龙珠软膏联合一清胶囊治疗寻常型痤疮的临床研究
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摘要
目的探究龙珠软膏联合一清胶囊治疗寻常型痤疮的临床疗效。方法选取2016年2月—2017年5月于广州中医药大学第一附属医院皮肤科就诊的72例寻常型痤疮患者,随机分为对照组和治疗组,每组各36例。对照组患者口服一清胶囊,2粒/次,3次/d。治疗组在对照组治疗基础上应用龙珠软膏,2次/d。两组均连续治疗8周。观察两组的临床疗效,比较两组治疗前后白介素-1(IL-1β)、白介素-6(IL-6)、白介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)、γ-干扰素(IFN-γ)、皮损积分的变化情况。结果治疗后,对照组和治疗组患者的总有效率分别为77.78%、97.22%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组血清IL-1β、IL-6、IL-8、TNF-α、IFN-γ、皮损积分均明显下降,同组治疗前后比较差异有统计学意义(P<0.05);治疗后,治疗组IL-1β、IL-6、IL-8、TNF-α、IFN-γ、皮损积分显著低于对照组,两组比较差异具有统计学意义(P<0.05)。结论龙珠软膏联合一清胶囊治疗寻常型痤疮具有较好的临床疗效,可较好地抑制炎症反应,降低皮损积分,具有一定的临床推广应用价值。
Objective To explore the clinical effect of Longzhu Ointment combined with Yiqing Capsules in treatment of acne vulgaris. Methods Patients(72 cases) with acne vulgaris in the First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine from February 2016 to May 2017 were randomly divided into control(36 cases) and treatment(36 cases) groups. Patients in the control group were po administered with Yiqing Capsules, 2 grains/time, three times daily. Patients in the treatment group were administered with Longzhu Ointment on the basis of the control group, twice daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacy was evaluated, and the changes of IL-1β, IL-6, IL-8, TNF-α, IFN-γ, and skin lesion integral in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment group were 77.78% and 97.22%, and there were differences between two groups(P < 0.05). After treatment, IL-1β, IL-6, IL-8, TNF-α, IFN-γ, and skin lesion integral in two group were significantly decreased, and there were differences in the same group(P < 0.05). After treatment, IL-1β, IL-6, IL-8, TNF-α, IFN-γ, and skin lesion integral in the treatment group were lower than those in the control group, and there were differences between two groups(P < 0.05). Conclusion Longzhu Ointment combined with Yiqing Capsules has significant clinical effect in treatment of acne vulgaris, and can inhibit inflammatory reaction and reduce skin damage score, which has a certain clinical application value.
Objective To explore the clinical effect of Longzhu Ointment combined with Yiqing Capsules in treatment of acne vulgaris. Methods Patients(72 cases) with acne vulgaris in the First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine from February 2016 to May 2017 were randomly divided into control(36 cases) and treatment(36 cases) groups. Patients in the control group were po administered with Yiqing Capsules, 2 grains/time, three times daily. Patients in the treatment group were administered with Longzhu Ointment on the basis of the control group, twice daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacy was evaluated, and the changes of IL-1β, IL-6, IL-8, TNF-α, IFN-γ, and skin lesion integral in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment group were 77.78% and 97.22%, and there were differences between two groups(P < 0.05). After treatment, IL-1β, IL-6, IL-8, TNF-α, IFN-γ, and skin lesion integral in two group were significantly decreased, and there were differences in the same group(P < 0.05). After treatment, IL-1β, IL-6, IL-8, TNF-α, IFN-γ, and skin lesion integral in the treatment group were lower than those in the control group, and there were differences between two groups(P < 0.05). Conclusion Longzhu Ointment combined with Yiqing Capsules has significant clinical effect in treatment of acne vulgaris, and can inhibit inflammatory reaction and reduce skin damage score, which has a certain clinical application value.
引文
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[14]杨强,蒲晓辉,李晓花.一清胶囊中7种指标成分的测定[J].华西药学杂志,2017,32(3):294-296.
[15]王媛,常晓丹,李春婷,等.龙珠软膏治疗颜面部皮炎湿疹的临床疗效观察[J].中国皮肤性病学杂志,2015,28(7):734-737.
[16]闫朝武.细胞因子与慢性炎症[J].国际免疫学杂志,2002,25(2):98-101.
[2]邵蕾,梁景耀,陈丽洁,等.痤疮发病机制的免疫学研究进展[J].国际皮肤性病学杂志,2017,43(6):361-364.
[3]强燕,李苏,李欣,等.中医治疗寻常痤疮的研究进展[J].世界临床药物,2017,38(3):154-158.
[4]陈越,秦淼鑫.一清胶囊联合头孢氨苄治疗慢性咽炎的疗效观察[J].中国全科医学,2016,30(B12):423-424.
[5]徐雄良,刘浪,刘小均,等.一清胶囊抗炎作用实验研究[J].西北药学杂志,2016,31(4):392-394.
[6]胡威,马源源,宋伟,等.龙珠软膏对变应性接触性皮炎作用研究[J].中国药师,2017,20(8):1360-1363.
[7]赵辨.中国临床皮肤病学[M].南京:江苏科学技术出版社,2010.
[8]项蕾红.中国痤疮治疗指南(2014修订版)[J].临床皮肤科杂志,2015,44(1):52-57.
[9]中国医师协会皮肤科医师分会《中国痤疮治疗指南》专家组.中国痤疮治疗指南(讨论稿)[J].临床皮肤科杂志,2008,37(5):339-342.
[10]孙莉,李娟,颜敏,等.痤疮的发病机制研究进展[J].山东医药,2013,53(32):97-100.
[11]谷玉琴,孙月吉.心理因素与痤疮[J].中华皮肤科杂志,2006,39(2):119-120.
[12]马英,项蕾红.痤疮发病机制及治疗目标的新认识[J].临床皮肤科杂志,2015,44(1):66-69.
[13]赵俊茹,胡冬裴.痤疮病因及外治法研究进展[J].现代中西医结合杂志,2015,24(9):1021-1023.
[14]杨强,蒲晓辉,李晓花.一清胶囊中7种指标成分的测定[J].华西药学杂志,2017,32(3):294-296.
[15]王媛,常晓丹,李春婷,等.龙珠软膏治疗颜面部皮炎湿疹的临床疗效观察[J].中国皮肤性病学杂志,2015,28(7):734-737.
[16]闫朝武.细胞因子与慢性炎症[J].国际免疫学杂志,2002,25(2):98-101.