持久性有机污染物的毒性及其机制研究进展
|
摘要
持久性有机污染物(POPs)是一类具有高毒性、蓄积性、亲脂性、半挥发性等性质的物质。大量的研究表明,POPs可以对生物体产生不良的健康效应,而其机制并未完全明确。本文主要介绍一些典型的POPs,如多氯代二苯并对二噁英和多氯代二苯并呋喃、多氯联苯等对神经、生殖、内分泌等系统及器官的毒性作用及其机制,为后续深入研究该类物质的毒性机制提供理论依据。
Persistent organic pollutants(POPs) are a sort of substances with high toxicity, biological accumulation, lipophilicity, and semivolatility. A large number of studies have shown that POPs can result in adverse health effects, and the mechanisms are not clear yet. This paper introduced the toxic effects and related mechanisms of such typical POPs as polychlorinated dibenzo-p-dioxins and dibenzofurans and polychlorinated biphenyls on nervous, reproductive, endocrine, and other systems or organs, aiming to provide a theoretical basis for further mechanism research.
Persistent organic pollutants(POPs) are a sort of substances with high toxicity, biological accumulation, lipophilicity, and semivolatility. A large number of studies have shown that POPs can result in adverse health effects, and the mechanisms are not clear yet. This paper introduced the toxic effects and related mechanisms of such typical POPs as polychlorinated dibenzo-p-dioxins and dibenzofurans and polychlorinated biphenyls on nervous, reproductive, endocrine, and other systems or organs, aiming to provide a theoretical basis for further mechanism research.
引文
[1]KATSOYIANNIS A,CINCINELLI A.On persistent organic pollutants in Italy-From Seveso to the Stockholm Convention and beyond[J].Sci Total Environ,2017,579:514-516.
[2]RíOS J M,LANA N B,CIOCCO N F,et al.Implications of biological factors on accumulation of persistent organic pollutants in Antarctic notothenioid fish[J].Ecotoxicol Environ Saf,2017,145:630-639.
[3]BERGHUIS S A,BOS A F,SAUER P J,et al.Developmental neurotoxicity of persistent organic pollutants:an update on childhood outcome[J].Arch Toxicol,2015,89(5):687-709.
[4]WINNEKE G.Developmental aspects of environmental neurotoxicology:lessons from lead and polychlorinated biphenyls[J].J Neurol Sci,2011,308(1/2):9-15.
[5]NISHIJO M,TAI P T,ANH N T,et al.Urinary amino acid alterations in 3-year-old children with neurodevelopmental effects due to perinatal dioxin exposure in Vietnam:a nested case-control study for neurobiomarker discovery[J].PLo S One,2015,10(1):e0116778.
[6]JOHANSSON N,FREDRIKSSON A,ERIKSSON P.Neonatal exposure to perfluorooctane sulfonate(PFOS)and perfluorooctanoic acid(PFOA)causes neurobehavioural defects in adult mice[J].Neuro Toxicology,2008,29(1):160-169.
[7]GUO X X,HE Q Z,LI W,et al.Brain-derived neurotrophic factor mediated perfluorooctane sulfonate induced-neurotoxicity via epigenetics regulation in SK-N-SH Cells[J].Int J Mol Sci,2017,18(4):893.
[8]ZHENG S,LIU C,HUANG Y,et al.Effects of 2,2',4,4'-tetrabromodiphenyl ether on neurobehavior and memory change and bcl-2,c-fos,grin1b and lingo1b gene expression in male zebrafish(Danio rerio)[J].Toxicol Appl Pharmacol,2017,333:10-16.
[9]李云秀,蒋友胜,张建清,等.2,2',4,4'-四溴联苯醚通过核受体介导神经毒性作用机制的初步研究[J].癌变·畸变·突变,2017,29(3):172-178.
[10]KOBAYASHI Y,HIRANO T,OMOTEHARA T,et al.Immunohistochemical analysis of 2,3,7,8-tetrachlorodibenzo-pdioxin(TCDD)toxicity on the developmental dentate gyrus and hippocampal fimbria in fetal mice[J].J Vet Med Sci,2015,77(11):1355-1361.
[11]LIDA M,FUJII S,UCHIDA M,et al.Identification of aryl hydrocarbon receptor signaling pathways altered in TCDDtreated red seabream embryos by transcriptome analysis[J].Aquat Toxicol,2016,177:156-170.
