甲真菌病激光治疗新进展
摘要
甲真菌病是由皮肤癣菌、酵母菌及霉菌所引起的甲板和甲下组织感染。甲真菌病不仅可以导致局部的健康问题,而且可以导致持续存在的整体健康问题。而目前口服抗真菌药是治疗的金标准,但是治疗失败是很常见的,且很多病人禁忌口服抗真菌药。近年来,随着激光的迅速发展,国外已经批准了多种激光设备用于治疗甲真菌病。因此本文为激光治疗甲真菌病的临床研究进展的综述。
引文
[1]甲真菌病指南专家工作组.甲真菌病诊治指南(2015版).中国真菌学杂志[J].2015,10(2):118-125.
[2]Ortiz AE,Avram MM,Wanner MA.A review of lasers and light for the treatment of onychomycosis[J].Lasers Surg Med,2014,46:117-124.
[3]Na G,Suh M,Sung Y,et al.A decreased growth rate of the toenail observed in patients with distal subungual onychomycosis[J].Ann Dermatol,1995,7:217-221.
[4]Hochman LG.Laser treatment of onychomycosis using a novel0.65-millisecond pulsed Nd:YAG 1064-nm laser[J].J Cosmer Laser Ther,2011,13:2-5.
[5]Hees H,Jger MW,Raulin C,et al.Treatment of onychomycosis using the 1064 nm Nd:YAG laser:a clinical pilot study[J].J Dtsch Dermatol Ges,2014,12:322-329.
[6]Kimura U,Takeuchi K,Kinoshita A,et al.Treating onychomycoses of the toenail:clinical efficacy of the sub-millisecond 1,064 nm Nd:YAG laser using a 5mm spot diameter[J].J Drugs Dermatol,2012,11:496-504.
[7]Noguchi H,Miyata K,Sugita T,et al.Treatment of onychomycosis using a 1064 nm Nd:YAG laser[J].Med Mycol J,2013,54:333-339.
[8]徐婧,禚凤麟,张蕊娜,等.Nd:YAG 1064 nm激光、伊曲康唑治疗轻中度甲真菌病近期疗效分析[J].中国真菌学杂志,2014,9(1):20-23.
[9]Xu Y,Miao X,Zhou B,et al.Combined oral terbinafine and longpulsed 1,064-nm Nd:YAG treatments is more effective for onychomycosis than either treatment alone[J].Dermatol Surg,2014,40:1201-1207.
[10]Zhang RN,Wang DK,Zhao FL,et al.Long-pulse Nd:YAG 1064nm laser treatment for onychomycosis[J].Chin Med J(Engl),2012,125:3288-3291.
[11]刘红芳,黄莉宁,陈勇军,等.不同疗程长脉宽Nd:YAG 1064 nm激光治疗甲真菌病的疗效观察[J].皮肤性病诊疗学杂志,2015,22(3):185-188.
[12]Kalokasidis K,Onder M,Trakatelli MG,et al.The effect of Qswitched Nd:YAG 1064 nm/532 nm laser in the treatment of onychomycosis in vivo[J].Dermatol Res Pract,2013,2013:379725.
[13]Landsman AS,Robbins AH,Angelini RF,et al.Treatment of mild,moderate,and severe onychomycosis using 870-and 930-nm light exposure[J].J Am Podiatr Med Assoc,2010,100:166-177.
[14]张佳音,钟咪,饶美荣,等.CO2激光联合盐酸阿莫罗芬搽剂治疗甲真菌病近期疗效观察[J].中国中西医结合皮肤性病学杂志,2014,13(3):165-166.
[15]Lim EH,Kim HR,Park YO,et al.Toenail onychomycosis treated with a fractional carbon-dioxide laser and topical antifungal cream[J].J Am Acad Dermatol,2014,70:918-923.
[16]毕晓东,宋明爱,翟磊.长脉宽1 064 nm激光与阿莫罗芬联用治疗甲真菌病患者临床疗效观察[J].中国皮肤性病学杂志,2015,29(5):475-477.
[17]Nenoff P,Grunewald S,Paasch U.Laser therapy of onychomycosis[J].J der Dtsch Dermatol Ges,2014,12:33-38.
