肿瘤治疗用高强度聚焦超声换能器的研究现状
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摘要
高强度聚集超声(High-intensity Focused Ultrasound,HIFU)作为一种非侵入性、无毒副作用、具有巨大潜力的肿瘤治疗手段,近年来已经越来越受到国内外学者的广泛关注。高强度聚焦超声换能器是HIFU肿瘤治疗设备的核心部件,直接影响治疗的效果。因此,本文就其发展过程、治疗机制及应用等相关问题做一综述。
As non-invasive technique with non-toxic side effects and great potential,high-intensity focused ultrasound(HIFU) has received widespread attention from scholars both at home and abroad in recent years.High-intensity focused ultrasound transducer is the core component of HIFU treatment equipment for oncotherapy,which chould affect the therapeutical result directly.therefore,this paper summarizes some related issues of high-intensity focused ultrasound transducer,including its development,working principle,applications and so on.
As non-invasive technique with non-toxic side effects and great potential,high-intensity focused ultrasound(HIFU) has received widespread attention from scholars both at home and abroad in recent years.High-intensity focused ultrasound transducer is the core component of HIFU treatment equipment for oncotherapy,which chould affect the therapeutical result directly.therefore,this paper summarizes some related issues of high-intensity focused ultrasound transducer,including its development,working principle,applications and so on.
引文
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[9]朱元光,张平,张晓静,等.高强度聚焦超声换能器声场的数值仿真与实验测量[J].国际生物医学工程杂志,2011,34(2):78-81.
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[11]张玮,扬婷婷,胡令军.高强度聚焦超声技术治疗213例子宫肌瘤及子宫腺肌瘤的疗效分析[J].中华中西医杂志,2007,8(9):809-810.
[12]Rebillard X,Gelet A,Davin JL,et al.Transrectal high-intensity focused ultrasound in the treatment oflocalized prostate cancer[J].Journal of Endourology,2005,19(6):693-701.
[13]Hubert P,David M,Apoutou N,et al.High-intensityfocused ultrasound ablation for the treatmentof colorectal liver metastases during an openprocedure:study on the pig[J].Ann Surg,2009,249(1):129-136.
[14]Guan LM,Wang ZB,Wu F,et al.The effect of highintensity focused ultrasound on breast cancer tissues andcarcinoma vascularities[J].Clinical Medical Journal ofChina,2006,13(4):675-677.
[15]金成兵,冉立峰,杨炜,等.高强度聚焦超声治疗放疗后残留肝癌的初步临床观察[J].中华超声影像学杂志,2011,20(1):22-25.
[16]高百春,庄兴俊,叶勇,等.高强度聚焦超声治疗肝癌疗效分析[J].中国医疗设备,2009,(11):87-88.
[2]Ji YH,Li QL,Yang Y,et al.Newly progress and application ofhigh intensity focused ultrasound in medical[J].Chinese Journalof Medical Physics,2008,25(4):759-780.
[3]刘东顺,菅喜岐.高强度聚焦超声治疗的现状及其展望[J].生物医学工程与临床,2006,(6):395-398.
[4]张涛,张舒音.高强度聚焦超声肿瘤治疗系统的安全应用[J].中国医疗设备,2012,27(2):111-113.
[5]Wang XD,Wang JL,Li P.Development of phased array highintensity focused ultrasound[J].Physics,2007,30(10):758-763.
[6]徐丰,万明习,陆明珠.遗传算法在256阵元相控阵高强度聚焦超声治疗系统多焦点控制中的应用[J].生物医学工程学杂志.2008,25(5):1093-1097.
[7]Li GW,Li Q,Chen YZ.Optimization for High Intensity FocusedUltrasound Phased Array Design[J].Journal of Shanghai JiaotongUniversity,2007,30(10):758-763.
[8]孟赟,白景峰,陈亚珠.双层组织中相控聚焦超声声场分布的建模与计[J].中国医学物理学杂志,2011,28(2):2567-2570.
[9]朱元光,张平,张晓静,等.高强度聚焦超声换能器声场的数值仿真与实验测量[J].国际生物医学工程杂志,2011,34(2):78-81.
[10]陈晓瑞,王韶林,李智华,等.高强度聚焦超声可治疗区域的仿真研究[J].生物物理学报,2012,28(1):73-80.
[11]张玮,扬婷婷,胡令军.高强度聚焦超声技术治疗213例子宫肌瘤及子宫腺肌瘤的疗效分析[J].中华中西医杂志,2007,8(9):809-810.
[12]Rebillard X,Gelet A,Davin JL,et al.Transrectal high-intensity focused ultrasound in the treatment oflocalized prostate cancer[J].Journal of Endourology,2005,19(6):693-701.
[13]Hubert P,David M,Apoutou N,et al.High-intensityfocused ultrasound ablation for the treatmentof colorectal liver metastases during an openprocedure:study on the pig[J].Ann Surg,2009,249(1):129-136.
[14]Guan LM,Wang ZB,Wu F,et al.The effect of highintensity focused ultrasound on breast cancer tissues andcarcinoma vascularities[J].Clinical Medical Journal ofChina,2006,13(4):675-677.
[15]金成兵,冉立峰,杨炜,等.高强度聚焦超声治疗放疗后残留肝癌的初步临床观察[J].中华超声影像学杂志,2011,20(1):22-25.
[16]高百春,庄兴俊,叶勇,等.高强度聚焦超声治疗肝癌疗效分析[J].中国医疗设备,2009,(11):87-88.