小檗属植物抗糖尿病及糖尿病并发症的研究进展
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摘要
小檗属植物资源丰富,药用历史悠久,可用于治疗多种疾病,其中刺檗、具芒小檗、毛叶黄耆和豪猪刺等植物的研究较为深入。小檗属植物的主要成分为生物碱类和黄酮类,研究最多的是小檗碱,其具有降血糖血脂、抗炎、抑菌等药理作用,可用于治疗糖尿病及其并发症。然而,对小檗碱的研究并不能代替对小檗属植物的研究。对小檗属植物提取物抗糖尿病及其并发症的药理作用和作用机制进行综述,为促进该属植物及其有效成分的临床应用提供理论基础。
Berberis plants are rich in resources and have a long history of medicinal use, and they can be used to treat a variety of diseases. Among them, plants such as B. integerrima, B. aristata, B. vulgaris, B. microphylla, and B. julianae are studied deeper. The main components of the genus Berberis are alkaloids and flavonoids, and the most studied agent is berberine. It has pharmacological effects such as hypoglycemic, anti-inflammatory, antibacterial, etc., which can be used to treat diabetes and its complications.However, the study of berberine is not a substitute for the study of Berberis plants. This paper summarizes the pharmacological studies and its mechanism of action on the anti-diabetes and its complications of Berberis extract, so as to provide theoretical basis for promoting the clinical application of Berberis plants and its components.
Berberis plants are rich in resources and have a long history of medicinal use, and they can be used to treat a variety of diseases. Among them, plants such as B. integerrima, B. aristata, B. vulgaris, B. microphylla, and B. julianae are studied deeper. The main components of the genus Berberis are alkaloids and flavonoids, and the most studied agent is berberine. It has pharmacological effects such as hypoglycemic, anti-inflammatory, antibacterial, etc., which can be used to treat diabetes and its complications.However, the study of berberine is not a substitute for the study of Berberis plants. This paper summarizes the pharmacological studies and its mechanism of action on the anti-diabetes and its complications of Berberis extract, so as to provide theoretical basis for promoting the clinical application of Berberis plants and its components.
引文
[1]卢福恭,王汉卿,付慧玲,等.消渴病历代学术考证[J].辽宁中医药大学学报, 2018, 20(5):66-68
[2]靳英辉,王丹琦,李艳,等.临床实践指南制定方法——国内外临床实践指南制定手册概要[J].中国循证心血管医学杂志, 2018, 10(1):1-10
[3]徐亚,郑敏.中医药治疗2型糖尿病脂代谢异常的临床研究进展[J].中国中医药现代远程教育, 2018, 16(5):151-154
[4]邸多隆,刘晔玮,马志刚,等. HPLC法测定甘肃产小檗属植物不同部位的生物碱[J].中国中药杂志, 2003, 28(12):32-34.
[5]施小平.中国小檗属18种植物叶片形态与微形态特征及其分类学意义[D].南京:南京农业大学, 2016.
[6]范东旭,包海鹰.小檗属植物中生物碱成分及药理活性研究概述[J].人参研究, 2012(2):55-62.
[7]李贵生,侯佰良,张志坤.大叶小檗嫩枝全光雾扦插繁殖技术[J].林业工程学报, 2008, 22(3):103-105.
[8]马志刚,马秀英,杨平荣.我国30年来对小檗属药用植物的研究[J].甘肃科学学报, 1999, 11(1):76-79.
[9] Lee H Y. Studies on the constituents of Berberis amurensis Ruprecht[J]. Korean J Pharm, 1997, 28(4):257-263.
[10]武永进,朴惠顺.大叶小檗化学成分分析[J].延边大学医学学报, 2017, 40(4):262-265.
[11]季宇彬,刘欣,于蕾,等.四氢小檗碱药理作用研究进展[J].中草药, 2017, 48(24):5270-5275.
[12]黄娟,胡维,林湘东.盐酸小檗碱对2型糖尿病胰岛素抵抗的改善作用及其机制[J].中国老年学杂志, 2018,38(17):4130-4132.
[13]何田轩.小檗碱联合缬沙坦治疗糖尿病肾病的临床疗效及安全性评价[J].实用中西医结合临床, 2018, 18(8):8-10.
[14]芦琨,赫金凤,常景芝,等.小檗碱对糖尿病大鼠心血管的保护作用[J].医药导报,2018,37(05):518-522.
[15]张燕,孟宪丽,岳丽珺,等.藏药小檗皮对糖尿病模型小鼠血糖水平影响的初步研究[J].现代生物医学进展,2013, 13(19):3619-3622.
