杜氏附子汤治疗恢复期脑梗死的临床疗效观察
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摘要
【目的】观察杜氏附子汤治疗恢复期脑梗死患者的临床疗效。【方法】将60例恢复期脑梗死患者随机分为治疗组和对照组,每组各30例。对照组给予西医常规治疗(包括口服阿司匹林肠溶片及阿托伐他汀钙片),治疗组在对照组西医常规治疗的基础上给予杜氏附子汤加减治疗,疗程1个月。观察2组患者治疗前后美国国立卫生研究院卒中量表(NIHSS)、改良Rankin量表(MRS)和日常生活活动能力量表(ADL)评分的变化情况,并以NIHSS评分为基础进行疗效判定。【结果】(1)治疗1个月后,治疗组的总有效率为90.00%,对照组为63.33%,治疗组的疗效明显优于对照组,差异有统计学意义(P<0.05)。(2)治疗后,2组患者NIHSS和MRS评分均较治疗前明显下降(P<0.01),ADL评分均较治疗前明显升高(P<0.01),且治疗组对NIHSS和MRS评分的下降作用及对ADL评分的升高作用均明显优于对照组,差异均有统计学意义(P<0.05)。【结论】在西医常规治疗基础上结合杜氏附子汤加减治疗恢复期脑梗死患者,疗效确切。
Objective To observe the clinical effect of DU's Fuzi Decoction in the treatment of cerebral infarction in convalescent period. Methods Sixty patients with convalescent cerebral infarction were randomly divided into treatment group and control group, 30 cases in each group. The control group was conventionally treated with Aspirin Enteric-coated Tablets and Atorvastatin Calcium Tablets. The treatment group was treated with modified DU's Fuzi Decoction based on the treatment for the control group. The treatment of the two groups lasted one month. Before and after treatment,the National Institutes of Health Stroke Scale(NIHSS),the modified Rankin Scale(MRS),and the activity of daily living(ADL)scale were used for the scoring of neurological deficit and ADL. And the efficacy evaluation was based on the NIHSS scores. Results(1)After treatment for one month,the total effective rate of the treatment group was 90.00%,was higher than that(63.33%)of the control group,the difference being significant(P < 0.05).(2)After treatment,the scores of NIHSS and MRS in the two groups were lower and ADL scores were higher than those before treatment(P<0.01),and the decrease of NIHSS and MRS scores as well as the increase of ADL scores in the treatment group were superior to those in the control group(P <0.05). Conclusion Modified DU's Fuzi Decoction combined with conventional western medicine exerts certain effects in the treatment of cerebral infarction patients in convalescent period.
Objective To observe the clinical effect of DU's Fuzi Decoction in the treatment of cerebral infarction in convalescent period. Methods Sixty patients with convalescent cerebral infarction were randomly divided into treatment group and control group, 30 cases in each group. The control group was conventionally treated with Aspirin Enteric-coated Tablets and Atorvastatin Calcium Tablets. The treatment group was treated with modified DU's Fuzi Decoction based on the treatment for the control group. The treatment of the two groups lasted one month. Before and after treatment,the National Institutes of Health Stroke Scale(NIHSS),the modified Rankin Scale(MRS),and the activity of daily living(ADL)scale were used for the scoring of neurological deficit and ADL. And the efficacy evaluation was based on the NIHSS scores. Results(1)After treatment for one month,the total effective rate of the treatment group was 90.00%,was higher than that(63.33%)of the control group,the difference being significant(P < 0.05).(2)After treatment,the scores of NIHSS and MRS in the two groups were lower and ADL scores were higher than those before treatment(P<0.01),and the decrease of NIHSS and MRS scores as well as the increase of ADL scores in the treatment group were superior to those in the control group(P <0.05). Conclusion Modified DU's Fuzi Decoction combined with conventional western medicine exerts certain effects in the treatment of cerebral infarction patients in convalescent period.
引文
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[2] Aldag M, Kocaaslan C, Bademci M S, et al. Consequence of ischemic stroke after coronary surgery with cardiopulmonary bypass according to stroke subtypes[J]. Braz J Cardiovasc Surg,2018,33(5):462.
[3]李茂清,付建英,钟俊杰,等.温脾补肾法对脑梗塞后遗症TLR4信号通路的影响[J].广州中医药大学学报,2017,34(5):631.
[4]中华医学会神经病学分会脑血管病学组急性缺血性脑卒中诊治指南撰写组.中国急性缺血性脑卒中诊治指南2010[J].中国全科医学,2011,14(128):4013.
[5]巫嘉陵.四个脑卒中量表的信度与效度研究[D].天津:天津医科大学,2007.
[6]全国第四届脑血管病学术会议.脑卒中患者临床神经功能缺损程度评分标准(1995)[J].中华神经科杂志,1996,29(6):381.
[7]张隐庵.伤寒论集注[M].北京:学苑出版社,2013:157-157.
[8]郑钦安.医学三书[M].太原:山西科学技术出版社,2016:219-220.
[9]卢崇汉.卢氏药物配合阐述[M].上海:上海图书馆,2012:7.
[10] Huang X, Tang J, Zhang Q, et al. Polysaccharide from fuzi(FPS)prevent hypercholesterolemia in rats[J]. Lipids Health Dis,2010,9:1.
[11]许青媛,于利森,张小利,等.附子、吴茱萸对实验性血栓形成及凝血系统的影响[J].西北药学杂志,1990,5(2):9.