一种高效快捷的肛肠外科给药装置临床应用效果及评价分析
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摘要
目的:分析自制的一种高效快捷肛肠外科给药装置的临床应用效果和评价情况。方法:分析医院收治的110例肛肠疾病患者临床资料,按照使用高效快捷肛肠外科的给药装置与否将其分为观察组和对照组,每组55例,观察组使用给药装置,对照组未使用给药装置,对两组临床效果、交叉感染发生概率进行观察和比较,按视觉模拟量表(VAS)评分法对患者疼痛情况加以评判,采用美国波士顿健康研究所的生活质量简式-36(SF-36)健康量表对患者生活质量予以评判。结果:观察组创面水肿消退时间、创面愈合时间、创面渗出物和疼痛的消失时间均较短,与对照组比较差异均有统计学意义(t=6.2359,t=13.5394,t=17.0297,t=6.3502;P<0.05);观察组交叉感染发生概率为1.82%,较对照组低,且重度、中度疼痛所占比例分别为0.00%和14.55%,均比对照组低,其差异有统计学意义(x~2=16.0417,x~2=6.8990;P<0.05),无疼痛所占比例30.91%,均比对照组高,其差异有统计学意义(x~2=20.1075,P<0.05);所有病例进行半年随访,观察组生活质量总评分(83.54±14.49)分,比对照组(65.40±13.31)分高,其差异有统计学意义(t=6.8375,P<0.05)。结论:应用一种高效快捷肛肠外科的给药装置可加速患者创面愈合,减轻疼痛和减少交叉感染发生,且提高患者生活质量,具有较高临床应用意义。
Objective: To analyze the clinical effect and evaluation of an efficient and rapid drug-delivery device of anus and intestine surgery. Methods: The clinical data of a total of 110 patients with anorectal disease were analyzed and all of them were divided into observation group(55 cases) and control group(55 cases) according to whether adopted drug-delivery device. The observation group adopted drug-delivery device and control group didn't adopted this device. The clinical effect and cross infection rate of the two groups were observed and compared. The pain feel of patients were assessed as visual analogue scale and the quality of life(QOL) of patients were assessed as simple formula(SF-36) of living quality of Boston institute for health of USA. Results: The times for edema regression and wound healing, the extinction times of transudation and pain of the surface of wound in the observation group were significantly shorter than those in the control group(t=6.2359, t=13.5394, t=17.0297, t=6.3502, P<0.05). The crossinfection rate of observation group(1.82%) was significantly lower than that(18.18%) of control group(x~2=8.1818, P<0.05). And the rates of severe pain and moderate pain of observation group(0.00% and 14.55%) were significantly lower than those of control group(x~2=16.0417, x~2=6.8990, P<0.05). And the rate of non-pain of observation group(30.91%) was significantly higher than that of control group(x~2=20.1075, P<0.05). After half-year, the results of follow-up for all of patients indicated the total score of QOL of observation group(83.54±14.49 points) was significantly higher than that(65.40±13.31 points) of control group(t=6.8375, P<0.05). Conclusion: The application of an efficient and rapid drug-delivery device of anus and intestine surgery can contribute to accelerate wound healing of patients, and alleviate pain and reduce the occurrence of cross-infection, and improve the patients' QOL. Therefore, it has higher value in popularization and application.
Objective: To analyze the clinical effect and evaluation of an efficient and rapid drug-delivery device of anus and intestine surgery. Methods: The clinical data of a total of 110 patients with anorectal disease were analyzed and all of them were divided into observation group(55 cases) and control group(55 cases) according to whether adopted drug-delivery device. The observation group adopted drug-delivery device and control group didn't adopted this device. The clinical effect and cross infection rate of the two groups were observed and compared. The pain feel of patients were assessed as visual analogue scale and the quality of life(QOL) of patients were assessed as simple formula(SF-36) of living quality of Boston institute for health of USA. Results: The times for edema regression and wound healing, the extinction times of transudation and pain of the surface of wound in the observation group were significantly shorter than those in the control group(t=6.2359, t=13.5394, t=17.0297, t=6.3502, P<0.05). The crossinfection rate of observation group(1.82%) was significantly lower than that(18.18%) of control group(x~2=8.1818, P<0.05). And the rates of severe pain and moderate pain of observation group(0.00% and 14.55%) were significantly lower than those of control group(x~2=16.0417, x~2=6.8990, P<0.05). And the rate of non-pain of observation group(30.91%) was significantly higher than that of control group(x~2=20.1075, P<0.05). After half-year, the results of follow-up for all of patients indicated the total score of QOL of observation group(83.54±14.49 points) was significantly higher than that(65.40±13.31 points) of control group(t=6.8375, P<0.05). Conclusion: The application of an efficient and rapid drug-delivery device of anus and intestine surgery can contribute to accelerate wound healing of patients, and alleviate pain and reduce the occurrence of cross-infection, and improve the patients' QOL. Therefore, it has higher value in popularization and application.