[16] Meliani N, Dib M E A, Allali H, et al. Hypoglycaemic effect of Berberis vulgaris L. in normal and streptozotocin-induced diabetic rats[J]. Asian Pac J Trop Biomed, 2011, 1(6):468-471.
[17] Ashraf H, Heidari R, Nejati V. Antihyperglycemic and antihyperlipidemic effects of fruit aqueous extract of Berberis integerrima Bge. in streptozotocin-induced diabetic rats[J]. Iran J Pharm Res, 2014, 13(4):1313-1318.
[18] Singh J, Kakkar P. Antihyperglycemic and antioxidant effect of Berberis aristata root extract and its role in regulating carbohydrate metabolism in diabetic rats[J]. J Ethnopharmacol, 2009, 123(1):22-26.
[19] Furrianca M C, Alvear M, Zambrano T, et al.Hypoglycemic effect of Berberis microphylla G. Forst root extract[J]. Trop J Pharm Res, 2017, 16(9):2179-2184.
[20]黄昭海.糖尿病肾病研究进展[J].中国中医药现代远程教育, 2011, 9(9):143-144.
[21] Alamgeer, Naz H, Rasool S, et al. Anti-inflammatory,analgesic and antipyretic activities of the aqueous methanolic extract of Berberis calliobotrys in albino mice[J]. Acta Polon Pharm, 73(3):717-723.
[22] Siddiqui F A, Ahmad M, Mehjabeen-et al. Phytochemical screening and assessment of analgesic, anti-inflammatory and hematological properties of the fruit of Berberis baluchistanica[J]. Pakistan J Pharmaceu Sci, 2017, 30(3Suppl):1007.
[23] Li Z, Geng Y N, Jiang J D, et al. Antioxidant and antiinflammatory activities of berberine in the treatment of diabetes mellitus[J]. Evid-Bas Comp Alter Med, 2014(33):289264.
[24] Choi B H, Ahn I S, Kim Y H, et al. Berberine reduces the expression of adipogenic enzymes and inflammatory molecules of 3T3-L1 adipocyte[J]. Exper Molec Med,2006, 38(6):599-605.
[25]王露.地黄水苏糖对糖尿病小鼠肠道菌群的影响[D].北京:北京协和医学院, 2013.
[26] Ali S, Igoli J, Clements C, et al. Antidiabetic and antimicrobial activities of fractions and compounds isolated from Berberis brevissima Jafri and Berberis parkeriana Schneid[J]. Bangladesh J Pharmacol, 2013, 8(3):336-342.
[27]朱慧敏,李莉.新疆黑果小檗根皮和根木质部提取物的体外抑菌活性比较研究[J].西北药学杂志, 2018, 33(4):492-495
[28] Singh M, Srivastava S, Rawat A. Antimicrobial activities of Indian Berberis species[J]. Fitoterapia, 2007, 78(7):574-576.
[29] Lutsar I, Friedland I R, Jafri H S, et al. Efficacy of gatifloxacin in experimental Escherichia coli meningitis[J]. Antimicrob Agen Chemother, 1999, 43(7):1805-1807.
[30]阿依西姑·巴伍敦,阿迪力·阿不都热合曼,赵双清,等.黑果小檗提取物对高脂血症大鼠血脂、血液流变学和脂质过氧化水平的影响[J].新疆医科大学学报,2018, 41(2):210-215
[31] Derosa G, Bonaventura A, Bianchi L, et al. Berberis aristata/Silybum marianum fixed combination on lipid profile and insulin secretion in dyslipidemic patients[J].Exp Opin Biol Ther, 2013, 13(11):1495-1506.
[32] Rajaei Z, Hajzadeh M A R, Shafiee S, et al. Effect of barberry fruit(Berberis vulgaris)on serum glucose and lipids in streptozotocin-diabetic rats[J]. Clinic Biochem,2011, 44(13):S334.
[33] Shidfar F, Ebrahimi S S, Hosseini S, et al. The effects of Berberis vulgaris fruit extract on serum lipoproteins,apoB, apoA-I, homocysteine, glycemic control and total antioxidant capacity in type 2 diabetic patients[J]. Iran J Pharm Res, 2012, 11(2):643-652.
[34]邹雪梅.中药方剂对妊娠期糖尿病氧化应激状态、细胞黏附因子及妊娠结局的影响[J].中医临床研究,2018, 10(2):12-15.
[35]黄河胜,马传庚.黄酮类化合物药理作用研究进展[J].中国中药杂志, 2000, 25(10):589-592.
[36]李莉,孙颖平,李思栋,等.黑果小檗总黄酮含量测定及体外抗氧化活性研究[J].安徽医药, 2013, 17(6):934-936.
