肠道菌群失调影响抑郁情绪的研究进展
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摘要
抑郁情绪与肠道菌群的改变息息相关,近年来研究表明肠道菌群失调在抑郁情绪的发生发展中发挥关键作用。肠道菌群失调能够激活体内神经、内分泌免疫系统,导致机体的炎症等反应,通过胃肠神经系统,上传到中枢神经系统,引起抑郁情绪的发生。近年来研究发现,中医药可通过干预肠道菌群调节抑郁情绪,此外益生菌制剂亦有调节和恢复肠道菌群的作用,给予益生菌调节肠道菌群已成为治疗抑郁情绪的重要方法。
Depression is closely related to the change of intestinal flora. In recent years, studies have shown that intestinal flora imbalance plays a key role in the development of depression. The intestinal flora imbalance can activate the nerve, endocrine and immune system in the body, and cause the inflammation of the body, and so on, through the gastrointestinal nervous system, uploaded to the central nervous system, causing the occurrence of depression. In recent years, the study found that Chinese medicine can adjust the depression through the intervention of intestinal flora, and probiotics are also in addition to regulate and restore the role of intestinal microflora, giving probiotics regulate intestinal flora has become an important method for the treatment of depression.
Depression is closely related to the change of intestinal flora. In recent years, studies have shown that intestinal flora imbalance plays a key role in the development of depression. The intestinal flora imbalance can activate the nerve, endocrine and immune system in the body, and cause the inflammation of the body, and so on, through the gastrointestinal nervous system, uploaded to the central nervous system, causing the occurrence of depression. In recent years, the study found that Chinese medicine can adjust the depression through the intervention of intestinal flora, and probiotics are also in addition to regulate and restore the role of intestinal microflora, giving probiotics regulate intestinal flora has become an important method for the treatment of depression.
引文
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[23]Bercik P,Denou E,Collins J,et al.The intestinal microbiota affect central levels of brain-derived neurotropic factor and behavior in mice[J].Gastroenterology,2011,141:599-609.
[24]Sudo N,Chida Y,Aiba Y,et al.Postnatal microbial colonizationprograms the hypothalamic-pituitary-adrenal system forstress response in mice.The Journal of Physiology,2004,558(1):263-275.
[25]Foster JA,Mcvey NK.Gut-brain axis:how the microbiome influences anxiety and depression[J].Trends Neurosci,2013,36:305-312.
[26]Kim YK,Lee HP,Won SD,et al.Low plasma BDNF is associated with suicidal behavior in major depression[J].Prog Neuropsychopharmacol Biol Psychiatry,2007,31(1):78-85.
[27]Quan X,Luo H,Fan H,et al.Brain-derived neurotrophic factor contributes to colonic hypermotility in a chronic stress rat model[J].Dig Dis Sci,2015,60(8):2316-2326.
[28]Greenwood BN,Strong PV,Foley TE,et al.Learned helplessness is independent of levels of brain-derived neurotrophic factor in the hippocampus[J].Neuroscience,2007,144(4):1193-1208.
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[30]Desbonnet L,Garrett L,Clarke G,et al.Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression[J].Neuroscience,2010,170(4):1179-1188.
[31]Messaoudi M,Lalonde R,Violle N,et al.Assessment of psychotropiclike properties of a probiotic formulation(Lactobacillushelveticus R0052 and Bifidobacterium longum R0175)in rats andhuman subjects[J].Br J Nutr,2011,105(5):755-764.
[32]Benton D,Williams C,Brown A.Impact of consuming a milk drink containing a probiotic on mood and cognition[J].Eur J Clin Nutr,2007,61:355-361.
[33]Tillisch K,Labus JS,Ebrat B,et al.589 modulation of the brain-gut axis after 4-week intervention with a probiotic fermented dairy product[J].Gastroenterology,2012,142-115.
