感音神经性耳聋治疗进展
摘要
感音神经性耳聋是由先天性或后天性因素导致的听觉系统对声音的感受和处理过程异常而致的听力障碍,主要病理改变为内耳螺旋器毛细胞的损伤,因其病因、发病机制、病理改变等的复杂性,目前的治疗手段有限。近年来,发展较快的有助听设备及人工耳蜗植入,这两种治疗手段目前都有弊端,仍然需要积极探索其他保护残存听力的方法,以促进内耳感觉细胞的修复和再生,预防内耳感觉细胞的凋亡。本文就感音神经性耳聋治疗在毛细胞再生、预防凋亡方面的研究进展进行综述。
引文
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[21]IZUMIKAWA M,MINODA R,KAWAMOTO K,et al.Auditory hair cell replacement and hearing improvement by Atoh1gene therapy in deaf mammals[J].Nat Med,2005,11(3):271-276.
[22]IZUMIKAWA M,BATTS S A,MIYAZAWA T,et al.Response of the flat cochlear epithelium to forced expression of Atoh1[J].Hear Res,2008,240(1/2):52-56.
[23]陈伟,郭维维,胡吟燕,等.Math1基因内耳导入后噪声性聋豚鼠听功能改变观察[J].中华耳科学杂志,2009,7(4):352-356.
[24]KAYYALI M N,WOOLTORTON J R,RAMSEY A J,et al.A novel nanoparticle delivery system for targeted therapy of noise-induced hearing loss[J].J Control Release,2018(279):243-250.
[25]KIL K,CHOI M Y,KONG J S,et al.Regenerative efficacy of mesenchymal stromal cells from human placenta in sensorineural hearing loss[J].Int J Pediatr Otorhinolaryngol,2016(91):72-81.
[26]LEE H S,KIM W J,GONG J S,et al.Clinical safety and efficacy of autologous bone Marrow-Derived mesenchymal stem cell transplantation in sensorineural hearing loss patients[J].J Audiol Otol,2018,22(2):105-109.
[27]XU Y P,SHAN X D,LIU Y Y,et al.Olfactory epithelium neural stem cell implantation restores noise-induced hearing loss in rats[J].Neurosci Lett,2016(616):19-25.
[2]WILSON B S,TUCCI D L,MERSON M H,et al.Global hearing health care:new findings and perspectives[J].Lancet,2017,390(1111):2503-2515.
[3]王斌,魏朝刚,曹克利,等.同期双侧人工耳蜗植入者言语识别长期效果研究[J].中华耳鼻咽喉头颈外科杂志,2018,53(3):189-195.
[4]刘军,李万鑫.人工耳蜗植入的残余听力保留技术[J].中国听力语言康复科学杂志,2017,15(1):1-5.
[5]ESHRAGHI A A,ARANKE M,SALVI R,et al.Preclinical and clinical otoprotective applications of cell-penetrating peptide D-JNKI-1(AM-111)[J].Hear Res,2018(368):86-91.
[6]SUCKFUELL M,LISOWSKA G,DOMKA W,et al.Efficacy and safety of AM-111in the treatment of acute sensorineural hearing loss:a double-blind,randomized,placebo-controlled phaseⅡstudy[J].Otol Neurotol,2014,35(8):1317-1326.
[7]RUSHWORTH G F,MEGSON I L.Existing and potential therapeutic uses for N-acetylcysteine:the need for conversion to intracellular glutathione for antioxidant benefits[J].Pharmacol Ther,2014,141(2):150-159.
[8]WU Y J,MULDOON L L,NEUWELT E A.The chemoprotective agent N-acetylcysteine blocks cisplatin-induced apoptosis through caspase signaling pathway[J].J Pharmacol Exp Ther,2005,312(2):424-431.
[9]EWERT D,HU N,DU X P,et al.HPN-07,a free radical spin trapping agent,protects against functional,cellular and electrophysiological changes in the cochlea induced by acute acoustic trauma[J].PLoS One,2017,12(8):e0183089.
