萆薢、土茯苓治疗高尿酸血症研究进展
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摘要
高尿酸血症是临床常见的代谢性疾病,发病率逐年上升,影响了患者的生活质量。中医临床治疗高尿酸血症经验丰富,大量临床经验方疗效确切,具有多成分、多靶点综合调节尿酸代谢网络失调特点。根据近年来相关研究文献,该文对临床常用中药及复方进行了总结综述,为基于中医临床治疗高尿酸血症中药新药研发提供借鉴。
Hyperuricemia is a common clinical metabolic disease,incidence has risen,affecting patients' quality of life. Chinese medicine has rich clinical experience in treatment of hyperuricemia,a large clinical experience effective,with multiple components,multiple target comprehensive adjustment disorders the hallmarks of uric acid metabolism. According to recent research,this paper summarizes and reviews the frequently used traditional Chinese medicine and its compound,provides reference for the clinical research of traditional Chinese medicine in the treatment of hyperuricemia.
Hyperuricemia is a common clinical metabolic disease,incidence has risen,affecting patients' quality of life. Chinese medicine has rich clinical experience in treatment of hyperuricemia,a large clinical experience effective,with multiple components,multiple target comprehensive adjustment disorders the hallmarks of uric acid metabolism. According to recent research,this paper summarizes and reviews the frequently used traditional Chinese medicine and its compound,provides reference for the clinical research of traditional Chinese medicine in the treatment of hyperuricemia.
引文
[1]刘佳,李玲.高尿酸血症的发病机制与药物治疗研究进展[J].国际药学研究杂志,2010,37(1):24-28.
[2]Magdalena Cristóbal-García,Fernando E García-Arroyo,Edilia Tapia,et al.Renal oxidative stress induced by longterm hyperuricemia alters mitochondrial function and maintains systemic hypertension[J].Oxidative Medicine and Cellular Longevity,2015(2015):1-8.
[3]Ming Jin,Fan Yang,Irene Yang,et al.Uric acid,hyperuricemia and vascular diseases[J].Frontiers in Bioscience:A Journal and Virtual Library,2012,17:656-669.
[4]倪青,孟祥.高尿酸血症和痛风中医认识与治疗[J].北京中医药,2016,36(6):529-535.
[5]戴顺琳,郑水庆,秦路平.中药萆薢临床作用的研究进展[C]//中华中医药学会第九届中药鉴定学术会议论文集.建德:中华中医药学会鉴定分会,2008:41-43.
[6]晁利平,刘艳霞,瞿璐,等.绵萆薢的化学成分及药理作用研究进展[J].药物评价研究,2015,38(3):325-330.
[7]陈光亮,朱立然,那莎,等.萆薢总皂苷对大鼠慢性高尿酸血症和肾小管尿酸转运体1表达的影响[J].中国中药杂志,2013,38(14):2348-2353.
[8]陈光亮,武松,那莎,等.萆薢总皂苷对慢性高尿酸血症大鼠尿酸排泄指标的影响[J].中国中西医结合杂志,2014,34(1):75-80.
[9]Junxia SU,Yuhui WEI,Minglong LIU,et al.Anti-hyperuricemic and nephroprotective effects of Rhizoma Dioscoreae septemlobae extracts and its main component dioscin via regulation of m OAT1,m URAT1 and m OCT2 in hypertensive mice[J].Archives of Pharmacal Research,2014,37(10):1336-1344.
[10]Qi ZHOU,Dong Hua YU,Chong ZHANG,et al.Total saponins from Discorea nipponica ameliorate urate excretion in hyperuricemic mice[J].Planta Medica,2014,80(15):1259-1268.
[11]Shan WU,Hui XU,Jinyong PENG,et al.Potent antiinflammatory effect of dioscin mediated by suppression of TNF-α-induced VCAM-1,ICAM-1and EL expression via the NF-κB pathway[J].Biochimie,2015,110:62-72.
[12]吴博,马跃平,袁久志,等.土茯苓化学成分的分离与鉴定[J].沈阳药科大学学报,2010,27(2):116-119.
[13]郭淑云,张薇,张琰.土茯苓对高尿酸症小鼠血清尿酸的影响[J].中国药业,2012,21(13):3-4.
[14]Wenai XU,Lian YIN,Hongying PAN,et al.Study on the correlation between constituents detected in serum from Rhizoma Smilacis Glabrae and the reduction of uric acid levels in hyperuricemia[J].J Ethnopharmacol,2013,150(2):747-754.
[15]Quan HONG,Shandong YU,Yan MEI,et al.Smilacis Glabrae Rhizoma reduces oxidative stress caused by hyperuricemia via upregulation of catalase[J].Cell Physiol Biochem,2014,34(5):1675-1685.
[16]寇俊梓,李钊.加味萆薢分清饮治疗痛风性关节炎临床研究[J].辽宁中医药大学学报,2014,16(3):171-172.
[17]刘淦新.加味萆薢分清饮治疗高尿酸血症25例[J].光明中医,2011,26(5):957-958.
