阿莫罗芬联合伊曲康唑治疗甲真菌病的临床观察
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摘要
目的 :观察阿莫罗芬联合伊曲康唑治疗甲真菌病的临床疗效和安全性。方法:将100例甲真菌病患者随机均分为对照组和联合用药组。对照组患者给予伊曲康唑胶囊200 mg,bid,餐中或餐后立即服用,连服7 d,停药3周,为1个疗程;指甲真菌病患者连用2个疗程,趾甲真菌病患者连用3个疗程。联合用药组患者在对照组治疗的基础上加用5%盐酸阿莫罗芬搽剂,局部外用,每周1次。两组患者疗程均为3个月。观察两组患者的临床疗效、真菌转阴率及不良反应发生情况。结果:联合用药组患者总有效率、转阴率均显著高于对照组,差异均有统计学意义(P<0.05)。两组患者不良反应发生率比较差异无统计学意义(P>0.05)。结论:阿莫罗芬联合伊曲康唑治疗甲真菌病较单用伊曲康唑疗效更显著,安全性相当。
OBJECTIVE:To observe the clinical efficacy and safety of amorolfine combined with itraconazole in the treatment of onychomycosis.METHODS:100 patients with onychomycosis were randomly divided into control group and combination group.Patients in control group were given itraconazole 200 mg(twice a day)in the meal or after meal for 7 d,then stopping for 3 weeks as 1 course,2 courses for nail fungal disease and 3 courses for toenail fungal disease.Patients in combination group were given5% amorolfine hydrochloride liniment for local external use,once a week.The course was 3 months.The clinical efficacy,fungal negative conversion rate and ADR were observed.RESULTS:The total effective rate and negative conversion rate in combination group were significantly higher than control group,with significant differences(P<0.05).There was no significant difference in the incidence of adverse reactions in 2 groups(P>0.05).CONCLUSIONS:Amorolfine combined with itraconazole has more significant efficacy than only itraconazole in the treatment of onychomycosis with similar safety.
OBJECTIVE:To observe the clinical efficacy and safety of amorolfine combined with itraconazole in the treatment of onychomycosis.METHODS:100 patients with onychomycosis were randomly divided into control group and combination group.Patients in control group were given itraconazole 200 mg(twice a day)in the meal or after meal for 7 d,then stopping for 3 weeks as 1 course,2 courses for nail fungal disease and 3 courses for toenail fungal disease.Patients in combination group were given5% amorolfine hydrochloride liniment for local external use,once a week.The course was 3 months.The clinical efficacy,fungal negative conversion rate and ADR were observed.RESULTS:The total effective rate and negative conversion rate in combination group were significantly higher than control group,with significant differences(P<0.05).There was no significant difference in the incidence of adverse reactions in 2 groups(P>0.05).CONCLUSIONS:Amorolfine combined with itraconazole has more significant efficacy than only itraconazole in the treatment of onychomycosis with similar safety.
引文
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[4]荆鲁华,刘卫兵,王燕飞.阿莫罗芬搽剂联合口服伊曲康唑治疗甲真菌病疗效观察[J].中国实用医药,2011,6(4):164.
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[6]于培,尤德渊.甲真菌病的治疗现状及研究进展[J].实用医院临床杂志,2013,10(4):211.
[7]董平,万喆,李若瑜.阿莫罗芬与特比萘芬和伊曲康唑联合对甲真菌病致病菌的体外药敏试验[J].中华皮肤科杂志,2004,37(8):478.
[2]卫国莲,温海.甲真菌病的局部治疗及研究进展[J].临床皮肤科杂志,2008,37(5):333.
[3]廖万清,李志刚,温海.伊曲康唑间歇冲击疗法治疗甲真菌病的多中心开放性研究[J].第二军医大学学报,2005,26(3):327.
[4]荆鲁华,刘卫兵,王燕飞.阿莫罗芬搽剂联合口服伊曲康唑治疗甲真菌病疗效观察[J].中国实用医药,2011,6(4):164.
[5]王红,刘维达.阿莫罗芬治疗甲真菌病作用机理的研究进展[J].中华皮肤科杂志,2001,34(5):401.
[6]于培,尤德渊.甲真菌病的治疗现状及研究进展[J].实用医院临床杂志,2013,10(4):211.
[7]董平,万喆,李若瑜.阿莫罗芬与特比萘芬和伊曲康唑联合对甲真菌病致病菌的体外药敏试验[J].中华皮肤科杂志,2004,37(8):478.