[12]XU G,ZHOU Q,WAN C,et al.2,3,7,8-TCDD induces neurotoxicity and neuronal apoptosis in the rat brain cortex and PC12 cell line through the down-regulation of the Wnt/β-catenin signaling pathway[J].Neuro Toxicology,2013,37:63-73.
[13]KING-HEIDEN T C,MEHTA V,XIONG K M,et al.Reproductive and developmental toxicity of dioxin in fish[J].Mol Cell Endocrinol,2012,354(1/2):121-138.
[14]MAKEY C M,MCCLEAN M D,BRAVERMAN L E,et al.Polybrominated diphenyl ether exposure and reproductive hormones in North American men[J].Reprod Toxicol,2016,62:46-52.
[15]KHEZRI A,LINDEMAN B,KROGENAS A K,et al.Maternal exposure to a mixture of persistent organic pollutants(POPs)affects testis histology,epididymal sperm count and induces sperm DNA fragmentation in mice[J].Toxicol Appl Pharmacol,2017,329:301-308.
[16]MA T,YIN X,HAN R,et al.Effects of in utero exposure to di-n-butyl phthalate on testicular development in rat[J].Int J Environ Res Public Health,2017,14(10):1284.
[17]MOTA P C,TAVARES R S,CORDEIRO M,et al.Acute effects of TCDD administration:Special emphasis on testicular and sperm mitochondrial function[J].Asian Pac J Reprod,2012,1(4):269-276.
[18]TRABERT B,CHEN Z,KANNAN K,et al.Persistent organic pollutants(POPs)and fibroids:results from the ENDO study[J].J Expo Sci Environ Epidemiol,2015,25(3):278-285.
[19]黄莉,黄韧,冯媛瑜,等.2,3,7,8-四氯苯并二噁英(TCDD)短期染毒可造成着床前胚胎丢失并伴随雌性生殖器官中毒物相关蛋白的诱导表达[J].生态毒理学报,2010,5(3):334-342.
[20]左驰,瞿鑫兰,张铭,等.多氯联苯暴露对着床期子宫内膜组织特定基因甲基化的影响[J].武汉大学学报(医学版),2017,38(5):735-739.
[21]WEBER C.Liver:Reprogramming a hepatocyte’s memory of liver disease[J].Nat Rev Gastroenterol Hepatol,2015,12(5):250.
[22]LU C,WANG Y,SHENG Z,et al.NMR-based metabonomic analysis of the hepatotoxicity induced by combined exposure to PCBs and TCDD in rats[J].Toxicol Appl Pharmacol,2010,248(3):178-184.
[23]KUMAR J,LIND L,SALIHOVIC S,et al.Persistent organic pollutants and liver dysfunction biomarkers in a populationbased human sample of men and women[J].Environ Res,2014,134:251-256.
[24]KRAUGERUD M,DOUGHTY R W,LYCHE J L,et al.Natural mixtures of persistent organic pollutants(POPs)suppress ovarian follicle development,liver vitellogenin immunostaining and hepatocyte proliferation in female zebrafish(Danio rerio)[J].Aquat Toxicol,2012,116-117(1):16-23.
[25]马晓明,马世伟,陈曦,等.低剂量二噁英慢性暴露对雄性大鼠血清蛋白表达的影响[J].环境与健康杂志,2009,26(3):195-198.
[26]GASPAR-RAMíREZ O,PéREZ-VáZQUEZ F J,SALGADOBUSTAMANTE M,et al.DDE and PCB 153 independently induce aryl hydrocarbon receptor(Ah R)expression in peripheral blood mononuclear cells[J].J Immunotoxicol,2015,12(3):266-272.
[27]YADETIE F,KARLSEN O A,EIDE M,et al.Liver transcriptome analysis of Atlantic cod(Gadus morhua)exposed to PCB 153indicates effects on cell cycle regulation and lipid metabolism[J].BMC Genomics,2014,15(1):481.
[28]YANG G,ZHOU Z,CEN Y,et al.Death receptor and mitochondriamediated hepatocyte apoptosis underlies liver dysfunction in rats exposed to organic pollutants from drinking water[J].Drug Des Devel Ther,2015,9:4719-4733.
[29]NGWA E N,KENGNE A P,TIEDEU-ATOGHO B,et al.Persistent organic pollutants as risk factors for type 2 diabetes[J].Diabetol Metab Syndr,2015,7:41.
