盐酸非索非那定片联合卡介菌多糖核酸治疗慢性荨麻疹效果分析
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摘要
目的研究盐酸非索非那定片联合卡介菌多糖核酸治疗慢性荨麻疹效果。方法选取2016年1月~2017年3月在我院就诊的慢性荨麻疹患者92例作为研究对象,根据治疗方法的不同分为对照组和治疗组,每组各46例。对照组采用盐酸非索非那定片治疗;治疗组采用盐酸非索非那定片联合卡介菌多糖核酸治疗。对两组患者症状消失时间和治疗总有效率、治疗前后症状评分、血浆组胺浓度、白细胞介素-10、风团数量进行比较。结果治疗组患者治疗总有效率为97.83%,明显高于对照组的76.09%,差异有统计学意义(P<0.05)。治疗前两组症状评分、血浆组胺浓度、白细胞介素-10、风团数量差异无统计学意义(P>0.05)。治疗后治疗组症状评分、血浆组胺浓度、白细胞介素-10、风团数量明显低于对照组,差异有统计学意义(P<0.05)。治疗组患者风团消失时间和瘙痒消失时间[(12.51±1.01)d、(13.24±2.21)d]均明显短于对照组[(16.01±2.73)、(17.19±3.51)d],差异有统计学意义(P<0.05)。结论盐酸非索非那定片联合卡介菌多糖核酸治疗慢性荨麻疹效果确切,可有效缩短疗程,加速症状消退,减轻炎症水平,值得推广。
Objective To study the effect of Fexofenadine Hydrochloride combined with BCG polysaccharide nucleic acid on chronic urticaria.Methods 92 patients with chronic urticaria treated in our hospital from January 2016 to March 2017 were selected as subject.They were divided into two groups according to the treatment methods,with 46 cases in each group.The control group was treated with Fexofenadine Hydrochloride;treatment group was treated with Fexofenadine Hydrochloride combined with BCG polysaccharide nucleic acid treatment.The total effective rate,the symptom score before and after the concentration of histamine,the number of interleukin-10 and the number of wind masses were compared between the two groups.Results The total effective rate of treatment group was significantly higher than that of the control group(P<0.05).The control group the total effective rate was 76.09%;the total effective rate was 97.83% in the treatment group.There were no significant differences in the symptom scores,plasma histamine concentration,interleukin-10 and the number of wind masses before treatment(P>0.05).The number of symptoms,plasma histamine concentration,interleukin-10 and wind group in the treatment group were significantly lower than those in the control group(P<0.05).The time of disappearance of wind masses and pruritus was(12.51 ±1.01) d and(13.24±2.21)days in the treatment group,which was significantly shorter than that in the control group(16.01±2.73) d,(17.19±3.51) d,(P<0.05).Conclusion The effect of Fexofenadine Hydrochloride combined with BCG polysaccharide nucleic acid on the treatment of chronic urticaria is effective,which can shorten the course of treatment,accelerate the symptoms subsided and reduce the level of inflammation.
Objective To study the effect of Fexofenadine Hydrochloride combined with BCG polysaccharide nucleic acid on chronic urticaria.Methods 92 patients with chronic urticaria treated in our hospital from January 2016 to March 2017 were selected as subject.They were divided into two groups according to the treatment methods,with 46 cases in each group.The control group was treated with Fexofenadine Hydrochloride;treatment group was treated with Fexofenadine Hydrochloride combined with BCG polysaccharide nucleic acid treatment.The total effective rate,the symptom score before and after the concentration of histamine,the number of interleukin-10 and the number of wind masses were compared between the two groups.Results The total effective rate of treatment group was significantly higher than that of the control group(P<0.05).The control group the total effective rate was 76.09%;the total effective rate was 97.83% in the treatment group.There were no significant differences in the symptom scores,plasma histamine concentration,interleukin-10 and the number of wind masses before treatment(P>0.05).The number of symptoms,plasma histamine concentration,interleukin-10 and wind group in the treatment group were significantly lower than those in the control group(P<0.05).The time of disappearance of wind masses and pruritus was(12.51 ±1.01) d and(13.24±2.21)days in the treatment group,which was significantly shorter than that in the control group(16.01±2.73) d,(17.19±3.51) d,(P<0.05).Conclusion The effect of Fexofenadine Hydrochloride combined with BCG polysaccharide nucleic acid on the treatment of chronic urticaria is effective,which can shorten the course of treatment,accelerate the symptoms subsided and reduce the level of inflammation.
引文
[1]蔡力,张孝友.盐酸非索非那定片联合卡介菌多糖核酸治疗慢性荨麻疹疗效观察[J].中国皮肤性病学杂志,2011,25(2):161-162.
[2]董颖,王翁鸣,靳卓,等.盐酸非索菲那定片联合卡介菌多糖核酸注射液治疗慢性湿疹的临床疗效观察[A].//第8届中国皮肤科医师年会论文集[C].2012:1-4.
[3]刘量.盐酸非索非那定联合卡介菌多糖核酸治疗慢性荨麻疹疗效观察[J].现代诊断与治疗,2013,24(2):265-266.
[4]Sharma V,Singh S,Ramam M,et al.A randomized placebocontrolled double-blind pilot study of methotrexate in the treatment of H1 antihistamine-resistant chronic spontaneous urticaria[J].Indian J Dermatol Venereol leprol,2014,80(2):122-128.
[5]封爱国.盐酸非索非那定联合卡介菌多糖核酸治疗慢性荨麻疹疗效观察[J].中国校医,2014,28(2):150-152.
