疏风明目方超声雾化对过敏性结膜炎患者泪膜稳定性及泪液相关指标的影响
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摘要
目的:观察疏风明目方超声雾化对过敏性结膜炎患者泪膜稳定性及泪液相关指标的影响。方法:将140例过敏性结膜炎患者随机分为两组,对照组70例给予盐酸奥洛他定滴眼液联合生理盐水雾化治疗,观察组70例给予盐酸奥洛他定滴眼液联合疏风明目方超声雾化治疗。连续治疗14d后,比较两组临床疗效、治疗前后单项症状(流泪、痒感、畏光、异物感)、泪膜稳定性(BUT、FL)、泪液相关指标[嗜酸性细胞阳离子蛋白(ECP)、HA、IgE]。结果:观察组治疗后总有效率高于对照组(90.7%vs 74.3%,P<0.05);两组治疗后单项症状积分均低于治疗前,且观察组均低于对照组(P<0.05);两组治疗后BUT均高于治疗前,FL均低于治疗前,且观察组改善程度均优于对照组(P<0.05);两组治疗后泪液HA、ECP、IgE水平均低于治疗前,且观察组改善程度均优于对照组(P<0.05)。结论:疏风明目方超声雾化治疗能够改善过敏性结膜炎患者泪液相关指标,提高泪膜稳定性,有助于缓解局部变态反应,改善患者临床症状。
?AIM: To observe the effect of ultrasonic atomization of Shufeng Mingmu Decoction on tear film stability and index of tear fluid in patients with allergic conjunctivitis.?METHODS: Totally 140 patients with allergic conjunctivitis were randomly divided into 2 groups. 70 patients in the control group were treated with olopatadine hydrochloride eye drops combined with normal saline atomization therapy, while the 70 patients in the observation group were treated with ultrasonic atomization of Shufeng Mingmu Decoction combined with oldpatadine hydrochloride eye drops. After 14 d of continuous treatment, the single symptoms(lacrimation, itching, photophobia, foreign body sensation), the stability of tear film(BUT, FL), and the index of tear fluid(ECP, HA, IgE) of the two groups were compared and analyzed. The clinical effects of the two groups were compared. ?RESULTS: The total effective rate of the observation group was significantly higher than that of the control group(90.7% vs 74.3%, P<0.05). After treatment, the scores of single symptoms in both groups were lower than those before treatment, and those in the observation group were lower than those in the control group(P<0.05). After treatment, the index of BUT in both groups were significantly higher than before treatment(P<0.05), while the index of FL was significantly lower than before treatment, and the improvement degree of which in the observation group was better than that of control group(P<0.05). After treatment, the levels of HA, ECP and IgE in the two groups were significantly lower than before treatment, and the improvement degree of which in the observation group was better than that in the control group(P<0.05).?CONCLUSION: Ultrasonic atomization treatment of Shufeng Mingmu Decoction can improve the index of tear fluid of allergic conjunctivitis patients and the stability of tear film, which help relieve local allergy and improve clinical symptoms of patients.
?AIM: To observe the effect of ultrasonic atomization of Shufeng Mingmu Decoction on tear film stability and index of tear fluid in patients with allergic conjunctivitis.?METHODS: Totally 140 patients with allergic conjunctivitis were randomly divided into 2 groups. 70 patients in the control group were treated with olopatadine hydrochloride eye drops combined with normal saline atomization therapy, while the 70 patients in the observation group were treated with ultrasonic atomization of Shufeng Mingmu Decoction combined with oldpatadine hydrochloride eye drops. After 14 d of continuous treatment, the single symptoms(lacrimation, itching, photophobia, foreign body sensation), the stability of tear film(BUT, FL), and the index of tear fluid(ECP, HA, IgE) of the two groups were compared and analyzed. The clinical effects of the two groups were compared. ?RESULTS: The total effective rate of the observation group was significantly higher than that of the control group(90.7% vs 74.3%, P<0.05). After treatment, the scores of single symptoms in both groups were lower than those before treatment, and those in the observation group were lower than those in the control group(P<0.05). After treatment, the index of BUT in both groups were significantly higher than before treatment(P<0.05), while the index of FL was significantly lower than before treatment, and the improvement degree of which in the observation group was better than that of control group(P<0.05). After treatment, the levels of HA, ECP and IgE in the two groups were significantly lower than before treatment, and the improvement degree of which in the observation group was better than that in the control group(P<0.05).?CONCLUSION: Ultrasonic atomization treatment of Shufeng Mingmu Decoction can improve the index of tear fluid of allergic conjunctivitis patients and the stability of tear film, which help relieve local allergy and improve clinical symptoms of patients.