[37]李金辉,王永,王绪英,等.威宁小檗中黄酮类化合物的抗氧化活性研究[J].六盘水师范学院学报, 2016, 28(4):4-8.
[38] Ali S, Igoli J, Clements C, et al. Antidiabetic and antimicrobial activities of fractions and compounds isolated from Berberis brevissima Jafri and Berberis parkeriana Schneid[J]. Bangladesh J Pharmacol, 2013, 8(3):336-342
[39] Pierro F D, Putignano P, Villanova N, et al. Preliminary study about the possible glycemic clinical advantage in using a fixed combination of Berberis aristata and Silybum marianum standardized extracts versus only Berberis aristata in patients with type 2 diabetes[J].Clinic Pharmacol Adv Appl, 2013, 5(Issue 1):167-174.
[40] Di P F, Bellone I, Rapacioli G, et al. Clinical role of a fixed combination of standardized Berberis aristata and Silybum marianum extracts in diabetic and hypercholesterolemic patients intolerant to statins[J].Diabet Metab Syndr Obes Targ Ther, 2015, 2015(default):89-96.
[41] Yang J, Zhao P, Wan D, et al. Antidiabetic effect of methanolic extract from Berberis julianae Schneid. via activation of AMP-activated protein kinase in type 2diabetic mice[J]. Evid-Bas Compl Alter Med, 2014, 2014(2):106206.
[42] Lazavi F, MIrmiran P, Sohrab G, et al. The barberry juice effects on metabolic factors and oxidative stress in patients with type 2 diabetes:A randomized clinical trial[J]. Comp Therap Clinic Pract, 2018, 31:170.
[43] Ni W J, Ding H H, Tang L Q. Berberine as a promising antidiabetic nephropathy drug:An analysis of its effects and mechanisms[J]. Eur J Pharmacol, 2015, 760:103-112.
[44] Ashraf H, Heidari R, Nejati V, et al. Aqueous extract of Berberis integerrima root improves renal dysfunction in streptozotocin induced diabetic rats[J]. Avicenna J Phytomed, 2013, 3(1):82-90.
[45] Pervez S, Saeed M, Khan H, et al. Nephroprotective effect of Berberis baluchistanica against gentamicin induced nephrotoxicity in rabbits[J]. Bangladesh J Pharmacol, 2018, 13(3):222-300.
[46] Tang L Q, Ni W J, Cai M, et al. Renoprotective effects of berberine and its potential effect on the expression ofβ-arrestins and intercellular adhesion molecule-1 and vascular cell adhesion molecule‐1 in streptozocin‐diabetic nephropathy rats[J]. J Diabet, 2016, 8(5):693-700.
[47] Zhu L, Han J, Yuan R, et al. Berberine ameliorates diabetic nephropathy by inhibiting TLR4/NF-κBpathway[J]. Biol Res, 2018, 51(1):9. DOI:10.1186/s40659-018-0157-8.
[48]岳丽珺,张燕,向丽,等.藏药吉尔巴对糖尿病性视网膜病变的影响及机制研究[J].中国实验方剂学杂志,2013, 19(20):149-153.
[49]岳丽珺,孟宪丽,张燕,等.藏药小檗皮对糖尿病大鼠视网膜PKC-β、VEGF、HIF-1α表达的影响[J].世界科学技术:中医药现代化, 2014, 16(1):181-186.
[50]赖先荣,叶凡,范刚,等.小檗皮水浸膏对db/db糖尿病小鼠视网膜病变的影响(Ⅰ)[J].中国实验方剂学杂志, 2016, 22(2):82-86.
[51]周邦华,叶凡,岳丽珺,等.小檗皮水浸膏对db/db糖尿病小鼠视网膜病变的影响(Ⅱ)[J].中国实验方剂学杂志, 2016, 22(24):116-121.
[52] Wei X C. Efficacy and safety of berberine in patients with type 2 diabetes mellitus:A Meta-analysis[J]. Chin Herb Medi, 2015, 7(4):344-353.
[2]靳英辉,王丹琦,李艳,等.临床实践指南制定方法——国内外临床实践指南制定手册概要[J].中国循证心血管医学杂志, 2018, 10(1):1-10
[3]徐亚,郑敏.中医药治疗2型糖尿病脂代谢异常的临床研究进展[J].中国中医药现代远程教育, 2018, 16(5):151-154
[4]邸多隆,刘晔玮,马志刚,等. HPLC法测定甘肃产小檗属植物不同部位的生物碱[J].中国中药杂志, 2003, 28(12):32-34.
[5]施小平.中国小檗属18种植物叶片形态与微形态特征及其分类学意义[D].南京:南京农业大学, 2016.
