三金片联合左氧氟沙星治疗尿路感染(湿热下注)随机平行对照研究
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摘要
[目的]观察三金片联合左氧氟沙星治疗尿路感染(湿热下注)疗效。[方法]使用随机平行对照方法,将248例住院及门诊患者按随机数字表法随机分为两组。对照组124例左氧氟沙星,0.2g,2次/d,静滴。治疗组124例三金片,3片/次,3次/d;左氧氟沙星治疗同对照组。连续治疗7d为1疗程。观测临床表现、尿白细胞、症状评分、不良反应。连续治疗1疗程(14d),判定疗效。[结果]治疗组临床痊愈44例,显效48例,有效28例,无效4例,总有效率96.77%;对照组临床痊愈28例,显效14例,有效36例,无效32例,总有效率74.19%;治疗组疗效优于对照组(P<0.05)。症状评分两组均有改善(P<0.01),治疗组改善优于对照组(P<0.01)。尿白细胞两组均有减少(P<0.01),治疗组减少多于对照组(P<0.01)。[结论]三金片联合左氧氟沙星治疗尿路感染(湿热下注),疗效满意,无严重不良反应,值得推广。
[Objective] To observe the curative effect of Sanjin tablet combined with levofloxacin in the treatment of urinary tract infection. [Method] 248 inpatients and outpatients were randomly divided into two groups by random number table method. Control group 124 cases of levofloxacin, 0.2 g, twice a day, intravenous drip. Treatment group 124 cases of Sanjin tablets, 3 tablets per time, 3 times per day;levofloxacin treatment with the control group. Continuous treatment for 7 days is a course of treatment.Clinical manifestations, urinary leukocytes, symptom scores and adverse reactions were observed. Continuous treatment for 1 course(14 days) to determine the efficacy. [Result] In the treatment group, 44 cases were cured, 48 cases were markedly effective, 28 cases were effective and 4 cases were ineffective, the total effective rate was 96.77%. In the control group, 28 cases were cured, 14 cases were markedly effective, 36 cases were effective and 32 cases were ineffective, the total effective rate was 74.19%. The curative effect of the treatment group was better than that of the control group(P<0.05). Symptom scores were improved in both groups(P<0.01), and the improvement in treatment group was better than that in control group(P<0.01).Leukocyte in urine decreased in both groups(P<0.01), and the decrease in treatment group was more than that in control group(P<0.01). [Conclusion] Sanjin Tablet combined with levofloxacin in the treatment of urinary tract infection(damp-heat injection) has satisfactory curative effect and no serious adverse reactions,which is worthy of promotion.
[Objective] To observe the curative effect of Sanjin tablet combined with levofloxacin in the treatment of urinary tract infection. [Method] 248 inpatients and outpatients were randomly divided into two groups by random number table method. Control group 124 cases of levofloxacin, 0.2 g, twice a day, intravenous drip. Treatment group 124 cases of Sanjin tablets, 3 tablets per time, 3 times per day;levofloxacin treatment with the control group. Continuous treatment for 7 days is a course of treatment.Clinical manifestations, urinary leukocytes, symptom scores and adverse reactions were observed. Continuous treatment for 1 course(14 days) to determine the efficacy. [Result] In the treatment group, 44 cases were cured, 48 cases were markedly effective, 28 cases were effective and 4 cases were ineffective, the total effective rate was 96.77%. In the control group, 28 cases were cured, 14 cases were markedly effective, 36 cases were effective and 32 cases were ineffective, the total effective rate was 74.19%. The curative effect of the treatment group was better than that of the control group(P<0.05). Symptom scores were improved in both groups(P<0.01), and the improvement in treatment group was better than that in control group(P<0.01).Leukocyte in urine decreased in both groups(P<0.01), and the decrease in treatment group was more than that in control group(P<0.01). [Conclusion] Sanjin Tablet combined with levofloxacin in the treatment of urinary tract infection(damp-heat injection) has satisfactory curative effect and no serious adverse reactions,which is worthy of promotion.
引文
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[2]中华人民共和国卫生部.涉及人的生物医学研究伦理审查办法(试行)[S].(2007-03-26)[2015-01-01].http://www.moh.gov.cn/qjjys/s3581/200804/b9f1bfee4ab344ec892e68097296e2a8.shtml.
[3]尿路感染诊断与治疗中国专家共识编写组.尿路感染诊断与治疗中国专家共识(2015版)——复杂性尿路感染[J].中华泌尿外科杂志,2015,36(4):241-244.
[4]周仲瑛.中医内科学[M].北京:中国中医药出版社,2004:360.
[5]中华人民共和国卫生部药政局.新药(中药)治疗淋症(泌尿系感染)临床研究指导原则[J].中华中医药杂志,1990,5(5):73-75.
[6]吴建军,杨翔.尿路感染的临床症状及日常预防[J].医学信息(下旬刊),2010,23(6):264.
[7]郭卫红.左氧氟沙星的药理与临床[J].实用医技杂志,2003,10(10):1207-1208.
[8]梁雁,鲁云兰.左氧氟沙星注射液不良反应及相关因素[J].药物不良反应杂志,2003,5(2):77-80.
[9]马春燕.尿液白细胞测定对尿路感染的诊断价值[J].中国现代医药杂志,2007,9(11):125.
[10]巢元方.诸病源候论[M].宋柏杨.校注.北京:中国医药科技出版社,2011:156.
[11]李昌煜.三金片(胶囊)临床应用价值与技术优势的分析[J].中国药物经济学,2007,2(3):35-41.
[12]高学敏.中药学[M].北京:中国中医药出版社,2007.
[13]邹健,阮金兰,孙传勇.菝葜的化学成分、药理作用与临床应用[J].中药材,2001,24(6):450-452.
[14]陈振南,林文清.大剂量积雪草在临床应用经验[J].海峡药学,1999,11(s1):88-89.
[15]蒋受军.羊开口药材的名实考证[J].中草药,2010,41(9):55-57.
[16]邹节明,潘佐静,陆浩.三金片临床研究综述[J].中医杂志,2003,44(4):311-312.
[17]邹节明,潘佐静,张家铨,等.三金片药效学实验研究[J].中华中医药杂志,1997,12(5):17-19.