[30]GRICE B A,NELSON R G,WILLIAMS D E,et al.Associations between persistent organic pollutants,type 2 diabetes,diabetic nephropathy and mortality.[J].Occup Environ Med,2017,74(7):521-527.
[31]SINGH K,CHAN H M.Persistent organic pollutants and diabetes among Inuit in the Canadian Arctic[J].Environ Int,2017,101:183-189.
[32]HENDRíQUEZ-HERNáNDEZ L A,LUZARDO O P,VALERóN P F,et al.Persistent organic pollutants and risk of diabetes and obesity on healthy adults:Results from a cross-sectional study in Spain[J].Sci Total Environ,2017,607-608:1096-1102.
[33]LEE Y M,KIM K S,KIM S A,et al.Prospective associations between persistent organic pollutants and metabolic syndrome:a nested case-control study[J].Sci Total Environ,2014,496:219-225.
[34]MUSTIELES V,FERNáNDEZ M F,MARTIN-OLMEDO P,et al.Human adipose tissue levels of persistent organic pollutants and metabolic syndrome components:combining a crosssectional with a 10-year longitudinal study using a multipollutant approach[J].Environ Int,2017,104:48-57.
[35]EVERETT C J,FRITHSEN I,PLAYER M.Relationship of polychlorinated biphenyls with type 2 diabetes and hypertension[J].J Environ Monit,2011,13(2):241-251.
[36]陶鸿,易丽娴,孙中文,等.多氯联苯(PCB1254)诱导胰岛细胞凋亡的机制研究[J].南京医科大学学报(自然科学版),2015,35(3):346-351.
[37]茅晓东,李兴佳,韦晓,等.PCB-118对大鼠胰岛细胞的生长抑制作用[J].江苏医药,2015,41(22):2650-2653.
[38]何平,阮晓倩,丁晶莹,等.PCB153对INS-1细胞毒性作用及机制[J].中国公共卫生,2013,29(1):76-78.
[39]KIM S,PARK J,KIM H J,et al.Association between several persistent organic pollutants and thyroid hormone levels in serum among the pregnant women of Korea[J].Environ Int,2013,59:442-448.
[40]WALTER K M,LIN Y P,KASS P H,et al.Association of polybrominated diphenyl ethers(PBDEs)and polychlorinated biphenyls(PCBs)with hyperthyroidism in domestic felines,sentinels for thyroid hormone disruption[J].BMC Vet Res,2017,13:120.
[41]LAU G,WALTER K,KASS P,et al.Comparison of polybrominated diphenyl ethers(PBDEs)and polychlorinated biphenyls(PCBs)in the serum of hypothyroxinemic and euthyroid dogs[J].Peer J,2017,5:e3780.
[42]MONTA?O M,COCCO E,GUIGNARD C,et al.New approaches to assess the transthyretin binding capacity of bioactivated thyroid hormone disruptors[J].Toxicol Sci,2012,130(1):94-105.
[43]YU W G,LIU W,JIN Y H.Effects of perfluorooctane sulfonate on rat thyroid hormone biosynthesis and metabolism[J].Environ Toxicol Chem,2009,28(5):990-996.
[44]杨慧,许波进,郑旭琴,等.多氯联苯118引起大鼠甲状腺炎症反应的研究[J].南京医科大学学报(自然科学版),2015,35(5):622-625.
[45]CATALANI S.IARC revision on dioxin and some dioxin-like compounds[J].G Ital Med Lav Ergon,2010,32(1):79-81.
[46]REAVES D K,GINSBURG E,BANG J J,et al.Persistent organic pollutants and obesity:are they potential mechanisms for breast cancer promotion?[J].Endocr Relat Cancer,2015,22(2):R69-R86.
[47]WIELS?E M,KERN P,BONEFELD-J?RGENSEN E C.Serum levels of environmental pollutants is a risk factor for breast cancer in Inuit:a case control study[J].Environ Health,2017,16(1):56.
[48]LIM J E,NAM C,YANG J,et al.Serum persistent organic pollutants(POPs)and prostate cancer risk:A case-cohort study[J].Int J Hyg Environ Health,2017,220(5):849-856.
[49]何晓波,景亚青,李克秋,等.持久性有机污染物暴露人群DNA损伤修复基因表达的研究[J].环境与健康杂志,2014,31(1):1-5.
[50]RIGNALL B,GROTE K,GAVRILOV A,et al.Biological and tumor-promoting effects of dioxin-like and non-dioxinlike polychlorinated biphenyls in mouse liver after single or combined treatment[J].Toxicol Sci,2013,133(1):29-41.