[6]范东旭,包海鹰.小檗属植物中生物碱成分及药理活性研究概述[J].人参研究, 2012(2):55-62.
[7]李贵生,侯佰良,张志坤.大叶小檗嫩枝全光雾扦插繁殖技术[J].林业工程学报, 2008, 22(3):103-105.
[8]马志刚,马秀英,杨平荣.我国30年来对小檗属药用植物的研究[J].甘肃科学学报, 1999, 11(1):76-79.
[9] Lee H Y. Studies on the constituents of Berberis amurensis Ruprecht[J]. Korean J Pharm, 1997, 28(4):257-263.
[10]武永进,朴惠顺.大叶小檗化学成分分析[J].延边大学医学学报, 2017, 40(4):262-265.
[11]季宇彬,刘欣,于蕾,等.四氢小檗碱药理作用研究进展[J].中草药, 2017, 48(24):5270-5275.
[12]黄娟,胡维,林湘东.盐酸小檗碱对2型糖尿病胰岛素抵抗的改善作用及其机制[J].中国老年学杂志, 2018,38(17):4130-4132.
[13]何田轩.小檗碱联合缬沙坦治疗糖尿病肾病的临床疗效及安全性评价[J].实用中西医结合临床, 2018, 18(8):8-10.
[14]芦琨,赫金凤,常景芝,等.小檗碱对糖尿病大鼠心血管的保护作用[J].医药导报,2018,37(05):518-522.
[15]张燕,孟宪丽,岳丽珺,等.藏药小檗皮对糖尿病模型小鼠血糖水平影响的初步研究[J].现代生物医学进展,2013, 13(19):3619-3622.
[16] Meliani N, Dib M E A, Allali H, et al. Hypoglycaemic effect of Berberis vulgaris L. in normal and streptozotocin-induced diabetic rats[J]. Asian Pac J Trop Biomed, 2011, 1(6):468-471.
[17] Ashraf H, Heidari R, Nejati V. Antihyperglycemic and antihyperlipidemic effects of fruit aqueous extract of Berberis integerrima Bge. in streptozotocin-induced diabetic rats[J]. Iran J Pharm Res, 2014, 13(4):1313-1318.
[18] Singh J, Kakkar P. Antihyperglycemic and antioxidant effect of Berberis aristata root extract and its role in regulating carbohydrate metabolism in diabetic rats[J]. J Ethnopharmacol, 2009, 123(1):22-26.
[19] Furrianca M C, Alvear M, Zambrano T, et al.Hypoglycemic effect of Berberis microphylla G. Forst root extract[J]. Trop J Pharm Res, 2017, 16(9):2179-2184.
[20]黄昭海.糖尿病肾病研究进展[J].中国中医药现代远程教育, 2011, 9(9):143-144.
[21] Alamgeer, Naz H, Rasool S, et al. Anti-inflammatory,analgesic and antipyretic activities of the aqueous methanolic extract of Berberis calliobotrys in albino mice[J]. Acta Polon Pharm, 73(3):717-723.
[22] Siddiqui F A, Ahmad M, Mehjabeen-et al. Phytochemical screening and assessment of analgesic, anti-inflammatory and hematological properties of the fruit of Berberis baluchistanica[J]. Pakistan J Pharmaceu Sci, 2017, 30(3Suppl):1007.
[23] Li Z, Geng Y N, Jiang J D, et al. Antioxidant and antiinflammatory activities of berberine in the treatment of diabetes mellitus[J]. Evid-Bas Comp Alter Med, 2014(33):289264.
[24] Choi B H, Ahn I S, Kim Y H, et al. Berberine reduces the expression of adipogenic enzymes and inflammatory molecules of 3T3-L1 adipocyte[J]. Exper Molec Med,2006, 38(6):599-605.
[25]王露.地黄水苏糖对糖尿病小鼠肠道菌群的影响[D].北京:北京协和医学院, 2013.
[26] Ali S, Igoli J, Clements C, et al. Antidiabetic and antimicrobial activities of fractions and compounds isolated from Berberis brevissima Jafri and Berberis parkeriana Schneid[J]. Bangladesh J Pharmacol, 2013, 8(3):336-342.
[27]朱慧敏,李莉.新疆黑果小檗根皮和根木质部提取物的体外抑菌活性比较研究[J].西北药学杂志, 2018, 33(4):492-495
[28] Singh M, Srivastava S, Rawat A. Antimicrobial activities of Indian Berberis species[J]. Fitoterapia, 2007, 78(7):574-576.
