人类着色性干皮病基因D基因多态性与前列腺癌易感性的Meta分析
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摘要
目的评价人类着色性干皮病基因D Asn312Asp和Gln751Lys多态性位点对于前列腺癌患病风险的影响。方法检索2004年至2014年间在PubMed、Embase、万方、中国知网、维普等数据库中所有相关文献,提取其中数据进行统计学分析。以比值比和95%可信区间评价该位点与前列腺癌易感性的关系。分析软件使用STATA10.0。结果最终筛选出9项研究,分别有3 165例前列腺癌患者和3 539例对照人群涉及Gln751Lys基因多态性,2 555例及3 182例对照涉及Asn312Asp基因多态性。总体上,未发现XPD Gln751Lys基因多态性与前列腺癌易感性相关。另一方面,在种族亚组中发现Asn312Asp多态性能增加亚洲(如:Asn vs.Asp:OR=1.54,95%CI=1.24~1.91)及非洲人群(如:Asn vs.Asp:OR=1.36,95%CI=1.00~1.83)罹患前列腺癌的易感性。结论我们的荟萃分析证实,XPD Asn312Asp基因多态性能增加亚洲人群及非洲人群罹患前列腺癌的易感性。
Objective To evaluate the effect of xeroderma pigmentosum group D(XPD)gene polymorphism on the susceptibility of prostate cancer(PCa).Methods All eligible studies in databases including Pubmed,Embase,WanFang,CNKI and VIP were searched and data were collected.The association between XPD gene polymorphismand and risk of PCa was evaluated with odds ratio(OR)and 95% confidence intervals(CI).Statistical analysis was performed with STATA10.0.Results A total of 9independent case-control studies with3 165 PCa patients and3 539 healthy controls for XPD Gln751 Lys SNP(single nucleotide polymorphism)and2 555 cases and3 182 controls for Asn312 Asp SNP were collected.No significant association was found between XPD Gln751 Lys SNP and PCa risk.On the other hand,in subgroup analysis based on ethnicity,associations were observed in Asian(eg.Asn vs.Asp:OR=1.34,95%CI=1.16-1.55)and African(eg.Asn vs.Asp:OR=1.31,95%CI=1.01-1.70)populations with Asn 312 Asp SNP.Conclusion Our investigations demonstrate that XPD Asn312 Asp SNP,instead of Gln751 Lys SNP,might increase PCa risk in Asians and Africans.
Objective To evaluate the effect of xeroderma pigmentosum group D(XPD)gene polymorphism on the susceptibility of prostate cancer(PCa).Methods All eligible studies in databases including Pubmed,Embase,WanFang,CNKI and VIP were searched and data were collected.The association between XPD gene polymorphismand and risk of PCa was evaluated with odds ratio(OR)and 95% confidence intervals(CI).Statistical analysis was performed with STATA10.0.Results A total of 9independent case-control studies with3 165 PCa patients and3 539 healthy controls for XPD Gln751 Lys SNP(single nucleotide polymorphism)and2 555 cases and3 182 controls for Asn312 Asp SNP were collected.No significant association was found between XPD Gln751 Lys SNP and PCa risk.On the other hand,in subgroup analysis based on ethnicity,associations were observed in Asian(eg.Asn vs.Asp:OR=1.34,95%CI=1.16-1.55)and African(eg.Asn vs.Asp:OR=1.31,95%CI=1.01-1.70)populations with Asn 312 Asp SNP.Conclusion Our investigations demonstrate that XPD Asn312 Asp SNP,instead of Gln751 Lys SNP,might increase PCa risk in Asians and Africans.
引文
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[20]SOBTI RC,BERHANE N,MELESE S,et al.Impact of XPD gene polymorphism on risk of prostate cancer on north Indian population[J].Mol Cell Biochem,2012,362(1-2):263-268.
[21]LAVENDER NA,KOMOLAFE OO,BENFORD M,et al.No association between variant DNA repair genes and prostate cancer risk among men of African descent[J].Prostate,2010,70(2):113-119.
[22]AGALLIU I,KWON EM,SALINAS CA,et al.Genetic variation in DNA repair genes and prostate cancer risk:results from a population-based study[J].Cancer Causes Control,2010,21(2):289-300.
[23]MANDAL RK,GANGWAR R,MANDHANI A,et al.DNA repair gene X-ray repair cross-complementing group 1and xeroderma pigmentosum group D polymorphisms and risk of prostate cancer:a study from North India[J].DNA Cell Biol,2010,29(4):183-190.
