摘要
PI3K/Akt信号通路是由酶联受体介导的信号转导通路,该通路不仅参与多种生长因子、细胞因子和细胞外基质等的信号转导,同时还参与细胞增殖、分化、凋亡和葡萄糖转运等多种细胞功能的调节,特别是在细胞凋亡、细胞存活以及调控细胞糖代谢等方面具有重要作用。本研究综述了PI3K-Akt信号通路的结构组成、通路活化、通信过程、调控机制及其生物学功能等方面的研究进展,为进一步研究PI3K/Akt信号通路的生物学调控作用机制提供启示。
PI3K/Akt signal pathway is a signal transduction pathway mediated by enzyme-linked receptor, which not only participates in signal transduction of various growth factors, cytokines and extracellular matrix, but also participates in the regulation of cell proliferation, differentiation, apoptosis, glucose transport and other cell functions.In particular, it plays an important role in cell apoptosis, cell survival, and regulation of cell sugar metabolism. This paper reviewed the research progress of PI3K/Akt signal pathway on the structure composition, pathway activation,communication process, regulatory mechanism and biological function, and provided suggestions for the further study on the mechanism of biological regulation of PI3K/Akt signaling pathway.
引文
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