短穗兔耳草的化学成分研究
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摘要
目的对短穗兔耳草的化学活性成分进行研究。方法利用各种柱色谱对其成分进行分离纯化,通过波谱解析进行化学结构鉴定。结果从中分离得到12个化合物,经鉴定分别为:β-谷甾醇(1),β-胡萝卜苷(2),8-十七醇(3),二十六烷酸(4),对羟基苯乙酮(5),柯伊利素(6),木犀草素(7),小麦黄素(8),兔耳草苷(9),木犀草素-7-O-β-葡萄糖苷(10),熊果酸(11)和荷包牡丹碱(12)。结论化合物3,4,5,8,11和12均为首次从该植物中分离得到。
Objective To study the chemical constituents of Lagotis brachystachy Maxim..Methods The chemical constituents were isolated and purified by various chromatographic techniques.Their structures were identified on the basis of physical properties and spectroscopic data.Results 12 compounds were isolated and elucidated asβ-sitosterol(1),β-daucosterol(2),heptadecan-8-ol(3),hexacosanoic acid(4),1-(4-hy-droxy-phenyl)-ethanone(5),chrysoeriol(6),luteolin(7),tricin(8),lagotisiside(9),luteolin-7-O-β-glucoside(10),ursolic acid(11),and bicuculline(12).Conclusion Compounds 3,4,5,8,11 and 12were isolated from the plant for the first time.
Objective To study the chemical constituents of Lagotis brachystachy Maxim..Methods The chemical constituents were isolated and purified by various chromatographic techniques.Their structures were identified on the basis of physical properties and spectroscopic data.Results 12 compounds were isolated and elucidated asβ-sitosterol(1),β-daucosterol(2),heptadecan-8-ol(3),hexacosanoic acid(4),1-(4-hy-droxy-phenyl)-ethanone(5),chrysoeriol(6),luteolin(7),tricin(8),lagotisiside(9),luteolin-7-O-β-glucoside(10),ursolic acid(11),and bicuculline(12).Conclusion Compounds 3,4,5,8,11 and 12were isolated from the plant for the first time.
引文
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[15]冯建勇,陈虹,孙燕,等.鹅绒藤地上部位化学成分研究[J].中国现代应用药学,2013,30(3):274-277.
[16]邱莉,姜志虎,刘红霞,等.酸浆宿萼的黄酮苷类化学成分[J].沈阳药科大学学报,2007,24(12):744-747.
[17]Jucélia Pizzetti Benincá,Juliana Bastos Dalmarco,Moacir Geraldo Pizzolatti,et al.Analysis of the anti-inflammatory properties of Rosmarinus officinalis L.in mice[J].Food Chem,2011,124(2):468-475.
[18]王志伟,谭晓杰,马婷婷,等.茵陈化学成分的分离与鉴定[J].沈阳药科大学学报,2008,25(10):781-784.
[19]R Shakirov,M V Telezhenetskaya,I A Bessonova,et al.Alkaloids,plants,structure,propreties[J].Chem Nat Compd,1996,32(2):216-334.
[20]李莉,左爱学,饶高雄.傣药波波罕的生物碱成分研究[J].云南中医学院学报,2012,35(3):14-19.
[2]青海省生物研究所.青藏高原药物图鉴[M].西宁:青海人民出版社,1972:214.
[3]中国植物志编委会.中国植物志[M].北京:科学出版社,1979.
[4]陈耀祖,张惠迪,张所明,等.藏药短穗兔耳草化学成分的研究[J].高等学校化学学报,1989,10(3):260-262.
[5]杨云裳,何荔,杨爱梅,等.藏药短穗兔耳草化学成分研究[J].中国中药杂志,2005,30(2):153-154.
[6]逯梦亚,葛恒,刘世军,等.葵花大蓟的化学成分研究[J].西北药学杂志,2013,28(2):118-121.
[7]梁成钦,苏小建,周先丽,等.茅莓化学成分研究[J].中药材,2011,34(1):64-66.
[8]Fujii T,Yamakawa R,Terashima Y,et al.Propionates and acetates of chiral secondary alcohols:novel sex pheromone components produced by a lichen moth Barsine expressa(Arctiidae:Lithosiinae)[J].J Chem Ecol,2013,39(1):28-36.
[9]吴志军,欧阳明安,杨崇仁.黄花远志茎皮的寡糖酯和酚类成分[J].云南植物研究,2000,22(4):482-494.
[10]马宏宇,孙奕,吕阿丽,等.茵陈蒿化学成分的分离与鉴定[J].中国药物化学杂志,2010,20(1):61-63,69.
[11]褚纯隽,李显伦,夏龙,等.乌饭树叶的抗补体活性成分研究[J].中草药,2014,45(4):458-465.
[12]郗峰,邓君,王彦涵.藏药短管兔耳草的化学成分研究[J].中国中药杂志,2010,35(7):869-871.
[13]骆桂法,刘超,纪兰菊.多腺悬钩子黄酮类化学成分研究[J].西北药学杂志,2014,29(1):5-8.
[14]梁宁,杨昕昕,王国才,等.白花地胆草化学成分研究[J].中药材,2012,35(11):1775-1778.
[15]冯建勇,陈虹,孙燕,等.鹅绒藤地上部位化学成分研究[J].中国现代应用药学,2013,30(3):274-277.
[16]邱莉,姜志虎,刘红霞,等.酸浆宿萼的黄酮苷类化学成分[J].沈阳药科大学学报,2007,24(12):744-747.
[17]Jucélia Pizzetti Benincá,Juliana Bastos Dalmarco,Moacir Geraldo Pizzolatti,et al.Analysis of the anti-inflammatory properties of Rosmarinus officinalis L.in mice[J].Food Chem,2011,124(2):468-475.
[18]王志伟,谭晓杰,马婷婷,等.茵陈化学成分的分离与鉴定[J].沈阳药科大学学报,2008,25(10):781-784.
[19]R Shakirov,M V Telezhenetskaya,I A Bessonova,et al.Alkaloids,plants,structure,propreties[J].Chem Nat Compd,1996,32(2):216-334.
[20]李莉,左爱学,饶高雄.傣药波波罕的生物碱成分研究[J].云南中医学院学报,2012,35(3):14-19.