引文
1杭丽.鱼腥草滴眼液联合吡嘧司特钾滴眼液治疗过敏性结膜炎的疗效观察.国际眼科杂志2013;13(12):2468-2470
2柏芳.中医整体护理干预对过敏性结膜炎患者临床疗效及依从性的影响.现代中西医结合杂志2018;27(3):329-332
3盛焱.各种类型过敏性结膜炎患者应用奥洛他定滴眼液联合双氯芬酸钠滴眼液治疗的临床效果评价.中国实用医药2015;10(29):133-134
4刘玲,周华祥,汪相芮,等.中药超声雾化治疗眼表疾病的研究进展.中医眼耳鼻喉杂志2015;5(1):49-52
5葛坚.眼科学.第2版.北京:人民卫生出版社2014:163
6唐由之,肖国士.中医眼科全书.第2版.北京:人民卫生出版社2011:769
7国家中医药管理局.中医病证诊断疗效标准.南京:南京大学出版社1995:101-103
8薛凤蕊.过敏性结膜炎的临床分析.基层医学论坛2017;21(26):3621-3622
9陈大复,于琨瑛.过敏性结膜炎的免疫学机制研究进展.中国医药导报2014;11(33):162-165
10 Sarker SJ,Chowdhury AN,Hussain Z,et al.Comparison of the therapeutic efficacy of 0.1% olopatadine hydrochloride and 0.025% ketotifen fumarate in allergic conjunctivitis.Therapy 2011;8(5):545-553
11王凤,温桃群,桑文涛,等.荆芥挥发油化学成分及药理作用研究现状.中南药学2017;15(3):312-318
12周晓鹰,陈洁,金柳,等.白鲜皮的药理作用及抗炎活性成分研究进展.常州大学学报(自然科学版)2018;30(1):82-86
13张艳华,汪荣斌,王存琴,等.中药地肤的研究进展.现代中药研究与实践2016;30(1):84-86
14吉晓丽.黄芩的化学成分与药理作用研究进展.中医临床研究2017;9(9):128-129
15于爱忠,牛广增,张宝凤,等.中药雾化联合奥洛他定滴眼液治疗过敏性结膜炎疗效分析.湖南师范大学学报(医学版)2015;12(4):87-89
16王丽明,梁先军,朱海,等.中药消风散超声雾化治疗过敏性结膜炎的临床研究.按摩与康复医学2015;6(3):9-11
17夏晶晶,李学永,周筱荣.中药超声雾化联合埃美丁滴眼液治疗过敏性结膜炎的临床观察.中医临床研究2019;11(1):103-104
18于静.奥洛他定对过敏性结膜炎患者血清及泪液中相关指标的影响.海南医学院学报2017;23(19):2742-2744
2柏芳.中医整体护理干预对过敏性结膜炎患者临床疗效及依从性的影响.现代中西医结合杂志2018;27(3):329-332
3盛焱.各种类型过敏性结膜炎患者应用奥洛他定滴眼液联合双氯芬酸钠滴眼液治疗的临床效果评价.中国实用医药2015;10(29):133-134
4刘玲,周华祥,汪相芮,等.中药超声雾化治疗眼表疾病的研究进展.中医眼耳鼻喉杂志2015;5(1):49-52
5葛坚.眼科学.第2版.北京:人民卫生出版社2014:163
6唐由之,肖国士.中医眼科全书.第2版.北京:人民卫生出版社2011:769
7国家中医药管理局.中医病证诊断疗效标准.南京:南京大学出版社1995:101-103
8薛凤蕊.过敏性结膜炎的临床分析.基层医学论坛2017;21(26):3621-3622
9陈大复,于琨瑛.过敏性结膜炎的免疫学机制研究进展.中国医药导报2014;11(33):162-165
10 Sarker SJ,Chowdhury AN,Hussain Z,et al.Comparison of the therapeutic efficacy of 0.1% olopatadine hydrochloride and 0.025% ketotifen fumarate in allergic conjunctivitis.Therapy 2011;8(5):545-553
11王凤,温桃群,桑文涛,等.荆芥挥发油化学成分及药理作用研究现状.中南药学2017;15(3):312-318
12周晓鹰,陈洁,金柳,等.白鲜皮的药理作用及抗炎活性成分研究进展.常州大学学报(自然科学版)2018;30(1):82-86
13张艳华,汪荣斌,王存琴,等.中药地肤的研究进展.现代中药研究与实践2016;30(1):84-86
14吉晓丽.黄芩的化学成分与药理作用研究进展.中医临床研究2017;9(9):128-129
15于爱忠,牛广增,张宝凤,等.中药雾化联合奥洛他定滴眼液治疗过敏性结膜炎疗效分析.湖南师范大学学报(医学版)2015;12(4):87-89
16王丽明,梁先军,朱海,等.中药消风散超声雾化治疗过敏性结膜炎的临床研究.按摩与康复医学2015;6(3):9-11
17夏晶晶,李学永,周筱荣.中药超声雾化联合埃美丁滴眼液治疗过敏性结膜炎的临床观察.中医临床研究2019;11(1):103-104
18于静.奥洛他定对过敏性结膜炎患者血清及泪液中相关指标的影响.海南医学院学报2017;23(19):2742-2744