[18]张蕊娜,禚凤麟,赵俊英.激光治疗甲真菌病的临床疗效评估及作用机制的研究[A].2012全国中西医结合皮肤性病学术会议论文汇编[C].2012.
[19]Waibel J,Wulkan AJ,Rudnick A.Prospective efficacy and safety evaluation of laser treatments with real-time temperature feedback for fungal onychomycosis[J].J Drugs Dermatol,2013,12:1237-1242.
[2]Ortiz AE,Avram MM,Wanner MA.A review of lasers and light for the treatment of onychomycosis[J].Lasers Surg Med,2014,46:117-124.
[3]Na G,Suh M,Sung Y,et al.A decreased growth rate of the toenail observed in patients with distal subungual onychomycosis[J].Ann Dermatol,1995,7:217-221.
[4]Hochman LG.Laser treatment of onychomycosis using a novel0.65-millisecond pulsed Nd:YAG 1064-nm laser[J].J Cosmer Laser Ther,2011,13:2-5.
[5]Hees H,Jger MW,Raulin C,et al.Treatment of onychomycosis using the 1064 nm Nd:YAG laser:a clinical pilot study[J].J Dtsch Dermatol Ges,2014,12:322-329.
[6]Kimura U,Takeuchi K,Kinoshita A,et al.Treating onychomycoses of the toenail:clinical efficacy of the sub-millisecond 1,064 nm Nd:YAG laser using a 5mm spot diameter[J].J Drugs Dermatol,2012,11:496-504.
[7]Noguchi H,Miyata K,Sugita T,et al.Treatment of onychomycosis using a 1064 nm Nd:YAG laser[J].Med Mycol J,2013,54:333-339.
[8]徐婧,禚凤麟,张蕊娜,等.Nd:YAG 1064 nm激光、伊曲康唑治疗轻中度甲真菌病近期疗效分析[J].中国真菌学杂志,2014,9(1):20-23.
[9]Xu Y,Miao X,Zhou B,et al.Combined oral terbinafine and longpulsed 1,064-nm Nd:YAG treatments is more effective for onychomycosis than either treatment alone[J].Dermatol Surg,2014,40:1201-1207.
[10]Zhang RN,Wang DK,Zhao FL,et al.Long-pulse Nd:YAG 1064nm laser treatment for onychomycosis[J].Chin Med J(Engl),2012,125:3288-3291.
[11]刘红芳,黄莉宁,陈勇军,等.不同疗程长脉宽Nd:YAG 1064 nm激光治疗甲真菌病的疗效观察[J].皮肤性病诊疗学杂志,2015,22(3):185-188.
[12]Kalokasidis K,Onder M,Trakatelli MG,et al.The effect of Qswitched Nd:YAG 1064 nm/532 nm laser in the treatment of onychomycosis in vivo[J].Dermatol Res Pract,2013,2013:379725.
[13]Landsman AS,Robbins AH,Angelini RF,et al.Treatment of mild,moderate,and severe onychomycosis using 870-and 930-nm light exposure[J].J Am Podiatr Med Assoc,2010,100:166-177.
[14]张佳音,钟咪,饶美荣,等.CO2激光联合盐酸阿莫罗芬搽剂治疗甲真菌病近期疗效观察[J].中国中西医结合皮肤性病学杂志,2014,13(3):165-166.
[15]Lim EH,Kim HR,Park YO,et al.Toenail onychomycosis treated with a fractional carbon-dioxide laser and topical antifungal cream[J].J Am Acad Dermatol,2014,70:918-923.
[16]毕晓东,宋明爱,翟磊.长脉宽1 064 nm激光与阿莫罗芬联用治疗甲真菌病患者临床疗效观察[J].中国皮肤性病学杂志,2015,29(5):475-477.
[17]Nenoff P,Grunewald S,Paasch U.Laser therapy of onychomycosis[J].J der Dtsch Dermatol Ges,2014,12:33-38.
[18]张蕊娜,禚凤麟,赵俊英.激光治疗甲真菌病的临床疗效评估及作用机制的研究[A].2012全国中西医结合皮肤性病学术会议论文汇编[C].2012.
[19]Waibel J,Wulkan AJ,Rudnick A.Prospective efficacy and safety evaluation of laser treatments with real-time temperature feedback for fungal onychomycosis[J].J Drugs Dermatol,2013,12:1237-1242.