[18]张娴娴,孙维峰,徐伟,等.泄浊除痹方治疗高尿酸血症疗效及安全性评价[J].中国中西医结合杂志,2011,31(9):1216-1219.
[19]周秋娴,周剑清,颜达航.泄浊除痹方治疗高尿酸血症疗效分析[J].内蒙古中医药,2016,35(2):38-39.
[20]Jiao CHEN,Jia ZHOU,Shuangshuang WEI,et al.Effect of a traditional Chinese medicine prescription Quzhuotongbi decoction on hyperuricemia model rats studied by using serum metabolomics based on gas chromatography-mass spectrometry[J].Journal of Chromatography B,2015,10:31-37.
[21]谢志军,温成平,鲍海军,等.祛浊通痹方对高尿酸模型大鼠血尿酸及黄嘌呤氧化酶的影响[J].中华中医药杂志,2011,26(6):1398-1400.
[22]瞿佶,吴弢,高翔.萆薢渗湿汤加减治疗急性痛风性关节炎30例[J].上海中医药杂志,2009,43(3):34-36.
[23]何惠芳,陈燕,张诗军,等.基于高尿酸血症小鼠OCT1表达的萆薢渗湿汤降尿酸机制研究[J].岭南急诊医学杂志,2015,20(4):301-303.
[24]缪建春,杨泰源,彭炜,等.萆薢车前茯苡汤对高尿酸血症大鼠血尿酸及黄嘌呤氧化酶的影响[J].中国医院用药评价与分析,2016,16(9):1166-1168.
[25]平凡,谭唱,颜至昭,等.萆薢除痹汤抗实验性痛风作用机制探讨[J].中国实验方剂学杂志,2015,21(9):129-132.
[26]江雪纯,平凡,张谨枫,等.萆薢除痹汤对大鼠尿酸性肾病防治作用的影响[J].中国实验方剂学杂志,2016,22(16):103-108.
[27]王天,孙维峰.复方土茯苓颗粒对高尿酸血症肾病模型小鼠肾功能及IL-1β,IL-6表达的影响[J].中国实验方剂学杂志,2012,18(16):191-194.
[28]朱明敏,师晓毅,孙维峰.复方土茯苓颗粒对HUA大鼠XO活性及其m RNA的抑制作用[J].中国实验方剂学杂志,2016,22(5):127-130.
[29]尉万春.活血四妙汤对高尿酸血症的作用及其延缓尿酸性肾损害的机制研究[D].北京:北京中医药大学,2014.
[30]Xiaoqin D,Ying P,Xing W,et al.Wuling san ameliorates urate under-excretion and renal dysfunction in hyperuricemic mice[J].Chinese Journal of Natural Medicines,2013,11(3):214-221.
[31]丁林宝.虎杖萆薢汤治疗湿热蕴结型痛风50例疗效分析[J].上海中医药杂志,2012,46(4):54-55.
[32]苏筠霞,徐筠,苏建平,等.复方萆薢汤治疗尿酸性肾病临床观察[J].西部中医药,2014,27(7):1-3.
[33]欧艳娟,韩东强,李景良,等.萆苓痛风方对大鼠急性痛风性关节炎的实验研究[J].风湿病与关节炎,2013,2(1):5-8.
[34]周琦,刘树民.基于“尿酸转运体组”的中药治疗高尿酸血症的研究进展[J].中国中药杂志,2015,40(22):4346-4350.
[2]Magdalena Cristóbal-García,Fernando E García-Arroyo,Edilia Tapia,et al.Renal oxidative stress induced by longterm hyperuricemia alters mitochondrial function and maintains systemic hypertension[J].Oxidative Medicine and Cellular Longevity,2015(2015):1-8.
[3]Ming Jin,Fan Yang,Irene Yang,et al.Uric acid,hyperuricemia and vascular diseases[J].Frontiers in Bioscience:A Journal and Virtual Library,2012,17:656-669.
[4]倪青,孟祥.高尿酸血症和痛风中医认识与治疗[J].北京中医药,2016,36(6):529-535.
[5]戴顺琳,郑水庆,秦路平.中药萆薢临床作用的研究进展[C]//中华中医药学会第九届中药鉴定学术会议论文集.建德:中华中医药学会鉴定分会,2008:41-43.
[6]晁利平,刘艳霞,瞿璐,等.绵萆薢的化学成分及药理作用研究进展[J].药物评价研究,2015,38(3):325-330.
[7]陈光亮,朱立然,那莎,等.萆薢总皂苷对大鼠慢性高尿酸血症和肾小管尿酸转运体1表达的影响[J].中国中药杂志,2013,38(14):2348-2353.
[8]陈光亮,武松,那莎,等.萆薢总皂苷对慢性高尿酸血症大鼠尿酸排泄指标的影响[J].中国中西医结合杂志,2014,34(1):75-80.
[9]Junxia SU,Yuhui WEI,Minglong LIU,et al.Anti-hyperuricemic and nephroprotective effects of Rhizoma Dioscoreae septemlobae extracts and its main component dioscin via regulation of m OAT1,m URAT1 and m OCT2 in hypertensive mice[J].Archives of Pharmacal Research,2014,37(10):1336-1344.