引文
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[12]王瑾,王淑娟,张蕊.肠道肿瘤局部给药新型纳肛器的研制与应用[J].护理学杂志,2015,21(19):56-60.
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[14]李根生,石更强,赵敏,等.一种干粉定量给药装置的结构设计与性能分析[J].生物医学工程研究,2016,21(1):102-106.
[15]吴敏,刘铁兵,汤黎明,等.呼吸道紧急救治用无源气动雾化给药装置的研制和应用研究[J].医疗卫生装备,2016,34(11):25-30.
[2]李强,宋伟,邵洪锦,等.鞠应东教授中药药线炮制及肛肠疾病治疗经验[J].中国肛肠病杂志,2015,35(6):55-56.
[3]Wu JF,Lu CH,Yang CH,et al.Diagnostic role of anal sphincter relaxation integral in high-resolution anorectal manometry for hirschsprung disease in infants[J].JPediatr,2018,194(25):120-125.
[4]Witvliet MJ,van Gasteren S,van den Hondel D,et al.Predicting sexual problems in young adults with an anorectal malformation or Hirschsprung disease[J].J Pediatr Surg,2018,84(20):54-60.
[5]Witvliet MJ,Petersen N,Ekkerman E,et al.Transitional health care for patients with Hirschsprung disease and anorectal malformations[J].Tech Coloproctol,2017,21(7):102-108.
[6]Takeda M,Miyahara K,Akazawa C,et al.Sensory innervation of the anal canal and anorectal line in Hirschsprung's disease:histological evidence from mouse models[J].JOral Maxillofac Surg,2017,33(8):48-51.
[7]于永红,张斌,丁健华,等.经肛吻合器直肠切除术治疗出口梗阻型便秘的远期疗效[J].中华胃肠外科杂志,2017,34(12):21-25,28.
[8]郑玲,丁曙晴,丁义江,等.针刺联合生物反馈治疗功能性肛门直肠痛疗效分析[J].中华胃肠外科杂志,2016,27(12):45-51.
[9]Inoue M,Uchida K,Otake K,et al.Longterm functional outcome after untethering surgery for a tethered spinal cord in patients with anorectal malformations[J].Surg Neurol Int,2017,33(9):41-46.
[10]何莹,金纯,诸葛林敏,等.头孢西丁预防肛肠外科患者术后切口感染的效果研究[J].中华医院感染学杂志,2017,27(23):5384-5386,5394.
[11]李红梅,靳露佳,王翠玲,等.头孢西丁在肛肠外科患者术后切口感染预防中的疗效分析[J].中华医院感染学杂志,2016,26(8):1810-1812.
[12]王瑾,王淑娟,张蕊.肠道肿瘤局部给药新型纳肛器的研制与应用[J].护理学杂志,2015,21(19):56-60.
[13]Bienvenu B,Aouba A,Gottenberg JE,et al.Singlecenter,single-dose,open-label,randomized,twoperiod crossover study on the bioavailability of methotrexate administered using a novel prefilled,needle-free delivery system[J].Curr Med Res Opin,2017,33(4):254-258.
[14]李根生,石更强,赵敏,等.一种干粉定量给药装置的结构设计与性能分析[J].生物医学工程研究,2016,21(1):102-106.
[15]吴敏,刘铁兵,汤黎明,等.呼吸道紧急救治用无源气动雾化给药装置的研制和应用研究[J].医疗卫生装备,2016,34(11):25-30.