参芪地黄汤对气阴两虚型狼疮性肾炎血生化相关指标的影响
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摘要
目的:观察参芪地黄汤对气阴两虚型狼疮性肾炎血生化相关指标的影响。方法:选取76例气阴两虚型狼疮性肾炎患者,随机分为对照组和观察组,每组38例。对照组采用常规西药治疗,观察组在对照组基础上加用参芪地黄汤治疗,比较两组血生化指标、系统性红斑狼疮病活动指数(SLEDAI)、血管内皮生长因子(VEGF)及不良反应情况。结果:观察组治疗3个月C反应蛋白(CRP)、血肌酐(SCr)、尿素氮(BUN)水平均低于对照组,白蛋白(ALB)、补体(C3)水平高于对照组,差异有统计学意义(P<0.05);与对照组比较,观察组治疗3个月时VEGF、SLEDAI均较低,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:参芪地黄汤可有效改善气阴两虚型狼疮性肾炎患者血生化指标,缓解临床症状,且安全性较好。
Objective To investigate the effect of Shenqi Dihuang decoction on blood biochemical indexes in patients with qi-yin deficiency type of lupus nephritis. Methods 76 patients with qi-yin deficiency type of lupus nephritis in our hospital were selected,and they were divided into control group and observation group by randomly,with 38 cases in each group. Control Group was given routine western medicine,while observation group was treated with Shenqi Dihuang decoction based on control group. The blood biochemical indexes,systemic lupus erythematosus-disease activity index( SLEDAI),vascular endothelial growth factor( VEGF) and adverse reactions were compared between the two groups. Results After treatment for 3 months,the levels of C-reactive protein( CRP),serum creatinine( SCr),blood urea nitrogen( BUN) in observation group were lower than those in control group,while the levels of albumin( ALB) and complement( C3) were higher than control group( P < 0. 05); After treatment for 3 months,the VEGF and SLEDAI in observation group were lower than those in control group( P < 0. 05); There was no statistical difference in the incidence of adverse reactions between the two groups( P > 0. 05). Conclusion Shenqi Dihuang decoction for patients with qi-yin deficiency type of lupus nephritis can effectively improve blood biochemical indexes,relieve clinical symptoms and have better safety.
Objective To investigate the effect of Shenqi Dihuang decoction on blood biochemical indexes in patients with qi-yin deficiency type of lupus nephritis. Methods 76 patients with qi-yin deficiency type of lupus nephritis in our hospital were selected,and they were divided into control group and observation group by randomly,with 38 cases in each group. Control Group was given routine western medicine,while observation group was treated with Shenqi Dihuang decoction based on control group. The blood biochemical indexes,systemic lupus erythematosus-disease activity index( SLEDAI),vascular endothelial growth factor( VEGF) and adverse reactions were compared between the two groups. Results After treatment for 3 months,the levels of C-reactive protein( CRP),serum creatinine( SCr),blood urea nitrogen( BUN) in observation group were lower than those in control group,while the levels of albumin( ALB) and complement( C3) were higher than control group( P < 0. 05); After treatment for 3 months,the VEGF and SLEDAI in observation group were lower than those in control group( P < 0. 05); There was no statistical difference in the incidence of adverse reactions between the two groups( P > 0. 05). Conclusion Shenqi Dihuang decoction for patients with qi-yin deficiency type of lupus nephritis can effectively improve blood biochemical indexes,relieve clinical symptoms and have better safety.
引文
[1]程玉婷,张雅兰,吴垚,等.狼疮性肾炎的中西医结合治疗进展[J].中国中西医结合肾病杂志,2017,18(3):278-280.
[2]张丹丹,温成平.运用水血并治法治疗狼疮性肾炎体会[J].中医杂志,2017,58(5):427-429.
[3]中华中医学会肾病分会.狼疮肾炎的诠断、辨证分型及疗效评定(试行方案)[J].上海中医药杂志,2008,42(2):9-10.
[4]郑筱萸.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:273.
[5]秦军建,邢艳芳,莫江彬.益气解毒活血方联合他克莫司治疗狼疮性肾炎肾病综合征临床观察[J].陕西中医,2017,38(8):1059-1060.
[6]戴凤洁,宋卫国,祝小波,等.益肾祛瘀化湿汤治疗肾气亏虚、湿瘀内阻型狼疮性肾炎临床观察[J].中医药通报,2017,16(2):52-54,58.
[7]麦地努尔·阿不力米提,桑晓红.狼疮性肾炎患者预后影响因素分析[J].中华实用诊断与治疗杂志,2017,31(2):139-141.
[8]黄晓青,黎飞猛,梁兆球.参芪地黄汤加减治疗缓解期狼疮性肾炎气阴两虚兼血瘀症的疗效分析[J].中医药信息,2017,34(2):80-83.
[9]邓晓蔚,熊有明,覃应媛,等.参芪地黄汤加减联合泼尼松片治疗气阴两虚证活动期狼疮性肾炎疗效观察[J].现代中西医结合杂志,2016,25(33):3698-3700.
[10]陈明,王海艳.张佩青教授应用参芪地黄汤合解毒活血汤治疗慢性肾脏病经验[J].中国中西医结合肾病杂志,2017,18(3):194-195.
[11]蔡朕,汪蕾,段昱方,等.参芪地黄汤对气阴两虚型特发性膜性肾病的疗效观察[J].中国医刊,2016,51(1):82-85.
[12]陈钢,李淑菊,毛阳,等.参芪地黄汤加减联合非布司他治疗尿酸性肾病临床观察[J].中国中医药科技,2016,23(5):591-593.
[2]张丹丹,温成平.运用水血并治法治疗狼疮性肾炎体会[J].中医杂志,2017,58(5):427-429.
[3]中华中医学会肾病分会.狼疮肾炎的诠断、辨证分型及疗效评定(试行方案)[J].上海中医药杂志,2008,42(2):9-10.
[4]郑筱萸.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:273.
[5]秦军建,邢艳芳,莫江彬.益气解毒活血方联合他克莫司治疗狼疮性肾炎肾病综合征临床观察[J].陕西中医,2017,38(8):1059-1060.
[6]戴凤洁,宋卫国,祝小波,等.益肾祛瘀化湿汤治疗肾气亏虚、湿瘀内阻型狼疮性肾炎临床观察[J].中医药通报,2017,16(2):52-54,58.
[7]麦地努尔·阿不力米提,桑晓红.狼疮性肾炎患者预后影响因素分析[J].中华实用诊断与治疗杂志,2017,31(2):139-141.
[8]黄晓青,黎飞猛,梁兆球.参芪地黄汤加减治疗缓解期狼疮性肾炎气阴两虚兼血瘀症的疗效分析[J].中医药信息,2017,34(2):80-83.
[9]邓晓蔚,熊有明,覃应媛,等.参芪地黄汤加减联合泼尼松片治疗气阴两虚证活动期狼疮性肾炎疗效观察[J].现代中西医结合杂志,2016,25(33):3698-3700.
[10]陈明,王海艳.张佩青教授应用参芪地黄汤合解毒活血汤治疗慢性肾脏病经验[J].中国中西医结合肾病杂志,2017,18(3):194-195.
[11]蔡朕,汪蕾,段昱方,等.参芪地黄汤对气阴两虚型特发性膜性肾病的疗效观察[J].中国医刊,2016,51(1):82-85.
[12]陈钢,李淑菊,毛阳,等.参芪地黄汤加减联合非布司他治疗尿酸性肾病临床观察[J].中国中医药科技,2016,23(5):591-593.