甲砜霉素联合阿维A胶囊对寻常性银屑病患者外周血VEGF、OPN、IL-17、IL-18表达的影响研究
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摘要
目的:研究甲砜霉素联合阿维A胶囊对寻常性银屑病患者外周血血管内皮生长因子(VEGF)、骨桥蛋白(OPN)、白细胞介素-17(IL-17)、白细胞介素-18(IL-18)表达的影响。方法:选取2016年9月-2017年8月笔者医院收治的73例寻常性银屑病患者,根据随机数字法分为观察组(39例)和对照组(34例)。对照组使用阿维A胶囊,观察组在此基础上联合使用甲砜霉素。比较两组患者临床疗效,外周血VEGF、OPN、IL-17、IL-18表达,血液流变学指标及不良反应。结果:治疗后,观察组临床总有效率显著高于对照组,差异有统计学意义(P<0.05)。治疗后观察组的外周血VEGF、OPN、IL-17、IL-18表达显著低于对照组,差异有统计学意义(P<0.05)。治疗后,观察组全血高切粘度、全血低切粘度、血沉、红细胞比积、变形指数显著低于对照组,差异有统计学意义(P<0.05)。观察组和对照组不良反应率比较无显著差异(P>0.05)。结论:甲砜霉素联合阿维A胶囊能有效降低寻常性银屑病患者外周血VEGF、OPN、IL-17、IL-18水平,临床疗效良好。
Objective To study the combination of thiamphenicol and avira capsules in peripheral blood vascular endothelial growth factor(VEGF), osteopontin(OPN), interleukin-17(IL-17) and interleukin-18(IL-18) in patients with psoriasis vulgaris.Methods Seventy-three patients with psoriasis vulgaris admitted to our hospital from September 2016 to August 2017 were enrolled. The patients were divided into observation group(39 cases) and control group(34 cases) according to random number method. Avira capsules were used in the control group, and thiamphenicol used in the observation group on the basis of control group. The clinical efficacy of the two groups of patients, peripheral blood VEGF, OPN, IL-17, IL-18 expression,hemorheology, adverse reactions were compared. Results After treatment, the total clinical effective rate of the observation group was significantly higher than that of the control group(P<0.05). After treatment, the expression of peripheral blood VEGF, OPN, IL-17 and IL-18 in the observation group was significantly lower than the control group(P <0.05). After treatment, the observation group with whole blood high-viscosity, whole blood low-cut viscosity, erythrocyte sedimentation rate, erythrocyte ratio, and deformation index were significantly lower than those in the control group(P<0.05). There was no significant difference in the adverse reaction rate between the observation group and the control group(P>0.05). Conclusion Thiamphenicol combined with avira capsules can effectively reduce the levels of VEGF, OPN, IL-17 and IL-18 in peripheral blood of patients with psoriasis vulgaris, and the clinical effect is good.
Objective To study the combination of thiamphenicol and avira capsules in peripheral blood vascular endothelial growth factor(VEGF), osteopontin(OPN), interleukin-17(IL-17) and interleukin-18(IL-18) in patients with psoriasis vulgaris.Methods Seventy-three patients with psoriasis vulgaris admitted to our hospital from September 2016 to August 2017 were enrolled. The patients were divided into observation group(39 cases) and control group(34 cases) according to random number method. Avira capsules were used in the control group, and thiamphenicol used in the observation group on the basis of control group. The clinical efficacy of the two groups of patients, peripheral blood VEGF, OPN, IL-17, IL-18 expression,hemorheology, adverse reactions were compared. Results After treatment, the total clinical effective rate of the observation group was significantly higher than that of the control group(P<0.05). After treatment, the expression of peripheral blood VEGF, OPN, IL-17 and IL-18 in the observation group was significantly lower than the control group(P <0.05). After treatment, the observation group with whole blood high-viscosity, whole blood low-cut viscosity, erythrocyte sedimentation rate, erythrocyte ratio, and deformation index were significantly lower than those in the control group(P<0.05). There was no significant difference in the adverse reaction rate between the observation group and the control group(P>0.05). Conclusion Thiamphenicol combined with avira capsules can effectively reduce the levels of VEGF, OPN, IL-17 and IL-18 in peripheral blood of patients with psoriasis vulgaris, and the clinical effect is good.
引文
[1]堵建岗.清热解毒口服液联合阿维A胶囊治疗难治性银屑病临床疗效及安全性研究[J].中华中医药学刊,2016,34(6):1517-1519.
[2]杨颜龙,张禁,易松柏,等.阿维A胶囊联合复方甘草酸苷注射液治疗红皮病型银屑病30例临床观察[J].中国皮肤性病学杂志,2015,29(2):217-218.
[3]潘晓东,吴平谷,姜维.超高效液相色谱-串联质谱法同时测定鱼肉中氯霉素、甲砜霉素和氟甲砜霉素[J].中国食品卫生杂志,2014,26(6):572-574.
[4]吴咏梅,李强.健脾解毒汤联合阿维A治疗斑块状银屑病80例[J].辽宁中医杂志,2015,42(3):547-548.
