胸腺五肽联合盐酸伐昔洛韦治疗复发性生殖器疱疹的疗效观察
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摘要
目的:观察胸腺五肽联合盐酸伐昔洛韦治疗复发性生殖器疱疹的疗效。方法:选取复发性生殖器疱疹患者62例,随机分为治疗组、对照组,2组患者的年龄、性别、病史、临床表现等方面比较,差异无显著性。治疗组口服盐酸伐昔洛韦分散片,300 mg/次,bid,同时给予胸腺五肽注射液10 mg皮下注射,隔日一次;对照组口服盐酸伐昔洛韦分散片,300 mg/次,bid。2组治疗时间均为3个月。结果:治疗后随访6个月,与对照组相比,治疗组复发间隔时间非常显著长于对照组(P<0.01),复发皮损面积显著小于对照组(P<0.05),皮损痊愈时间非常显著短于对照组(P<0.01),复发频率非常显著小于对照组(P<0.01)。结论:盐酸伐昔洛韦联合胸腺五肽治疗复发性生殖器疱疹疗效好,复发率低,无明显不良反应。
OBJECTIVE To evaluate the therapeutic effect of valacyclovir combined with thymopentin in treatment of patients with recurrent genital herpes. METHODS 62 outpatients with recurrent genital herpes were divided into treatment group and control group randomly,and there was no significant difference in age,gender,history of disease,clinical manifestation,ect between the two groups(P>0.05).The treatment group(32 cases) was treated with valacyclovir 300 mg orally twice a day and thymopentin 10 mg injected subcutaneously once every other day for 3 months,compared with the control group(30 cases) treated only with valacyclovir300 mg orally twice a day for 3 months. RESULTS In the follow up study after withdrwal for 6 month,compared with control group,the recurrent lesion area,lesion healing time,recurrence frequency in treatment group were significantly lower(P<0.05,P<0.01 and P<0.01 respectively),and recurrent interval in treatment group were significantly longer(P<0.01). CONCLUSION Thymopentin combined with valacyclovir is very effective and safe to prevent relapse of genital herpes and worthy to be popularized clinically.
OBJECTIVE To evaluate the therapeutic effect of valacyclovir combined with thymopentin in treatment of patients with recurrent genital herpes. METHODS 62 outpatients with recurrent genital herpes were divided into treatment group and control group randomly,and there was no significant difference in age,gender,history of disease,clinical manifestation,ect between the two groups(P>0.05).The treatment group(32 cases) was treated with valacyclovir 300 mg orally twice a day and thymopentin 10 mg injected subcutaneously once every other day for 3 months,compared with the control group(30 cases) treated only with valacyclovir300 mg orally twice a day for 3 months. RESULTS In the follow up study after withdrwal for 6 month,compared with control group,the recurrent lesion area,lesion healing time,recurrence frequency in treatment group were significantly lower(P<0.05,P<0.01 and P<0.01 respectively),and recurrent interval in treatment group were significantly longer(P<0.01). CONCLUSION Thymopentin combined with valacyclovir is very effective and safe to prevent relapse of genital herpes and worthy to be popularized clinically.
引文
[1]莫家亮,聂金汉,马福生,等.卡介菌多糖核酸联合泛昔洛韦治疗复发性生殖器疱疹疗效观察[J].岭南皮肤性病科杂志,2009,16(3):177-178.
[2]曾文军.泛昔洛韦联合匹多莫德治疗频发性生殖器疱疹的临床观察[J].中国性科学,2009,18(4):26-28.
[3]中华人民共和国卫生部卫生防疫司.性病防治手册[M].南京:江苏科学技术出版社,1990:58-60.
[4]中华医学会皮肤性病学分会临床诊疗指南工作委员会中国医师协会皮肤科医师分会临床诊疗指南委员会.生殖器疱疹临床诊疗指南(2009)[J].中华皮肤科杂志,2009,42(12):877-878.
[5]Westhoff GL,Little SE,Caughey AB.Herpes simplex virusand pregnancy:a review of the management of antenatal andperipartum herpes infections[J].Obstet Gynecol Surv,2011,66(10):629-638.
[6]Van de Perre P,Segondy M,Foulongne V,et al.Herpes sim-plex virus and HIV-1:deciphering viral synergy[J].Lancet In-fect Dis,2008,8(8):490-497.