[51]马萍,杨旭.TSLP和TRPV1通路对邻苯二甲酸酯诱发Allergic March的介导作用[J].公共卫生与预防医学,2017,28(2):1-5.
[52]崔建升,高瑜,王立新,等.PCB77和Cd共同暴露诱导的线粒体损伤及其介导的联合毒性效应[J].环境化学,2016,35(3):590-596.
[53]XIE J,YANG D,SUN X,et al.Individual and combined toxicities of benzo[a]pyrene and 2,2',4,4'-tetrabromodiphenyl ether on early life stages of the pacific oyster,Crassostrea gigas[J].Bull Environ Contam Toxicol,2017,99(5):582-588.
[54]杨蓉,李娜,饶凯峰,等.环境混合物的联合毒性研究方法[J].生态毒理学报,2016,11(1):1-13.
[2]RíOS J M,LANA N B,CIOCCO N F,et al.Implications of biological factors on accumulation of persistent organic pollutants in Antarctic notothenioid fish[J].Ecotoxicol Environ Saf,2017,145:630-639.
[3]BERGHUIS S A,BOS A F,SAUER P J,et al.Developmental neurotoxicity of persistent organic pollutants:an update on childhood outcome[J].Arch Toxicol,2015,89(5):687-709.
[4]WINNEKE G.Developmental aspects of environmental neurotoxicology:lessons from lead and polychlorinated biphenyls[J].J Neurol Sci,2011,308(1/2):9-15.
[5]NISHIJO M,TAI P T,ANH N T,et al.Urinary amino acid alterations in 3-year-old children with neurodevelopmental effects due to perinatal dioxin exposure in Vietnam:a nested case-control study for neurobiomarker discovery[J].PLo S One,2015,10(1):e0116778.
[6]JOHANSSON N,FREDRIKSSON A,ERIKSSON P.Neonatal exposure to perfluorooctane sulfonate(PFOS)and perfluorooctanoic acid(PFOA)causes neurobehavioural defects in adult mice[J].Neuro Toxicology,2008,29(1):160-169.
[7]GUO X X,HE Q Z,LI W,et al.Brain-derived neurotrophic factor mediated perfluorooctane sulfonate induced-neurotoxicity via epigenetics regulation in SK-N-SH Cells[J].Int J Mol Sci,2017,18(4):893.
[8]ZHENG S,LIU C,HUANG Y,et al.Effects of 2,2',4,4'-tetrabromodiphenyl ether on neurobehavior and memory change and bcl-2,c-fos,grin1b and lingo1b gene expression in male zebrafish(Danio rerio)[J].Toxicol Appl Pharmacol,2017,333:10-16.
[9]李云秀,蒋友胜,张建清,等.2,2',4,4'-四溴联苯醚通过核受体介导神经毒性作用机制的初步研究[J].癌变·畸变·突变,2017,29(3):172-178.
[10]KOBAYASHI Y,HIRANO T,OMOTEHARA T,et al.Immunohistochemical analysis of 2,3,7,8-tetrachlorodibenzo-pdioxin(TCDD)toxicity on the developmental dentate gyrus and hippocampal fimbria in fetal mice[J].J Vet Med Sci,2015,77(11):1355-1361.
[11]LIDA M,FUJII S,UCHIDA M,et al.Identification of aryl hydrocarbon receptor signaling pathways altered in TCDDtreated red seabream embryos by transcriptome analysis[J].Aquat Toxicol,2016,177:156-170.
[12]XU G,ZHOU Q,WAN C,et al.2,3,7,8-TCDD induces neurotoxicity and neuronal apoptosis in the rat brain cortex and PC12 cell line through the down-regulation of the Wnt/β-catenin signaling pathway[J].Neuro Toxicology,2013,37:63-73.
[13]KING-HEIDEN T C,MEHTA V,XIONG K M,et al.Reproductive and developmental toxicity of dioxin in fish[J].Mol Cell Endocrinol,2012,354(1/2):121-138.
[14]MAKEY C M,MCCLEAN M D,BRAVERMAN L E,et al.Polybrominated diphenyl ether exposure and reproductive hormones in North American men[J].Reprod Toxicol,2016,62:46-52.
[15]KHEZRI A,LINDEMAN B,KROGENAS A K,et al.Maternal exposure to a mixture of persistent organic pollutants(POPs)affects testis histology,epididymal sperm count and induces sperm DNA fragmentation in mice[J].Toxicol Appl Pharmacol,2017,329:301-308.