[34]郑晓者.益生菌治疗大鼠结肠炎的疗效观察及肠道菌群变化的研究[D].昆明:昆明医科大学,2015.
[35]史晓艳.双歧杆菌对化疗后肠道菌群紊乱及相关性肠炎的防治[D].大连:大连医科大学,2017.
[36]陈治珍,罗菲,李宏贵.益生菌与中医辨证法治疗儿童轮状病毒肠炎的疗效比较[J].广州中医药大学学报,2017,10(9):842-845..
[37]Guo M,Ding S,Zhao C,et al.Red ginseng and Semen Coicis can improve the structure of gut microbiota and relieve the symptoms of ulcerative colitis[J].Ethnopharmacol,2015,162:7.
[38]Chang CJ,Lin CS,Lu CC,et al.Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota[J].Nat Commun,2015,6:7489.
[39]王丽芳,高文远,徐鑫,等.神曲鲜干品组方对食积小鼠胃肠动力及肠道菌群调整的影响[J].中国实验方剂学杂志,2017,23(4):20-24.
[40]瞿慧琴,张柏岳,段智璇,等.口服大黄与肠道菌群的相互影响[J].亚太传统医药,2017,13(13):39-40.
[41]冯兴忠,张娅南,姜欣,等.加味补中益气汤促进肠道益生菌生长的实验研究[J].中国微生态学杂志,2008,20(2):159-160.
[42]王广,马淑霞,胡新俊,等.党参多糖对双歧杆菌和大肠埃希菌体外生长的影响[J].中国微生态学杂志,2010,22(3):199-201.
[43]陈琛,江振友,宋克玉,等.中草药对小鼠肠道菌群影响的实验研究[J].中国微生态学杂志,2011,23(1):15-17.
[44]舒文将,姚昕利,陈宗游,等.中药柴胡的药理研究与临床应用[J].广西科学,2017,9(15):1-7.
[45]刘欢,陈磊,孙海峰,等.ERIC-PCR指纹图谱分析逍遥散对抑郁模型大鼠肠道菌群的影响[J].山西医科大学学报,2015,46(2):160-165.
[46]Xie W,Gu D,Li J,et al.Effects and action mechanisms of berberine and rhizoma coptidis gue microbes and obesity in high-fat diet-fed C57TBL16J mice[J].Plo S One,2001,6:e245209.
[47]宋梦微.黄连解毒汤对高脂血症小鼠肠道菌群及其炎症状态的影响[D].广州中医药大学,2014.
[48]吴云,陈瑞,田维毅.苦寒中药对肠道菌群结构影响的研究进展[J].中国微生态学杂志,2015,27(2):235-239.
[2]郭慧玲,邵玉宇,孟和毕力格,等.肠道菌群与疾病关系的研究进展[J].微生物学通报,2015,42(2):400-410.
[3]林璋,祖先鹏,谢海胜,等.肠道菌群与人体疾病发病机制的研究进展[J].药学学报,2016,64(6):843-852.
[4]郑晓皎.肠道菌-宿主代谢物组的分析平台的建立及应用[D].上海交通大学,2013.
[5]Moloney RD,Desbonnet L,Clarke G,et al.The microbiome:stress,health and disease[J].Mamm Genome,2014,25:49,74.
[6]仇艳光,时兰春,孙芳,等.肠道微生物菌群对脑及行为的影响[J].生命的化学,2014,35(4):572-576.
[7]肠道内菌群异常可能导致行为异常[J].中华中医药学刊,2013,31(9):2071.
[8]Maes M,Vandoolaeghe E,Ranjan R,et al.Increased serum interleukin-1-receptor-antagonist concentrations in major depressio[J].J Affect Disord,1995,36(1-2):29-36.
[9]Wang Y,Lawson MA,Dantzer R,et al.LPS-induced indoleamine2,3-dioxygenase is regulated in an interferon-gamma-independent manner by a JNK signaling pathway in primary murine microglia[J].Brain Behav Immun,2010,24(2):201-209.
