkers for nonsmall cell lung cancer diagnosis[J].Im J Cancer,2012,130(7):1620-1628.
[10]Nadal E,Truird A,Nakata A,et a1.A Novel Serum 4-microRNA Signature for Lung Cancer Detection[J].Sci Rep,2015,5(3):12464.
[11]Hu Z,Chen X,Zhao Y,et al,Serum microRNA signatures identified in a genome-wide serum microRNA expression profiling predict survival of non-small-cell lung cancer[J].J Clin Oncol,2010,28(10):1721-1726.
[12]江美林,彭文颖,李佳,陈柏林,邬麟.非小细胞肺癌免疫治疗生物标志物研究进展[J].肿瘤防治研究,2018,45(10):805-810.
[13]支修益.小细胞肺癌生物标志物临床应用进展[J].中国医学前沿杂志(电子版),2017,9(03):1-7+153.
[14]马兴元.非小细胞肺癌治疗性疫苗及相关生物标志物研发进展[J].生物产业技术,2013(05):22-29.