[10]Qi ZHOU,Dong Hua YU,Chong ZHANG,et al.Total saponins from Discorea nipponica ameliorate urate excretion in hyperuricemic mice[J].Planta Medica,2014,80(15):1259-1268.
[11]Shan WU,Hui XU,Jinyong PENG,et al.Potent antiinflammatory effect of dioscin mediated by suppression of TNF-α-induced VCAM-1,ICAM-1and EL expression via the NF-κB pathway[J].Biochimie,2015,110:62-72.
[12]吴博,马跃平,袁久志,等.土茯苓化学成分的分离与鉴定[J].沈阳药科大学学报,2010,27(2):116-119.
[13]郭淑云,张薇,张琰.土茯苓对高尿酸症小鼠血清尿酸的影响[J].中国药业,2012,21(13):3-4.
[14]Wenai XU,Lian YIN,Hongying PAN,et al.Study on the correlation between constituents detected in serum from Rhizoma Smilacis Glabrae and the reduction of uric acid levels in hyperuricemia[J].J Ethnopharmacol,2013,150(2):747-754.
[15]Quan HONG,Shandong YU,Yan MEI,et al.Smilacis Glabrae Rhizoma reduces oxidative stress caused by hyperuricemia via upregulation of catalase[J].Cell Physiol Biochem,2014,34(5):1675-1685.
[16]寇俊梓,李钊.加味萆薢分清饮治疗痛风性关节炎临床研究[J].辽宁中医药大学学报,2014,16(3):171-172.
[17]刘淦新.加味萆薢分清饮治疗高尿酸血症25例[J].光明中医,2011,26(5):957-958.
[18]张娴娴,孙维峰,徐伟,等.泄浊除痹方治疗高尿酸血症疗效及安全性评价[J].中国中西医结合杂志,2011,31(9):1216-1219.
[19]周秋娴,周剑清,颜达航.泄浊除痹方治疗高尿酸血症疗效分析[J].内蒙古中医药,2016,35(2):38-39.
[20]Jiao CHEN,Jia ZHOU,Shuangshuang WEI,et al.Effect of a traditional Chinese medicine prescription Quzhuotongbi decoction on hyperuricemia model rats studied by using serum metabolomics based on gas chromatography-mass spectrometry[J].Journal of Chromatography B,2015,10:31-37.
[21]谢志军,温成平,鲍海军,等.祛浊通痹方对高尿酸模型大鼠血尿酸及黄嘌呤氧化酶的影响[J].中华中医药杂志,2011,26(6):1398-1400.
[22]瞿佶,吴弢,高翔.萆薢渗湿汤加减治疗急性痛风性关节炎30例[J].上海中医药杂志,2009,43(3):34-36.
[23]何惠芳,陈燕,张诗军,等.基于高尿酸血症小鼠OCT1表达的萆薢渗湿汤降尿酸机制研究[J].岭南急诊医学杂志,2015,20(4):301-303.
[24]缪建春,杨泰源,彭炜,等.萆薢车前茯苡汤对高尿酸血症大鼠血尿酸及黄嘌呤氧化酶的影响[J].中国医院用药评价与分析,2016,16(9):1166-1168.
[25]平凡,谭唱,颜至昭,等.萆薢除痹汤抗实验性痛风作用机制探讨[J].中国实验方剂学杂志,2015,21(9):129-132.
[26]江雪纯,平凡,张谨枫,等.萆薢除痹汤对大鼠尿酸性肾病防治作用的影响[J].中国实验方剂学杂志,2016,22(16):103-108.
[27]王天,孙维峰.复方土茯苓颗粒对高尿酸血症肾病模型小鼠肾功能及IL-1β,IL-6表达的影响[J].中国实验方剂学杂志,2012,18(16):191-194.
[28]朱明敏,师晓毅,孙维峰.复方土茯苓颗粒对HUA大鼠XO活性及其m RNA的抑制作用[J].中国实验方剂学杂志,2016,22(5):127-130.
[29]尉万春.活血四妙汤对高尿酸血症的作用及其延缓尿酸性肾损害的机制研究[D].北京:北京中医药大学,2014.
[30]Xiaoqin D,Ying P,Xing W,et al.Wuling san ameliorates urate under-excretion and renal dysfunction in hyperuricemic mice[J].Chinese Journal of Natural Medicines,2013,11(3):214-221.
[31]丁林宝.虎杖萆薢汤治疗湿热蕴结型痛风50例疗效分析[J].上海中医药杂志,2012,46(4):54-55.
[32]苏筠霞,徐筠,苏建平,等.复方萆薢汤治疗尿酸性肾病临床观察[J].西部中医药,2014,27(7):1-3.
[33]欧艳娟,韩东强,李景良,等.萆苓痛风方对大鼠急性痛风性关节炎的实验研究[J].风湿病与关节炎,2013,2(1):5-8.
[34]周琦,刘树民.基于“尿酸转运体组”的中药治疗高尿酸血症的研究进展[J].中国中药杂志,2015,40(22):4346-4350.