[29] Lutsar I, Friedland I R, Jafri H S, et al. Efficacy of gatifloxacin in experimental Escherichia coli meningitis[J]. Antimicrob Agen Chemother, 1999, 43(7):1805-1807.
[30]阿依西姑·巴伍敦,阿迪力·阿不都热合曼,赵双清,等.黑果小檗提取物对高脂血症大鼠血脂、血液流变学和脂质过氧化水平的影响[J].新疆医科大学学报,2018, 41(2):210-215
[31] Derosa G, Bonaventura A, Bianchi L, et al. Berberis aristata/Silybum marianum fixed combination on lipid profile and insulin secretion in dyslipidemic patients[J].Exp Opin Biol Ther, 2013, 13(11):1495-1506.
[32] Rajaei Z, Hajzadeh M A R, Shafiee S, et al. Effect of barberry fruit(Berberis vulgaris)on serum glucose and lipids in streptozotocin-diabetic rats[J]. Clinic Biochem,2011, 44(13):S334.
[33] Shidfar F, Ebrahimi S S, Hosseini S, et al. The effects of Berberis vulgaris fruit extract on serum lipoproteins,apoB, apoA-I, homocysteine, glycemic control and total antioxidant capacity in type 2 diabetic patients[J]. Iran J Pharm Res, 2012, 11(2):643-652.
[34]邹雪梅.中药方剂对妊娠期糖尿病氧化应激状态、细胞黏附因子及妊娠结局的影响[J].中医临床研究,2018, 10(2):12-15.
[35]黄河胜,马传庚.黄酮类化合物药理作用研究进展[J].中国中药杂志, 2000, 25(10):589-592.
[36]李莉,孙颖平,李思栋,等.黑果小檗总黄酮含量测定及体外抗氧化活性研究[J].安徽医药, 2013, 17(6):934-936.
[37]李金辉,王永,王绪英,等.威宁小檗中黄酮类化合物的抗氧化活性研究[J].六盘水师范学院学报, 2016, 28(4):4-8.
[38] Ali S, Igoli J, Clements C, et al. Antidiabetic and antimicrobial activities of fractions and compounds isolated from Berberis brevissima Jafri and Berberis parkeriana Schneid[J]. Bangladesh J Pharmacol, 2013, 8(3):336-342
[39] Pierro F D, Putignano P, Villanova N, et al. Preliminary study about the possible glycemic clinical advantage in using a fixed combination of Berberis aristata and Silybum marianum standardized extracts versus only Berberis aristata in patients with type 2 diabetes[J].Clinic Pharmacol Adv Appl, 2013, 5(Issue 1):167-174.
[40] Di P F, Bellone I, Rapacioli G, et al. Clinical role of a fixed combination of standardized Berberis aristata and Silybum marianum extracts in diabetic and hypercholesterolemic patients intolerant to statins[J].Diabet Metab Syndr Obes Targ Ther, 2015, 2015(default):89-96.
[41] Yang J, Zhao P, Wan D, et al. Antidiabetic effect of methanolic extract from Berberis julianae Schneid. via activation of AMP-activated protein kinase in type 2diabetic mice[J]. Evid-Bas Compl Alter Med, 2014, 2014(2):106206.
[42] Lazavi F, MIrmiran P, Sohrab G, et al. The barberry juice effects on metabolic factors and oxidative stress in patients with type 2 diabetes:A randomized clinical trial[J]. Comp Therap Clinic Pract, 2018, 31:170.
[43] Ni W J, Ding H H, Tang L Q. Berberine as a promising antidiabetic nephropathy drug:An analysis of its effects and mechanisms[J]. Eur J Pharmacol, 2015, 760:103-112.
[44] Ashraf H, Heidari R, Nejati V, et al. Aqueous extract of Berberis integerrima root improves renal dysfunction in streptozotocin induced diabetic rats[J]. Avicenna J Phytomed, 2013, 3(1):82-90.
[45] Pervez S, Saeed M, Khan H, et al. Nephroprotective effect of Berberis baluchistanica against gentamicin induced nephrotoxicity in rabbits[J]. Bangladesh J Pharmacol, 2018, 13(3):222-300.
[46] Tang L Q, Ni W J, Cai M, et al. Renoprotective effects of berberine and its potential effect on the expression ofβ-arrestins and intercellular adhesion molecule-1 and vascular cell adhesion molecule‐1 in streptozocin‐diabetic nephropathy rats[J]. J Diabet, 2016, 8(5):693-700.
[47] Zhu L, Han J, Yuan R, et al. Berberine ameliorates diabetic nephropathy by inhibiting TLR4/NF-κBpathway[J]. Biol Res, 2018, 51(1):9. DOI:10.1186/s40659-018-0157-8.
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