血清VEGF和MMP-2检测在结直肠癌诊断中的临床意义
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摘要
为探讨血清血管内皮因子(VEGF)和基质金属蛋白酶-2(MMP-2)检测在结直肠癌诊断中的临床意义,采用随机抽取法选取行结直肠癌根治术患者60例(结直肠癌组)和健康体检者60名(对照组)作为研究对象。检测2组受检者血液样本血清VEGF和MMP-2水平,对比2组检测结果。结果显示,结直肠癌组患者术前血清VEGF和MMP-2水平均明显高于对照组;结直肠癌患者术后3个月的血清VEGF和MMP-2水平明显低于术前检测结果(P <0.05)。结直肠癌患者术后3个月的血清VEGF和MMP-2水平与对照组相比,差异无统计学意义(P>0.05)。结果表明,血清VEGF和MMP-2检测在结直肠癌的诊断中具有较高的临床应用价值。
In order to investigate the clinical significance of serum vascular endothelial growth factor(VEGF)and matrix metalloproteinase-2(MMP-2)detection in the diagnosis of colorectal cancer,60 patients(colorectal cancer group)and 60 healthy persons(control group)were randomly selected as subjects.The level of blood samples of two groups was detected by serum VEGF and MMP-2,and their detection results were compared.As results,before operation the levels of serum VEGF and MMP-2 in colorectal cancer group were significantly higher than those in control group.At 3 months after operation the levels of serum VEGF and MMP-2 in patients with colorectal cancer were significantly lower than those in patients with colorectal cancer before operation(P <0.05).At 3 months after operation,there was no significant difference in the levels of serum VEGF and MMP-2 between the patients with colorectal cancer and those in the control group(P >0.05).The results show that the detection of serum VEGF and MMP-2 has high clinical applicaton value in the diagnosis of colorectal cancer.
In order to investigate the clinical significance of serum vascular endothelial growth factor(VEGF)and matrix metalloproteinase-2(MMP-2)detection in the diagnosis of colorectal cancer,60 patients(colorectal cancer group)and 60 healthy persons(control group)were randomly selected as subjects.The level of blood samples of two groups was detected by serum VEGF and MMP-2,and their detection results were compared.As results,before operation the levels of serum VEGF and MMP-2 in colorectal cancer group were significantly higher than those in control group.At 3 months after operation the levels of serum VEGF and MMP-2 in patients with colorectal cancer were significantly lower than those in patients with colorectal cancer before operation(P <0.05).At 3 months after operation,there was no significant difference in the levels of serum VEGF and MMP-2 between the patients with colorectal cancer and those in the control group(P >0.05).The results show that the detection of serum VEGF and MMP-2 has high clinical applicaton value in the diagnosis of colorectal cancer.
引文
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[5]朱幼鸣,卢振,张卫卫.联合检测癌胚抗原、糖类抗原724在结直肠癌诊断中的应用价值[J].国际检验医学杂志,2017,38(13):1822-1824.
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[8]Denters MJ,Deutekom M,Bossuyt PM,et al.A feces collection paper does not enhance participation in a fecal immunochemical test-based colorectal cancer screening program:Randomized clinical trial[J].Eur J C Prev,2013,22(4):299-304.
[9]Steele RJC,McClements PL,Libby G,et al.Patterns of uptake in a biennial faecal occult blood test screening programme for colorectal cancer[J].Colorectal Dis,2014,16(1):28-32.
[2]张辉,赵莹,蒋惠莉,等.六种血清肿瘤标志物联合检测对结直肠癌患者的诊断治疗价值[J].中国综合临床,2017,33(9):834-838.
[3]喻茂文.CYFRA-21、CA125、CA19-9、CEA联合检测在结直肠癌的诊断中的价值研究[J].标记免疫分析与临床,2018,25(6):907-910.
[4]卢旭妹,容亓,杨碧颖.血清多种肿瘤标志物联合检测对结直肠癌的诊断意义[J].临床检验杂志(电子版),2018,7(4):702-703.
[5]朱幼鸣,卢振,张卫卫.联合检测癌胚抗原、糖类抗原724在结直肠癌诊断中的应用价值[J].国际检验医学杂志,2017,38(13):1822-1824.
[6]刘学勇.血清肿瘤标志物联合检测在结直肠癌患者病情监测中的应用研究[J].中国继续医学教育,2016,8(25):40-42.
[7]李延东,姜训忠,耿正伟.联合检测血清CEA、AFP、CA19-9对结直肠癌的诊断价值[J].解放军医药杂志,2015,27(5):53-55.
[8]Denters MJ,Deutekom M,Bossuyt PM,et al.A feces collection paper does not enhance participation in a fecal immunochemical test-based colorectal cancer screening program:Randomized clinical trial[J].Eur J C Prev,2013,22(4):299-304.
[9]Steele RJC,McClements PL,Libby G,et al.Patterns of uptake in a biennial faecal occult blood test screening programme for colorectal cancer[J].Colorectal Dis,2014,16(1):28-32.