[10]Catena-Dell'Osso M,Bellantuono C,Consoli G,et al.Inflammatoryand neurodegenerative pathways in depression:a new avenue forantidepressant development[J].Curr Med Chem,2011,18(2):245-55.
[11]Tsao CW,Lin YS,Chen CC,et al.Cytokines and serotonintransporter in patients with major depression[J].Prog Neuropsy-chopharmacol Biol Psychiatry,2006,30(5):899-905.
[12]Levine J,Barak Y,Chengappa KN,et al.Cerebrospinal cytokine levels in patients with acute depression.Neuropsychobiology,1999,40(4):171-176.
[13]吴腾云,林华军,蒋春雷,等.肠道菌群紊乱所致炎症反应与抑郁症[J].现代生物医学进展,2014,14(36):7175-7177,7193.
[14]罗佳,金锋.肠道菌群影响宿主行为的研究进展[J].科学报,2014,59(22):2169-2190.
[15]Weber MD,Frank MG,Sobcsky JL,ct al.Blocking toll-like receptor 2and 4 signalig during a stressor prevents stress-induced priming of neuroinflammatory responses to a subsequent immune challenge[J].Brain Behav Immun,2013,32:112-121
[16]Rhee SH,Pothoulakis C,Mayer EA.Principles and clinical implications of thebrain-gut-enteric microbiota axis.Nature Reviews Gastroenterology and Hepatology,2009,6(5),306-314.doi:10.1038/nrgastro.2009.35.
[17]Mackowiak M,Czyrak A,Wedzony K.The involvement of 5-HT1aserotonin receptors in the pathophysio1ogy and pharmacotherapy of schizophrenia[J].Psychiatr Pol,2000,34(4):607-621.
[18]Lopez-Figuera AL,Norton CS,Lopez-Figuera MO,et al.Seroto-nin5-HT1A,5-HT1B,and 5-HT2A receptor m RNA expression insubjects with major depression,bipolar disorder,and schizophreni[J].Biol Psychiatry,2004,55(3):225-233.
[19]León-Ponte M,Ahern GP,O’Connell PJ.Serotonin provides an accessory signal to enhance T-cell activation by signaling through the 5-HT7 receptor[J].Blood,2007,109(8):3139-3146.
[20]Szadejko K,Szabat K,Ludwichowska A,et al.Homocysteine and its role in pathogenesis of Parkinson’s disease and other neurodegenerative disorders[J].Przegl Lek,2013,70(7):443-457.
[21]Seppi K,Weintraub D,Coelho M,et al.The movement disorder society evidence-based medicine review update:Treatments for the non-motor symptoms of Parkinson's disease[J].Mov Disord,2011,3(10):42-50.
[22]Gareau MG,Wine E,Rodrigues DM,et al.Bacterial infection causes stress-induced memory dysfunction in mice[J].Gut,2011,60:307-317.
[23]Bercik P,Denou E,Collins J,et al.The intestinal microbiota affect central levels of brain-derived neurotropic factor and behavior in mice[J].Gastroenterology,2011,141:599-609.
[24]Sudo N,Chida Y,Aiba Y,et al.Postnatal microbial colonizationprograms the hypothalamic-pituitary-adrenal system forstress response in mice.The Journal of Physiology,2004,558(1):263-275.
[25]Foster JA,Mcvey NK.Gut-brain axis:how the microbiome influences anxiety and depression[J].Trends Neurosci,2013,36:305-312.
[26]Kim YK,Lee HP,Won SD,et al.Low plasma BDNF is associated with suicidal behavior in major depression[J].Prog Neuropsychopharmacol Biol Psychiatry,2007,31(1):78-85.
[27]Quan X,Luo H,Fan H,et al.Brain-derived neurotrophic factor contributes to colonic hypermotility in a chronic stress rat model[J].Dig Dis Sci,2015,60(8):2316-2326.