[24]MUNAFMR,FLINT J.Meta-analysis of genetic association studies[J].Trends Genet,2004,20(9):439-444.
[25]YUAN H,NIU YM,WANG RX,et al.Association between XPD Lys751Gln polymorphism and risk of head and neck cancer:a meta-analysis[J].Genet Mol Res,2011,10(4):3356-3364.
[26]DING DP,MA WL,HE XF,et al.XPD Lys751Gln polymorphism and esophageal cancer susceptibility:a meta-analysis of case-control studies[J].Mol Biol Rep,2012,39(3):2533-2540.
[27]FENG Z,NI Y,DONG W,et al.Association of ERCC2/XPD polymorphisms and interaction with tobacco smoking in lung cancer susceptibility:a systemic review and meta-analysis[J].Mol Biol Rep,2012,39(1):57-69.
[28]PABALAN N,FRANCISCO-PABALAN O,SUNG L,et al.Meta-analysis of two ERCC2(XPD)polymorphisms,Asp312Asn and Lys751Gln,in breast cancer[J].Breast Cancer Res Treat,2010,124(2):531-541.
[29]GOODE EL,ULRICH CM,POTTER JD.Polymorphisms in DNA repair genes and associations with cancer risk[J].Cancer Epidemiol Biomarkers Prev,2002,11(12):1513-1530.
[30]CAMPS C,SIRERA R,IRANZO V,et al.Gene expression and polymorphisms of DNA repair enzymes:cancer susceptibility and response to chemotherapy[J].Clin Lung Cancer,2007,8(6):369-375.
[31]LUNN RM,HELZLSOUER KJ,PARSHAD R,et al.XPD polymorphisms:effects on DNA repair proficiency[J].Carcinogenesis,2000,21(4):551-555.
[32]BAADE PD,YOULDEN DR,KRNJACKI LJ.International epidemiology of prostate cancer:geographical distribution and secular trends[J].Mol Nutr Food Res,2009,53(2):171-184.
[33]BRAY F,LORTET-TIEULENT J,FERLAY J,et al.Prostate cancer incidence and mortality trends in 37European countries:an overview[J].Eur J Cancer,2010,46(17):3040-3052.
[2]DUNN MW,KAZER MW.Prostate cancer overview[J].Semin Oncol Nurs,2011,27(4):241-250.
[3]POWELL IJ.The precise role of ethnicity and family history on aggressive prostate cancer:a review analysis[J].Arch Esp Urol,2011,64(8):711-719.
[4]BERWICK M,VINEIS P.Markers of DNA repair and susceptibility to cancer in humans:an epidemiologic review[J].J Natl Cancer Inst,2000,92(11):874-897.
[5]WOOD RD,MITCHELL M,SGOUROS J,et al.Human DNA repair genes[J].Science,2001,291(5507):1284-1289.
[6]CLEAVER JE.Common pathways for ultraviolet skin carcinogenesis in the repair and replication defective groups of xeroderma pigmentosum[J].J Dermatol Sci,2000,23(1):1-11.
[7]EVANS E,MOGGS JG,HWANG JR,et al.Mechanism of open complex and dual incision formation by human nucleotide excision repair factors[J].EMBO J,1997,16(21):6559-6573.
[8]RYBICKI BA,CONTI DV,MOREIRA A,et al.DNA repair gene XRCC1and XPD polymorphisms and risk of prostate cancer[J].Cancer Epidemiol Biomarkers Prev,2004,13(1):23-29.
[9]SHEN MR,JONES IM,MOHRENWEISER H.Nonconservative amino acid substitution variants exist at polymorphic frequency in DNA repair genes in healthy humans[J].Cancer Res,1998,58(4):604-608.
[10]LUNN RM,HELZLSOUER KJ,PARSHAD R,et al.XPD polymorphisms:effects on DNA repair proficiency[J].Carcinogenesis,2000,21(4):551-555.
[11]BAU DT,WU HC,CHIU CF,et al.Association of XPD polymorphisms with prostate cancer in Taiwanese patients[J].Anticancer Res,2007,27(4c):2893-2896.
[12]HIGGINS JP,THOMPSON SG.Quantifying heterogeneity in a meta-analysis[J].Stat Med,2002,21(11):1539-1558.