[16]MA T,YIN X,HAN R,et al.Effects of in utero exposure to di-n-butyl phthalate on testicular development in rat[J].Int J Environ Res Public Health,2017,14(10):1284.
[17]MOTA P C,TAVARES R S,CORDEIRO M,et al.Acute effects of TCDD administration:Special emphasis on testicular and sperm mitochondrial function[J].Asian Pac J Reprod,2012,1(4):269-276.
[18]TRABERT B,CHEN Z,KANNAN K,et al.Persistent organic pollutants(POPs)and fibroids:results from the ENDO study[J].J Expo Sci Environ Epidemiol,2015,25(3):278-285.
[19]黄莉,黄韧,冯媛瑜,等.2,3,7,8-四氯苯并二噁英(TCDD)短期染毒可造成着床前胚胎丢失并伴随雌性生殖器官中毒物相关蛋白的诱导表达[J].生态毒理学报,2010,5(3):334-342.
[20]左驰,瞿鑫兰,张铭,等.多氯联苯暴露对着床期子宫内膜组织特定基因甲基化的影响[J].武汉大学学报(医学版),2017,38(5):735-739.
[21]WEBER C.Liver:Reprogramming a hepatocyte’s memory of liver disease[J].Nat Rev Gastroenterol Hepatol,2015,12(5):250.
[22]LU C,WANG Y,SHENG Z,et al.NMR-based metabonomic analysis of the hepatotoxicity induced by combined exposure to PCBs and TCDD in rats[J].Toxicol Appl Pharmacol,2010,248(3):178-184.
[23]KUMAR J,LIND L,SALIHOVIC S,et al.Persistent organic pollutants and liver dysfunction biomarkers in a populationbased human sample of men and women[J].Environ Res,2014,134:251-256.
[24]KRAUGERUD M,DOUGHTY R W,LYCHE J L,et al.Natural mixtures of persistent organic pollutants(POPs)suppress ovarian follicle development,liver vitellogenin immunostaining and hepatocyte proliferation in female zebrafish(Danio rerio)[J].Aquat Toxicol,2012,116-117(1):16-23.
[25]马晓明,马世伟,陈曦,等.低剂量二噁英慢性暴露对雄性大鼠血清蛋白表达的影响[J].环境与健康杂志,2009,26(3):195-198.
[26]GASPAR-RAMíREZ O,PéREZ-VáZQUEZ F J,SALGADOBUSTAMANTE M,et al.DDE and PCB 153 independently induce aryl hydrocarbon receptor(Ah R)expression in peripheral blood mononuclear cells[J].J Immunotoxicol,2015,12(3):266-272.
[27]YADETIE F,KARLSEN O A,EIDE M,et al.Liver transcriptome analysis of Atlantic cod(Gadus morhua)exposed to PCB 153indicates effects on cell cycle regulation and lipid metabolism[J].BMC Genomics,2014,15(1):481.
[28]YANG G,ZHOU Z,CEN Y,et al.Death receptor and mitochondriamediated hepatocyte apoptosis underlies liver dysfunction in rats exposed to organic pollutants from drinking water[J].Drug Des Devel Ther,2015,9:4719-4733.
[29]NGWA E N,KENGNE A P,TIEDEU-ATOGHO B,et al.Persistent organic pollutants as risk factors for type 2 diabetes[J].Diabetol Metab Syndr,2015,7:41.
[30]GRICE B A,NELSON R G,WILLIAMS D E,et al.Associations between persistent organic pollutants,type 2 diabetes,diabetic nephropathy and mortality.[J].Occup Environ Med,2017,74(7):521-527.
[31]SINGH K,CHAN H M.Persistent organic pollutants and diabetes among Inuit in the Canadian Arctic[J].Environ Int,2017,101:183-189.
[32]HENDRíQUEZ-HERNáNDEZ L A,LUZARDO O P,VALERóN P F,et al.Persistent organic pollutants and risk of diabetes and obesity on healthy adults:Results from a cross-sectional study in Spain[J].Sci Total Environ,2017,607-608:1096-1102.
[33]LEE Y M,KIM K S,KIM S A,et al.Prospective associations between persistent organic pollutants and metabolic syndrome:a nested case-control study[J].Sci Total Environ,2014,496:219-225.