[7]Zereu M,Zettler CG,Cambruzzi E,et al.Herpes simplex virustype 2 and Chlamydia trachomatis in adenocarcinoma of the u-terine cervix[J].Gynecol Oncol,2007,105(1):172-175.
[8]王侠生,廖康煌.杨国亮皮肤病学[M].上海:上海科学技术文献出版社,2005:375-377.
[9]Miller RL,Tomai MA,Harrison CJ,et al.Immunomodulationas a treatment strategy for genital herpes:review of the evi-dence[J].Int Immunopharmacol,2002,2(4):443-451.
[10]白丽珍,郑定辉.胸腺五肽治疗女性复发性生殖器疱疹的临床研究[J].黑龙江医学,2011,35(3):183-184.
[11]陈永忠.阿昔洛韦联合胸腺五肽治疗频发性生殖器疱疹疗效观察[J].中国麻风皮肤病杂志,2009,25(8):625.
[12]陈宏,赖永旭.盐酸伐昔洛韦的临床研究综述[J].四川医学,2005,26(4):467-468.
[13]盛家琦,贾杰,胡晓愚.胸腺五肽的研究与应用[J].厂矿医药卫生,1999,15(2):68-70.
[14]Waymack JP,Alexander JW.Immunostimulation by TP-5 inimmuno compromised patients and animals--current status ofinvestigation[J].Comp Immunol Microbiol Infect Dis,1986,9(2-3):225-232.
[15]Haneke E,Bolla K,Degreef H,et al.The effect of thymopentintreatment on the relapse rate in frequently relapsing herpessimplex virus infections[J].Int J Clin Pharmacol Res,1984,4(6):439-443.
[2]曾文军.泛昔洛韦联合匹多莫德治疗频发性生殖器疱疹的临床观察[J].中国性科学,2009,18(4):26-28.
[3]中华人民共和国卫生部卫生防疫司.性病防治手册[M].南京:江苏科学技术出版社,1990:58-60.
[4]中华医学会皮肤性病学分会临床诊疗指南工作委员会中国医师协会皮肤科医师分会临床诊疗指南委员会.生殖器疱疹临床诊疗指南(2009)[J].中华皮肤科杂志,2009,42(12):877-878.
[5]Westhoff GL,Little SE,Caughey AB.Herpes simplex virusand pregnancy:a review of the management of antenatal andperipartum herpes infections[J].Obstet Gynecol Surv,2011,66(10):629-638.
[6]Van de Perre P,Segondy M,Foulongne V,et al.Herpes sim-plex virus and HIV-1:deciphering viral synergy[J].Lancet In-fect Dis,2008,8(8):490-497.
[7]Zereu M,Zettler CG,Cambruzzi E,et al.Herpes simplex virustype 2 and Chlamydia trachomatis in adenocarcinoma of the u-terine cervix[J].Gynecol Oncol,2007,105(1):172-175.
[8]王侠生,廖康煌.杨国亮皮肤病学[M].上海:上海科学技术文献出版社,2005:375-377.
[9]Miller RL,Tomai MA,Harrison CJ,et al.Immunomodulationas a treatment strategy for genital herpes:review of the evi-dence[J].Int Immunopharmacol,2002,2(4):443-451.
[10]白丽珍,郑定辉.胸腺五肽治疗女性复发性生殖器疱疹的临床研究[J].黑龙江医学,2011,35(3):183-184.
[11]陈永忠.阿昔洛韦联合胸腺五肽治疗频发性生殖器疱疹疗效观察[J].中国麻风皮肤病杂志,2009,25(8):625.
[12]陈宏,赖永旭.盐酸伐昔洛韦的临床研究综述[J].四川医学,2005,26(4):467-468.
[13]盛家琦,贾杰,胡晓愚.胸腺五肽的研究与应用[J].厂矿医药卫生,1999,15(2):68-70.
[14]Waymack JP,Alexander JW.Immunostimulation by TP-5 inimmuno compromised patients and animals--current status ofinvestigation[J].Comp Immunol Microbiol Infect Dis,1986,9(2-3):225-232.
[15]Haneke E,Bolla K,Degreef H,et al.The effect of thymopentintreatment on the relapse rate in frequently relapsing herpessimplex virus infections[J].Int J Clin Pharmacol Res,1984,4(6):439-443.