[13]MANTEL N,HAENSZEL W.Statistical aspects of the analysis of data from retrospective studies of disease[J].J Natl Cancer Inst,1959,22(4):719-748.
[14]DERSIMONIAN R,LAIRD N.Meta-analysis in clinical trials[J].Control Clin Trials,1986,7(3):177-188.
[15]HAYASHINO Y,NOGUCHI Y,FUKUI T.Systematic evaluation and comparison of statistical tests for publication bias[J].J Epidemiol,2005,15(6):235-243.
[16]PETERS JL,SUTTON AJ,JONES DR,et al.Comparison of two methods to detect publication bias in meta-analysis[J].JAMA,2006,295(6):676-680.
[17]DHILLON VS,YEOH E,FENECH M.DNA repair gene polymorphisms and prostate cancer risk in South Australia--results of apilot study[J].Urol Oncol,2011,29(6):641-646.
[18]RITCHEY JD,HUANG WY,CHOKKALINGAM AP,et al.Genetic variants of DNA repair genes and prostate cancer:apopulation-based study[J].Cancer Epidemiol Biomarkers Prev,2005,14(7):1703-1709.
[19]GAO R,PRICE DK,DAHUT WL,et al.Genetic polymorphisms in XRCC1associated with radiation therapy in prostate cancer[J].Cancer Biol Ther,2010,10(1):13-18.
[20]SOBTI RC,BERHANE N,MELESE S,et al.Impact of XPD gene polymorphism on risk of prostate cancer on north Indian population[J].Mol Cell Biochem,2012,362(1-2):263-268.
[21]LAVENDER NA,KOMOLAFE OO,BENFORD M,et al.No association between variant DNA repair genes and prostate cancer risk among men of African descent[J].Prostate,2010,70(2):113-119.
[22]AGALLIU I,KWON EM,SALINAS CA,et al.Genetic variation in DNA repair genes and prostate cancer risk:results from a population-based study[J].Cancer Causes Control,2010,21(2):289-300.
[23]MANDAL RK,GANGWAR R,MANDHANI A,et al.DNA repair gene X-ray repair cross-complementing group 1and xeroderma pigmentosum group D polymorphisms and risk of prostate cancer:a study from North India[J].DNA Cell Biol,2010,29(4):183-190.
[24]MUNAFMR,FLINT J.Meta-analysis of genetic association studies[J].Trends Genet,2004,20(9):439-444.
[25]YUAN H,NIU YM,WANG RX,et al.Association between XPD Lys751Gln polymorphism and risk of head and neck cancer:a meta-analysis[J].Genet Mol Res,2011,10(4):3356-3364.
[26]DING DP,MA WL,HE XF,et al.XPD Lys751Gln polymorphism and esophageal cancer susceptibility:a meta-analysis of case-control studies[J].Mol Biol Rep,2012,39(3):2533-2540.
[27]FENG Z,NI Y,DONG W,et al.Association of ERCC2/XPD polymorphisms and interaction with tobacco smoking in lung cancer susceptibility:a systemic review and meta-analysis[J].Mol Biol Rep,2012,39(1):57-69.
[28]PABALAN N,FRANCISCO-PABALAN O,SUNG L,et al.Meta-analysis of two ERCC2(XPD)polymorphisms,Asp312Asn and Lys751Gln,in breast cancer[J].Breast Cancer Res Treat,2010,124(2):531-541.
[29]GOODE EL,ULRICH CM,POTTER JD.Polymorphisms in DNA repair genes and associations with cancer risk[J].Cancer Epidemiol Biomarkers Prev,2002,11(12):1513-1530.
[30]CAMPS C,SIRERA R,IRANZO V,et al.Gene expression and polymorphisms of DNA repair enzymes:cancer susceptibility and response to chemotherapy[J].Clin Lung Cancer,2007,8(6):369-375.
[31]LUNN RM,HELZLSOUER KJ,PARSHAD R,et al.XPD polymorphisms:effects on DNA repair proficiency[J].Carcinogenesis,2000,21(4):551-555.
[32]BAADE PD,YOULDEN DR,KRNJACKI LJ.International epidemiology of prostate cancer:geographical distribution and secular trends[J].Mol Nutr Food Res,2009,53(2):171-184.
[33]BRAY F,LORTET-TIEULENT J,FERLAY J,et al.Prostate cancer incidence and mortality trends in 37European countries:an overview[J].Eur J Cancer,2010,46(17):3040-3052.