[34]MUSTIELES V,FERNáNDEZ M F,MARTIN-OLMEDO P,et al.Human adipose tissue levels of persistent organic pollutants and metabolic syndrome components:combining a crosssectional with a 10-year longitudinal study using a multipollutant approach[J].Environ Int,2017,104:48-57.
[35]EVERETT C J,FRITHSEN I,PLAYER M.Relationship of polychlorinated biphenyls with type 2 diabetes and hypertension[J].J Environ Monit,2011,13(2):241-251.
[36]陶鸿,易丽娴,孙中文,等.多氯联苯(PCB1254)诱导胰岛细胞凋亡的机制研究[J].南京医科大学学报(自然科学版),2015,35(3):346-351.
[37]茅晓东,李兴佳,韦晓,等.PCB-118对大鼠胰岛细胞的生长抑制作用[J].江苏医药,2015,41(22):2650-2653.
[38]何平,阮晓倩,丁晶莹,等.PCB153对INS-1细胞毒性作用及机制[J].中国公共卫生,2013,29(1):76-78.
[39]KIM S,PARK J,KIM H J,et al.Association between several persistent organic pollutants and thyroid hormone levels in serum among the pregnant women of Korea[J].Environ Int,2013,59:442-448.
[40]WALTER K M,LIN Y P,KASS P H,et al.Association of polybrominated diphenyl ethers(PBDEs)and polychlorinated biphenyls(PCBs)with hyperthyroidism in domestic felines,sentinels for thyroid hormone disruption[J].BMC Vet Res,2017,13:120.
[41]LAU G,WALTER K,KASS P,et al.Comparison of polybrominated diphenyl ethers(PBDEs)and polychlorinated biphenyls(PCBs)in the serum of hypothyroxinemic and euthyroid dogs[J].Peer J,2017,5:e3780.
[42]MONTA?O M,COCCO E,GUIGNARD C,et al.New approaches to assess the transthyretin binding capacity of bioactivated thyroid hormone disruptors[J].Toxicol Sci,2012,130(1):94-105.
[43]YU W G,LIU W,JIN Y H.Effects of perfluorooctane sulfonate on rat thyroid hormone biosynthesis and metabolism[J].Environ Toxicol Chem,2009,28(5):990-996.
[44]杨慧,许波进,郑旭琴,等.多氯联苯118引起大鼠甲状腺炎症反应的研究[J].南京医科大学学报(自然科学版),2015,35(5):622-625.
[45]CATALANI S.IARC revision on dioxin and some dioxin-like compounds[J].G Ital Med Lav Ergon,2010,32(1):79-81.
[46]REAVES D K,GINSBURG E,BANG J J,et al.Persistent organic pollutants and obesity:are they potential mechanisms for breast cancer promotion?[J].Endocr Relat Cancer,2015,22(2):R69-R86.
[47]WIELS?E M,KERN P,BONEFELD-J?RGENSEN E C.Serum levels of environmental pollutants is a risk factor for breast cancer in Inuit:a case control study[J].Environ Health,2017,16(1):56.
[48]LIM J E,NAM C,YANG J,et al.Serum persistent organic pollutants(POPs)and prostate cancer risk:A case-cohort study[J].Int J Hyg Environ Health,2017,220(5):849-856.
[49]何晓波,景亚青,李克秋,等.持久性有机污染物暴露人群DNA损伤修复基因表达的研究[J].环境与健康杂志,2014,31(1):1-5.
[50]RIGNALL B,GROTE K,GAVRILOV A,et al.Biological and tumor-promoting effects of dioxin-like and non-dioxinlike polychlorinated biphenyls in mouse liver after single or combined treatment[J].Toxicol Sci,2013,133(1):29-41.
[51]马萍,杨旭.TSLP和TRPV1通路对邻苯二甲酸酯诱发Allergic March的介导作用[J].公共卫生与预防医学,2017,28(2):1-5.
[52]崔建升,高瑜,王立新,等.PCB77和Cd共同暴露诱导的线粒体损伤及其介导的联合毒性效应[J].环境化学,2016,35(3):590-596.
[53]XIE J,YANG D,SUN X,et al.Individual and combined toxicities of benzo[a]pyrene and 2,2',4,4'-tetrabromodiphenyl ether on early life stages of the pacific oyster,Crassostrea gigas[J].Bull Environ Contam Toxicol,2017,99(5):582-588.
[54]杨蓉,李娜,饶凯峰,等.环境混合物的联合毒性研究方法[J].生态毒理学报,2016,11(1):1-13.