[10]GUISCARDO L,STAVROS H,GORAN L,et al.Dosedependent protection on cisplatin-induced ototoxicity-an electrophysiological study on the effect of three antioxidants in the sprague-dawley rat animal model[J].Med Sci Monit,2011,17(8):179-186.
[11]KIL J,LYNCH E D,GRIFFITHS S,et al.Efficacy of SPI-1005for prevention of noise-induced hearing loss:phase 2clinical trial results[J].Otolaryngol Head Neck Surg,2014,151(1):83-84.
[12]VILLANI V,ZUCCHELLA C,CRISTALLI G,et al.Vitamin E neuroprotection against cisplatin ototoxicity:preliminary results from a randomized,placebo-controlled trial[J].Head Neck,2016,38Suppl 1:S2118-2121.
[13]SO H S,KIM H J,KIM Y,et al.Evidence that cisplatininduced auditory damage is attenuated by downregulation of pro-inflammatory cytokines via Nrf2/HO-1[J].J Assoc Res Otolaryngol,2008,9(3):290-306.
[14]SUMIT P,GURBAX S,MOHIT V,et al.Protective role of calcium channel blocker flunarizine on cisplatin induced ototoxicity:a clinical study[J].Int J Contem Med Res,2016,3(5):2454-7379.
[15]MULDOON L L,PAGEL M A,KROLL R A,et al.Delayed administration of Sodium thiosulfate in animal models reduces platinum ototoxicity without reduction of antitumor activity[J].Clin Cancer Res,2000,6(1):309-315.
[16]ISHIKAWA E,SUGIMOTO H,HATANO M,et al.Protective effects of sodium thiosulfate for cisplatin-mediated ototoxicity in patients with head and neck cancer[J].Acta Otolaryngol,2015(135):919-924.
[17]FREYER D R,CHEN L,KRAILO M D,et al.Effects of sodium thiosulfate versus observation on development of cisplatininduced hearing loss in children with cancer(ACCL0431):a multicentre,randomised,controlled,open-label,phase 3trial[J].Lancet Oncol,2017,18(1):63-74.
[18]陈道森,熊鹰.Sox2在内耳发育中的作用[J].生命科学,2011,23(1):32-36.
[19]BERMINGHAM N A,HASSAN B A,PRICE S D,et al.Math1:an essential gene for the generation of inner ear hair cells[J].Science,1999,284(5421):1837-1841.
[20]CROWSON M G,HERTZANO R,TUCCI D L.Emerging therapies for sensorineural hearing loss[J].Otol Neurotol,2017,38(6):792-803.
[21]IZUMIKAWA M,MINODA R,KAWAMOTO K,et al.Auditory hair cell replacement and hearing improvement by Atoh1gene therapy in deaf mammals[J].Nat Med,2005,11(3):271-276.
[22]IZUMIKAWA M,BATTS S A,MIYAZAWA T,et al.Response of the flat cochlear epithelium to forced expression of Atoh1[J].Hear Res,2008,240(1/2):52-56.
[23]陈伟,郭维维,胡吟燕,等.Math1基因内耳导入后噪声性聋豚鼠听功能改变观察[J].中华耳科学杂志,2009,7(4):352-356.
[24]KAYYALI M N,WOOLTORTON J R,RAMSEY A J,et al.A novel nanoparticle delivery system for targeted therapy of noise-induced hearing loss[J].J Control Release,2018(279):243-250.
[25]KIL K,CHOI M Y,KONG J S,et al.Regenerative efficacy of mesenchymal stromal cells from human placenta in sensorineural hearing loss[J].Int J Pediatr Otorhinolaryngol,2016(91):72-81.
[26]LEE H S,KIM W J,GONG J S,et al.Clinical safety and efficacy of autologous bone Marrow-Derived mesenchymal stem cell transplantation in sensorineural hearing loss patients[J].J Audiol Otol,2018,22(2):105-109.
[27]XU Y P,SHAN X D,LIU Y Y,et al.Olfactory epithelium neural stem cell implantation restores noise-induced hearing loss in rats[J].Neurosci Lett,2016(616):19-25.