[28]Greenwood BN,Strong PV,Foley TE,et al.Learned helplessness is independent of levels of brain-derived neurotrophic factor in the hippocampus[J].Neuroscience,2007,144(4):1193-1208.
[29]Campbell S,Macqueen G.The role of the hippocampus in the pathophysiology of major depression[J].Psychiatry Neurosci,2004,29(6):417-426.
[30]Desbonnet L,Garrett L,Clarke G,et al.Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression[J].Neuroscience,2010,170(4):1179-1188.
[31]Messaoudi M,Lalonde R,Violle N,et al.Assessment of psychotropiclike properties of a probiotic formulation(Lactobacillushelveticus R0052 and Bifidobacterium longum R0175)in rats andhuman subjects[J].Br J Nutr,2011,105(5):755-764.
[32]Benton D,Williams C,Brown A.Impact of consuming a milk drink containing a probiotic on mood and cognition[J].Eur J Clin Nutr,2007,61:355-361.
[33]Tillisch K,Labus JS,Ebrat B,et al.589 modulation of the brain-gut axis after 4-week intervention with a probiotic fermented dairy product[J].Gastroenterology,2012,142-115.
[34]郑晓者.益生菌治疗大鼠结肠炎的疗效观察及肠道菌群变化的研究[D].昆明:昆明医科大学,2015.
[35]史晓艳.双歧杆菌对化疗后肠道菌群紊乱及相关性肠炎的防治[D].大连:大连医科大学,2017.
[36]陈治珍,罗菲,李宏贵.益生菌与中医辨证法治疗儿童轮状病毒肠炎的疗效比较[J].广州中医药大学学报,2017,10(9):842-845..
[37]Guo M,Ding S,Zhao C,et al.Red ginseng and Semen Coicis can improve the structure of gut microbiota and relieve the symptoms of ulcerative colitis[J].Ethnopharmacol,2015,162:7.
[38]Chang CJ,Lin CS,Lu CC,et al.Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota[J].Nat Commun,2015,6:7489.
[39]王丽芳,高文远,徐鑫,等.神曲鲜干品组方对食积小鼠胃肠动力及肠道菌群调整的影响[J].中国实验方剂学杂志,2017,23(4):20-24.
[40]瞿慧琴,张柏岳,段智璇,等.口服大黄与肠道菌群的相互影响[J].亚太传统医药,2017,13(13):39-40.
[41]冯兴忠,张娅南,姜欣,等.加味补中益气汤促进肠道益生菌生长的实验研究[J].中国微生态学杂志,2008,20(2):159-160.
[42]王广,马淑霞,胡新俊,等.党参多糖对双歧杆菌和大肠埃希菌体外生长的影响[J].中国微生态学杂志,2010,22(3):199-201.
[43]陈琛,江振友,宋克玉,等.中草药对小鼠肠道菌群影响的实验研究[J].中国微生态学杂志,2011,23(1):15-17.
[44]舒文将,姚昕利,陈宗游,等.中药柴胡的药理研究与临床应用[J].广西科学,2017,9(15):1-7.
[45]刘欢,陈磊,孙海峰,等.ERIC-PCR指纹图谱分析逍遥散对抑郁模型大鼠肠道菌群的影响[J].山西医科大学学报,2015,46(2):160-165.
[46]Xie W,Gu D,Li J,et al.Effects and action mechanisms of berberine and rhizoma coptidis gue microbes and obesity in high-fat diet-fed C57TBL16J mice[J].Plo S One,2001,6:e245209.
[47]宋梦微.黄连解毒汤对高脂血症小鼠肠道菌群及其炎症状态的影响[D].广州中医药大学,2014.
[48]吴云,陈瑞,田维毅.苦寒中药对肠道菌群结构影响的研究进展[J].中国微生态学杂志,2015,27(2):235-239.