[6]Weller K,Groffik A,Church MK,et al.Development and validation of the Urticaria Control Test:A patient-reported outcome instrument for assessing urticaria control[J].J Allergy Clin Immunol,2014,133(5):1365-1372.
[7]黄韵然,卢克伟,陈玲,等.盐酸伪麻黄碱/盐酸非索非那定复方缓释胶囊的研究Ⅰ.基于Qb D理念的处方优化[J].中国医药工业杂志,2016,47(4):419-423.
[8]谢佳蓉,涂家生,孙春萌,等.盐酸非索非那定磺丁基醚-β-环糊精包合物鼻用温敏凝胶的制备及黏附效果评价[J].中国药房,2016,27(28):3961-3963.
[9]Koti I,Weller K,Makris M,et al.Disease activity only moderately correlates with quality of life impairment in patients with chronic spontaneous urticaria[J].Dermatology,2013,226(4):371-379.
[10]Bernstein JA,Lang DM,Khan DA,et al.The diagnosis and management of acute and chronic urticaria:2014 update[J].J Allergy Clin Immunol,2014,133(5):1270-1277.
[11]黄韵然,王晓玲,谢志宏,等.盐酸伪麻黄碱/盐酸非索非那定复方缓释胶囊的研究Ⅱ.质量研究[J].中国医药工业杂志,2016,47(4):448-453.
[12]宋志强,罗娜,陈曙光,等.盐酸非索非那定片递减疗法治疗慢性自发性荨麻疹的疗效观察[J].中华皮肤科杂志,2016,49(8):547-550.
[13]闫婵娟,陈璐,陈乐,等.消风汤合盐酸非索非那定治疗风热型急性荨麻疹疗效观察[J].中西医结合心血管病电子杂志,2016,4(19):189-190.
[14]张桂桃,粱利伟,宋德锋,等.鼻渊通窍颗粒联合盐酸非索非那定治疗过敏性鼻炎的疗效、预后及血清炎症因子水平分析[J].中国现代医学杂志,2016,26(13):122-125.
[15]黄韵然,陈玲,卢克伟,等.盐酸伪麻黄碱/盐酸非索非那定复方缓释胶囊的研究.Ⅲ.体内外评价[J].中国医药工业杂志,2016,47(5):582-586.
[2]董颖,王翁鸣,靳卓,等.盐酸非索菲那定片联合卡介菌多糖核酸注射液治疗慢性湿疹的临床疗效观察[A].//第8届中国皮肤科医师年会论文集[C].2012:1-4.
[3]刘量.盐酸非索非那定联合卡介菌多糖核酸治疗慢性荨麻疹疗效观察[J].现代诊断与治疗,2013,24(2):265-266.
[4]Sharma V,Singh S,Ramam M,et al.A randomized placebocontrolled double-blind pilot study of methotrexate in the treatment of H1 antihistamine-resistant chronic spontaneous urticaria[J].Indian J Dermatol Venereol leprol,2014,80(2):122-128.
[5]封爱国.盐酸非索非那定联合卡介菌多糖核酸治疗慢性荨麻疹疗效观察[J].中国校医,2014,28(2):150-152.
[6]Weller K,Groffik A,Church MK,et al.Development and validation of the Urticaria Control Test:A patient-reported outcome instrument for assessing urticaria control[J].J Allergy Clin Immunol,2014,133(5):1365-1372.
[7]黄韵然,卢克伟,陈玲,等.盐酸伪麻黄碱/盐酸非索非那定复方缓释胶囊的研究Ⅰ.基于Qb D理念的处方优化[J].中国医药工业杂志,2016,47(4):419-423.
[8]谢佳蓉,涂家生,孙春萌,等.盐酸非索非那定磺丁基醚-β-环糊精包合物鼻用温敏凝胶的制备及黏附效果评价[J].中国药房,2016,27(28):3961-3963.
[9]Koti I,Weller K,Makris M,et al.Disease activity only moderately correlates with quality of life impairment in patients with chronic spontaneous urticaria[J].Dermatology,2013,226(4):371-379.
[10]Bernstein JA,Lang DM,Khan DA,et al.The diagnosis and management of acute and chronic urticaria:2014 update[J].J Allergy Clin Immunol,2014,133(5):1270-1277.
[11]黄韵然,王晓玲,谢志宏,等.盐酸伪麻黄碱/盐酸非索非那定复方缓释胶囊的研究Ⅱ.质量研究[J].中国医药工业杂志,2016,47(4):448-453.
[12]宋志强,罗娜,陈曙光,等.盐酸非索非那定片递减疗法治疗慢性自发性荨麻疹的疗效观察[J].中华皮肤科杂志,2016,49(8):547-550.
[13]闫婵娟,陈璐,陈乐,等.消风汤合盐酸非索非那定治疗风热型急性荨麻疹疗效观察[J].中西医结合心血管病电子杂志,2016,4(19):189-190.
[14]张桂桃,粱利伟,宋德锋,等.鼻渊通窍颗粒联合盐酸非索非那定治疗过敏性鼻炎的疗效、预后及血清炎症因子水平分析[J].中国现代医学杂志,2016,26(13):122-125.
[15]黄韵然,陈玲,卢克伟,等.盐酸伪麻黄碱/盐酸非索非那定复方缓释胶囊的研究.Ⅲ.体内外评价[J].中国医药工业杂志,2016,47(5):582-586.