[5]郑志忠.中国银屑病治疗指南(2 0 0 8版)[J].中华皮肤科杂志,2009,42(3):213-214.
[6]中华中医药学会皮肤科分会.寻常型银屑病(白疕)中医药循证临床实践指南(2013版)[J].中医杂志,2014,55(1):76-82.
[7]梁杨丽,李连琨,杨延华.芩珠凉血方联合阿维A胶囊治疗血热证寻常性银屑病的疗效[J].广东医学,2014,35(5):768-769.
[8]Wu JJ,Feldman SR,Koo J,et al.Epidemiology of mental health comorbidity in psoriasis[J].J Dermatol Treat,2018,29(5):487-495.
[9]Morita A,Muramatsu S,Kubo R,et al.Low incidence of hypercalcemia following combined calcipotriol hydrate/betamethasone dipropionate ointment treatment in Japanese patients with severe psoriasis vulgaris[J].J Dermatol Treat,2018,29(5):496-500.
[10]毛荣超,唐美,邓仁远,等.紫丹银屑颗粒联合阿维A胶囊和复方氟米松软膏治疗寻常型银屑病的临床观察[J].中国药房,2018,29(6):800-804.
[11]刘素霞,张淑宁.阿维A胶囊联合银屑胶囊治疗血虚风燥型银屑病48例临床观察[J].中国皮肤性病学杂志,2017,31(4):474-476.
[12]杨洪波,王荻,卢彤岩.甲砜霉素对松浦镜鲤血细胞及血清生化指标的影响[J].江西农业大学学报,2014,36(4):841-847.
[13]Ramaekers BLT,Wolff RF,Pouwels X,et al.Ixekizumab for treating moderate-to-severe plaque psoriasis:an evidence review group perspective of a nice single technology appraisal[J].Pharmacoeconomics,2018,36(8):917-927.
[14]陈慧君,陈治国.白芍总苷胶囊治疗前、后寻常性银屑病患者外周血IL-17,TNF-α和IFN-γ的变化[J].中国皮肤性病学杂志,2014,28(2):135-137.
[15]温静,陈宏,薛梅,等.寻常性银屑病患者外周血中白介素18及白介素27的水平变化[J].临床皮肤科杂志,2015,44(10):611-614.
[2]杨颜龙,张禁,易松柏,等.阿维A胶囊联合复方甘草酸苷注射液治疗红皮病型银屑病30例临床观察[J].中国皮肤性病学杂志,2015,29(2):217-218.
[3]潘晓东,吴平谷,姜维.超高效液相色谱-串联质谱法同时测定鱼肉中氯霉素、甲砜霉素和氟甲砜霉素[J].中国食品卫生杂志,2014,26(6):572-574.
[4]吴咏梅,李强.健脾解毒汤联合阿维A治疗斑块状银屑病80例[J].辽宁中医杂志,2015,42(3):547-548.
[5]郑志忠.中国银屑病治疗指南(2 0 0 8版)[J].中华皮肤科杂志,2009,42(3):213-214.
[6]中华中医药学会皮肤科分会.寻常型银屑病(白疕)中医药循证临床实践指南(2013版)[J].中医杂志,2014,55(1):76-82.
[7]梁杨丽,李连琨,杨延华.芩珠凉血方联合阿维A胶囊治疗血热证寻常性银屑病的疗效[J].广东医学,2014,35(5):768-769.
[8]Wu JJ,Feldman SR,Koo J,et al.Epidemiology of mental health comorbidity in psoriasis[J].J Dermatol Treat,2018,29(5):487-495.
[9]Morita A,Muramatsu S,Kubo R,et al.Low incidence of hypercalcemia following combined calcipotriol hydrate/betamethasone dipropionate ointment treatment in Japanese patients with severe psoriasis vulgaris[J].J Dermatol Treat,2018,29(5):496-500.
[10]毛荣超,唐美,邓仁远,等.紫丹银屑颗粒联合阿维A胶囊和复方氟米松软膏治疗寻常型银屑病的临床观察[J].中国药房,2018,29(6):800-804.
[11]刘素霞,张淑宁.阿维A胶囊联合银屑胶囊治疗血虚风燥型银屑病48例临床观察[J].中国皮肤性病学杂志,2017,31(4):474-476.
[12]杨洪波,王荻,卢彤岩.甲砜霉素对松浦镜鲤血细胞及血清生化指标的影响[J].江西农业大学学报,2014,36(4):841-847.
[13]Ramaekers BLT,Wolff RF,Pouwels X,et al.Ixekizumab for treating moderate-to-severe plaque psoriasis:an evidence review group perspective of a nice single technology appraisal[J].Pharmacoeconomics,2018,36(8):917-927.
[14]陈慧君,陈治国.白芍总苷胶囊治疗前、后寻常性银屑病患者外周血IL-17,TNF-α和IFN-γ的变化[J].中国皮肤性病学杂志,2014,28(2):135-137.
[15]温静,陈宏,薛梅,等.寻常性银屑病患者外周血中白介素18及白介素27的水平变化[J].临床皮肤科杂志,2015,44(10):611-614.