乌灵胶囊联合安非他酮治疗老年抑郁症的疗效观察
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摘要
目的研究乌灵胶囊联合盐酸安非他酮缓释片治疗老年抑郁症的临床疗效。方法选取2015年12月—2017年12月青海大学附属医院接收的120例老年抑郁症患者作为研究对象,将所有患者随机分为对照组和治疗组,每组各60例。对照组患者口服盐酸安非他酮缓释片,1片/次,2次/d。治疗组患者在对照组治疗的基础上口服乌灵胶囊,3粒/次,3次/d,温开水送下。7 d为1个疗程,两组患者持续治疗8个疗程。观察并记录两组患者的临床疗效,对比两组治疗前后的汉密尔顿焦虑量表(HAMA)评分和汉密尔顿抑郁量表(HAMD)评分。结果治疗4、8周后,两组HAMA和HAMD评分均显著低于治疗前,且治疗8周后HAMA和HAMD评分显著低于治疗4周后,同组治疗前后比较差异具有统计学意义(P<0.05)。治疗4、8周后,治疗组患者HAMA和HAMD评分显著低于对照组,两组比较差异具有统计学意义(P<0.05)。结论乌灵胶囊联合盐酸安非他酮缓释片治疗老年抑郁症具有较好的临床疗效,能够改善患者HAMD和HAMA评分,安全性较高,值得临床推广应用。
Objective To study the clinical efficacy of Wuling Capsules combined with Bupropion Hydrochloride Sustained-Release Tablets in treatment of geriatric depression. Methods Patients(120 cases) with geriatric depression in Affiliated Hospital of Qinghai University from December 2015 to December 2017 were randomly divided into control and treatment groups, and each group had 60 cases. Patients in the control group were po administered with Bupropion Hydrochloride Sustained-Release Tablets, 1 tablet/time, twice daily. Patients in the treatment group were po administered with Wuling Capsules on the basis of the control group with warm water, 3 grains/time, three times daily. A course of treatment had 7 d, and patients in two groups were treated for 8 courses. After treatment, the clinical efficacy was evaluated, and the HAMA and HAMD scores in two groups before and after treatment were compared. Results After treatment of 4 and 8 weeks, the HAMA and HAMD scores in two groups were significantly lower than before treatment, and the HAMA and HAMD scores after treatment of 8 weeks were significantly lower than 4 weeks after treatment, the difference were statistically significant in the same group(P < 0.05). After treatment of 4 and 8 weeks, the HAMA and HAMD scores in the treatment group were lower than those in the control group, with significant difference between two groups(P < 0.05). Conclusion Wuling Capsules combined with Bupropion Hydrochloride Sustained-Release Tablets has clinical curative effect in treatment of geriatric depression, can improve the HAMA and HAMD scores, with high safety, which has a certain clinical application value.
Objective To study the clinical efficacy of Wuling Capsules combined with Bupropion Hydrochloride Sustained-Release Tablets in treatment of geriatric depression. Methods Patients(120 cases) with geriatric depression in Affiliated Hospital of Qinghai University from December 2015 to December 2017 were randomly divided into control and treatment groups, and each group had 60 cases. Patients in the control group were po administered with Bupropion Hydrochloride Sustained-Release Tablets, 1 tablet/time, twice daily. Patients in the treatment group were po administered with Wuling Capsules on the basis of the control group with warm water, 3 grains/time, three times daily. A course of treatment had 7 d, and patients in two groups were treated for 8 courses. After treatment, the clinical efficacy was evaluated, and the HAMA and HAMD scores in two groups before and after treatment were compared. Results After treatment of 4 and 8 weeks, the HAMA and HAMD scores in two groups were significantly lower than before treatment, and the HAMA and HAMD scores after treatment of 8 weeks were significantly lower than 4 weeks after treatment, the difference were statistically significant in the same group(P < 0.05). After treatment of 4 and 8 weeks, the HAMA and HAMD scores in the treatment group were lower than those in the control group, with significant difference between two groups(P < 0.05). Conclusion Wuling Capsules combined with Bupropion Hydrochloride Sustained-Release Tablets has clinical curative effect in treatment of geriatric depression, can improve the HAMA and HAMD scores, with high safety, which has a certain clinical application value.
引文
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[12]燕虹,王蓓芸,崔亮,等.乌灵胶囊联合氢溴酸西酞普兰片治疗老年抑郁伴失眠患者的临床研究[J].中成药, 2012, 34(12):2295-2298.
[2]范永红,王宁兰.老年期抑郁症的临床特点及护理[J].山西医药杂志, 2014, 43(11):1279-1280.
[3]樊小兵,徐格林,朱武生,等.盐酸安非他酮缓释片治疗抑郁症的疗效及安全性[J].医学研究生学报,2007,20(12):1339-1340.
[4]李冬梅.乌灵菌粉抗抑郁作用及机制研究[D].北京:北京协和医学院, 2016.
[5]中华医学会精神科分会.中国精神障碍分类与诊断标准第3版(CCMD-3)[M].济南:山东科学技术出版社,2001:87-89.
[6]孙传兴.临床疾病诊断依据治愈好转标准[M].第2版.北京:人民军医出版社, 1998:222-223.
[7]张明园.精神科评定量表手册[M].长沙:湖南科学技术出版社, 1993:198-204.
[8]汤毓华,张明园.汉密顿抑郁量表(HAMD)[J].上海精神医学, 1984(2):61-64.
[9]张存琪.关于老年心血管病人抑郁症的临床研究[J].心血管康复医学杂志, 2002, 11(2):120-121.
[10]张维东,张炜悦,白云,等.老年抑郁症患者的药物治疗[J].中华保健医学杂志, 2013, 15(2):202-203.
[11]韩继阳,刘果,王旭梅.安非他酮与艾司西酞普兰治疗老年期抑郁症的临床疗效及安全性[J].山西医药杂志, 2016, 45(18):2119-2122.
[12]燕虹,王蓓芸,崔亮,等.乌灵胶囊联合氢溴酸西酞普兰片治疗老年抑郁伴失眠患者的临床研究[J].中成药, 2012, 34(12):2295-2298.